Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.588 | 0.5169 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0181 | 0.1472 | 0.5 |
Echinococcus granulosus | AMP deaminase 2 | 0.0181 | 0.1472 | 0.1472 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0181 | 0.1472 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0181 | 0.1472 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0554 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0554 | 1 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0185 | 0.1582 | 0.083 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0554 | 1 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.0181 | 0.1472 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.588 | 0.5169 |
Leishmania major | adenine aminohydrolase | 0.0554 | 1 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.0554 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0181 | 0.1472 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.588 | 0.5169 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0181 | 0.1472 | 0.5 |
Echinococcus multilocularis | AMP deaminase 2 | 0.0181 | 0.1472 | 0.071 |
Trypanosoma brucei | AMP deaminase, putative | 0.0181 | 0.1472 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0185 | 0.1582 | 0.1582 |
Loa Loa (eye worm) | hypothetical protein | 0.0554 | 1 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.082 | 0.082 |
Plasmodium vivax | adenosine deaminase, putative | 0.0554 | 1 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.0554 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0181 | 0.1472 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.0554 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.0554 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0554 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0554 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.0181 | 0.1472 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.588 | 0.5169 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0181 | 0.1472 | 0.5 |
Schistosoma mansoni | adenosine deaminase | 0.0554 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0554 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.082 | 0.082 |
Trypanosoma cruzi | AMP deaminase 2, putative | 0.0181 | 0.1472 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0554 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.0554 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0181 | 0.1472 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0554 | 1 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.0554 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0185 | 0.1582 | 0.1582 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0554 | 1 | 1 |
Schistosoma mansoni | AMP deaminase | 0.0181 | 0.1472 | 0.1472 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 8 nM | Agonist activity towards thyroid hormone receptor expressed in human HepG2 cells | ChEMBL. | 15780617 |
EC50 (functional) | = 8 nM | Agonist activity towards thyroid hormone receptor expressed in human HepG2 cells | ChEMBL. | 15780617 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.