TDR Targets

Basic information

Technical information

TDR Targets ID: 318070
Name: N-(4-tert-butylphenyl)-4-(3-methylpyridin-2-y l)benzamide
MW: 344.449 | Formula: C23H24N2O
H donors: 1 H acceptors: 2 LogP: 5.39 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc(cc1)c1ncccc1C)Nc1ccc(cc1)C(C)(C)C
InChi: 1S/C23H24N2O/c1-16-6-5-15-24-21(16)17-7-9-18(10-8-17)22(26)25-20-13-11-19(12-14-20)23(2,3)4/h5-15H,1-4H3,(H,25,26)
InChiKey: HNENYCYVYIYIHV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-tert-butylphenyl)-4-(3-methyl-2-pyridyl)benzamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	transient receptor potential cation channel, subfamily V, member 1	Starlite/ChEMBL	References
Rattus norvegicus	Vanilloid receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0542	0.2394	0.2394
Entamoeba histolytica	hypothetical protein	0.0038	0.0096	0.0208
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0087	0.0316	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0107	0.0093
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.0143	0.0143
Schistosoma mansoni	nuclear receptor	0.0041	0.0107	0.017
Brugia malayi	thymidylate synthase	0.0106	0.0403	0.0403
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0087	0.0316	0.0302
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.184	0.831	1
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0316	0.0302
Echinococcus granulosus	nuclear receptor nhr 48	0.0041	0.0107	0.0111
Schistosoma mansoni	nuclear hormone receptor	0.0041	0.0107	0.017
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0087	0.0316	0.0554
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0087	0.0316	0.0363
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0172	0.0703	0.0689
Brugia malayi	nuclear hormone receptor	0.0087	0.0316	0.0316
Loa Loa (eye worm)	hypothetical protein	0.0371	0.1611	0.1599
Brugia malayi	Steroid receptor seven-up type 2	0.0087	0.0316	0.0316
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0875	0.3909	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0041	0.0107	0.0107
Brugia malayi	RNA recognition motif domain containing protein	0.0068	0.0229	0.0229
Giardia lamblia	Flap structure-specific endonuclease	0.0028	0.0048	1
Echinococcus multilocularis	dna polymerase eta	0.0048	0.0139	0.0149
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0041	0.0107	0.0111
Brugia malayi	nuclear receptor NHR-88	0.0041	0.0107	0.0107
Schistosoma mansoni	hypothetical protein	0.0345	0.1492	0.2716
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0041	0.0107	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0107	0.0093
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.0143	0.0129
Echinococcus multilocularis	nuclear receptor nhr 48	0.0041	0.0107	0.0111
Trypanosoma cruzi	DNA polymerase eta, putative	0.0048	0.0139	0.0318
Leishmania major	DNA polymerase eta, putative	0.0048	0.0139	0.0318
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0087	0.0316	0.0316
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0875	0.3909	0.39
Schistosoma mansoni	nuclear receptor	0.0041	0.0107	0.017
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0875	0.3909	0.4695
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0149	0.0599	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0107	0.0093
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0149	0.0599	0.1501
Schistosoma mansoni	nuclear hormone receptor	0.0087	0.0316	0.0554
Brugia malayi	steroid hormone receptor	0.0087	0.0316	0.0316
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0087	0.0316	0.0302
Echinococcus granulosus	thyroid hormone receptor alpha	0.0041	0.0107	0.0111
Leishmania major	DNA polymerase eta, putative	0.0034	0.0074	0.0152
Schistosoma mansoni	RAR-like nuclear receptor	0.0087	0.0316	0.0554
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0043	0.0117	0.2645
Echinococcus granulosus	thymidylate synthase	0.0106	0.0403	0.0468
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0087	0.0316	0.0363
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0229	0.0394
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0028	0.0048	0.0084
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0087	0.0316	0.0316
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0316	0.0302
Brugia malayi	hypothetical protein	0.0041	0.0107	0.0107
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0087	0.0316	0.0316
Brugia malayi	ecdysteroid receptor	0.0087	0.0316	0.0316
Brugia malayi	nuclear hormone receptor	0.0041	0.0107	0.0107
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0087	0.0316	0.0363
Brugia malayi	hypothetical protein	0.005	0.015	0.015
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0041	0.0107	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0107	0.0093
Echinococcus multilocularis	GPCR, family 2	0.0172	0.0703	0.083
Plasmodium falciparum	flap endonuclease 1	0.0028	0.0048	0.0073
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0015	0.0015
Leishmania major	hypothetical protein, conserved	0.0027	0.0043	0.0074
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0046	0.0129	0.0138
Brugia malayi	ImpB/MucB/SamB family protein	0.0048	0.0139	0.0139
Brugia malayi	conserved hypotetical protein	0.0041	0.0107	0.0107
Loa Loa (eye worm)	thymidylate synthase	0.0106	0.0403	0.0389
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0028	0.0048	0.0084
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0087	0.0316	0.0302
Loa Loa (eye worm)	nuclear hormone receptor	0.0041	0.0107	0.0093
Schistosoma mansoni	hypothetical protein	0.0345	0.1492	0.2716
Entamoeba histolytica	hypothetical protein	0.0038	0.0096	0.0208
Brugia malayi	photoreceptor-specific nuclear receptor	0.0087	0.0316	0.0316
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0087	0.0316	0.0316
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0087	0.0316	0.0554
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0316	0.0302
Trypanosoma brucei	DNA polymerase eta, putative	0.0048	0.0139	0.0318
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0034	0.0074	0.0548
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0149	0.0599	1
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0875	0.3909	1
Brugia malayi	nuclear receptor RXR	0.0046	0.0129	0.0129
Loa Loa (eye worm)	steroid hormone receptor	0.0087	0.0316	0.0302
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0043	0.0074
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0143	0.0155
Echinococcus multilocularis	tar DNA binding protein	0.0068	0.0229	0.0258
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0041	0.0107	0.017
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0542	0.2394	0.2382
Schistosoma mansoni	retinoic acid receptor RXR	0.1214	0.5453	1
Brugia malayi	hypothetical protein	0.0046	0.0129	0.0129
Brugia malayi	Nuclear hormone receptor E75	0.0041	0.0107	0.0107
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0149	0.0599	0.1501
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0875	0.3909	1
Brugia malayi	nuclear receptor RXR	0.0041	0.0107	0.0107
Loa Loa (eye worm)	RNA binding protein	0.0068	0.0229	0.0215
Loa Loa (eye worm)	TAR-binding protein	0.0068	0.0229	0.0215
Brugia malayi	hypothetical protein	0.0038	0.0096	0.0096
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0087	0.0316	0.0554
Brugia malayi	orphan nuclear receptor NR2E1	0.0041	0.0107	0.0107
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0041	0.0107	0.0111
Onchocerca volvulus	Protein ultraspiracle homolog	0.0087	0.0316	0.7058
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0143	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0107	0.0093
Echinococcus granulosus	FTZ F1 alpha	0.0087	0.0316	0.0363
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0087	0.0316	0.0554
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0087	0.0316	0.0363
Entamoeba histolytica	hypothetical protein	0.0038	0.0096	0.0208
Onchocerca volvulus		0.0087	0.0316	0.7058
Echinococcus granulosus	GPCR family 2	0.0172	0.0703	0.083
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0041	0.0107	0.0111
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0087	0.0316	0.0363
Echinococcus multilocularis	thymidylate synthase	0.0106	0.0403	0.0468
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0041	0.0107	0.0111
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0087	0.0316	0.0316
Echinococcus granulosus	dna polymerase eta	0.0048	0.0139	0.0149
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0043	0.0117	0.2645
Schistosoma mansoni	hypothetical protein	0.0172	0.0703	0.1266
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0107	0.0093
Brugia malayi	Nuclear hormone receptor E75	0.0041	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0129	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0316	0.0302
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0096	0.0098
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0143	0.0155
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.015	1
Brugia malayi	dihydrofolate reductase family protein	0.0043	0.0117	0.0117
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0087	0.0316	0.0316
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0875	0.3909	0.3909
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0041	0.0107	0.017
Brugia malayi	Nuclear hormone receptor-like 1	0.0046	0.0129	0.0129
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0106	0.0403	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0143	0.0237
Schistosoma mansoni	thyroid hormone receptor	0.0087	0.0316	0.0554
Schistosoma mansoni	hypothetical protein	0.0371	0.1611	0.2936
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0875	0.3909	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.0041	0.0107	0.0107
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0087	0.0316	0.0302
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0316	0.0302
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0875	0.3909	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0041	0.0107	0.0111
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0028	0.0048	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0316	0.0302
Schistosoma mansoni	DNA polymerase eta	0.0048	0.0139	0.0228
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0041	0.0107	0.0107
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0106	0.0403	1
Brugia malayi	tailless protein	0.0041	0.0107	0.0107
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0043	0.0074
Mycobacterium ulcerans	thymidylate synthase	0.0106	0.0403	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0087	0.0316	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0129	0.0115
Echinococcus multilocularis	geminin	0.0345	0.1492	0.178
Plasmodium vivax	flap endonuclease 1, putative	0.0028	0.0048	0.0073
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0068	0.0229	0.0215
Brugia malayi	Latrophilin receptor protein 2	0.0172	0.0703	0.0703
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0106	0.0403	0.0714
Schistosoma mansoni	hypothetical protein	0.0038	0.0096	0.0149
Schistosoma mansoni	thyroid hormone receptor	0.0087	0.0316	0.0554
Brugia malayi	ecdysone receptor	0.0041	0.0107	0.0107
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.1214	0.5453	0.6556
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0043	0.0074
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0087	0.0316	0.0554
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0149	0.0599	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0087	0.0316	0.0554
Echinococcus multilocularis	ecdysone induced protein 78C	0.0087	0.0316	0.0363
Brugia malayi	hypothetical protein	0.0027	0.0043	0.0043
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0087	0.0316	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0316	0.0302
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0139	0.0124
Brugia malayi	hypothetical protein	0.0041	0.0107	0.0107
Echinococcus granulosus	flap endonuclease 1	0.0028	0.0048	0.004
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0149	0.0599	0.1501
Loa Loa (eye worm)	flap endonuclease-1	0.0028	0.0048	0.0033
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0143	0.0155
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0172	0.0703	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0107	0.0093
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0087	0.0316	0.0363
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0028	0.0048	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0129	0.0115
Brugia malayi	hypothetical protein	0.0046	0.0129	0.0129
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0087	0.0316	0.0554
Echinococcus granulosus	dihydrofolate reductase	0.0043	0.0117	0.0124
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0087	0.0316	0.0363
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0143	0.0237
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0143	0.0155
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0046	0.0129	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0043	0.0029
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0087	0.0316	0.0316
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0087	0.0316	0.0316
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0087	0.0316	0.0316
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0107	0.0093
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0875	0.3909	0.7161
Onchocerca volvulus		0.0106	0.0403	1
Schistosoma mansoni	nuclear hormone receptor	0.0041	0.0107	0.017
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0107	0.0093
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.1168	0.5244	0.6304
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0087	0.0316	0.0302
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.005	0.015	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0107	0.0093
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0041	0.0107	0.0093
Brugia malayi	latrophilin 2 splice variant baaae	0.0371	0.1611	0.1611
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0129	0.0115
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0172	0.0703	0.083
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0875	0.3909	0.4695
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0046	0.0129	0.0211
Loa Loa (eye worm)	DR-78	0.0041	0.0107	0.0093
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0087	0.0316	0.0302
Brugia malayi	Nuclear hormone receptor-like 1	0.0087	0.0316	0.0316
Brugia malayi	Nuclear hormone receptor-like 1	0.0046	0.0129	0.0129
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.184	0.831	1
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0229	0.0394
Schistosoma mansoni	dihydrofolate reductase	0.0043	0.0117	0.0189
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0087	0.0316	0.0316
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0129	0.0115
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0041	0.0107	0.0111
Loa Loa (eye worm)	dihydrofolate reductase	0.0043	0.0117	0.0103
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0046	0.0129	0.0211
Brugia malayi	Dihydrofolate reductase	0.0043	0.0117	0.0117
Schistosoma mansoni	coup transcription factor	0.0087	0.0316	0.0554
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0087	0.0316	0.0302
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0316	0.0302
Echinococcus granulosus	tar DNA binding protein	0.0068	0.0229	0.0258
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0229	0.0394
Echinococcus multilocularis	FTZ F1 alpha	0.0087	0.0316	0.0363
Schistosoma mansoni	hypothetical protein	0.0172	0.0703	0.1266
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0087	0.0316	0.0316
Schistosoma mansoni	zinc finger protein	0.0041	0.0107	0.017
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0096	0.0098
Schistosoma mansoni	hypothetical protein	0.0172	0.0703	0.1266
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0172	0.0703	0.083
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0229	0.0394
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0087	0.0316	0.0363
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0229	0.0394
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0087	0.0316	0.0363
Echinococcus granulosus	ecdysone induced protein 78C	0.0087	0.0316	0.0363
Brugia malayi	Flap endonuclease-1	0.0028	0.0048	0.0048
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0087	0.0316	0.0316
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0046	0.0129	0.0138
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0087	0.0316	0.7058
Schistosoma mansoni	hypothetical protein	0.0172	0.0703	0.1266
Chlamydia trachomatis	dihydrofolate reductase	0.0043	0.0117	0.5
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0107	0.0093
Schistosoma mansoni	flap endonuclease-1	0.0025	0.0035	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0107	0.0093
Entamoeba histolytica	Flap nuclease, putative	0.0028	0.0048	0.0084
Echinococcus granulosus	geminin	0.0345	0.1492	0.178
Echinococcus multilocularis	dihydrofolate reductase	0.0043	0.0117	0.0124
Entamoeba histolytica	hypothetical protein	0.0038	0.0096	0.0208
Onchocerca volvulus	Bile acid receptor homolog	0.0087	0.0316	0.7058
Trichomonas vaginalis	flap endonuclease-1, putative	0.0028	0.0048	0.2423
Loa Loa (eye worm)	hypothetical protein	0.2211	1	1
Schistosoma mansoni	nuclear receptor nhr-48	0.0041	0.0107	0.017
Trypanosoma cruzi	DNA polymerase eta, putative	0.0034	0.0074	0.0152
Echinococcus granulosus	transcription factor Dp 1	0.0506	0.2229	0.267
Brugia malayi	TAR-binding protein	0.0068	0.0229	0.0229
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0087	0.0316	0.0363
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0041	0.0107	0.0093
Echinococcus multilocularis	flap endonuclease 1	0.0028	0.0048	0.004
Mycobacterium tuberculosis	Hypothetical protein	0.005	0.015	0.3489
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0096	0.0149
Brugia malayi	nuclear receptor NHR-67	0.0041	0.0107	0.0107
Brugia malayi	RNA binding protein	0.0068	0.0229	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0172	0.0703	0.0689
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0087	0.0316	0.0316
Brugia malayi	nuclear receptor NHR-88	0.0087	0.0316	0.0316
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0107	0.0093
Echinococcus multilocularis	transcription factor Dp 1	0.0506	0.2229	0.267

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 9 nM	Antagonist activity against low pH(5.0-5.5)-activated rat VR1	ChEMBL.	16870426
IC50 (functional)	= 9 nM	Antagonist activity against low pH(5.0-5.5)-activated rat VR1	ChEMBL.	16870426
IC50 (functional)	= 11 nM	Antagonist activity against capsaicin-activated human VR1 by FLIPR assay	ChEMBL.	16870426
IC50 (functional)	= 11 nM	Antagonist activity against capsaicin-activated human VR1 by FLIPR assay	ChEMBL.	16870426
IC50 (functional)	uM	In vitro agonistic activity on VR1 receptor in [Ca2+] influx assay in rat dorsal root ganglion (NE: not effective at 30 uM)	ChEMBL.	15664827
IC50 (functional)	0 uM	In vitro agonistic activity on VR1 receptor in [Ca2+] influx assay in rat dorsal root ganglion (NE: not effective at 30 uM)	ChEMBL.	15664827
IC50 (functional)	= 0.031 uM	In vitro antagonistic activity on VR1 receptor in [Ca2+] influx assay in rat dorsal root ganglion	ChEMBL.	15664827
IC50 (functional)	= 0.031 uM	In vitro antagonistic activity on VR1 receptor in [Ca2+] influx assay in rat dorsal root ganglion	ChEMBL.	15664827

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL180138
PubChem: 11187009

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 318070