Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0842 | 0.33 | 0.33 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0842 | 0.33 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0842 | 0.33 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0842 | 0.33 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0842 | 0.33 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0578 | 0.105 | 0.105 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0842 | 0.33 | 0.2514 |
Echinococcus multilocularis | cysteine protease | 0.0842 | 0.33 | 0.33 |
Brugia malayi | Cathepsin L-like precursor | 0.0578 | 0.105 | 0.105 |
Plasmodium vivax | vivapain-2 | 0.0842 | 0.33 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0842 | 0.33 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0842 | 0.33 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0842 | 0.33 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0842 | 0.33 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1626 | 1 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0842 | 0.33 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0578 | 0.105 | 0.105 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0635 | 0.1538 | 0.1538 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0842 | 0.33 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0842 | 0.33 | 1 |
Leishmania major | cathepsin L-like protease | 0.0842 | 0.33 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0842 | 0.33 | 0.33 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0842 | 0.33 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0842 | 0.33 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0578 | 0.105 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0842 | 0.33 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0842 | 0.33 | 0.33 |
Onchocerca volvulus | 0.0842 | 0.33 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0842 | 0.33 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0842 | 0.33 | 1 |
Onchocerca volvulus | 0.0842 | 0.33 | 1 | |
Loa Loa (eye worm) | cathepsin B | 0.0635 | 0.1538 | 0.0546 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0842 | 0.33 | 0.33 |
Leishmania major | cathepsin L-like protease | 0.0842 | 0.33 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0842 | 0.33 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0578 | 0.105 | 0.3182 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0842 | 0.33 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0842 | 0.33 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0842 | 0.33 | 0.33 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0842 | 0.33 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1626 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0842 | 0.33 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0842 | 0.33 | 1 |
Leishmania major | cathepsin L-like protease | 0.0842 | 0.33 | 1 |
Echinococcus granulosus | cathepsin b | 0.1626 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1626 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0842 | 0.33 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0842 | 0.33 | 0.33 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0842 | 0.33 | 0.33 |
Onchocerca volvulus | Cathepsin F homolog | 0.0842 | 0.33 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0842 | 0.33 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0842 | 0.33 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0842 | 0.33 | 0.33 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0842 | 0.33 | 0.33 |
Echinococcus granulosus | cathepsin l1 | 0.0842 | 0.33 | 0.33 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0842 | 0.33 | 0.33 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0842 | 0.33 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0578 | 0.105 | 0.105 |
Leishmania major | cathepsin L-like protease | 0.0842 | 0.33 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0842 | 0.33 | 0.33 |
Loa Loa (eye worm) | fibroinase | 0.0842 | 0.33 | 0.2514 |
Leishmania major | cathepsin L-like protease | 0.0842 | 0.33 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0635 | 0.1538 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0842 | 0.33 | 1 |
Onchocerca volvulus | 0.0842 | 0.33 | 1 | |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0578 | 0.105 | 0.105 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0842 | 0.33 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0842 | 0.33 | 0.33 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0842 | 0.33 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0842 | 0.33 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0842 | 0.33 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0842 | 0.33 | 0.2514 |
Leishmania major | cathepsin L-like protease | 0.0842 | 0.33 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0842 | 0.33 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0842 | 0.33 | 0.2514 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0842 | 0.33 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0842 | 0.33 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0842 | 0.33 | 0.33 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0842 | 0.33 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0842 | 0.33 | 1 |
Leishmania major | cathepsin L-like protease | 0.0842 | 0.33 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0635 | 0.1538 | 0.4661 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0842 | 0.33 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1626 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0842 | 0.33 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0842 | 0.33 | 0.33 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0842 | 0.33 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0842 | 0.33 | 0.33 |
Giardia lamblia | Cathepsin B precursor | 0.0635 | 0.1538 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0842 | 0.33 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0842 | 0.33 | 1 |
Plasmodium vivax | vivapain-2 | 0.0842 | 0.33 | 1 |
Echinococcus granulosus | cathepsin b | 0.1626 | 1 | 1 |
Onchocerca volvulus | 0.0842 | 0.33 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0842 | 0.33 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0842 | 0.33 | 0.33 |
Loa Loa (eye worm) | hypothetical protein | 0.1626 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0578 | 0.105 | 0.105 |
Brugia malayi | Cathepsin L-like precursor | 0.0842 | 0.33 | 0.33 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0842 | 0.33 | 0.2514 |
Brugia malayi | cathepsin L-like precursor | 0.0578 | 0.105 | 0.105 |
Brugia malayi | Cathepsin L-like precursor | 0.0842 | 0.33 | 0.33 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1626 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.1626 | 1 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0842 | 0.33 | 0.2514 |
Onchocerca volvulus | 0.0842 | 0.33 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0578 | 0.105 | 0.3182 |
Onchocerca volvulus | 0.0842 | 0.33 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0842 | 0.33 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0842 | 0.33 | 0.33 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0635 | 0.1538 | 0.4661 |
Echinococcus multilocularis | cathepsin b | 0.1626 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0842 | 0.33 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0842 | 0.33 | 0.33 |
Brugia malayi | Cathepsin L-like precursor | 0.0842 | 0.33 | 0.33 |
Onchocerca volvulus | 0.0842 | 0.33 | 1 | |
Giardia lamblia | Cathepsin B precursor | 0.0635 | 0.1538 | 0.5 |
Onchocerca volvulus | Cathepsin L homolog | 0.0842 | 0.33 | 1 |
Leishmania major | cathepsin L-like protease | 0.0842 | 0.33 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0842 | 0.33 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0635 | 0.1538 | 0.1538 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | NA 0 uM | Cytoprotective activity of the compound on rat tunicamycin treated rat pheochromocytoma cell line PC12 from apoptosis induced by Endoplasmic reticulum stress; NA = Not active upto 100 uM | ChEMBL. | 16002288 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.