Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IX | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0324 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.023 | 0.1421 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.023 | 0.1421 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.023 | 0.1421 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.023 | 0.1421 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.023 | 0.1421 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0324 | 1 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0324 | 1 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.023 | 0.1421 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0324 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.023 | 0.1421 | 0.5 |
Brugia malayi | thymidylate synthase | 0.023 | 0.1421 | 1 |
Onchocerca volvulus | 0.023 | 0.1421 | 0.5 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0324 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 20 nM | Inhibitory activity against cytosolic human carbonic anhydrase I | ChEMBL. | 15664816 |
Ki (binding) | > 20 nM | Inhibitory activity against cytosolic human carbonic anhydrase I | ChEMBL. | 15664816 |
Ki (binding) | = 61.6 nM | Inhibitory activity against membrane bound tumour associated human carbonic anhydrase IX | ChEMBL. | 15664816 |
Ki (binding) | = 61.6 nM | Inhibitory activity against membrane bound tumour associated human carbonic anhydrase IX | ChEMBL. | 15664816 |
Ki (binding) | = 643 nM | Inhibitory activity against cytosolic human carbonic anhydrase II | ChEMBL. | 15664816 |
Ki (binding) | = 643 nM | Inhibitory activity against cytosolic human carbonic anhydrase II | ChEMBL. | 15664816 |
Ratio (binding) | = 10.43 | Ratio of inhibitory activity of human cytosolic carbonic anhydrase II to tumour associated carbonic anhydrase IX | ChEMBL. | 15664816 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.