Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.424 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.4147 | 0.9546 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.4147 | 0.9546 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.4147 | 0.9546 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.4147 | 0.9546 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.424 | 1 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.424 | 1 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.4147 | 0.9546 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.424 | 1 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.4147 | 0.9546 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.4147 | 0.9546 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.424 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.4147 | 0.9546 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.4147 | 0.9546 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.4147 | 0.9546 | 1 |
Onchocerca volvulus | 0.2185 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cleavage (functional) | = 43.7 % | Percentage of cleavage in single stranded peptide nucleic acid (PNA) | ChEMBL. | 15664802 |
Cleavage (functional) | = 69.1 % | Percentage of cleavage in single stranded peptide nucleic acid was measured after treating with compound for 30 min; selectivity factor=1.6; PNA:DNA=5a:6 | ChEMBL. | 15664802 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.