Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | No references |
Rattus norvegicus | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 614 aa | 577 aa | 40.7 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 614 aa | 564 aa | 29.8 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 614 aa | 547 aa | 32.5 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 614 aa | 573 aa | 30.5 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 614 aa | 602 aa | 24.3 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 614 aa | 642 aa | 34.1 % |
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 583 aa | 30.7 % | |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 614 aa | 642 aa | 34.0 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 581 aa | 27.0 % | |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 632 aa | 25.6 % | |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 614 aa | 531 aa | 39.7 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 614 aa | 570 aa | 25.4 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 614 aa | 507 aa | 26.4 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 614 aa | 574 aa | 24.0 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 614 aa | 496 aa | 24.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.4886 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.4886 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.4886 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.4886 | 0.4886 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0093 | 0.1083 | 0.1083 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.4886 | 0.4886 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0183 | 0.5936 | 0.5936 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.4886 | 0.4886 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.4886 | 0.5 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0157 | 0.4507 | 0.5 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0144 | 0.3803 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.4886 | 0.4886 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.4886 | 0.0859 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0165 | 0.4973 | 0.4973 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0238 | 0.8917 | 1 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.0157 | 0.4507 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.4886 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0259 | 1 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0183 | 0.5936 | 0.5936 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.4886 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.4886 | 0.4886 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0165 | 0.4973 | 0.4973 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.4886 | 0.4886 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.85 | Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman method | ChEMBL. | No reference |
IC50 (binding) | = 0.14 uM | In vitro inhibitory concentration against rat cortex acetylcholinesterase | ChEMBL. | 15993600 |
IC50 (binding) | = 0.14 uM | In vitro inhibitory concentration against rat cortex acetylcholinesterase | ChEMBL. | 15993600 |
IC50 (binding) | = 130 uM | In vitro inhibitory concentration against butyrylcholinesterase was determined using rat serum homogenate | ChEMBL. | 15993600 |
IC50 (binding) | = 130 uM | In vitro inhibitory concentration against butyrylcholinesterase was determined using rat serum homogenate | ChEMBL. | 15993600 |
IC50 (binding) | = 0.14 umol/L | Inhibition of acetylcholinesterase in Rattus norvegicus (rat) cortex by Ellman method | ChEMBL. | No reference |
Ki (binding) | = 402.85 nM | Binding affinity to acetylcholinesterase (unknown origin) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.