Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0111 | 0.035 | 0.0364 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.0726 | 0.0726 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0111 | 0.035 | 0.045 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0111 | 0.035 | 0.035 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0111 | 0.035 | 0.035 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0111 | 0.035 | 0.045 |
Echinococcus granulosus | transcription factor Dp 1 | 0.071 | 0.4336 | 0.4336 |
Brugia malayi | thymidylate synthase | 0.013 | 0.0475 | 0.0611 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.0475 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0342 | 0.1886 | 0.1886 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0111 | 0.035 | 0.045 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0111 | 0.035 | 0.045 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0111 | 0.035 | 0.045 |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0.0475 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0111 | 0.035 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.035 | 0.045 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.0829 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0111 | 0.035 | 0.045 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0111 | 0.035 | 0.045 |
Onchocerca volvulus | 0.013 | 0.0475 | 1 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0111 | 0.035 | 0.045 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.0475 | 0.0611 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0111 | 0.035 | 0.035 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0111 | 0.035 | 0.045 |
Echinococcus multilocularis | geminin | 0.0168 | 0.0726 | 0.0755 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0111 | 0.035 | 0.035 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0111 | 0.035 | 0.0364 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0111 | 0.035 | 0.045 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0111 | 0.035 | 0.035 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.0475 | 0.0475 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.1226 | 0.7775 | 0.7775 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0111 | 0.035 | 0.035 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.1226 | 0.7775 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0111 | 0.035 | 0.045 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0111 | 0.035 | 0.0364 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0.0021 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.0475 | 0.0495 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0111 | 0.035 | 0.035 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0111 | 0.035 | 0.0364 |
Echinococcus multilocularis | snurportin 1 | 0.0342 | 0.1886 | 0.1963 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0111 | 0.035 | 0.045 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0111 | 0.035 | 0.045 |
Brugia malayi | nuclear receptor NHR-88 | 0.0111 | 0.035 | 0.045 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.071 | 0.4336 | 0.4512 |
Echinococcus granulosus | geminin | 0.0168 | 0.0726 | 0.0726 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.1226 | 0.7775 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0111 | 0.035 | 0.0364 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0111 | 0.035 | 0.045 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.035 | 0.045 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0111 | 0.035 | 0.0364 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0111 | 0.035 | 0.0364 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.1501 | 0.9608 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0111 | 0.035 | 0.035 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.1226 | 0.7775 | 0.7775 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0111 | 0.035 | 0.045 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0111 | 0.035 | 0.035 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0111 | 0.035 | 0.0364 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.035 | 0.045 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0111 | 0.035 | 0.045 |
Brugia malayi | hypothetical protein | 0.0062 | 0.0021 | 0.0027 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0111 | 0.035 | 0.035 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0111 | 0.035 | 0.035 |
Schistosoma mansoni | thyroid hormone receptor | 0.0111 | 0.035 | 0.035 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0111 | 0.035 | 0.035 |
Brugia malayi | steroid hormone receptor | 0.0111 | 0.035 | 0.045 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.0726 | 0.0726 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.0475 | 0.0475 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.156 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0111 | 0.035 | 0.045 |
Schistosoma mansoni | nuclear hormone receptor | 0.0111 | 0.035 | 0.035 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.035 | 0.045 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.0829 | 0.1042 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.035 | 0.045 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.035 | 0.045 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.0829 | 0.5 |
Echinococcus granulosus | snurportin 1 | 0.0342 | 0.1886 | 0.1886 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0111 | 0.035 | 0.045 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0342 | 0.1886 | 0.2426 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0111 | 0.035 | 0.045 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0111 | 0.035 | 0.045 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0111 | 0.035 | 0.045 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0111 | 0.035 | 0.045 |
Echinococcus granulosus | FTZ F1 alpha | 0.0111 | 0.035 | 0.035 |
Schistosoma mansoni | thyroid hormone receptor | 0.0111 | 0.035 | 0.035 |
Brugia malayi | RNA, U transporter 1 | 0.0091 | 0.0215 | 0.0276 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0111 | 0.035 | 0.045 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0111 | 0.035 | 0.0364 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.1226 | 0.7775 | 0.8093 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.035 | 0.045 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0111 | 0.035 | 0.035 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.013 | 0.0475 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0111 | 0.035 | 0.035 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0111 | 0.035 | 0.045 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.1226 | 0.7775 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.1226 | 0.7775 | 0.5 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.1226 | 0.7775 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.1226 | 0.7775 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.1226 | 0.7775 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0111 | 0.035 | 0.045 |
Brugia malayi | ecdysteroid receptor | 0.0111 | 0.035 | 0.045 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0111 | 0.035 | 0.035 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0183 | 0.0829 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.035 | 0.045 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0 uM | Inhibitory activity against HIV-1 mutant strain 103N; ND = Not determined | ChEMBL. | 15481987 |
IC50 (functional) | 0 uM | Inhibitory activity against HIV-1 mutant strain 181C; ND = Not determined | ChEMBL. | 15481987 |
IC50 (functional) | 0 uM | Inhibitory activity against HIV-1 mutant strain 188L; ND = not determined | ChEMBL. | 15481987 |
IC50 (functional) | = 1.25 uM | Inhibitory activity against wild type HIV-1 LAI cell line | ChEMBL. | 15481987 |
Selectivity index (functional) | = 79 uM | Selectivity index of cytotoxic activity (CC50) to inhibitory activity (IC50) relative to LAI cell line | ChEMBL. | 15481987 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.