TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 471.571 | Formula: C27H25N3O3S
H donors: 2 H acceptors: 3 LogP: 6.33 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C1CCCCC1)Nc1nc2c(s1)cc(cc2)NC(=O)c1ccccc1Oc1ccccc1
InChi: 1S/C27H25N3O3S/c31-25(18-9-3-1-4-10-18)30-27-29-22-16-15-19(17-24(22)34-27)28-26(32)21-13-7-8-14-23(21)33-20-11-5-2-6-12-20/h2,5-8,11-18H,1,3-4,9-10H2,(H,28,32)(H,29,30,31)
InChiKey: WPZCORTWYNZVRV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0184	0.0184
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0112	0.0589	0.0589
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0059	0.0248	0.038
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0116	0.0121
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0112	0.0589	0.0902
Trypanosoma brucei	DNA polymerase eta, putative	0.0048	0.0177	0.0271
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0307	0.0307
Brugia malayi	TAR-binding protein	0.0068	0.0307	0.0469
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0112	0.0589	0.0902
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0112	0.0589	0.0589
Brugia malayi	ecdysteroid receptor	0.0112	0.0589	0.0902
Echinococcus multilocularis	ecdysone induced protein 78C	0.0112	0.0589	0.0613
Plasmodium falciparum	flap endonuclease 1	0.0028	0.0047	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0207	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0207	0.0317
Loa Loa (eye worm)	DR-78	0.0053	0.0207	0.0317
Schistosoma mansoni	nuclear receptor	0.0053	0.0207	0.0207
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0184	0.0184
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0059	0.0248	0.0248
Trypanosoma cruzi	DNA polymerase eta, putative	0.0034	0.0085	0.013
Brugia malayi	hypothetical protein	0.0059	0.0248	0.038
Brugia malayi	hypothetical protein	0.0027	0.0041	0.0063
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0034	0.0085	1
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0589	0.0902
Brugia malayi	ImpB/MucB/SamB family protein	0.0048	0.0177	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0589	0.0902
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0053	0.0207	0.0207
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0112	0.0589	0.0589
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0207	0.0317
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0059	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0207	0.0317
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0112	0.0589	0.0589
Schistosoma mansoni	thyroid hormone receptor	0.0112	0.0589	0.0589
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0207	0.0317
Loa Loa (eye worm)	nuclear hormone receptor	0.0053	0.0207	0.0317
Trichomonas vaginalis	flap endonuclease-1, putative	0.0028	0.0047	1
Schistosoma mansoni	retinoic acid receptor RXR	0.1564	1	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0248	0.038
Schistosoma mansoni	zinc finger protein	0.0053	0.0207	0.0207
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0053	0.0207	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0207	0.0317
Brugia malayi	hypothetical protein	0.0039	0.0116	0.0178
Brugia malayi	Nuclear hormone receptor-like 1	0.0059	0.0248	0.038
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0112	0.0589	0.0589
Echinococcus granulosus	flap endonuclease 1	0.0028	0.0047	0.0047
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0112	0.0589	0.0902
Schistosoma mansoni	flap endonuclease-1	0.0025	0.003	0.003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0112	0.0589	0.0902
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0053	0.0207	0.0207
Entamoeba histolytica	hypothetical protein	0.0039	0.0116	0.0178
Onchocerca volvulus	Protein ultraspiracle homolog	0.0112	0.0589	1
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.1029	0.6532	1
Brugia malayi	nuclear hormone receptor	0.0112	0.0589	0.0902
Schistosoma mansoni	hypothetical protein	0.0039	0.0116	0.0116
Echinococcus multilocularis	transcription factor Dp 1	0.0596	0.3724	0.3872
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0053	0.0207	0.0317
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.1029	0.6532	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0112	0.0589	0.0902
Leishmania major	DNA polymerase eta, putative	0.0034	0.0085	0.013
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0112	0.0589	0.0613
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0053	0.0207	0.0207
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0059	0.0248	0.0248
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0112	0.0589	0.0902
Entamoeba histolytica	Flap nuclease, putative	0.0028	0.0047	0.0072
Echinococcus granulosus	thyroid hormone receptor alpha	0.0053	0.0207	0.0207
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0112	0.0589	0.0902
Schistosoma mansoni	nuclear hormone receptor	0.0112	0.0589	0.0589
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0116	0.0116
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0116	0.0116
Echinococcus granulosus	nuclear receptor nhr 48	0.0053	0.0207	0.0207
Schistosoma mansoni	nuclear hormone receptor	0.0053	0.0207	0.0207
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0184	0.0184
Loa Loa (eye worm)	TAR-binding protein	0.0068	0.0307	0.0469
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0248	0.038
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0307	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0207	0.0317
Schistosoma mansoni	nuclear receptor	0.0053	0.0207	0.0207
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0053	0.0207	0.0215
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0053	0.0207	0.0215
Brugia malayi	Steroid receptor seven-up type 2	0.0112	0.0589	0.0902
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0112	0.0589	0.0613
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0112	0.0589	0.0613
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0112	0.0589	0.0902
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0207	0.0317
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0112	0.0589	0.0902
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0021	0	0.5
Brugia malayi	steroid hormone receptor	0.0112	0.0589	0.0902
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0028	0.0047	0.1335
Brugia malayi	nuclear receptor RXR	0.0059	0.0248	0.038
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0207	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0589	0.0902
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.1029	0.6532	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0112	0.0589	0.0589
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0028	0.0047	0.0072
Brugia malayi	Nuclear hormone receptor E75	0.0053	0.0207	0.0317
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0112	0.0589	0.0589
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.1029	0.6532	0.6791
Echinococcus multilocularis	geminin	0.0347	0.2112	0.2196
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.1029	0.6532	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.0053	0.0207	0.0215
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0184	0.0191
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0112	0.0589	0.0613
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0184	0.0191
Schistosoma mansoni	DNA polymerase eta	0.0048	0.0177	0.0177
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0112	0.0589	0.0902
Brugia malayi	nuclear receptor NHR-88	0.0053	0.0207	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0589	0.0902
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0068	0.0307	0.0469
Brugia malayi	Nuclear hormone receptor-like 1	0.0059	0.0248	0.038
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.0184	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0177	0.0271
Schistosoma mansoni	hypothetical protein	0.0347	0.2112	0.2112
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0053	0.0207	0.0207
Trypanosoma cruzi	DNA polymerase eta, putative	0.0048	0.0177	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0589	0.0902
Entamoeba histolytica	hypothetical protein	0.0039	0.0116	0.0178
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0307	0.0307
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.1029	0.6532	0.6532
Loa Loa (eye worm)	steroid hormone receptor	0.0112	0.0589	0.0902
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.1029	0.6532	0.6532
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0041	0.0063
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0112	0.0589	0.0902
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0112	0.0589	0.0589
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0307	0.0307
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0112	0.0589	0.0902
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0112	0.0589	0.0902
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0589	0.0902
Echinococcus multilocularis	FTZ F1 alpha	0.0112	0.0589	0.0613
Brugia malayi	RNA recognition motif domain containing protein	0.0068	0.0307	0.0469
Entamoeba histolytica	hypothetical protein	0.0039	0.0116	0.0178
Brugia malayi	ecdysone receptor	0.0053	0.0207	0.0317
Echinococcus multilocularis	dna polymerase eta	0.0048	0.0177	0.0184
Schistosoma mansoni	thyroid hormone receptor	0.0112	0.0589	0.0589
Loa Loa (eye worm)	flap endonuclease-1	0.0028	0.0047	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0589	0.0902
Brugia malayi	tailless protein	0.0053	0.0207	0.0317
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0053	0.0207	0.0215
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0053	0.0207	0.0317
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.1029	0.6532	1
Loa Loa (eye worm)	RNA binding protein	0.0068	0.0307	0.0469
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0184	0.0184
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0112	0.0589	0.0613
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0112	0.0589	0.0902
Brugia malayi	nuclear hormone receptor family member odr-7	0.0053	0.0207	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0248	0.038
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0248	0.038
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0589	0.0902
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0053	0.0207	0.0207
Brugia malayi	orphan nuclear receptor NR2E1	0.0053	0.0207	0.0317
Brugia malayi	hypothetical protein	0.0059	0.0248	0.038
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0041	0.0063
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.0184	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0207	0.0317
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0184	0.0184
Brugia malayi	Nuclear hormone receptor-like 1	0.0112	0.0589	0.0902
Schistosoma mansoni	coup transcription factor	0.0112	0.0589	0.0589
Echinococcus multilocularis	flap endonuclease 1	0.0028	0.0047	0.0049
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0112	0.0589	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0059	0.0248	0.0258
Brugia malayi	nuclear receptor RXR	0.0053	0.0207	0.0317
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0112	0.0589	0.0589
Echinococcus granulosus	tar DNA binding protein	0.0068	0.0307	0.0307
Brugia malayi	nuclear receptor NHR-88	0.0112	0.0589	0.0902
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0207	0.0317
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0112	0.0589	0.0589
Brugia malayi	nuclear receptor NHR-67	0.0053	0.0207	0.0317
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0053	0.0207	0.0207
Schistosoma mansoni	nuclear receptor nhr-48	0.0053	0.0207	0.0207
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0028	0.0047	0.0072
Brugia malayi	RNA binding protein	0.0068	0.0307	0.0469
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0112	0.0589	0.0902
Giardia lamblia	Flap structure-specific endonuclease	0.0028	0.0047	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0112	0.0589	0.0902
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.1505	0.9618	1
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.1029	0.6532	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0112	0.0589	0.0589
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0112	0.0589	0.0902
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0112	0.0589	0.0902
Echinococcus multilocularis	tar DNA binding protein	0.0068	0.0307	0.0319
Echinococcus granulosus	geminin	0.0347	0.2112	0.2112
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0041	0.0063
Schistosoma mansoni	nuclear hormone receptor	0.0053	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0207	0.0317
Schistosoma mansoni	hypothetical protein	0.0347	0.2112	0.2112
Echinococcus granulosus	dna polymerase eta	0.0048	0.0177	0.0177
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0307	0.0307
Plasmodium vivax	flap endonuclease 1, putative	0.0028	0.0047	1
Brugia malayi	nuclear hormone receptor	0.0053	0.0207	0.0317
Entamoeba histolytica	hypothetical protein	0.0039	0.0116	0.0178
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0112	0.0589	0.0613
Brugia malayi	conserved hypotetical protein	0.0053	0.0207	0.0317
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0112	0.0589	0.0589
Brugia malayi	Flap endonuclease-1	0.0028	0.0047	0.0072
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0053	0.0207	0.0317
Echinococcus granulosus	FTZ F1 alpha	0.0112	0.0589	0.0589
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0041	0.0063
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0	0.5
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0112	0.0589	0.0589
Brugia malayi	hypothetical protein	0.0053	0.0207	0.0317
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0112	0.0589	0.0589
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0112	0.0589	0.0902
Brugia malayi	hypothetical protein	0.0053	0.0207	0.0317
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.1029	0.6532	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0112	0.0589	0.0902
Leishmania major	DNA polymerase eta, putative	0.0048	0.0177	0.0271
Leishmania major	hypothetical protein, conserved	0.0027	0.0041	0.0063
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0112	0.0589	0.0902
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0112	0.0589	0.0613
Echinococcus granulosus	ecdysone induced protein 78C	0.0112	0.0589	0.0589
Brugia malayi	Nuclear hormone receptor E75	0.0053	0.0207	0.0317
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0053	0.0207	0.0317
Echinococcus granulosus	transcription factor Dp 1	0.0596	0.3724	0.3724
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0028	0.0047	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0248	0.038
Onchocerca volvulus		0.0112	0.0589	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0207	0.0317
Onchocerca volvulus	Bile acid receptor homolog	0.0112	0.0589	1

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 100 ng ml-1	Cytotoxicity against tumorigenic cell line WI-38 VA-13 subline 2RA (VA-13);no cytotoxicity against parental cell line WI-38	ChEMBL.	15955697
EC50 (functional)	= 100 ng ml-1	Cytotoxicity against tumorigenic cell line WI-38 VA-13 subline 2RA (VA-13);no cytotoxicity against parental cell line WI-38	ChEMBL.	15955697

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 318544