Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0734 | 0.7579 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0373 | 0.0727 | 0.0727 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0861 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0734 | 0.7579 | 0.1688 |
Schistosoma mansoni | hypothetical protein | 0.0861 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0734 | 0.7579 | 0.7579 |
Loa Loa (eye worm) | hypothetical protein | 0.0861 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0734 | 0.7579 | 0.7579 |
Brugia malayi | Carboxylesterase family protein | 0.0734 | 0.7579 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0734 | 0.7579 | 0.7579 |
Loa Loa (eye worm) | hypothetical protein | 0.0734 | 0.7579 | 0.7579 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0861 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | < 5 ppm | Minimum inhibitory concentration of the compound against Pseudomonas aeruginosa NCIB 6749 was determined in complex medium | ChEMBL. | 15664826 |
MIC (functional) | = 10 ppm | Minimum inhibitory concentration of the compound against Pseudomonas aeruginosa NCIB 6749 was determined in chem. def. medium | ChEMBL. | 15664826 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.