Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.033 | 1 | 1 |
Schistosoma mansoni | patched 1 | 0.0136 | 0.2746 | 0.2746 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0136 | 0.2746 | 0.2746 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0155 | 0.3454 | 0.5 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.033 | 1 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.033 | 1 | 0.5 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.033 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.033 | 1 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0155 | 0.3454 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.033 | 1 | 0.5 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.033 | 1 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.033 | 1 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0155 | 0.3454 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.5304 | 0.5304 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0155 | 0.3454 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.5304 | 0.3527 |
Echinococcus granulosus | geminin | 0.0205 | 0.5304 | 0.3527 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.5304 | 0.5304 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10 nM | Inhibitory concentration against 3-hydroxy-3-methylglutaryl-CoA reductase | ChEMBL. | 15686906 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.