Detailed information for compound 318677

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 501.739 | Formula: C25H13Cl3F2N2O
  • H donors: 0 H acceptors: 2 LogP: 7.74 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: N#Cc1cc(c2ccc(cc2)Cl)c(nc1OCc1cc(F)cc(c1)F)c1ccc(cc1Cl)Cl
  • InChi: 1S/C25H13Cl3F2N2O/c26-17-3-1-15(2-4-17)22-9-16(12-31)25(33-13-14-7-19(29)11-20(30)8-14)32-24(22)21-6-5-18(27)10-23(21)28/h1-11H,13H2
  • InChiKey: NJTKTPGFVGYUCD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cannabinoid receptor 1 (brain) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0054 0.0278 0.0643
Echinococcus granulosus Tubulin beta 2C chain 0.0021 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0058 0.0307 0.0307
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0059 0.1394
Toxoplasma gondii beta-tubulin, putative 0.0021 0.0066 0.0021
Echinococcus multilocularis fibrillin 1 0.0026 0.0103 0.0103
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0037 0.0173 0.5908
Brugia malayi Trypsin family protein 0.0016 0.0035 0.0035
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0019 0.0056 0.0053
Giardia lamblia Beta tubulin 0.0021 0.0066 0.452
Onchocerca volvulus Arrow homolog 0.0026 0.0103 0.1221
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0016 0.0035 0.002
Echinococcus multilocularis voltage gated potassium channel 0.0016 0.004 0.004
Trypanosoma brucei beta tubulin 0.0021 0.0066 0.0154
Loa Loa (eye worm) hypothetical protein 0.0029 0.0119 0.0119
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0035 0.016 0.016
Brugia malayi EGF-like domain containing protein 0.0029 0.0119 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0027 0.0172
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0016 0.0035 0.002
Onchocerca volvulus 0.0029 0.0119 0.1521
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0026 0.0104 0.0104
Echinococcus granulosus neural cadherin 0.0029 0.0119 0.0119
Onchocerca volvulus Chorion peroxidase homolog 0.0058 0.0307 0.4925
Echinococcus granulosus protein jagged 1 0.0029 0.0119 0.0119
Brugia malayi Calcium binding EGF domain containing protein 0.0029 0.0119 0.0119
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0064 0.0346 0.0753
Echinococcus multilocularis protein jagged 2 0.0029 0.0119 0.0119
Echinococcus granulosus Tubulin beta 2C chain 0.0021 0.0066 0.0066
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0026 0.0103 0.0103
Giardia lamblia GTOR 0.0025 0.0098 0.7758
Trypanosoma cruzi target of rapamycin kinase 3 0.0021 0.0067 0.008
Toxoplasma gondii kringle domain-containing protein 0.0035 0.0156 0.0262
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0026 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0058 0.0307 0.0307
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0016 0.0035 0.002
Echinococcus multilocularis tissue type plasminogen activator 0.0035 0.0156 0.0156
Loa Loa (eye worm) tubulin beta-2A chain 0.0021 0.0066 0.0066
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0023 0.0023
Trichomonas vaginalis tubulin alpha chain, putative 0.0021 0.0066 0.1703
Echinococcus multilocularis neural cadherin 0.0029 0.0119 0.0119
Loa Loa (eye worm) phosphatidylinositol 3 0.0089 0.0503 0.0503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0047 0.0956
Echinococcus granulosus voltage gated potassium channel 0.0016 0.004 0.004
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0026 0.0103 0.0103
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0014 0.0023 0.0023
Schistosoma mansoni notch 0.0029 0.0119 0.0104
Echinococcus granulosus mitogen activated protein kinase 14 0.0127 0.0748 0.0748
Echinococcus multilocularis glycoprotein Antigen 5 0.0016 0.0035 0.0035
Trichomonas vaginalis tubulin, putative 0.0021 0.0066 0.1703
Brugia malayi Protein kinase domain containing protein 0.0026 0.0104 0.0104
Plasmodium falciparum cysteine repeat modular protein 1 0.0035 0.0156 0.0242
Toxoplasma gondii beta-1 tubulin, putative 0.0021 0.0066 0.0021
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0029 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0058 0.0307 0.0307
Brugia malayi Delta serrate ligand family protein 0.0029 0.0119 0.0119
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0054 0.0278 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0016 0.0035 0.0035
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0025 0.0098 0.0163
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0019 0.0056 0.1305
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0025 0.0098 0.1869
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0098 0.293
Echinococcus multilocularis neurogenic locus protein delta 0.0029 0.0119 0.0119
Toxoplasma gondii EGF family domain-containing protein 0.0029 0.0119 0.0163
Schistosoma mansoni notch 0.0029 0.0119 0.0104
Brugia malayi hypothetical protein 0.0016 0.0035 0.0035
Onchocerca volvulus 0.0102 0.0587 1
Schistosoma mansoni notch 0.0029 0.0119 0.0104
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0064 0.0346 0.0346
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0603 0.3783 1
Brugia malayi Cadherin domain containing protein 0.0029 0.0119 0.0119
Echinococcus multilocularis neurogenic locus protein delta 0.0029 0.0119 0.0119
Echinococcus multilocularis mitogen activated protein kinase 14 0.0127 0.0748 0.0748
Brugia malayi Dihydrofolate reductase 0.1577 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0027 0.0106 0.325
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0023 0.0007
Schistosoma mansoni cercarial elastase (S01 family) 0.0016 0.0035 0.002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0056 0.0056
Loa Loa (eye worm) beta-tubulin 0.0021 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0058 0.0307 0.0307
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0098 0.293
Echinococcus granulosus protein jagged 1 0.0029 0.0119 0.0119
Echinococcus multilocularis slit 2 protein 0.0029 0.0119 0.0119
Echinococcus multilocularis sodium channel protein 0.0064 0.0346 0.0346
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.004 0.0024
Echinococcus granulosus tubulin beta 4A class IVa 0.0021 0.0066 0.0066
Echinococcus multilocularis neurogenic locus notch protein 0.0029 0.0119 0.0119
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0127 0.0748 0.0748
Loa Loa (eye worm) BEN-1 protein 0.0021 0.0066 0.0066
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0023 0.0007
Brugia malayi Trypsin-like protease protein 5 0.0016 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0058 0.0307 0.0307
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.016 0.016
Brugia malayi hypothetical protein 0.0058 0.0307 0.0307
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0026 0.0103 0.0087
Giardia lamblia Beta tubulin 0.0021 0.0066 0.452
Loa Loa (eye worm) hypothetical protein 0.0029 0.0119 0.0119
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0016 0.004 0.004
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0016 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0058 0.0307 0.0307
Onchocerca volvulus 0.0058 0.0307 0.4925
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0058 0.0307 0.0307
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.017 0.017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0036 0.0517
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0104 0.3177
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0026 0.0104 0.0104
Echinococcus multilocularis Tubulin beta 2C chain 0.0021 0.0066 0.0066
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0025 0.0093 0.1637
Schistosoma mansoni hypothetical protein 0.0016 0.0035 0.002
Loa Loa (eye worm) hypothetical protein 0.0058 0.0307 0.0307
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0603 0.3783 1
Trypanosoma cruzi beta tubulin, putative 0.0021 0.0066 0.008
Loa Loa (eye worm) hypothetical protein 0.0029 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0029 0.0119 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0059 0.1394
Echinococcus granulosus dihydrofolate reductase 0.1577 1 1
Entamoeba histolytica hypothetical protein 0.0043 0.021 0.6931
Trypanosoma brucei beta tubulin 0.0021 0.0066 0.0154
Brugia malayi Muscle positioning protein 4 0.0029 0.0119 0.0119
Echinococcus multilocularis Tubulin beta 2C chain 0.0021 0.0066 0.0066
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0013 0.0017 0.0023
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0023 0.0023
Toxoplasma gondii beta tubulin 0.0021 0.0066 0.0021
Brugia malayi EGF-like domain containing protein 0.0029 0.0119 0.0119
Brugia malayi EGF-like domain containing protein 0.0029 0.0119 0.0119
Loa Loa (eye worm) tubulin beta chain 0.0021 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0029 0.0119 0.0119
Schistosoma mansoni cercarial elastase (S01 family) 0.0016 0.0035 0.002
Leishmania major hypothetical protein, conserved 0.0035 0.0156 0.0242
Schistosoma mansoni hypothetical protein 0.0029 0.0119 0.0104
Giardia lamblia High cysteine protein 0.0029 0.0119 1
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0027 0.0106 0.8575
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.017 0.017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0066 0.1703
Onchocerca volvulus 0.0029 0.0119 0.1521
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0027 0.0167
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Loa Loa (eye worm) TK/ROR protein kinase 0.0035 0.0156 0.0156
Echinococcus multilocularis Mastin 0.0016 0.0035 0.0035
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0054 0.0278 0.0643
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0027 0.0172
Trichomonas vaginalis tubulin gamma chain, putative 0.0021 0.0066 0.1703
Echinococcus granulosus calcium activated potassium channel 0.0011 0.0003 0.0003
Brugia malayi Animal haem peroxidase family protein 0.0058 0.0307 0.0307
Schistosoma mansoni tubulin subunit beta 0.0021 0.0066 0.0051
Echinococcus granulosus neurogenic locus notch protein 0.0029 0.0119 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0027 0.0167
Echinococcus multilocularis notch 0.0029 0.0119 0.0119
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0014 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0058 0.0307 0.0307
Loa Loa (eye worm) animal heme peroxidase 0.0058 0.0307 0.0307
Schistosoma mansoni cercarial elastase (S01 family) 0.0016 0.0035 0.002
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0016 0.0035 0.0035
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0016 0.004 0.004
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0023 0.0023
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0014 0.0023 0.0023
Onchocerca volvulus Dual oxidase homolog 0.0058 0.0307 0.4925
Schistosoma mansoni egf-like domain protein 0.0026 0.0103 0.0087
Loa Loa (eye worm) dihydrofolate reductase 0.1577 1 1
Brugia malayi EGF-like domain containing protein 0.0029 0.0119 0.0119
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0051 0.0258 0.911
Echinococcus multilocularis protein jagged 1 0.0029 0.0119 0.0119
Schistosoma mansoni slit 0.0029 0.0119 0.0104
Schistosoma mansoni hypothetical protein 0.0029 0.0119 0.0104
Onchocerca volvulus 0.0058 0.0307 0.4925
Schistosoma mansoni cercarial elastase (S01 family) 0.0016 0.0035 0.002
Loa Loa (eye worm) hypothetical protein 0.0058 0.0307 0.0307
Schistosoma mansoni cercarial elastase (S01 family) 0.0016 0.0035 0.002
Echinococcus multilocularis mitogen activated protein kinase 11 0.0127 0.0748 0.0748
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0016 0.0035 0.0035
Brugia malayi phosphoinositide-dependent protein kinase I 0.0026 0.0104 0.0104
Echinococcus multilocularis peroxidasin 0.0058 0.0307 0.0307
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0044 0.0827
Loa Loa (eye worm) tubulin beta-1 chain 0.0021 0.0066 0.0066
Schistosoma mansoni cercarial elastase (S01 family) 0.0016 0.0035 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0059 0.1394
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0035
Echinococcus granulosus mitogen activated protein kinase 11 0.0127 0.0748 0.0748
Toxoplasma gondii calcium binding egf domain-containing protein 0.0026 0.0103 0.0119
Brugia malayi Trypsin family protein 0.0016 0.0035 0.0035
Loa Loa (eye worm) trypsin family protein 0.0016 0.0035 0.0035
Echinococcus granulosus Tubulin beta 2C chain 0.0021 0.0066 0.0066
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0104 0.3177
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0025 0.0098 0.0084
Echinococcus granulosus Tubulin beta 2C chain 0.0021 0.0066 0.0066
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0016 0.0035 0.002
Loa Loa (eye worm) hypothetical protein 0.0029 0.0119 0.0119
Echinococcus multilocularis beta tubulin 0.0021 0.0066 0.0066
Schistosoma mansoni notch 0.0029 0.0119 0.0104
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0035 0.016 0.016
Echinococcus granulosus delta-like protein 1 0.0029 0.0119 0.0119
Echinococcus multilocularis Tubulin beta 2C chain 0.0021 0.0066 0.0066
Echinococcus multilocularis mitogen activated protein kinase 14 0.0127 0.0748 0.0748
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0027 0.0172
Echinococcus granulosus protein jagged 2 0.0029 0.0119 0.0119
Schistosoma mansoni hypothetical protein 0.0029 0.0119 0.0104
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0603 0.3783 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0021 0.0066 0.1703
Loa Loa (eye worm) animal heme peroxidase 0.0058 0.0307 0.0307
Onchocerca volvulus 0.0086 0.0487 0.8186
Brugia malayi beta-tubulin, identical 0.0021 0.0066 0.0066
Schistosoma mansoni tubulin subunit beta 0.0021 0.0066 0.0051
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0098 0.293
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0104 0.0088
Echinococcus granulosus tubulin subunit beta 0.0021 0.0066 0.0066
Brugia malayi Cadherin domain containing protein 0.0029 0.0119 0.0119
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0025 0.0098 0.0084
Schistosoma mansoni cercarial elastase (S01 family) 0.0016 0.0035 0.002
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0127 0.0748 0.1959
Schistosoma mansoni notch 0.0029 0.0119 0.0104
Brugia malayi Kringle domain containing protein 0.0035 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0029 0.0119 0.0119
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.01 0.0571 0.0571
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0025 0.0098 0.0236
Brugia malayi Protein kinase domain containing protein 0.0035 0.0156 0.0156
Echinococcus multilocularis Tubulin beta 2C chain 0.0021 0.0066 0.0066
Echinococcus multilocularis fibropellin Ia 0.0029 0.0119 0.0119
Onchocerca volvulus 0.0029 0.0119 0.1521
Brugia malayi Peroxidasin 0.0058 0.0307 0.0307
Schistosoma mansoni hypothetical protein 0.0016 0.0035 0.002
Schistosoma mansoni peroxidasin 0.0058 0.0307 0.0292
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0016 0.0035 0.0035
Entamoeba histolytica tubulin family protein 0.0021 0.0066 0.0458
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0023 0.0007
Onchocerca volvulus Putative cubilin 0.0029 0.0119 0.1521
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0102 0.0587 0.0573
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0156 0.0319
Loa Loa (eye worm) hypothetical protein 0.0033 0.0145 0.0145
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0127 0.0748 0.1898
Brugia malayi Calcium binding EGF domain containing protein 0.0029 0.0119 0.0119
Echinococcus multilocularis tubulin subunit beta 0.0021 0.0066 0.0066
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0029 0.0119 0.0104
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0026 0.0103 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0059 0.1394
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0021 0.0067 0.0154
Loa Loa (eye worm) tubulin beta-4 chain 0.0021 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0029 0.0119 0.0119
Brugia malayi notch-like transmembrane receptor 0.0029 0.0119 0.0119
Onchocerca volvulus 0.0035 0.0156 0.219
Trichomonas vaginalis tubulin beta chain, putative 0.0021 0.0066 0.1703
Entamoeba histolytica protein kinase, putative 0.0026 0.0104 0.2153
Echinococcus multilocularis beta tubulin 0.0021 0.0066 0.0066
Echinococcus granulosus neurogenic locus notch protein 0.0029 0.0119 0.0119
Echinococcus granulosus Mastin 0.0016 0.0035 0.0035
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0016 0.0035 0.002
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0026 0.0104 0.0104
Schistosoma mansoni hypothetical protein 0.0035 0.0156 0.0141
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.1577 1 1
Brugia malayi EGF-like domain containing protein 0.0029 0.0119 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0066 0.1703
Brugia malayi Calcium binding EGF domain containing protein 0.0026 0.0103 0.0103
Schistosoma mansoni tubulin subunit beta 0.0021 0.0066 0.0051
Echinococcus multilocularis laminin 0.0026 0.0103 0.0103
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0127 0.0748 0.1898
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0036 0.0517
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0023 0.0007
Brugia malayi P38 map kinase family protein 2 0.0127 0.0748 0.0748
Loa Loa (eye worm) hypothetical protein 0.0029 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0603 0.3783 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0102 0.0587 0.0573
Brugia malayi Animal haem peroxidase family protein 0.0058 0.0307 0.0307
Brugia malayi EGF-like domain containing protein 0.0029 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0029 0.0119 0.0119
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0037 0.0037
Trypanosoma brucei beta tubulin 0.0021 0.0066 0.0154
Schistosoma mansoni hypothetical protein 0.0029 0.0119 0.0104
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0603 0.3783 1
Loa Loa (eye worm) BEN-1 protein 0.0021 0.0066 0.0066
Schistosoma mansoni laminin gamma-3 chain 0.0029 0.0119 0.0104
Loa Loa (eye worm) hypothetical protein 0.0058 0.0307 0.0307
Onchocerca volvulus Neurogenic locus notch homolog 0.0029 0.012 0.154
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0029 0.0119 0.0119
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0104 0.3177
Brugia malayi Animal haem peroxidase family protein 0.0058 0.0307 0.0307
Schistosoma mansoni dihydrofolate reductase 0.1577 1 1
Echinococcus granulosus tubulin beta 1 chain 0.0021 0.0066 0.0066
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0043 0.021 0.6931
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0035 0.0156 0.0242
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0037 0.0173 0.5908
Brugia malayi Tubulin beta-1 chain 0.0021 0.0066 0.0066
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0014 0.0023 0.0023
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0023 0.0023
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0098 0.0098
Loa Loa (eye worm) notch protein 0.0029 0.0119 0.0119
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0029 0.0119 0.1521
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0014 0.0023 0.0023
Echinococcus granulosus laminin 0.0026 0.0103 0.0103
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0026 0.0104 0.0104
Echinococcus granulosus tissue type plasminogen activator 0.0035 0.0156 0.0156
Brugia malayi Trypsin family protein 0.0102 0.0587 0.0587
Echinococcus granulosus notch 0.0029 0.0119 0.0119
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.01 0.0571 0.0556
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0019 0.0056 0.1305
Schistosoma mansoni tubulin subunit beta 0.0021 0.0066 0.0051
Brugia malayi Blistered cuticle protein 3 0.0058 0.0307 0.0307
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0019 0.0056 0.1305
Brugia malayi Animal haem peroxidase family protein 0.0058 0.0307 0.0307
Loa Loa (eye worm) animal heme peroxidase 0.0058 0.0307 0.0307
Onchocerca volvulus Peroxidase homolog 0.0058 0.0307 0.4925
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0075 0.2053
Echinococcus multilocularis Tubulin beta 2C chain 0.0021 0.0066 0.0066
Echinococcus granulosus neurogenic locus protein delta 0.0029 0.0119 0.0119
Onchocerca volvulus 0.0029 0.0119 0.1521
Echinococcus granulosus neurogenic locus notch protein 4 0.0029 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0102 0.0587 0.0587
Echinococcus granulosus Tubulin beta 2C chain 0.0021 0.0066 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0059 0.1394
Schistosoma mansoni cell polarity protein 0.0029 0.0119 0.0104
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0029 0.0119 0.0104
Loa Loa (eye worm) hypothetical protein 0.0029 0.0119 0.0119
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0029 0.0119 0.0104
Echinococcus granulosus beta tubulin 0.0021 0.0066 0.0066
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0186 0.0171
Schistosoma mansoni cercarial elastase (S01 family) 0.0016 0.0035 0.002
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.1577 1 0.5
Echinococcus granulosus fibropellin Ia 0.0029 0.0119 0.0119
Echinococcus multilocularis protein jagged 1 0.0029 0.0119 0.0119
Echinococcus multilocularis tubulin beta 1 chain 0.0021 0.0066 0.0066
Echinococcus granulosus glycoprotein Antigen 5 0.0016 0.0035 0.0035
Echinococcus multilocularis fat cadherin tumor suppressor 0.0029 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0029 0.0119 0.0119
Onchocerca volvulus Peroxidase homolog 0.0058 0.0307 0.4925
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0054 0.0278 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0025 0.0098 0.0098
Echinococcus granulosus peroxidasin 0.0058 0.0307 0.0307
Schistosoma mansoni cercarial elastase (S01 family) 0.0016 0.0035 0.002
Loa Loa (eye worm) blistered cuticle protein 3 0.0058 0.0307 0.0307
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0025 0.0098 0.0082
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.017 0.017
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0014 0.0023 0.0023
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0023 0.0023
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0016 0.0035 0.002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0278 0.0278
Echinococcus granulosus beta tubulin 0.0021 0.0066 0.0066
Echinococcus multilocularis Tolloid protein 1 0.0026 0.0103 0.0103
Chlamydia trachomatis dihydrofolate reductase 0.1577 1 0.5
Echinococcus granulosus slit 2 protein 0.0029 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0102 0.0587 0.0587
Onchocerca volvulus Slit protein homolog 0.0029 0.0119 0.1521
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0036 0.0517
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0066 0.1703
Brugia malayi Trypsin family protein 0.0016 0.0035 0.0035
Trypanosoma brucei beta tubulin 0.0021 0.0066 0.0154
Loa Loa (eye worm) hypothetical protein 0.0058 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0035
Schistosoma mansoni tubulin subunit beta 0.0021 0.0066 0.0051
Loa Loa (eye worm) phosphatidylinositol 3 0.0025 0.0098 0.0098
Echinococcus multilocularis calcium activated potassium channel 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0119 0.0119
Onchocerca volvulus Peroxidasin homolog 0.0058 0.0307 0.4925
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0029 0.0119 0.0119
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0025 0.0098 0.0163
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.004 0.0024
Loa Loa (eye worm) hypothetical protein 0.0029 0.0119 0.0119
Schistosoma mansoni tubulin subunit beta 0.0021 0.0066 0.0051
Loa Loa (eye worm) hypothetical protein 0.0029 0.0119 0.0119
Onchocerca volvulus Peroxidasin homolog 0.0058 0.0307 0.4925
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0021 0.0066 0.0066
Echinococcus granulosus transmembrane protease serine 3 0.0016 0.0035 0.0035
Brugia malayi Fibulin-1 precursor 0.0026 0.0103 0.0103
Echinococcus granulosus sodium channel protein 0.0064 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0029 0.0119 0.0119
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0023 0.0007
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0103
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.01 0.0571 0.0571
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0186 0.0171
Giardia lamblia Beta tubulin 0.0021 0.0066 0.452
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0054 0.0278 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0156 0.0156
Trichomonas vaginalis tubulin epsilon chain, putative 0.0021 0.0066 0.1703
Loa Loa (eye worm) hypothetical protein 0.0029 0.0119 0.0119
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0023 0.0007
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0025 0.0098 0.0236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0027 0.0172
Brugia malayi EGF-like domain containing protein 0.0029 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0058 0.0307 0.0307
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0025 0.0098 0.0098
Schistosoma mansoni cercarial elastase (S01 family) 0.0016 0.0035 0.002
Brugia malayi Cyclic-nucleotide gated cation channel 0.0014 0.0023 0.0023
Echinococcus multilocularis dihydrofolate reductase 0.1577 1 1
Echinococcus multilocularis mitogen activated protein kinase 11 0.0127 0.0748 0.0748
Brugia malayi GCC2 and GCC3 family protein 0.0029 0.0119 0.0119
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0019 0.0056 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0066 0.1703
Loa Loa (eye worm) hypothetical protein 0.0029 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0029 0.0119 0.0119
Schistosoma mansoni peroxidasin 0.0058 0.0307 0.0292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0035 0.0482
Echinococcus granulosus Tolloid protein 1 0.0026 0.0103 0.0103
Echinococcus multilocularis transmembrane protease serine 3 0.0016 0.0035 0.0035
Loa Loa (eye worm) Notch2 0.0029 0.0119 0.0119
Onchocerca volvulus 0.0029 0.0119 0.1521
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0603 0.3783 1
Schistosoma mansoni notch 0.0029 0.012 0.0105
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.017 0.017
Schistosoma mansoni septate junction protein 0.0029 0.0119 0.0104
Echinococcus multilocularis neurogenic locus notch protein 4 0.0029 0.0119 0.0119
Schistosoma mansoni cercarial elastase (S01 family) 0.0016 0.0035 0.002
Entamoeba histolytica tubulin family protein 0.0021 0.0066 0.0458
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0046 0.0228 0.0228
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0014 0.0023 0.0023
Echinococcus multilocularis neurogenic locus notch protein 0.0029 0.0119 0.0119
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0056 0.0127
Echinococcus granulosus enteropeptidase 0.0016 0.0035 0.0035
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0127 0.0748 0.1833
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0066 0.1703
Echinococcus multilocularis enteropeptidase 0.0016 0.0035 0.0035
Loa Loa (eye worm) animal heme peroxidase 0.0058 0.0307 0.0307
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0027 0.0106 0.325
Brugia malayi Calcium binding EGF domain containing protein 0.0029 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0058 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0035 0.016 0.016
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0025 0.0098 0.1869
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0059 0.1394
Toxoplasma gondii calcium binding egf domain-containing protein 0.0026 0.0103 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0059 0.1394
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0054 0.0278 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0119 0.0119
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0016 0.004 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0027 0.0167
Echinococcus granulosus protein jagged 2 0.0029 0.0119 0.0119
Onchocerca volvulus 0.0058 0.0307 0.4925
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0035 0.0482
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.1577 1 0.5
Brugia malayi Animal haem peroxidase family protein 0.0058 0.0307 0.0307
Schistosoma mansoni hypothetical protein 0.0029 0.0119 0.0104

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.8 nM Inhibitory concentration tested against human Cannabinoid receptor 1 (hCB1) ChEMBL. 15664830
IC50 (binding) = 1.8 nM Inhibitory concentration tested against human Cannabinoid receptor 1 (hCB1) ChEMBL. 15664830

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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