Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0486 | 0.1364 | 0.1364 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.118 | 1 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0486 | 0.1364 | 0.1364 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.118 | 1 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.118 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.118 | 1 | 0.5 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.118 | 1 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0554 | 0.2207 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0554 | 0.2207 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0486 | 0.1364 | 0.1364 |
Loa Loa (eye worm) | hypothetical protein | 0.118 | 1 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0486 | 0.1364 | 0.1364 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.118 | 1 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.118 | 1 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0554 | 0.2207 | 1 |
Schistosoma mansoni | patched 1 | 0.0486 | 0.1364 | 0.1364 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.118 | 1 | 0.5 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0554 | 0.2207 | 0.5 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0486 | 0.1364 | 0.1364 |
Echinococcus multilocularis | protein patched | 0.0486 | 0.1364 | 0.1364 |
Echinococcus multilocularis | protein dispatched 1 | 0.0486 | 0.1364 | 0.1364 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0486 | 0.1364 | 0.1364 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 20 uM | Inhibitory concentration against Hepatitis C virus RNA dependent RNA polymerase Nonstructural protein 5B | ChEMBL. | 15745795 |
IC50 (binding) | > 20 uM | Inhibitory concentration against Hepatitis C virus RNA dependent RNA polymerase Nonstructural protein 5B | ChEMBL. | 15745795 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.