Detailed information for compound 318849

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 385.501 | Formula: C25H27N3O
  • H donors: 0 H acceptors: 1 LogP: 4.83 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C(C(n1cncc1)c1ccc2c(c1)ccc(c2)OCc1ccccc1)C)C
  • InChi: 1S/C25H27N3O/c1-19(27(2)3)25(28-14-13-26-18-28)23-10-9-22-16-24(12-11-21(22)15-23)29-17-20-7-5-4-6-8-20/h4-16,18-19,25H,17H2,1-3H3
  • InChiKey: XNPARDFAECDMGN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 26, subfamily A, polypeptide 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei cytochrome P450, putative cytochrome P450, family 26, subfamily A, polypeptide 1 497 aa 515 aa 21.9 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax replication factor C subunit 1, putative 0.0039 0.0076 0.3195
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0486 0.6052
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0065 0.0651
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0019 0.0013 0.0046
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.003 0.0048 0.0681
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0063 0.063
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0035 0.0063 0.5773
Schistosoma mansoni neuropeptide receptor 0.0019 0.0013 0.0027
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0246 0.0712 0.0709
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0113 0.0304 0.1033
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0084 0.0215 0.3239
Loa Loa (eye worm) hypothetical protein 0.0039 0.0076 0.0258
Brugia malayi Cation transporter family protein 0.0742 0.2241 0.7601
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0084 0.0081
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0041 0.0081 0.0275
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0084 0.0114
Brugia malayi Carboxylesterase family protein 0.0972 0.2948 1
Toxoplasma gondii patched family protein 0.0018 0.0011 0.0164
Brugia malayi steroid hormone receptor 0.003 0.0047 0.016
Loa Loa (eye worm) patched family protein 0.0018 0.0011 0.0037
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0149 0.0146
Echinococcus multilocularis Niemann Pick C1 protein 0.03 0.0878 0.0874
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0047 0.0043
Loa Loa (eye worm) hypothetical protein 0.0132 0.0363 0.1232
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0047 0.0119
Loa Loa (eye worm) hypothetical protein 0.0036 0.0065 0.022
Schistosoma mansoni histamine h1 receptor 0.0019 0.0013 0.0027
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0019 0.0013 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0047 0.016
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0232 0.0786
Echinococcus multilocularis Niemann Pick C1 protein 0.0428 0.1274 0.127
Brugia malayi ecdysteroid receptor 0.003 0.0047 0.016
Schistosoma mansoni transient receptor potential channel 4 0.0098 0.0258 0.0696
Entamoeba histolytica hypothetical protein 0.0039 0.0076 0.0158
Plasmodium vivax acetyl-CoA synthetase, putative 0.0035 0.0063 0.2626
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0013 0.001
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0047 0.016
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0048 0.0104 0.4412
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0047 0.0061
Leishmania major 4-coumarate:coa ligase-like protein 0.012 0.0323 1
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0175 0.047
Echinococcus granulosus survival motor neuron protein 1 0.0709 0.2139 0.301
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0063 0.5773
Onchocerca volvulus 0.0036 0.0065 0.0241
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0039 0.0076 0.0258
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0041 0.0081 0.0275
Echinococcus multilocularis nAChR subunit 0.0132 0.0363 0.036
Schistosoma mansoni lamin 0.0027 0.0039 0.0096
Loa Loa (eye worm) hypothetical protein 0.0113 0.0304 0.1033
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0246 0.0712 0.1938
Echinococcus multilocularis microtubule associated protein 2 0.0697 0.2102 0.2099
Schistosoma mansoni cpg binding protein 0.0089 0.023 0.0619
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0084 0.022
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0047 0.0061
Brugia malayi Carboxylesterase family protein 0.0164 0.0461 0.1563
Brugia malayi CHE-14 protein 0.0129 0.0351 0.1191
Brugia malayi Cytochrome P450 family protein 0.0019 0.0014 0.0047
Schistosoma mansoni mixed-lineage leukemia protein mll 0.018 0.051 0.1385
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0084 0.0114
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0013 0.0014
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0047 0.016
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0063 0.063
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0047 0.0043
Echinococcus multilocularis orexin receptor type 2 0.0019 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0129 0.0351 0.1191
Onchocerca volvulus 0.0019 0.0013 0.0011
Onchocerca volvulus 0.0052 0.0116 0.0469
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0048 0.0104 0.4412
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0063 0.5773
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0047 0.0162
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0013 0.0046
Brugia malayi Patched protein homolog 1 0.0018 0.0011 0.0037
Echinococcus multilocularis muscleblind protein 0.0148 0.0411 0.0407
Onchocerca volvulus 0.0019 0.0013 0.0011
Entamoeba histolytica hypothetical protein 0.0072 0.0175 0.1379
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0065 0.0061
Brugia malayi hypothetical protein 0.0113 0.0304 0.1033
Mycobacterium tuberculosis Conserved protein 0.0036 0.0065 0.0937
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0459 0.5704
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Loa Loa (eye worm) hypothetical protein 0.003 0.0047 0.016
Entamoeba histolytica hypothetical protein 0.0072 0.0175 0.1379
Echinococcus granulosus allatostatin A receptor 0.0019 0.0013 0.0014
Echinococcus multilocularis protein dispatched 1 0.0147 0.0407 0.0403
Loa Loa (eye worm) hypothetical protein 0.0027 0.0039 0.0132
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0136 0.0361
Loa Loa (eye worm) hypothetical protein 0.0246 0.0712 0.2417
Mycobacterium ulcerans glutaminase 0.0273 0.0795 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0164 0.0461 0.125
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0089 0.023 0.3469
Brugia malayi MAP kinase sur-1 0.0049 0.0107 0.0362
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0048 0.0104 0.0351
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0246 0.0712 0.2417
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0035 0.0063 0.0911
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0065 0.0651
Loa Loa (eye worm) hypothetical protein 0.0113 0.0304 0.1033
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0019 0.0013 0.001
Brugia malayi hypothetical protein 0.0709 0.2139 0.7256
Echinococcus granulosus g protein coupled receptor 0.0019 0.0013 0.0014
Brugia malayi intermediate filament protein 0.0027 0.0039 0.0132
Echinococcus granulosus tar DNA binding protein 0.0124 0.0337 0.0469
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0337 0.091
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0246 0.0712 0.0999
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0132 0.0363 0.1232
Schistosoma mansoni microtubule-associated protein tau 0.0697 0.2102 0.5736
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0246 0.0712 0.2417
Schistosoma mansoni glutaminase 0.0273 0.0795 0.2162
Schistosoma mansoni biogenic amine receptor 0.0019 0.0013 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0047 0.016
Schistosoma mansoni DNA ligase IV 0.0039 0.0076 0.0198
Mycobacterium ulcerans acyl-CoA synthetase 0.012 0.0323 0.3961
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0107 0.0282
Brugia malayi AKH receptor 0.0019 0.0013 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0047 0.016
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0004 0.0012
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0107 0.0103
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0113 0.0304 0.1033
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0076 0.7023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Brugia malayi Patched related family protein 10 0.0018 0.0011 0.0037
Echinococcus multilocularis carboxylesterase 5A 0.0972 0.2948 0.2946
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0034 0.1348
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0107 0.0362
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0041 0.0081 0.0275
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0019 0.0013 0.0027
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.012 0.0323 0.4894
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0023 0.0019
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0063 0.0214
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0052 0.0068
Echinococcus multilocularis acetylcholinesterase 0.0972 0.2948 0.2946
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0175 0.0242
Loa Loa (eye worm) hypothetical protein 0.0246 0.0712 0.2417
Brugia malayi beta-lactamase family protein 0.0036 0.0065 0.022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0047 0.016
Schistosoma mansoni thyroid hormone receptor 0.003 0.0047 0.0119
Echinococcus multilocularis g-protein coupled receptor 0.0019 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Schistosoma mansoni intermediate filament proteins 0.0027 0.0039 0.0096
Schistosoma mansoni neuropeptide receptor 0.0019 0.0013 0.0027
Brugia malayi nuclear hormone receptor 0.003 0.0047 0.016
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0065 0.5939
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0246 0.0712 0.0709
Onchocerca volvulus 0.0019 0.0013 0.0011
Echinococcus multilocularis allatostatin A receptor 0.0019 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0013 0.0027
Loa Loa (eye worm) hypothetical protein 0.0032 0.0053 0.0179
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0113 0.0304 0.0424
Echinococcus granulosus geminin 0.068 0.2049 0.2883
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Onchocerca volvulus 0.0035 0.0063 0.0234
Brugia malayi hypothetical protein 0.0018 0.0011 0.0037
Echinococcus granulosus acetylcholinesterase 0.0972 0.2948 0.4151
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0107 0.1187
Entamoeba histolytica acyl-CoA synthetase, putative 0.012 0.0323 0.3192
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.0459 0.201
Schistosoma mansoni patched 1 0.0129 0.0351 0.095
Onchocerca volvulus 0.0246 0.0712 0.3146
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0337 0.091
Loa Loa (eye worm) hypothetical protein 0.0742 0.2241 0.7601
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0039 0.0076 0.7023
Brugia malayi CXXC zinc finger family protein 0.0084 0.0215 0.073
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0246 0.0712 0.0709
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0014 0.1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0039 0.005
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0034 0.2963
Toxoplasma gondii ATPase, AAA family protein 0.0039 0.0076 0.1616
Onchocerca volvulus 0.0246 0.0712 0.3146
Loa Loa (eye worm) acetylcholine receptor protein 0.0113 0.0304 0.1033
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0246 0.0712 0.2417
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0113 0.0304 0.0301
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0035 0.0063 0.006
Brugia malayi protein C24B5.3 0.0018 0.0011 0.0037
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0337 0.091
Schistosoma mansoni survival motor neuron protein 0.0145 0.0401 0.1085
Brugia malayi Patched family protein 0.0018 0.0011 0.0037
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0132 0.0363 0.1232
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0232 0.0321
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0013 0.001
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0246 0.0712 0.1938
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0013 0.001
Echinococcus granulosus Niemann Pick C1 protein 0.03 0.0878 0.1232
Loa Loa (eye worm) hypothetical protein 0.0059 0.0136 0.0463
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0014 0.0047
Brugia malayi sulfakinin receptor protein 0.0019 0.0013 0.0046
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0084 0.2689
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0076 0.0794
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0013 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0047 0.016
Echinococcus granulosus dro:myosuppressin receptor 0.0019 0.0013 0.0014
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0136 0.0361
Onchocerca volvulus 0.0036 0.0065 0.0241
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0232 0.0623
Loa Loa (eye worm) hypothetical protein 0.0132 0.0363 0.1232
Schistosoma mansoni neurotransmitter gated ion channel 0.0113 0.0304 0.0822
Loa Loa (eye worm) oxidoreductase 0.0035 0.0063 0.0214
Brugia malayi neuropeptide F receptor 0.0019 0.0013 0.0046
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0065 0.2701
Brugia malayi hypothetical protein 0.0026 0.0034 0.0116
Loa Loa (eye worm) hypothetical protein 0.0089 0.023 0.0781
Echinococcus multilocularis survival motor neuron protein 1 0.0709 0.2139 0.2136
Loa Loa (eye worm) patched family protein 0.0018 0.0011 0.0037
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0035 0.0063 0.0911
Brugia malayi Serotonin receptor 0.0019 0.0013 0.0046
Trichomonas vaginalis spcc417.12 protein, putative 0.0164 0.0461 0.5724
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0013 0.0014
Trichomonas vaginalis antibiotic synthetase, putative 0.0035 0.0063 0.0629
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0459 0.5704
Brugia malayi TAR-binding protein 0.0124 0.0337 0.1142
Echinococcus multilocularis expressed protein 0.0048 0.0104 0.01
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0486 0.6052
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0065 0.5939
Echinococcus multilocularis tumor protein p63 0.0356 0.1052 0.1048
Echinococcus multilocularis transient receptor potential gamma protein 0.0098 0.0258 0.0255
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0246 0.0712 0.1938
Brugia malayi Patched family protein 0.0018 0.0011 0.0037
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0013 0.001
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0047 0.0043
Loa Loa (eye worm) hypothetical protein 0.012 0.0323 0.1096
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0047 0.0119
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0047 0.0061
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0065 0.0937
Loa Loa (eye worm) hypothetical protein 0.0036 0.0065 0.022
Loa Loa (eye worm) RNA binding protein 0.0124 0.0337 0.1142
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0013 0.0027
Loa Loa (eye worm) ACC-1 protein 0.0246 0.0712 0.2417
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0004 0.0000017871
Schistosoma mansoni opsin-like receptor 0.0019 0.0013 0.0027
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Loa Loa (eye worm) hypothetical protein 0.03 0.0878 0.2977
Brugia malayi DKFZp564C0469 protein 0.0039 0.0076 0.0258
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0199 0.0569 0.1931
Loa Loa (eye worm) hypothetical protein 0.0164 0.0461 0.1563
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0063 0.1861
Loa Loa (eye worm) hypothetical protein 0.0246 0.0712 0.2417
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0035 0.0063 0.063
Schistosoma mansoni opsin-like receptor 0.0019 0.0013 0.0027
Echinococcus multilocularis transient receptor potential ion channel A 0.0091 0.0234 0.0231
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0089 0.023 0.2769
Loa Loa (eye worm) hypothetical protein 0.0136 0.0375 0.1272
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0113 0.0304 0.1033
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0013 0.0046
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0013 0.0027
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0113 0.0304 0.1033
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0047 0.0119
Onchocerca volvulus 0.0019 0.0013 0.0011
Schistosoma mansoni nAChR subunit 0.0246 0.0712 0.1938
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0113 0.0304 0.1033
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0013 0.0027
Loa Loa (eye worm) hypothetical protein 0.0246 0.0712 0.2417
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0019 0.0013 0.0046
Echinococcus granulosus glycine receptor subunit alpha 1 0.0246 0.0712 0.0999
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0013 0.0014
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0454 0.1355 0.1351
Loa Loa (eye worm) hypothetical protein 0.0039 0.0076 0.0258
Brugia malayi Serotonin receptor 0.0019 0.0013 0.0046
Loa Loa (eye worm) hypothetical protein 0.0036 0.0065 0.022
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0065 0.022
Brugia malayi Pre-SET motif family protein 0.0208 0.0595 0.2019
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0013 0.001
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0035 0.0063 0.0911
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0047 0.0061
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0047 0.0119
Schistosoma mansoni neurotransmitter gated ion channel 0.0113 0.0304 0.0822
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0014 0.0047
Schistosoma mansoni hypothetical protein 0.0124 0.0337 0.0911
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0035 0.0063 0.0214
Toxoplasma gondii propionate-CoA ligase 0.0035 0.0063 0.1328
Loa Loa (eye worm) hypothetical protein 0.0246 0.0712 0.2417
Echinococcus granulosus expressed protein 0.0048 0.0104 0.0141
Loa Loa (eye worm) carboxylesterase 0.0972 0.2948 1
Brugia malayi Patched family protein 0.0018 0.0011 0.0037
Echinococcus granulosus cpg binding protein 0.0089 0.023 0.0319
Leishmania major 4-coumarate:coa ligase-like protein 0.012 0.0323 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0454 0.1355 0.1351
Echinococcus multilocularis para nitrobenzyl esterase 0.0164 0.0461 0.0457
Onchocerca volvulus 0.0019 0.0013 0.0011
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0035 0.0063 0.1328
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0035 0.0063 0.1328
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0337 0.091
Trichomonas vaginalis replication factor C large subunit, putative 0.0039 0.0076 0.0794
Brugia malayi hypothetical protein 0.0037 0.0069 0.0234
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0164 0.0461 0.0644
Mycobacterium tuberculosis Carboxylesterase LipT 0.0164 0.0461 0.7003
Onchocerca volvulus 0.0036 0.0065 0.0241
Brugia malayi G protein-coupled receptor F59B2.13 0.0019 0.0013 0.0046
Onchocerca volvulus 0.0084 0.0215 0.0916
Brugia malayi beta-lactamase family protein 0.0036 0.0065 0.022
Schistosoma mansoni adenoreceptor 0.0019 0.0013 0.0027
Schistosoma mansoni neuropeptide f receptor 76f 0.0019 0.0013 0.0027
Schistosoma mansoni acetyl-CoA synthetase 0.0035 0.0063 0.0163
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0048 0.0104 0.0351
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Plasmodium falciparum lipid/sterol:H+ symporter 0.0018 0.0011 0.0324
Loa Loa (eye worm) hypothetical protein 0.0246 0.0712 0.2417
Loa Loa (eye worm) patched family protein 0.0018 0.0011 0.0037
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0047 0.016
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0047 0.016
Loa Loa (eye worm) hypothetical protein 0.0113 0.0304 0.1033
Loa Loa (eye worm) hypothetical protein 0.0036 0.0065 0.022
Echinococcus granulosus Protein patched homolog 1 0.0129 0.0351 0.049
Schistosoma mansoni topbp1 0.0039 0.0076 0.0198
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Schistosoma mansoni nAChR subunit 0.0113 0.0304 0.0822
Brugia malayi isocitrate dehydrogenase 0.0016 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0035 0.0063 0.0214
Onchocerca volvulus 0.0019 0.0013 0.0011
Loa Loa (eye worm) hypothetical protein 0.0113 0.0304 0.1033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0232 0.0321
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0035 0.0063 0.5773
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0132 0.0363 0.1232
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0113 0.0304 0.1033
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0246 0.0712 0.2417
Onchocerca volvulus 0.0164 0.0461 0.2017
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0034 0.2963
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0149 0.0507
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0019 0.0013 0.0046
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0454 0.1355 0.1904
Trichomonas vaginalis glutaminase, putative 0.0273 0.0795 1
Echinococcus multilocularis protein patched 0.0129 0.0351 0.0347
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0013 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0013 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0129 0.0351 0.4317
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0246 0.0712 0.2417
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0047 0.0162
Onchocerca volvulus 0.0246 0.0712 0.3146
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0019 0.0013 0.0027
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0063 0.0214
Brugia malayi hypothetical protein 0.0016 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0039 0.0076 0.7023
Schistosoma mansoni acetylcholine receptor-related 0.0113 0.0304 0.0822
Echinococcus multilocularis tar DNA binding protein 0.0124 0.0337 0.0333
Brugia malayi excitatory GABA receptor EXP-1A 0.0246 0.0712 0.2417
Echinococcus multilocularis cpg binding protein 0.0089 0.023 0.0227
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0052 0.0132
Brugia malayi Patched family protein 0.0018 0.0011 0.0037
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0199 0.0569 0.1931
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0116 0.0306
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0019 0.0013 0.0014
Schistosoma mansoni nAChR subunit 0.0246 0.0712 0.1938
Echinococcus granulosus Niemann Pick C1 protein 0.0428 0.1274 0.179
Brugia malayi ORL1-like opioid receptor 0.0019 0.0013 0.0046
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.0724 0.9089
Echinococcus granulosus dnaJ subfamily B 0.1203 0.3662 0.5156
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0459 0.5704
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0164 0.0461 0.5724
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0047 0.016
Loa Loa (eye worm) hypothetical protein 0.0972 0.2948 1
Brugia malayi GnHR receptor homolog 0.0019 0.0013 0.0046
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0107 0.1187
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0013 0.0014
Brugia malayi hypothetical protein 0.0019 0.0013 0.0046
Echinococcus granulosus acetylcholinesterase 0.0972 0.2948 0.4151
Brugia malayi Calcitonin receptor-like protein seb-1 0.0199 0.0569 0.1931
Loa Loa (eye worm) hypothetical protein 0.003 0.0047 0.016
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.0724 0.9089
Loa Loa (eye worm) hypothetical protein 0.0042 0.0084 0.0286
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.0595 0.2019
Schistosoma mansoni hypothetical protein 0.0041 0.0081 0.0212
Brugia malayi Carboxylesterase family protein 0.0164 0.0461 0.1563
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0164 0.0461 0.7003
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0041 0.0081 0.173
Onchocerca volvulus 0.0019 0.0013 0.0011
Schistosoma mansoni gliotactin 0.0164 0.0461 0.125
Brugia malayi AMP-binding enzyme family protein 0.012 0.0323 0.1096
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0013 0.0027
Echinococcus multilocularis expressed conserved protein 0.0281 0.0822 0.0818
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0047 0.016
Loa Loa (eye worm) hypothetical protein 0.0246 0.0712 0.2417
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0035 0.0063 0.2626
Brugia malayi Muscleblind-like protein 0.0148 0.0411 0.1393
Loa Loa (eye worm) hypothetical protein 0.0063 0.0149 0.0507
Brugia malayi hypothetical protein 0.0072 0.0175 0.0595
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.0724 0.9089
Loa Loa (eye worm) hypothetical protein 0.0246 0.0712 0.2417
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0035 0.0063 0.063
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Echinococcus multilocularis somatostatin receptor 0.0019 0.0013 0.001
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0107 0.23
Echinococcus granulosus microtubule associated protein 2 0.0697 0.2102 0.2957
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0084 0.7824
Brugia malayi Patched family protein 0.0018 0.0011 0.0037
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0013 0.001
Onchocerca volvulus 0.0039 0.0075 0.0286
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0035 0.0063 0.0911
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0084 0.0081
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0084 0.09
Onchocerca volvulus 0.0742 0.2241 1
Schistosoma mansoni BC026374 protein (S09 family) 0.0164 0.0461 0.125
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0012
Echinococcus granulosus lamin 0.0027 0.0039 0.005
Schistosoma mansoni acetylcholine receptor subunit beta 0.0113 0.0304 0.0822
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0019 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0132 0.0363 0.1232
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Loa Loa (eye worm) hypothetical protein 0.0036 0.0065 0.022
Echinococcus multilocularis short transient receptor potential channel 6 0.0067 0.0161 0.0157
Mycobacterium tuberculosis Conserved protein 0.0036 0.0065 0.0937
Echinococcus granulosus nAChR subunit 0.0132 0.0363 0.0507
Echinococcus granulosus neuropeptide s receptor 0.2319 0.7098 1
Loa Loa (eye worm) carboxylesterase 0.0164 0.0461 0.1563
Entamoeba histolytica acyl-CoA synthetase, putative 0.012 0.0323 0.3192
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0047 0.0061
Loa Loa (eye worm) hypothetical protein 0.0246 0.0712 0.2417
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0047 0.0061
Brugia malayi hypothetical protein 0.0113 0.0304 0.1033
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0113 0.0304 0.1033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0013 0.0027
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Schistosoma mansoni amine GPCR 0.0019 0.0013 0.0027
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0035 0.0063 0.0214
Loa Loa (eye worm) hypothetical protein 0.012 0.0323 0.1096
Loa Loa (eye worm) hypothetical protein 0.0246 0.0712 0.2417
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0035 0.0063 0.0084
Echinococcus granulosus glycine receptor subunit alpha 1 0.0246 0.0712 0.0999
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0246 0.0712 0.2417
Brugia malayi Patched family protein 0.0018 0.0011 0.0037
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0232 0.0228
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0065 0.0651
Brugia malayi Melatonin receptor type 1A 0.0019 0.0013 0.0046
Echinococcus granulosus neuropeptide receptor A26 0.2319 0.7098 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0136 0.0186
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0047 0.0061
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0063 0.0911
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0004 0.0012
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0039 0.0076 0.0794
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0149 0.0205
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.012 0.0323 0.3961
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.0724 0.9089
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Loa Loa (eye worm) hypothetical protein 0.0164 0.0461 0.1563
Brugia malayi hypothetical protein 0.0019 0.0013 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0076 0.0794
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Loa Loa (eye worm) ACC-1 protein 0.0246 0.0712 0.2417
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0047 0.016
Onchocerca volvulus 0.012 0.0323 0.14
Echinococcus granulosus short transient receptor potential channel 6 0.0067 0.0161 0.0221
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Schistosoma mansoni hypothetical protein 0.0145 0.0401 0.1085
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0013 0.001
Echinococcus granulosus nibrin 0.0039 0.0076 0.0102
Schistosoma mansoni transient receptor potential channel 0.0098 0.0258 0.0696
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0047 0.016
Schistosoma mansoni lamin 0.0027 0.0039 0.0096
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0065 0.0937
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.012 0.0323 0.4894
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0459 0.5704
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.012 0.0323 1
Toxoplasma gondii hypothetical protein 0.0018 0.0011 0.0164
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0052 0.1074
Loa Loa (eye worm) hypothetical protein 0.0164 0.0461 0.1563
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0063 0.063
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0972 0.2948 0.805
Brugia malayi hypothetical protein 0.0037 0.0069 0.0234
Echinococcus multilocularis lamin 0.0027 0.0039 0.0035
Schistosoma mansoni hypothetical protein 0.0063 0.0149 0.0398
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0013 0.0014
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0014 0.1
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0039 0.0132
Brugia malayi hypothetical protein 0.0019 0.0013 0.0046
Toxoplasma gondii ABC1 family protein 0.0036 0.0065 0.1366
Brugia malayi Carboxylesterase family protein 0.0164 0.0461 0.1563
Brugia malayi AMP-binding enzyme family protein 0.012 0.0323 0.1096
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0246 0.0712 0.2417
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0039 0.0076 0.0495
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0107 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0246 0.0712 0.2417
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0246 0.0712 0.2417
Loa Loa (eye worm) hypothetical protein 0.003 0.0047 0.016
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0136 0.156
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0124 0.0337 0.1142
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0013 0.0014
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0013 0.0014
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0157 0.044 0.1493
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0065 0.0652
Onchocerca volvulus 0.0164 0.0461 0.2017
Schistosoma mansoni nAChR subunit 0.0246 0.0712 0.1938
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0065 0.0167
Leishmania major acetyl-CoA synthetase, putative 0.0035 0.0063 0.1861
Brugia malayi hypothetical protein 0.0018 0.0011 0.0037
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Echinococcus multilocularis sterol regulatory element binding protein 0.0129 0.0351 0.0347
Leishmania major hypothetical protein, conserved 0.0036 0.0065 0.1915
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0047 0.0119
Loa Loa (eye worm) hypothetical protein 0.0132 0.0363 0.1232
Echinococcus multilocularis short transient receptor potential channel 6 0.0067 0.0161 0.0157
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0035 0.0063 0.063
Schistosoma mansoni neuropeptide receptor 0.0019 0.0013 0.0027
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0214
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.012 0.0323 0.3961
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0047 0.0043
Onchocerca volvulus 0.0113 0.0304 0.1316
Brugia malayi hypothetical protein 0.0019 0.0013 0.0046
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0132 0.0363 0.1232
Schistosoma mansoni neuropeptide receptor 0.0019 0.0013 0.0027
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.0656 1
Onchocerca volvulus 0.0019 0.0013 0.0011
Onchocerca volvulus 0.0019 0.0013 0.0011
Schistosoma mansoni nAChR subunit 0.0246 0.0712 0.1938
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0013 0.0014
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0136 0.2949
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0039 0.0076 0.5
Brugia malayi Dopamine receptor protein 2 0.0019 0.0013 0.0046
Onchocerca volvulus 0.0035 0.0063 0.0234
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0047 0.016
Echinococcus multilocularis dro:myosuppressin receptor 0.0019 0.0013 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0167 0.0468 0.5821
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0063 0.063
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0454 0.1355 0.4594
Echinococcus granulosus short transient receptor potential channel 6 0.0067 0.0161 0.0221
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0246 0.0712 0.0709
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0107 0.0145
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Loa Loa (eye worm) hypothetical protein 0.003 0.0047 0.016
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0013 0.001
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0107 0.3224
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0019 0.0013 0.0027
Loa Loa (eye worm) hypothetical protein 0.0164 0.0461 0.1563
Echinococcus multilocularis acetylcholinesterase 0.0972 0.2948 0.2946
Echinococcus multilocularis replication factor c subunit 1 0.0039 0.0076 0.0072
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0065 0.0651
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0164 0.0461 0.0457
Schistosoma mansoni amine GPCR 0.0019 0.0013 0.0027
Brugia malayi Pre-SET motif family protein 0.0031 0.0052 0.0176
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0047 0.0043
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.012 0.0323 0.3961
Onchocerca volvulus Neuropeptide F receptor homolog 0.0019 0.0013 0.0011
Echinococcus granulosus replication factor c subunit 1 0.0039 0.0076 0.0102
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.0724 0.9089
Loa Loa (eye worm) hypothetical protein 0.0113 0.0304 0.1033
Brugia malayi Patched family protein 0.0018 0.0011 0.0037
Plasmodium falciparum replication factor C subunit 1, putative 0.0039 0.0076 0.3195
Echinococcus multilocularis lamin dm0 0.0027 0.0039 0.0035
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0013 0.0046
Loa Loa (eye worm) hypothetical protein 0.0113 0.0304 0.1033
Loa Loa (eye worm) LGC-31 protein 0.0246 0.0712 0.2417
Schistosoma mansoni amine GPCR 0.0019 0.0013 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0065 0.5939
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0084 0.0259
Brugia malayi Patched family protein 0.0018 0.0011 0.0037
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0034 0.2963
Brugia malayi protein C24B5.3 0.0018 0.0011 0.0037
Echinococcus multilocularis geminin 0.068 0.2049 0.2046
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0145 0.0401 0.1359
Brugia malayi hypothetical protein 0.0017 0.0006 0.0021
Loa Loa (eye worm) hypothetical protein 0.0039 0.0076 0.0258
Echinococcus granulosus orexin receptor type 2 0.0019 0.0013 0.0014
Schistosoma mansoni hypothetical protein 0.0072 0.0175 0.047
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0019 0.0013 0.0046
Onchocerca volvulus 0.0019 0.0013 0.0011
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0047 0.0162
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0164 0.0461 0.125
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0063 0.0911
Brugia malayi Cytochrome P450 family protein 0.0019 0.0014 0.0047
Schistosoma mansoni neurotransmitter gated ion channel 0.0132 0.0363 0.0983
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0089 0.023 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0019 0.0013 0.0014
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0019 0.0013 0.0046
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0019 0.0013 0.0027
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0304 0.0892 0.2429
Brugia malayi beta-lactamase 0.0036 0.0065 0.022
Brugia malayi Pax transcription activation domain interacting protein 0.0039 0.0076 0.0258
Echinococcus granulosus 7tm_1 domain containing protein 0.0019 0.0013 0.0014
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0041 0.0081 0.0078
Schistosoma mansoni transient receptor potential channel 0.0067 0.0161 0.0429
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0047 0.0119
Loa Loa (eye worm) hypothetical protein 0.0113 0.0304 0.1033
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0065 0.0937
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Schistosoma mansoni hypothetical protein 0.0124 0.0337 0.0911
Treponema pallidum DNA ligase (lig) 0.0039 0.0076 0.5
Loa Loa (eye worm) hypothetical protein 0.0174 0.0492 0.167
Echinococcus granulosus g-protein coupled receptor 0.0019 0.0013 0.0014
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0039 0.0076 0.0158
Echinococcus multilocularis sex peptide receptor 0.0019 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0052 0.0132
Onchocerca volvulus Putative nachr subunit 0.0454 0.1355 0.6025
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0047 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0076 0.0794
Loa Loa (eye worm) hypothetical protein 0.0089 0.023 0.0781
Echinococcus multilocularis neuropeptide receptor A26 0.2319 0.7098 0.7097
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0047 0.0119
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0013 0.001
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0000017871
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0019 0.0013 0.0027
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0136 0.0132
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0004 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0052 0.0132
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0076 0.7023
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0149 0.0146
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0629 0.1892 0.6416
Loa Loa (eye worm) hypothetical protein 0.0132 0.0363 0.1232
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0246 0.0712 0.0709
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0107 0.0103
Plasmodium vivax SET domain protein, putative 0.0031 0.0052 0.2124
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0052 0.0132
Schistosoma mansoni cpg binding protein 0.0084 0.0215 0.0579
Trypanosoma cruzi FHA domain containing protein, putative 0.0039 0.0076 0.7023
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0246 0.0712 0.0709
Brugia malayi Carboxylesterase family protein 0.0164 0.0461 0.1563
Echinococcus granulosus serotonin receptor 0.0019 0.0013 0.0014
Echinococcus granulosus g protein coupled receptor 0.0019 0.0013 0.0014
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0023 0.0027
Onchocerca volvulus 0.0019 0.0013 0.0011
Echinococcus multilocularis nAChR subunit 0.0246 0.0712 0.0709
Brugia malayi Patched family protein 0.0018 0.0011 0.0037
Leishmania major 4-coumarate:coa ligase-like protein 0.012 0.0323 1
Echinococcus granulosus lamin dm0 0.0027 0.0039 0.005
Schistosoma mansoni nAChR subunit 0.0113 0.0304 0.0822
Echinococcus granulosus nAChR subunit 0.0246 0.0712 0.0999
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0246 0.0712 0.2417
Loa Loa (eye worm) hypothetical protein 0.0164 0.0461 0.1563
Brugia malayi hypothetical protein 0.0019 0.0013 0.0046
Loa Loa (eye worm) hypothetical protein 0.0246 0.0712 0.2417
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0013 0.0027
Brugia malayi hypothetical protein 0.0113 0.0304 0.1033
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0012
Onchocerca volvulus 0.0742 0.2241 1
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0063 0.0214
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Echinococcus granulosus neuropeptide FF receptor 2 0.0019 0.0013 0.0014
Brugia malayi Patched related family protein 4 0.0018 0.0011 0.0037
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0047 0.0061
Loa Loa (eye worm) patched family protein 0.0018 0.0011 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0047 0.016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Schistosoma mansoni neuroligin 3 (S09 family) 0.0164 0.0461 0.125
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0174 0.0492 0.167
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0459 0.5704
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0246 0.0712 0.2417
Mycobacterium ulcerans fatty-acid-CoA ligase 0.012 0.0323 0.3961
Onchocerca volvulus 0.0019 0.0013 0.0011
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0113 0.0304 0.0301
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0246 0.0712 0.2417
Loa Loa (eye worm) hypothetical protein 0.0113 0.0304 0.1033
Schistosoma mansoni hypothetical protein 0.068 0.2049 0.5591
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0038 0.0129
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0013 0.001
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0052 0.0048
Entamoeba histolytica acyl-coA synthetase, putative 0.012 0.0323 0.3192
Brugia malayi topoisomerase 0.0039 0.0076 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0076 0.0794
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0164 0.0461 0.7003
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0107 0.0145
Loa Loa (eye worm) patched family protein 0.0018 0.0011 0.0037
Leishmania major cytochrome p450-like protein 0.0019 0.0014 0.0322
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Onchocerca volvulus 0.0132 0.0363 0.1579
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Echinococcus granulosus intermediate filament protein 0.0027 0.0039 0.005
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0013 0.001
Echinococcus granulosus neuroligin 0.0164 0.0461 0.0644
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0019 0.0013 0.001
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0063 0.0214
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0047 0.016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Schistosoma mansoni cpg binding protein 0.0089 0.023 0.0619
Loa Loa (eye worm) hypothetical protein 0.0027 0.0037 0.0127
Loa Loa (eye worm) hypothetical protein 0.0132 0.0363 0.1232
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0065 0.022
Schistosoma mansoni opsin-like receptor 0.0019 0.0013 0.0027
Loa Loa (eye worm) hypothetical protein 0.0246 0.0712 0.2417
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0048 0.0104 0.2231
Echinococcus granulosus glycine receptor subunit alpha 1 0.0246 0.0712 0.0999
Brugia malayi Myosin head containing protein 0.0018 0.0011 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0047 0.016
Onchocerca volvulus 0.0164 0.0461 0.2017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0013 0.0027
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0459 0.5704
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0065 0.0937
Plasmodium vivax patched family protein, putative 0.0018 0.0011 0.0324
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0107 0.1187
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0084 0.022
Schistosoma mansoni hypothetical protein 0.0063 0.0149 0.0398
Echinococcus multilocularis nibrin 0.0039 0.0076 0.0072
Brugia malayi Transient-receptor-potential like protein 0.004 0.0077 0.0261
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0013 0.001
Mycobacterium ulcerans acyl-CoA synthetase 0.012 0.0323 0.3961
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0013 0.0027
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0039 0.0132
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0132 0.0363 0.0983
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0013 0.0046
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Brugia malayi hypothetical protein 0.0019 0.0013 0.0046
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Echinococcus granulosus para nitrobenzyl esterase 0.0164 0.0461 0.0644
Loa Loa (eye worm) hypothetical protein 0.0164 0.0461 0.1563
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0041 0.0081 0.3421
Schistosoma mansoni hypothetical protein 0.0063 0.0149 0.0398
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Brugia malayi hypothetical protein 0.0019 0.0013 0.0046
Loa Loa (eye worm) beta-lactamase 0.0036 0.0065 0.022
Echinococcus granulosus neuropeptide receptor 0.0019 0.0013 0.0014
Schistosoma mansoni growth hormone secretagogue receptor 0.0019 0.0013 0.0027
Echinococcus granulosus muscleblind protein 0.0148 0.0411 0.0574
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.03 0.0878 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Plasmodium falciparum acyl-CoA synthetase 0.0089 0.023 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0084 0.7824
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0043 0.0055
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0065 0.0652
Mycobacterium ulcerans acyl-CoA synthetase 0.012 0.0323 0.3961
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0047 0.016
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0084 0.7824
Echinococcus multilocularis serotonin receptor 0.0019 0.0013 0.001
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0013 0.001
Echinococcus multilocularis GPCR, family 2 0.0063 0.0149 0.0146
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0246 0.0712 0.2417
Onchocerca volvulus 0.0019 0.0013 0.0011
Echinococcus granulosus glycine receptor subunit beta 0.0246 0.0712 0.0999
Brugia malayi Patched family protein 0.0018 0.0011 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0084 0.09
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0035 0.0063 0.0911
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0065 0.0167
Schistosoma mansoni amine GPCR 0.0019 0.0013 0.0027
Brugia malayi G-protein coupled receptor 0.0019 0.0013 0.0046
Loa Loa (eye worm) hypothetical protein 0.0113 0.0304 0.1033
Schistosoma mansoni hypothetical protein 0.0136 0.0375 0.1015
Loa Loa (eye worm) hypothetical protein 0.0113 0.0304 0.1033
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Brugia malayi Patched related family protein 12 0.0018 0.0011 0.0037
Brugia malayi hypothetical protein 0.0113 0.0304 0.1033
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0164 0.0461 0.125
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0136 0.2023
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0113 0.0304 0.1033
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0084 0.0286
Trichomonas vaginalis set domain proteins, putative 0.0236 0.0683 0.8571
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0063 0.063
Loa Loa (eye worm) hypothetical protein 0.0039 0.0076 0.0258
Brugia malayi Carboxylesterase family protein 0.0972 0.2948 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0019 0.0013 0.001
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0013 0.0027
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0454 0.1355 0.4594
Schistosoma mansoni hypothetical protein 0.0124 0.0337 0.0911
Schistosoma mansoni myosin xvIII 0.0019 0.0013 0.0027
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0019 0.0013 0.001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0013 0.0027
Echinococcus granulosus fmrfamide receptor 0.0019 0.0013 0.0014
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0454 0.1355 0.1904
Brugia malayi neuropeptide F receptor 0.0019 0.0013 0.0046
Echinococcus multilocularis muscleblind protein 1 0.0148 0.0411 0.0407
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0249 0.0724 0.2454
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0013 0.0014
Brugia malayi hypothetical protein 0.0018 0.0011 0.0037
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0039 0.0076 0.1616
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0019 0.0013 0.001
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0013 0.001
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0013 0.001
Schistosoma mansoni hypothetical protein 0.0019 0.0013 0.0027
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0013 0.0027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0013 0.001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0136 0.156
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0014 0.0047
Brugia malayi Patched family protein 0.0018 0.0011 0.0037
Schistosoma mansoni nAChR subunit 0.0246 0.0712 0.1938
Loa Loa (eye worm) hypothetical protein 0.0246 0.0712 0.2417
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Brugia malayi larval opioid receptor 0.0019 0.0013 0.0046
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0023 0.0027
Brugia malayi Tachykinin-like peptides receptor 99D 0.0019 0.0013 0.0046
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0113 0.0304 0.1033
Loa Loa (eye worm) hypothetical protein 0.0039 0.0076 0.0258
Onchocerca volvulus 0.0164 0.0461 0.2017
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0019 0.0013 0.0014
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0047 0.016
Mycobacterium ulcerans acetyl-CoA synthetase 0.0035 0.0063 0.063
Echinococcus multilocularis glycine receptor subunit beta 0.0246 0.0712 0.0709
Loa Loa (eye worm) hypothetical protein 0.0098 0.0258 0.0876
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0065 0.0937
Loa Loa (eye worm) carboxylesterase 0.0164 0.0461 0.1563
Loa Loa (eye worm) hypothetical protein 0.0742 0.2241 0.7601
Loa Loa (eye worm) hypothetical protein 0.0052 0.0116 0.0392
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0019 0.0013 0.0027
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0035 0.0063 0.063
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Brugia malayi Niemann-Pick C1 protein precursor 0.03 0.0878 0.2977
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0232 0.0623
Loa Loa (eye worm) TAR-binding protein 0.0124 0.0337 0.1142
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0019 0.0013 0.001
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0035 0.0063 0.0911
Loa Loa (eye worm) hypothetical protein 0.0039 0.0076 0.0258
Brugia malayi nuclear receptor NHR-88 0.003 0.0047 0.016
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0065 0.0651
Toxoplasma gondii patched family protein 0.0018 0.0011 0.0164
Brugia malayi G-protein coupled receptor 0.0019 0.0013 0.0046
Mycobacterium ulcerans hypothetical protein 0.0036 0.0065 0.0652
Loa Loa (eye worm) hypothetical protein 0.0041 0.0081 0.0275
Schistosoma mansoni coup transcription factor 0.003 0.0047 0.0119
Brugia malayi RNA binding protein 0.0124 0.0337 0.1142
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0084 0.0215 0.3239
Schistosoma mansoni hypothetical protein 0.0019 0.0013 0.0027
Onchocerca volvulus 0.0164 0.0461 0.2017
Onchocerca volvulus 0.0019 0.0013 0.0011
Mycobacterium ulcerans hypothetical protein 0.012 0.0323 0.3961
Mycobacterium tuberculosis Conserved protein 0.0036 0.0065 0.0937
Schistosoma mansoni hypothetical protein 0.1203 0.3662 1
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0454 0.1355 0.1904
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0035 0.0063 0.0214
Echinococcus granulosus alpha 1A adrenergic receptor 0.0019 0.0013 0.0014
Echinococcus multilocularis G protein coupled receptor 139 0.0019 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Echinococcus multilocularis neuropeptide FF receptor 2 0.0019 0.0013 0.001
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0107 0.3224
Loa Loa (eye worm) hypothetical protein 0.0246 0.0712 0.2417
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0013 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0034 0.1348
Loa Loa (eye worm) hypothetical protein 0.0036 0.0065 0.022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0013 0.0027
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.012 0.0323 1
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0035 0.0063 0.063
Schistosoma mansoni hypothetical protein 0.0019 0.0013 0.0027
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0132 0.0363 0.1232
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0034 0.1348
Echinococcus multilocularis musashi 0.0027 0.0039 0.0035
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.0375 0.1272
Echinococcus granulosus GPCR family 2 0.0063 0.0149 0.0205
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0063 0.0911
Onchocerca volvulus 0.0145 0.0401 0.1747
Schistosoma mansoni hypothetical protein 0.0124 0.0337 0.0911
Loa Loa (eye worm) hypothetical protein 0.003 0.0047 0.016
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0019 0.0013 0.0011
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0246 0.0712 0.2417
Schistosoma mansoni hypothetical protein 0.0063 0.0149 0.0398
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0019 0.0013 0.0014
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0107 1
Echinococcus multilocularis neuroligin 0.0164 0.0461 0.0457
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0013 0.0027
Schistosoma mansoni nAChR subunit 0.0246 0.0712 0.1938
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0084 0.0081
Loa Loa (eye worm) hypothetical protein 0.0199 0.0569 0.1931
Echinococcus multilocularis glycine receptor subunit beta 0.0246 0.0712 0.0709
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0063 0.063
Echinococcus multilocularis serotonin receptor 0.0019 0.0013 0.001
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0004 0.0000048836
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0107 1
Echinococcus multilocularis dnaJ subfamily B 0.1203 0.3662 0.3659
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0023 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.0724 0.9089
Onchocerca volvulus 0.0236 0.0683 0.3013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Loa Loa (eye worm) hypothetical protein 0.0113 0.0304 0.1033
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0246 0.0712 0.2417
Echinococcus multilocularis BC026374 protein (S09 family) 0.0164 0.0461 0.0457
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0129 0.0351 0.1191
Brugia malayi hypothetical protein 0.0019 0.0013 0.0046
Loa Loa (eye worm) hypothetical protein 0.0454 0.1355 0.4594
Trichomonas vaginalis esterase, putative 0.0036 0.0065 0.0651
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0013 0.0014
Toxoplasma gondii histone lysine methyltransferase SET1 0.0161 0.0451 1
Brugia malayi Patched family protein 0.0018 0.0011 0.0037
Brugia malayi RE15519p 0.0019 0.0013 0.0046
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0013 0.0014
Onchocerca volvulus 0.0035 0.0063 0.0234
Onchocerca volvulus 0.0742 0.2241 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Brugia malayi hypothetical protein 0.0019 0.0013 0.0046
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0107 1
Toxoplasma gondii patched family protein 0.0018 0.0011 0.0164
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0149 0.0507
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0035 0.0063 0.0911
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0246 0.0712 0.2417
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0136 0.4133
Loa Loa (eye worm) hypothetical protein 0.0089 0.023 0.0781
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0004 0.0012
Schistosoma mansoni nAChR subunit 0.0246 0.0712 0.1938
Schistosoma mansoni amine GPCR 0.0019 0.0013 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0047 0.016
Loa Loa (eye worm) hypothetical protein 0.0164 0.0461 0.1563
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0246 0.0712 0.2417
Brugia malayi hypothetical protein 0.0039 0.0076 0.0258
Loa Loa (eye worm) hypothetical protein 0.0148 0.0411 0.1393
Onchocerca volvulus 0.003 0.0047 0.0162
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0149 0.0205
Loa Loa (eye worm) hypothetical protein 0.004 0.0077 0.0261
Loa Loa (eye worm) hypothetical protein 0.012 0.0323 0.1096
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0246 0.0712 0.1938
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0013 0.0014
Brugia malayi Patched family protein 0.0018 0.0011 0.0037
Brugia malayi glutaminase DH11.1 0.0273 0.0795 0.2695
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0013 0.001
Echinococcus granulosus sex peptide receptor 0.0019 0.0013 0.0014
Onchocerca volvulus 0.0039 0.0076 0.0291
Toxoplasma gondii patched family protein 0.0018 0.0011 0.0164
Loa Loa (eye worm) hypothetical protein 0.003 0.0047 0.016
Onchocerca volvulus 0.0019 0.0013 0.0011
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0035 0.0063 0.063
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0107 1
Schistosoma mansoni thyroid hormone receptor 0.003 0.0047 0.0119
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0214
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0013 0.001
Onchocerca volvulus 0.0027 0.0039 0.0125
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0039 0.0132
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0034 0.0682
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0039 0.0132
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0047 0.016
Echinococcus granulosus TRP transient receptor potential channel 0.004 0.0077 0.0103
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0742 0.2241 0.6117
Loa Loa (eye worm) hypothetical protein 0.0113 0.0304 0.1033
Echinococcus multilocularis neuropeptide s receptor 0.2319 0.7098 0.7097
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0041 0.0081 0.3421
Leishmania major hypothetical protein, conserved 0.0026 0.0034 0.0955
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0019 0.0013 0.0046
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0246 0.0712 0.2417
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0035 0.0063 0.5773
Schistosoma mansoni transient receptor potential channel 0.0067 0.0161 0.0429
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0019 0.0013 0.0046
Entamoeba histolytica hypothetical protein 0.0072 0.0175 0.1379
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0039 0.0076 0.0794
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0013 0.001
Brugia malayi G protein-coupled receptor 0.0019 0.0013 0.0046
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0246 0.0712 0.2417
Schistosoma mansoni tar DNA-binding protein 0.0124 0.0337 0.091
Echinococcus granulosus G protein coupled receptor 139 0.0019 0.0013 0.0014
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0246 0.0712 0.2417
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Schistosoma mansoni biogenic amine receptor 0.0019 0.0013 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0013 0.0027
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0065 0.0937
Plasmodium vivax acyl-CoA synthetase, putative 0.0089 0.023 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0000017871
Mycobacterium ulcerans beta-lactamase 0.0036 0.0065 0.0652
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0246 0.0712 0.0999
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0000025181
Brugia malayi hypothetical protein 0.0164 0.0461 0.1563
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0047 0.0043
Echinococcus granulosus glycine receptor subunit beta 0.0246 0.0712 0.0999
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0084 0.0215 0.3239
Echinococcus granulosus sterol regulatory element binding protein 0.0129 0.0351 0.049
Loa Loa (eye worm) hypothetical protein 0.0148 0.0411 0.1393
Echinococcus granulosus tachykinin peptides receptor 99D 0.0019 0.0013 0.0014
Brugia malayi RNA recognition motif domain containing protein 0.0124 0.0337 0.1142
Loa Loa (eye worm) hypothetical protein 0.0113 0.0304 0.1033
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0246 0.0712 0.0999
Loa Loa (eye worm) GABA receptor subunit 0.0132 0.0363 0.1232
Brugia malayi AMP-binding enzyme family protein 0.012 0.0323 0.1096
Echinococcus granulosus BC026374 protein S09 family 0.0164 0.0461 0.0644
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0047 0.0043
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0132 0.0363 0.0983
Brugia malayi hypothetical protein 0.0019 0.0013 0.0046
Trichomonas vaginalis antibiotic synthetase, putative 0.0035 0.0063 0.0629
Loa Loa (eye worm) hypothetical protein 0.0709 0.2139 0.7256
Brugia malayi putative neuropeptide receptor 0.0019 0.0013 0.0046
Trypanosoma brucei protein kinase, putative 0.0049 0.0107 1
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0084 0.0114
Onchocerca volvulus 0.0027 0.0039 0.0125
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0063 0.063
Onchocerca volvulus 0.0113 0.0304 0.1316
Loa Loa (eye worm) hypothetical protein 0.0972 0.2948 1
Brugia malayi putative neuropeptide receptor NPR1 0.0019 0.0013 0.0046
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0035 0.0063 0.063
Brugia malayi Dopamine receptor 0.0019 0.0013 0.0046
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0004 0.0000017871
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0454 0.1355 0.1351
Loa Loa (eye worm) hypothetical protein 0.0089 0.023 0.0781
Loa Loa (eye worm) glutaminase 2 0.0273 0.0795 0.2695
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0246 0.0712 0.2417
Mycobacterium ulcerans carboxylesterase, LipT 0.0164 0.0461 0.5724
Echinococcus granulosus somatostatin receptor 0.0019 0.0013 0.0014
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0084 0.09
Onchocerca volvulus 0.0019 0.0013 0.0011
Brugia malayi Patched family protein 0.0018 0.0011 0.0037
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0136 0.156
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0039 0.0076 0.0794
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0175 0.0172
Toxoplasma gondii TIM10 family protein, putative 0.0048 0.0104 0.2231
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0232 0.0228
Brugia malayi nuclear receptor RXR 0.0016 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0014 0.1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0047 0.016
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0742 0.2241 0.6117
Brugia malayi Dopamine receptor protein 1 0.0019 0.0013 0.0046
Brugia malayi follicle stimulating hormone receptor 0.0019 0.0013 0.0046
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0065 0.0937
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0047 0.0119
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0039 0.0076 0.0794
Loa Loa (eye worm) hypothetical protein 0.0031 0.0052 0.0176
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0019 0.0013 0.0046
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0149 0.0507
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0019 0.0013 0.0046
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0047 0.0043
Schistosoma mansoni biogenic amine receptor 0.0019 0.0013 0.0027
Entamoeba histolytica hypothetical protein 0.0072 0.0175 0.1379
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0065 0.0066
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0019 0.0013 0.0027
Loa Loa (eye worm) hypothetical protein 0.003 0.0047 0.016
Brugia malayi hypothetical protein 0.0016 0.0004 0.0012
Schistosoma mansoni alpha-1 adrenergic receptor 0.0019 0.0013 0.0027
Echinococcus granulosus peptide allatostatin:somatostatin 0.0019 0.0013 0.0014
Echinococcus granulosus FTZ F1 alpha 0.003 0.0047 0.0061
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0107 1
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0107 0.1187
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Brugia malayi hypothetical protein 0.0018 0.0011 0.0037
Loa Loa (eye worm) CXXC zinc finger family protein 0.0084 0.0215 0.073
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0012
Loa Loa (eye worm) glutaminase 0.0273 0.0795 0.2695
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0232 0.0786
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0000017871
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0063 0.063
Echinococcus granulosus tumor protein p63 0.0356 0.1052 0.1477
Brugia malayi Patched family protein 0.0018 0.0011 0.0037
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Onchocerca volvulus 0.0019 0.0013 0.0011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0023 0.0053
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0046
Schistosoma mansoni chromosome transmission fidelity factor 0.0039 0.0076 0.0198
Onchocerca volvulus 0.0031 0.0052 0.0183
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0246 0.0712 0.0999
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0047 0.016
Loa Loa (eye worm) hypothetical protein 0.0246 0.0712 0.2417
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0076 0.0794
Mycobacterium leprae Probable lipase LipE 0.0036 0.0065 0.0066
Echinococcus granulosus transient receptor potential ion channel A 0.0091 0.0234 0.0325
Echinococcus granulosus neuropeptide receptor 0.0019 0.0013 0.0014
Onchocerca volvulus 0.0132 0.0363 0.1579
Brugia malayi Cation transporter family protein 0.0246 0.0712 0.2417
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0019 0.0013 0.001
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0047 0.016
Loa Loa (eye worm) hypothetical protein 0.003 0.0047 0.016
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0052 0.0048
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0113 0.0304 0.0424
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0249 0.0724 0.2454
Loa Loa (eye worm) hypothetical protein 0.0132 0.0363 0.1232
Echinococcus granulosus hypothetical protein 0.0019 0.0013 0.0014
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0013 0.0014
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0063 0.5773
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0063 0.0911
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0013 0.001
Loa Loa (eye worm) acetylcholinesterase 1 0.0972 0.2948 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0019 0.0013 0.0046
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0013 0.0014
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0065 0.0086
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0035 0.0063 0.063
Loa Loa (eye worm) TYRA-2 protein 0.0019 0.0013 0.0046
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0013 0.001
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0113 0.0304 0.0301
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0039 0.0076 0.0795
Echinococcus granulosus carboxylesterase 5A 0.0972 0.2948 0.4151
Echinococcus granulosus expressed conserved protein 0.0281 0.0822 0.1153
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0013 0.0014
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0039 0.0035
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0048 0.0104 0.0273
Entamoeba histolytica hypothetical protein 0.0132 0.0363 0.3682
Loa Loa (eye worm) hypothetical protein 0.0089 0.023 0.0781
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0246 0.0712 0.0999
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0246 0.0712 0.0709
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0459 0.5704
Schistosoma mansoni topbp1 0.0039 0.0076 0.0198
Echinococcus multilocularis G-protein coupled receptor, putative 0.0019 0.0013 0.001
Schistosoma mansoni nuclear hormone receptor 0.003 0.0047 0.0119
Echinococcus granulosus transient receptor potential gamma protein 0.0098 0.0258 0.0359
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0084 0.2522
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0019 0.0013 0.0046
Brugia malayi hypothetical protein 0.0039 0.0076 0.0258
Brugia malayi Cation transporter family protein 0.0246 0.0712 0.2417
Schistosoma mansoni hypothetical protein 0.068 0.2049 0.5591
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0232 0.0623
Onchocerca volvulus 0.0113 0.0304 0.1316
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0113 0.0304 0.1033
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0084 0.0215 0.3239
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0047 0.0119
Leishmania major acetyl-CoA synthetase, putative 0.0035 0.0063 0.1861
Echinococcus multilocularis TRP (transient receptor potential) channel 0.004 0.0077 0.0073
Brugia malayi hypothetical protein 0.0113 0.0304 0.1033
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0037
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0116
Schistosoma mansoni hypothetical protein 0.0019 0.0013 0.0027
Schistosoma mansoni acetylcholinesterase 0.0164 0.0461 0.125
Echinococcus granulosus g protein coupled receptor 0.0019 0.0013 0.0014
Mycobacterium ulcerans lipase LipD 0.0036 0.0065 0.0652

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 50 nM Potency towards cytochrome P 450 26 enzyme activity ChEMBL. 15745819
IC50 (binding) = 50 nM Potency towards cytochrome P 450 26 enzyme activity ChEMBL. 15745819
IC50 (binding) = 50 nM Inhibition of CYP26A1 (unknown origin) ChEMBL. 26365710
IC50 (ADMET) = 200 nM Selectivity towards cytochrome P450 3A4 enzyme activity ChEMBL. 15745819
IC50 (ADMET) = 200 nM Selectivity towards cytochrome P450 3A4 enzyme activity ChEMBL. 15745819

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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