Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor IX | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 0.12 uM | Inhibitory constant against human purified Coagulation factor IXa (fIXa) | ChEMBL. | 15582405 |
Ki (binding) | > 0.12 uM | Inhibitory constant against human purified Coagulation factor IXa (fIXa) | ChEMBL. | 15582405 |
Ki (binding) | > 0.18 uM | Inhibitory constant against human purified Coagulation factor Xa (fXa) | ChEMBL. | 15582405 |
Ki (binding) | > 0.18 uM | Inhibitory constant against human purified Coagulation factor Xa (fXa) | ChEMBL. | 15582405 |
Ratio (binding) | = 0.7 | Relative inhibition of human purifed Coagulation factor IXa and Xa, ratio of Ki | ChEMBL. | 15582405 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.