Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.1869 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1869 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1869 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1869 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1869 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1869 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1869 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1869 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1869 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.1869 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1869 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.1869 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 63.2 mg kg-1 | Effective dose of the compound against maximal electroshock (MES) induced convulsants in mice | ChEMBL. | 15780622 |
ED50 (functional) | = 63.2 mg kg-1 | Effective dose of the compound against maximal electroshock (MES) induced convulsants in mice | ChEMBL. | 15780622 |
ED50 (functional) | = 82.9 mg kg-1 | Effective dose of the compound against maximal electroshock (MES) induced convulsions in presence of flumazenil at 10 mg/kg in mice; Range: 41.9-82.9 | ChEMBL. | 15780622 |
ED50 (functional) | = 82.9 mg kg-1 | Effective dose of the compound against maximal electroshock (MES) induced convulsions in presence of flumazenil at 10 mg/kg in mice; Range: 41.9-82.9 | ChEMBL. | 15780622 |
ED50 (functional) | = 85.2 mg kg-1 | Effective dose of the compound against pentylentetrazole (PTZ) induced anticonvulsant activity in mice | ChEMBL. | 15780622 |
ED50 (functional) | = 85.2 mg kg-1 | Effective dose of the compound against pentylentetrazole (PTZ) induced anticonvulsant activity in mice | ChEMBL. | 15780622 |
ED50 (functional) | = 125.9 mg kg-1 | Effective dose of the compound against pentylentetrazole (PTZ) induced anticonvulsant activity in presence of flumazenil at 10 mg/kg in mice; range 62.1-125.9 | ChEMBL. | 15780622 |
ED50 (functional) | = 125.9 mg kg-1 | Effective dose of the compound against pentylentetrazole (PTZ) induced anticonvulsant activity in presence of flumazenil at 10 mg/kg in mice; range 62.1-125.9 | ChEMBL. | 15780622 |
LD50 (ADMET) | > 300 mg kg-1 | Lethal dose of the compound tested against mice | ChEMBL. | 15780622 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.