Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Brugia malayi | Integrin beta pat-3 precursor | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus multilocularis | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Loa Loa (eye worm) | integrin beta-2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-3 precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma mansoni | integrin beta subunit | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-PS precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | ko:K06464 integrin beta 2, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0252 | 0.0038 | 0.0038 |
Echinococcus granulosus | enteropeptidase | 0.0252 | 0.0038 | 0.0145 |
Loa Loa (eye worm) | hypothetical protein | 0.206 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0297 | 0.0286 | 0.0286 |
Loa Loa (eye worm) | thymidylate synthase | 0.0727 | 0.2658 | 0.2658 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0297 | 0.0286 | 0.0944 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0346 | 0.0558 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0252 | 0.0038 | 0.0038 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0577 | 0.1833 | 0.6896 |
Mycobacterium ulcerans | thymidylate synthase | 0.0727 | 0.2658 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0252 | 0.0038 | 0.0038 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0727 | 0.2658 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.0038 | 0.0038 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0252 | 0.0038 | 0.0038 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0252 | 0.0038 | 0.0038 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0252 | 0.0038 | 0.0038 |
Brugia malayi | Trypsin family protein | 0.0252 | 0.0038 | 0.0038 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0252 | 0.0038 | 0.0038 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0577 | 0.1833 | 0.3415 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0577 | 0.1833 | 0.1833 |
Onchocerca volvulus | 0.1808 | 0.8614 | 0.8614 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1024 | 0.4291 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1024 | 0.4291 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.206 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1024 | 0.4291 | 1 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0252 | 0.0038 | 0.0145 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0252 | 0.0038 | 0.0038 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0252 | 0.0038 | 0.0038 |
Onchocerca volvulus | 0.0727 | 0.2658 | 0.2658 | |
Echinococcus multilocularis | integrin beta 2 | 0.0322 | 0.0424 | 0.1595 |
Schistosoma mansoni | hypothetical protein | 0.0252 | 0.0038 | 0.0038 |
Brugia malayi | Trypsin family protein | 0.0252 | 0.0038 | 0.0038 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0252 | 0.0038 | 0.0145 |
Schistosoma mansoni | integrin beta subunit | 0.0253 | 0.0044 | 0.0044 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1024 | 0.4291 | 1 |
Onchocerca volvulus | 0.0252 | 0.0038 | 0.0038 | |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0252 | 0.0038 | 0.0145 |
Schistosoma mansoni | hypothetical protein | 0.0252 | 0.0038 | 0.0038 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0252 | 0.0038 | 0.0038 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0439 | 0.1072 | 0.1072 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0252 | 0.0038 | 0.0038 |
Echinococcus multilocularis | thymidylate synthase | 0.0727 | 0.2658 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.0038 | 0.0038 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0252 | 0.0038 | 0.0038 |
Echinococcus multilocularis | Mastin | 0.0252 | 0.0038 | 0.0145 |
Schistosoma mansoni | dihydrofolate reductase | 0.0297 | 0.0286 | 0.0286 |
Brugia malayi | Kringle domain containing protein | 0.0577 | 0.1833 | 0.1833 |
Schistosoma mansoni | hypothetical protein | 0.0577 | 0.1833 | 0.1833 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.0038 | 0.0038 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0252 | 0.0038 | 0.0145 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0252 | 0.0038 | 0.0038 |
Brugia malayi | hypothetical protein | 0.0346 | 0.0558 | 0.0558 |
Brugia malayi | thymidylate synthase | 0.0727 | 0.2658 | 0.2658 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0252 | 0.0038 | 0.0145 |
Echinococcus multilocularis | enteropeptidase | 0.0252 | 0.0038 | 0.0145 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0252 | 0.0038 | 0.0038 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0252 | 0.0038 | 0.0038 |
Toxoplasma gondii | kringle domain-containing protein | 0.0577 | 0.1833 | 0.4271 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0252 | 0.0038 | 0.0145 |
Onchocerca volvulus | 0.0252 | 0.0038 | 0.0038 | |
Echinococcus granulosus | tissue type plasminogen activator | 0.0577 | 0.1833 | 0.6896 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0252 | 0.0038 | 0.0038 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0252 | 0.0038 | 0.0038 |
Onchocerca volvulus | 0.0252 | 0.0038 | 0.0038 | |
Brugia malayi | dihydrofolate reductase family protein | 0.0297 | 0.0286 | 0.0286 |
Loa Loa (eye worm) | hypothetical protein | 0.0577 | 0.1833 | 0.1833 |
Echinococcus granulosus | thymidylate synthase | 0.0727 | 0.2658 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0346 | 0.0558 | 0.1148 |
Echinococcus granulosus | integrin beta 2 | 0.0322 | 0.0424 | 0.1595 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.206 | 1 | 1 |
Onchocerca volvulus | 0.0252 | 0.0038 | 0.0038 | |
Echinococcus granulosus | dihydrofolate reductase | 0.0297 | 0.0286 | 0.1075 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.0038 | 0.0038 |
Onchocerca volvulus | 0.206 | 1 | 1 | |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0252 | 0.0038 | 0.0145 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0252 | 0.0038 | 0.0038 |
Onchocerca volvulus | 0.0252 | 0.0038 | 0.0038 | |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0297 | 0.0286 | 0.0286 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1024 | 0.4291 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0577 | 0.1833 | 0.1833 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0252 | 0.0038 | 0.0145 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.206 | 1 | 1 |
Echinococcus granulosus | Mastin | 0.0252 | 0.0038 | 0.0145 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0297 | 0.0286 | 0.1075 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0297 | 0.0286 | 0.5 |
Loa Loa (eye worm) | trypsin family protein | 0.0252 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | integrin beta-2 | 0.0439 | 0.1072 | 0.1072 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0252 | 0.0038 | 0.0038 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0252 | 0.0038 | 0.0038 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0727 | 0.2658 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1024 | 0.4291 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0252 | 0.0038 | 0.0038 |
Onchocerca volvulus | 0.0577 | 0.1833 | 0.1833 | |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0727 | 0.2658 | 0.2658 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.