Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0537 | 0.0992 |
Onchocerca volvulus | 0.0088 | 0.0803 | 0.3023 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.032 | 0.1375 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0702 | 0.1298 |
Plasmodium vivax | hypothetical protein, conserved | 0.0029 | 0.0061 | 0.8746 |
Brugia malayi | Bromodomain containing protein | 0.0029 | 0.0061 | 0.0262 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0454 | 0.5412 | 0.5412 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.007 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.007 | 0.0129 |
Loa Loa (eye worm) | voltage-gated potassium channel | 0.0106 | 0.1028 | 0.19 |
Onchocerca volvulus | 0.003 | 0.007 | 0.0262 | |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0095 | 0.089 | 0.1645 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0803 | 0.1484 |
Trypanosoma brucei | aminopeptidase, putative | 0.0024 | 0 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0061 | 0.0112 |
Leishmania major | puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0024 | 0 | 0.5 |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.0024 | 0 | 0.5 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0029 | 0.0061 | 0.8746 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0727 | 0.1343 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0088 | 0.0803 | 0.1484 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.007 | 0.0129 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0035 | 0.0138 | 0.0138 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0454 | 0.5412 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0235 | 0.2658 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0207 | 0.2298 | 0.9889 |
Brugia malayi | hypothetical protein | 0.0209 | 0.2324 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0207 | 0.2298 | 0.4247 |
Mycobacterium ulcerans | ion transport protein | 0.0079 | 0.0696 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0095 | 0.089 | 0.089 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0024 | 0 | 0.5 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.007 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0321 | 0.0594 |
Schistosoma mansoni | lipoxygenase | 0.0115 | 0.1149 | 0.2123 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.007 | 0.007 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0035 | 0.0138 | 0.0254 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0029 | 0.0061 | 0.0112 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0024 | 0 | 0.5 |
Onchocerca volvulus | Alhambra homolog | 0.0029 | 0.0061 | 0.0229 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.007 | 0.0129 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0029 | 0.0061 | 0.0061 |
Entamoeba histolytica | aminopeptidase, putative | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | jun protein | 0.0082 | 0.0731 | 0.135 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0029 | 0.0061 | 0.0112 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.0061 | 0.0112 |
Schistosoma mansoni | jun-related protein | 0.0067 | 0.0537 | 0.0992 |
Onchocerca volvulus | 0.0088 | 0.0803 | 0.3023 | |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0122 | 0.0226 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.007 | 0.007 |
Echinococcus granulosus | potassium channel KvQLT family member kqt 1 | 0.0109 | 0.107 | 0.1978 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.007 | 0.0299 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.032 | 0.1375 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0056 | 0.0103 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0024 | 0 | 0.5 |
Onchocerca volvulus | 0.0088 | 0.0803 | 0.3023 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.007 | 0.0129 |
Echinococcus multilocularis | jun protein | 0.0082 | 0.0731 | 0.0731 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0138 | 0.0254 |
Schistosoma mansoni | lipoxygenase | 0.0081 | 0.0712 | 0.1315 |
Echinococcus granulosus | jumonji domain containing protein | 0.004 | 0.0204 | 0.0376 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0138 | 0.0254 |
Plasmodium falciparum | phd finger protein, putative | 0.0029 | 0.0061 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0095 | 0.089 | 0.383 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0088 | 0.0803 | 0.1484 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0048 | 0.0297 | 0.0549 |
Brugia malayi | bZIP transcription factor family protein | 0.0082 | 0.0731 | 0.3144 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0082 | 0.0731 | 0.135 |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.0109 | 0.107 | 0.107 |
Echinococcus multilocularis | peregrin | 0.0029 | 0.0061 | 0.0061 |
Brugia malayi | hypothetical protein | 0.0065 | 0.0508 | 0.2188 |
Brugia malayi | Cytochrome P450 family protein | 0.0048 | 0.0297 | 0.1278 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0024 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0454 | 0.5412 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0122 | 0.0226 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.032 | 0.0591 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0024 | 0 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0035 | 0.0138 | 0.0592 |
Schistosoma mansoni | jumonji domain containing protein | 0.0075 | 0.0645 | 0.1191 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0035 | 0.0138 | 0.0254 |
Echinococcus multilocularis | jumonji domain containing protein | 0.004 | 0.0204 | 0.0204 |
Onchocerca volvulus | 0.0065 | 0.0508 | 0.1913 | |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.007 | 0.0129 |
Giardia lamblia | PHD finger protein 15 | 0.0029 | 0.0061 | 0.5 |
Onchocerca volvulus | 0.0235 | 0.2658 | 1 | |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.006 | 0.0449 | 0.083 |
Echinococcus granulosus | peregrin | 0.0029 | 0.0061 | 0.0112 |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0082 | 0.0731 | 0.0731 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0122 | 0.0527 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.032 | 0.0591 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0115 | 0.1149 | 0.1149 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0454 | 0.5412 | 1 |
Brugia malayi | Cation transporter family protein | 0.0088 | 0.0803 | 0.3457 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0029 | 0.0061 | 0.0112 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0115 | 0.1149 | 0.2123 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0803 | 0.1484 |
Schistosoma mansoni | voltage-gated potassium channel KCNQ | 0.0109 | 0.107 | 0.1978 |
Brugia malayi | PHD-finger family protein | 0.0029 | 0.0061 | 0.0262 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0029 | 0.0061 | 0.8746 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.007 | 0.0129 |
Brugia malayi | Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog | 0.0109 | 0.107 | 0.4605 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 14 mm | Antimicrobial activity of the compound against Candida albicans was determined | ChEMBL. | 15686905 |
Zone of inhibition (functional) | = 10 mm | Antimicrobial activity of the compound against Aspergillus niger was determined | ChEMBL. | 15686905 |
Zone of inhibition (functional) | = 14 mm | Antimicrobial activity of the compound against Candida albicans was determined | ChEMBL. | 15686905 |
Zone of inhibition (functional) | = 33 mm | Antimicrobial activity of thecompound against Bacillus subtiliswas determined | ChEMBL. | 15686905 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.