Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0026 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0014 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0026 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0014 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0026 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0026 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0014 | 0.131 | 0.131 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0026 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0026 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0014 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0014 | 0.131 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0026 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0026 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0014 | 0.1071 | 0.1071 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0026 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0026 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0026 | 1 | 1 |
Onchocerca volvulus | 0.0026 | 1 | 1 | |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0026 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0026 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.1071 | 0.1071 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0026 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0026 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0026 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.1071 | 0.1071 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0026 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0026 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0014 | 0.131 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0026 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.131 | 0.131 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.131 | 0.131 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0026 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0026 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0014 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0026 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 0.131 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.1071 | 0.1071 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0026 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0014 | 0.131 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 0.131 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0014 | 0.1071 | 0.1071 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0014 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0026 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0026 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0026 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0026 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0026 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0026 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0026 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0026 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0026 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0026 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0026 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0026 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.131 | 0.131 |
Brugia malayi | nuclear receptor NHR-88 | 0.0026 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0026 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0026 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0026 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0026 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0026 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0026 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0026 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0026 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0014 | 0.131 | 0.131 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0014 | 0.1071 | 0.1071 |
Schistosoma mansoni | nuclear hormone receptor | 0.0026 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0026 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0014 | 0.1071 | 0.1071 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0026 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0026 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0026 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0014 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0026 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0026 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
cLogP | = 3.51 | c Log P value of the compound was determined | ChEMBL. | 15664824 |
IC50 (functional) | = 1.39 uM | Inhibitory concentration of the compound against Vascular Endothelial Growth Factor dependent Human Umbilical Vascular Endothelial Cells (VEGF-HUVEC) | ChEMBL. | 15664824 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.