Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bacillus subtilis (strain 168) | DNA polymerase III subunit alpha | Starlite/ChEMBL | References |
Bacillus subtilis (strain 168) | DNA polymerase III | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Chlamydia trachomatis | DNA polymerase III subunit alpha | Get druggable targets OG5_132143 | All targets in OG5_132143 |
Mycobacterium tuberculosis | Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) | Get druggable targets OG5_132143 | All targets in OG5_132143 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase III alpha subunit | Get druggable targets OG5_132143 | All targets in OG5_132143 |
Treponema pallidum | DNA polymerase III subunit alpha | Get druggable targets OG5_132143 | All targets in OG5_132143 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE) | Get druggable targets OG5_132143 | All targets in OG5_132143 |
Mycobacterium ulcerans | DNA polymerase III subunit alpha | Get druggable targets OG5_132143 | All targets in OG5_132143 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.399 | 1 | 0.5 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.399 | 1 | 1 |
Treponema pallidum | DNA polymerase III subunit alpha | 0.0868 | 0.1821 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.399 | 1 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.1643 | 0.3851 | 0.3851 |
Schistosoma mansoni | patched 1 | 0.1643 | 0.3851 | 0.3851 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.399 | 1 | 0.5 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.399 | 1 | 1 |
Echinococcus multilocularis | protein patched | 0.1643 | 0.3851 | 0.3851 |
Mycobacterium ulcerans | DNA polymerase III subunit alpha | 0.0868 | 0.1821 | 0.0601 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.399 | 1 | 1 |
Mycobacterium tuberculosis | Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) | 0.0871 | 0.183 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1872 | 0.4452 | 1 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE) | 0.0871 | 0.183 | 0.5 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.1872 | 0.4452 | 0.5 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.399 | 1 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.1643 | 0.3851 | 0.3851 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.399 | 1 | 0.5 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.1643 | 0.3851 | 0.3851 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1872 | 0.4452 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase III alpha subunit | 0.0868 | 0.1821 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.399 | 1 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.1643 | 0.3851 | 0.3851 |
Echinococcus granulosus | Protein patched homolog 1 | 0.1643 | 0.3851 | 0.3851 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.1643 | 0.3851 | 0.3851 |
Chlamydia trachomatis | DNA polymerase III subunit alpha | 0.0868 | 0.1821 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1872 | 0.4452 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.1643 | 0.3851 | 0.3851 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.11 uM | Inhibitory constant against DNA polymerases IIIE from Bacillus subtilis; (a) | ChEMBL. | 15664846 |
Ki (binding) | = 0.11 uM | Inhibitory constant against DNA polymerases IIIE from Bacillus subtilis; (a) | ChEMBL. | 15664846 |
Ki (binding) | = 0.37 uM | Inhibitory constant against DNA polymerases IIIC produced by Bacillus subtilis; (a) | ChEMBL. | 15664846 |
Ki (binding) | = 0.37 uM | Inhibitory constant against DNA polymerases IIIC produced by Bacillus subtilis; (a) | ChEMBL. | 15664846 |
Ki (binding) | = 45 uM | Inhibitory constant against DNA polymerases IIIE from Escherichia coli; (a) | ChEMBL. | 15664846 |
Ki (binding) | = 45 uM | Inhibitory constant against DNA polymerases IIIE from Escherichia coli; (a) | ChEMBL. | 15664846 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.