Detailed information for compound 319730

Basic information

Technical information
  • TDR Targets ID: 319730
  • Name: tert-butyl N-[2-[[4-(diethylamino)phenyl]carb amoyl]-3,4-dihydro-1H-naphthalen-2-yl]-N-meth ylcarbamate
  • MW: 451.601 | Formula: C27H37N3O3
  • H donors: 1 H acceptors: 2 LogP: 5.08 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1ccc(cc1)NC(=O)C1(CCc2c(C1)cccc2)N(C(=O)OC(C)(C)C)C)CC
  • InChi: 1S/C27H37N3O3/c1-7-30(8-2)23-15-13-22(14-16-23)28-24(31)27(29(6)25(32)33-26(3,4)5)18-17-20-11-9-10-12-21(20)19-27/h9-16H,7-8,17-19H2,1-6H3,(H,28,31)
  • InChiKey: XBXQULUWEPTITC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • tert-butyl N-[2-[[4-(diethylamino)phenyl]carbamoyl]tetralin-2-yl]-N-methyl-carbamate
  • N-[2-[[4-(diethylamino)anilino]-oxomethyl]-2-tetralinyl]-N-methylcarbamic acid tert-butyl ester
  • tert-butyl N-[2-[[4-(diethylamino)phenyl]carbamoyl]-3,4-dihydro-1H-naphthalen-2-yl]-N-methyl-carbamate
  • N-[2-[[4-(diethylamino)phenyl]carbamoyl]tetralin-2-yl]-N-methyl-carbamic acid tert-butyl ester
  • tert-butyl N-[2-[(4-diethylaminophenyl)carbamoyl]-3,4-dihydro-1H-naphthalen-2-yl]-N-methylcarbamate
  • tert-butyl N-[2-[(4-diethylaminophenyl)carbamoyl]tetralin-2-yl]-N-methyl-carbamate
  • N-[2-[[(4-diethylaminophenyl)amino]-oxomethyl]-2-tetralinyl]-N-methylcarbamic acid tert-butyl ester
  • N-[2-[(4-diethylaminophenyl)carbamoyl]tetralin-2-yl]-N-methyl-carbamic acid tert-butyl ester
  • tert-butyl N-[2-[(4-diethylaminophenyl)carbamoyl]-3,4-dihydro-1H-naphthalen-2-yl]-N-methyl-carbamate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.009 0.0184
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.009 0.1902
Echinococcus granulosus shaker cognate 0.0033 0.0066 0.0065
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0053 0.1108
Echinococcus granulosus jun protein 0.0085 0.0314 0.0313
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0135
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0138 0.2802
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0201 0.02
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.009 0.0398
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.0126 0.0261
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.0076
Entamoeba histolytica Hypothetical protein T24C12.3, putative 0.0117 0.0466 1
Mycobacterium ulcerans fructokinase, PfkB 0.0117 0.0466 0.3745
Brugia malayi Nuclear hormone receptor E75 0.0048 0.0139 0.0287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0082 0.0363
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0033 0.0066 0.0065
Schistosoma mansoni cytochrome P450 0.0029 0.0047 0.0046
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0048 0.0139 0.0137
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0033 0.0066 0.0065
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0029 0.0047 0.0941
Loa Loa (eye worm) glutaminase 0.0281 0.1241 0.259
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0053 0.2574
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0033 0.0066 0.0065
Mycobacterium tuberculosis 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) 0.0117 0.0466 0.9559
Echinococcus granulosus sodium channel protein 0.0033 0.0066 0.0065
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0201 0.02
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0029 0.0047 0.0369
Schistosoma mansoni inositol monophosphatase 0.0038 0.009 0.0088
Leishmania major adenosine kinase-like protein 0.0117 0.0466 0.097
Echinococcus granulosus apoptotic protease activating factor 1 0.0042 0.0111 0.0109
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0054 0.0167 0.0345
Brugia malayi Thioredoxin reductase 0.0048 0.0138 0.0284
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0206 0.0426
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0027 0.0113
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0053 0.1108
Entamoeba histolytica tagatose-6-phosphate kinase, putative 0.0117 0.0466 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0102 0.0396 0.0394
Brugia malayi Nuclear hormone receptor-like 1 0.0054 0.0167 0.0345
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0048 0.0139 0.0137
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0048 0.0139 0.0137
Echinococcus multilocularis ribokinase 0.0117 0.0466 0.0464
Plasmodium vivax glutathione reductase, putative 0.0048 0.0138 0.6812
Schistosoma mansoni lozenge 0.0057 0.0181 0.0179
Schistosoma mansoni nuclear receptor 0.0048 0.0139 0.0137
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0428 0.194 0.4052
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0053 0.0232
Loa Loa (eye worm) hypothetical protein 0.0102 0.0396 0.0823
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0033 0.0066 0.0065
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0086 0.038
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0102 0.0396 0.0394
Echinococcus granulosus lysosomal alpha glucosidase 0.0167 0.0703 0.0702
Echinococcus granulosus ribokinase 0.0117 0.0466 0.0464
Leishmania major cytochrome p450-like protein 0.0047 0.0132 0.0273
Toxoplasma gondii hypothetical protein 0.0033 0.0066 0.0135
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0735 0.3304
Onchocerca volvulus 0.0912 0.423 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0068 0.0233 0.0484
Leishmania major DNA polymerase kappa, putative 0.0021 0.0012 0.0021
Leishmania major ribokinase, putative 0.0117 0.0466 0.097
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0029 0.0047 0.0369
Brugia malayi nuclear receptor NHR-67 0.0048 0.0139 0.0287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0071 0.0312
Loa Loa (eye worm) hypothetical protein 0.0048 0.0139 0.0287
Onchocerca volvulus Putative pyridoxal kinase 0.0117 0.0466 0.102
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0086 0.038
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.0439 0.0438
Trypanosoma brucei trypanothione reductase 0.0048 0.0138 0.0288
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.0487 1
Echinococcus granulosus hypothetical protein 0.0033 0.0066 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0102 0.0396 0.0823
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0066 0.0065
Onchocerca volvulus 0.0061 0.0201 0.0389
Loa Loa (eye worm) hypothetical protein 0.0061 0.0201 0.0417
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0053 0.5
Echinococcus multilocularis potassium voltage gated channel protein 0.0033 0.0066 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0102 0.0396 0.0823
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.0126 0.0125
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0135
Trichomonas vaginalis set domain proteins, putative 0.0488 0.2221 1
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0108 0.0106
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0029 0.0047 0.0369
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0033 0.0066 0.0065
Schistosoma mansoni hypothetical protein 0.0042 0.0111 0.0109
Brugia malayi Ribokinase 0.0117 0.0466 0.097
Loa Loa (eye worm) hypothetical protein 0.0048 0.0139 0.0287
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0054 0.0167 0.0165
Echinococcus multilocularis voltage gated potassium channel 0.0033 0.0066 0.0065
Brugia malayi Inositol-1 0.0038 0.009 0.0184
Brugia malayi conserved hypotetical protein 0.0048 0.0139 0.0287
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0033 0.0066 0.0065
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0265 0.1167 0.2436
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.1167 0.5252
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0071 0.0312
Schistosoma mansoni nuclear hormone receptor 0.0102 0.0396 0.0394
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0033 0.0066 0.0067
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0206 0.1647
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.006 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0082 0.0363
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0038 0.0076
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0066 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0082 0.0363
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0206 0.1647
Trypanosoma brucei ribokinase, putative 0.0117 0.0466 0.0973
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0039 0.017
Echinococcus granulosus voltage dependent calcium channel 0.0033 0.0066 0.0065
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0126 0.0261
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0033 0.0066 0.0065
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0102 0.0396 0.0394
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0033 0.0066 0.0065
Echinococcus granulosus potassium voltage gated channel protein 0.0033 0.0066 0.0065
Plasmodium vivax SET domain protein, putative 0.0061 0.0201 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0071 0.0312
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0029 0.0047 0.0941
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0071 0.0312
Loa Loa (eye worm) hypothetical protein 0.0048 0.0139 0.0287
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0102 0.0396 0.0823
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0066 0.0065
Echinococcus granulosus hyperpolarization activated cyclic 0.0033 0.0066 0.0065
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0053 0.0232
Echinococcus granulosus caspase 2 0.006 0.0197 0.0195
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0048 0.0139 0.0137
Schistosoma mansoni retinoic acid receptor RXR 0.0102 0.0396 0.0394
Loa Loa (eye worm) hypothetical protein 0.0102 0.0396 0.0823
Giardia lamblia GTOR 0.0046 0.0126 0.2688
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0027 0.0114
Loa Loa (eye worm) hypothetical protein 0.0048 0.0139 0.0287
Mycobacterium ulcerans glutaminase 0.0281 0.1241 1
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.0466 0.2091
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0054 0.0167 0.0165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0102 0.0396 0.0823
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0033 0.0066 0.0065
Onchocerca volvulus 0.0097 0.0369 0.0789
Schistosoma mansoni alpha-glucosidase 0.0144 0.0593 0.0591
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0054 0.0167 0.0165
Schistosoma mansoni nuclear hormone receptor 0.0048 0.0139 0.0137
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0033 0.0066 0.0065
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0033 0.0066 0.0065
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0086 0.0176
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0102 0.0396 0.0394
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0102 0.0396 0.0394
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0029 0.0047 0.0941
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.1167 0.5252
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0033 0.0066 0.0065
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0029 0.0047 0.0369
Schistosoma mansoni inositol monophosphatase 0.0038 0.009 0.0088
Schistosoma mansoni transient receptor potential channel 0.0034 0.0072 0.0071
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0033 0.0066 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0108 0.0225
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.0703 0.0702
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0066 0.0065
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0053 0.3779
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.009 0.0184
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.009 0.0398
Loa Loa (eye worm) hypothetical protein 0.0117 0.0466 0.097
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0054 0.0167 0.0165
Echinococcus granulosus potassium voltage gated channel protein 0.0033 0.0066 0.0065
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0048 0.0139 0.0137
Toxoplasma gondii kinase, pfkB family protein 0.0117 0.0466 0.097
Toxoplasma gondii transporter, cation channel family protein 0.0033 0.0066 0.0135
Brugia malayi Cytochrome P450 family protein 0.0068 0.0233 0.0484
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0029 0.0047 0.0369
Brugia malayi hypothetical protein 0.0455 0.2066 0.4315
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0071 0.054
Brugia malayi nuclear hormone receptor 0.0102 0.0396 0.0823
Echinococcus granulosus ecdysone induced protein 78C 0.0102 0.0396 0.0394
Onchocerca volvulus 0.0489 0.2227 0.5221
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0029 0.0047 0.0941
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0086 0.0084
Schistosoma mansoni hypothetical protein 0.0106 0.0411 0.0409
Echinococcus multilocularis transient receptor potential cation channel 0.0034 0.0072 0.0071
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0033 0.0066 0.0065
Loa Loa (eye worm) CYP4Cod1 0.0047 0.0132 0.0273
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0108 0.0222
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0086 0.038
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0033 0.0066 0.0135
Brugia malayi polk-prov protein 0.0032 0.006 0.0121
Giardia lamblia Ribokinase 0.0117 0.0466 1
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.0117 0.0466 0.0464
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0439 0.1972
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0033 0.0066 0.0067
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0076 0.0159
Brugia malayi Pre-SET motif family protein 0.0061 0.0201 0.0417
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0108 0.0225
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0206 0.0426
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0033 0.0066 0.0135
Loa Loa (eye worm) DR-78 0.0048 0.0139 0.0287
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0066 0.0291
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.1167 0.5252
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0201 0.02
Echinococcus multilocularis transient receptor potential gamma protein 0.0033 0.0066 0.0065
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0012 0.0026
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0033 0.0066 0.0135
Schistosoma mansoni microtubule-associated protein tau 0.2129 1 1
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0033 0.0066 0.0065
Onchocerca volvulus 0.0033 0.0066 0.0067
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0033 0.0066 0.0065
Echinococcus multilocularis Protein lozenge 0.0057 0.0181 0.0179
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0029 0.0047 0.0369
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.0076
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0066 0.0065
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0029 0.0047 0.0369
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0038 0.0076
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0048 0.0139 0.0287
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0085 0.0314 0.0313
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0071 0.0312
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0066 0.0135
Echinococcus granulosus cytochrome P450 2K1 0.0029 0.0047 0.0046
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0102 0.0396 0.0823
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0033 0.0066 0.0065
Schistosoma mansoni zinc finger protein 0.0048 0.0139 0.0137
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0033 0.0066 0.0065
Leishmania major trypanothione reductase 0.0048 0.0138 0.0284
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0108 0.0225
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0029 0.0047 0.0941
Echinococcus multilocularis transient receptor potential cation channel 0.0033 0.0066 0.0065
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.1167 0.5252
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0033 0.0066 0.0065
Echinococcus multilocularis voltage gated potassium channel 0.0033 0.0066 0.0065
Brugia malayi nuclear receptor RXR 0.0048 0.0139 0.0287
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0085 0.0084
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0108 0.0478
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.009 0.0184
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0135
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0033 0.0066 0.0135
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0033 0.0066 0.0065
Echinococcus granulosus voltage gated potassium channel 0.0033 0.0066 0.0065
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.0076
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0135
Echinococcus multilocularis 0.0029 0.0047 0.0046
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.0439 0.9429
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0086 0.0176
Echinococcus granulosus voltage dependent calcium channel 0.0033 0.0066 0.0065
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0029 0.0047 0.0941
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.0076
Schistosoma mansoni transient receptor potential channel 0.0033 0.0066 0.0065
Echinococcus multilocularis potassium large conductance calcium activated 0.0033 0.0066 0.0065
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.0126 0.0125
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0053 0.3779
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0029 0.0047 0.0941
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0033 0.0066 0.0135
Echinococcus granulosus TRP transient receptor potential channel 0.0033 0.0066 0.0065
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0033 0.0066 0.0065
Echinococcus multilocularis transfer RNA-Gly 0.0033 0.0066 0.0065
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0206 0.0204
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.0076
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0029 0.0047 0.0369
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0108 0.0225
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0135
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0029 0.0047 0.0941
Schistosoma mansoni steroid hormone receptor ad4bp 0.0102 0.0396 0.0394
Loa Loa (eye worm) hypothetical protein 0.0048 0.0139 0.0287
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0138 0.0284
Loa Loa (eye worm) hypothetical protein 0.0048 0.0139 0.0287
Echinococcus multilocularis microtubule associated protein 2 0.2129 1 1
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0038 0.0076
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0135
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0102 0.0396 0.0853
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.0429 0.8807
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0029 0.0047 0.0941
Echinococcus granulosus short transient receptor potential channel 6 0.0034 0.0072 0.0071
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0086 0.038
Echinococcus multilocularis caspase 2 0.006 0.0197 0.0195
Echinococcus granulosus thyroid hormone receptor alpha 0.0048 0.0139 0.0137
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0086 0.0176
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0082 0.0169
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0029 0.0047 0.0369
Toxoplasma gondii kinase, pfkB family protein 0.1029 0.4786 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0102 0.0396 0.0823
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0735 0.3304
Brugia malayi hypothetical protein 0.0067 0.0227 0.0472
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0033 0.0066 0.0065
Loa Loa (eye worm) voltage-gated calcium channel 0.0033 0.0066 0.0135
Brugia malayi nuclear hormone receptor 0.0048 0.0139 0.0287
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0108 0.0225
Onchocerca volvulus Cell death protein 3 homolog 0.006 0.0197 0.0379
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0033 0.0066 0.0135
Schistosoma mansoni transient receptor potential channel 0.0033 0.0066 0.0065
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.0487 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.0126 0.0125
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0102 0.0396 0.0823
Echinococcus multilocularis conserved hypothetical protein 0.0033 0.0066 0.0065
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0033 0.0066 0.0065
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.0439 0.9429
Loa Loa (eye worm) hypothetical protein 0.0102 0.0396 0.0823
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0102 0.0396 0.0823
Loa Loa (eye worm) hypothetical protein 0.0102 0.0396 0.0823
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0033 0.0066 0.0065
Loa Loa (eye worm) hypothetical protein 0.0455 0.2066 0.4315
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0112 0.0439 0.8911
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0027 0.0114
Entamoeba histolytica hypothetical protein 0.0037 0.0085 0.1801
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0735 0.3304
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.009 0.0088
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0086 0.038
Loa Loa (eye worm) calcium channel 0.0033 0.0066 0.0135
Brugia malayi Steroid receptor seven-up type 2 0.0102 0.0396 0.0823
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0029 0.0047 0.0941
Loa Loa (eye worm) hypothetical protein 0.1029 0.4786 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0086 0.038
Echinococcus granulosus Nuclear hormone receptor HR96 0.0048 0.0139 0.0137
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0033 0.0066 0.0065
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0735 0.3304
Trypanosoma cruzi adenosine kinase, putative 0.1029 0.4786 1
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0439 0.1972
Toxoplasma gondii transporter, cation channel family protein 0.0033 0.0066 0.0135
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0029 0.0047 0.0941
Schistosoma mansoni hypothetical protein 0.0037 0.0085 0.0084
Brugia malayi nuclear receptor RXR 0.0054 0.0167 0.0345
Schistosoma mansoni peroxidasin 0.0027 0.0038 0.0036
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0439 0.1972
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0066 0.0065
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0033 0.0066 0.0135
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0033 0.0066 0.0135
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0082 0.0172
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.0429 0.8807
Loa Loa (eye worm) voltage-gated potassium channel 0.0033 0.0066 0.0135
Mycobacterium tuberculosis Adenosine kinase 0.0117 0.0466 0.9559
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0033 0.0066 0.0065
Brugia malayi orphan nuclear receptor NR2E1 0.0048 0.0139 0.0287
Leishmania major tagatose-6-phosphate kinase-like protein 0.0117 0.0466 0.097
Schistosoma mansoni adenosine kinase 0.1029 0.4786 0.4785
Brugia malayi Blistered cuticle protein 3 0.0027 0.0038 0.0076
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0033 0.0066 0.0139
Plasmodium falciparum thioredoxin reductase 0.0048 0.0138 1
Brugia malayi Transient-receptor-potential like protein 0.0033 0.0066 0.0135
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0029 0.0047 0.0095
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0085 0.0084
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.0076
Brugia malayi tailless protein 0.0048 0.0139 0.0287
Echinococcus multilocularis short transient receptor potential channel 6 0.0034 0.0072 0.0071
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0029 0.0047 0.0941
Echinococcus multilocularis FTZ F1 alpha 0.0102 0.0396 0.0394
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0033 0.0066 0.0065
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0038 0.0076
Brugia malayi hypothetical protein 0.0033 0.0066 0.0135
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0029 0.0047 0.0941
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0167 0.0703 0.1466
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0201 0.02
Schistosoma mansoni transient receptor potential channel 4 0.0033 0.0066 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0201 0.02
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0012 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0102 0.0396 0.0823
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0066 0.0065
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0135
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0053 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0071 0.0312
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0029 0.0047 0.0369
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0102 0.0396 0.0394
Brugia malayi glutaminase DH11.1 0.0281 0.1241 0.259
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0132 0.0273
Echinococcus granulosus sodium leak channel non selective protein 0.0033 0.0066 0.0065
Echinococcus granulosus transient receptor potential cation channel 0.0033 0.0066 0.0065
Loa Loa (eye worm) ryanodine receptor 0.0033 0.0066 0.0135
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.009 0.0088
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0029 0.0047 0.0369
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0012 0.0203
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0066 0.0065
Loa Loa (eye worm) hypothetical protein 0.0048 0.0139 0.0287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0126 0.0562
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0135
Leishmania major cytochrome p450-like protein 0.0029 0.0047 0.0095
Echinococcus granulosus voltage gated potassium channel 0.0033 0.0066 0.0065
Echinococcus granulosus potassium large conductance calcium activated 0.0033 0.0066 0.0065
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0046 0.0126 0.2688
Mycobacterium leprae Probable adenosine kinase adk 0.0117 0.0466 0.9513
Brugia malayi hypothetical protein 0.0042 0.0111 0.0228
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0135
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0102 0.0396 0.0394
Echinococcus granulosus two pore calcium channel protein 1 0.0033 0.0066 0.0065
Echinococcus granulosus ryanodine receptor 44f 0.0033 0.0066 0.0065
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0053 0.0232
Loa Loa (eye worm) hypothetical protein 0.0054 0.0167 0.0345
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.0126 0.0261
Schistosoma mansoni nuclear receptor 0.0048 0.0139 0.0137
Leishmania major tagatose-6-phosphate kinase-like protein 0.0117 0.0466 0.097
Trypanosoma cruzi adenosine kinase, putative 0.0117 0.0466 0.097
Onchocerca volvulus 0.0048 0.0139 0.0241
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0102 0.0396 0.0823
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0012 0.0021
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0779 0.3504
Entamoeba histolytica hypothetical protein 0.0037 0.0085 0.1801
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0033 0.0066 0.0065
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0029 0.0047 0.0941
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0033 0.0066 0.0135
Echinococcus granulosus transient receptor potential cation channel 0.0033 0.0066 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0027 0.0114
Brugia malayi olfactory channel protein osm-9 0.0034 0.0072 0.0147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0095 0.042
Trypanosoma brucei adenosine kinase, putative 0.1029 0.4786 1
Onchocerca volvulus 0.0042 0.0111 0.0173
Schistosoma mansoni coup transcription factor 0.0102 0.0396 0.0394
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0047 0.0132 0.1053
Loa Loa (eye worm) hypothetical protein 0.0034 0.0072 0.0147
Schistosoma mansoni voltage-gated ion channel 0.0033 0.0066 0.0065
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0126 0.0261
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0033 0.0066 0.0065
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0033 0.0066 0.0135
Schistosoma mansoni glutaminase 0.0281 0.1241 0.1239
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0066 0.0065
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0033 0.0066 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0038 0.0164
Echinococcus granulosus transient receptor potential cation channel 0.0033 0.0066 0.0065
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0033 0.0066 0.0065
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0029 0.0047 0.0095
Echinococcus multilocularis ecdysone induced protein 78C 0.0102 0.0396 0.0394
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.0126 0.0261
Mycobacterium tuberculosis Ribokinase RbsK 0.0117 0.0466 0.9559
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0102 0.0396 0.0823
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0053 0.2574
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0029 0.0047 0.0941
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0033 0.0066 0.0135
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0735 0.3304
Brugia malayi 6-phosphofructokinase 0.0112 0.0439 0.0915
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0066 0.0065
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.009 0.0184
Brugia malayi hypothetical protein 0.0037 0.0085 0.0175
Loa Loa (eye worm) hypothetical protein 0.0102 0.0396 0.0823
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0135
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0066 0.0065
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0071 0.143
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0102 0.0396 0.0394
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0102 0.0396 0.0823
Schistosoma mansoni adenosine kinase 0.1029 0.4786 0.4785
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0029 0.0047 0.0369
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.0076
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.0126 0.0264
Brugia malayi Peroxidasin 0.0027 0.0038 0.0076
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0085 0.0314 0.0313
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0029 0.0047 0.0099
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0033 0.0066 0.0065
Loa Loa (eye worm) ion channel NompC 0.0033 0.0066 0.0135
Mycobacterium ulcerans 6-phosphofructokinase 0.0112 0.0439 0.3531
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0027 0.0113
Onchocerca volvulus 0.0455 0.2066 0.4838
Echinococcus granulosus FTZ F1 alpha 0.0102 0.0396 0.0394
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0029 0.0047 0.0369
Schistosoma mansoni 60S ribosomal protein L21 0.0033 0.0066 0.0065
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0033 0.0066 0.0065
Entamoeba histolytica kinase, PfkB family 0.0117 0.0466 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0139 0.0287
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0033 0.0066 0.0065
Loa Loa (eye worm) runx1 0.0057 0.0181 0.0374
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0779 0.3504
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0132 0.0273
Onchocerca volvulus Protein ultraspiracle homolog 0.0102 0.0396 0.0853
Schistosoma mansoni voltage-gated cation channel 0.0033 0.0066 0.0065
Loa Loa (eye worm) hypothetical protein 0.0048 0.0139 0.0287
Loa Loa (eye worm) hypothetical protein 0.0042 0.0111 0.0228
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0033 0.0066 0.0135
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0048 0.0139 0.0241
Echinococcus granulosus short transient receptor potential channel 6 0.0033 0.0066 0.0065
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0102 0.0396 0.0394
Echinococcus multilocularis potassium voltage gated channel protein 0.0033 0.0066 0.0065
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0138 0.0284
Brugia malayi nuclear receptor NHR-88 0.0102 0.0396 0.0823
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0206 0.0204
Leishmania major adenosine kinase-like protein 0.0117 0.0466 0.097
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0135
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0206 0.1647
Echinococcus granulosus adenosine kinase 0.1029 0.4786 0.4785
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0038 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0051 0.022
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0048 0.0139 0.0137
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0029 0.0047 0.0369
Echinococcus granulosus peroxidasin 0.0027 0.0038 0.0036
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.0439 0.9429
Loa Loa (eye worm) hypothetical protein 0.006 0.0197 0.0408
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.0076
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0135
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0102 0.0396 0.0394
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.0429 0.8807
Trypanosoma brucei glucosidase, putative 0.0037 0.0086 0.018
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0033 0.0066 0.0065
Trypanosoma brucei adenosine kinase, putative 0.1029 0.4786 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0108 0.0225
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0033 0.0066 0.0065
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.009 0.0712
Brugia malayi hypothetical protein 0.0117 0.0466 0.097
Echinococcus granulosus 6 phosphofructokinase 0.0112 0.0439 0.0438
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0086 0.038
Schistosoma mansoni voltage-dependent calcium channel 0.0033 0.0066 0.0065
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0048 0.0139 0.0137
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0112 0.0439 0.9013
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.0439 0.0915
Brugia malayi hypothetical protein 0.0048 0.0139 0.0287
Schistosoma mansoni nuclear hormone receptor 0.0048 0.0139 0.0137
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.0117 0.0466 0.0464
Echinococcus multilocularis shaker cognate 0.0033 0.0066 0.0065
Echinococcus multilocularis short transient receptor potential channel 6 0.0033 0.0066 0.0065
Brugia malayi Adenosine kinase-like 0.1029 0.4786 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0167 0.0345
Loa Loa (eye worm) inositol-1 0.0038 0.009 0.0184
Onchocerca volvulus Ribokinase homolog 0.0117 0.0466 0.102
Schistosoma mansoni caspase-7 (C14 family) 0.006 0.0197 0.0195
Echinococcus multilocularis apoptotic protease activating factor 1 0.0042 0.0111 0.0109
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0108 0.0225
Loa Loa (eye worm) hypothetical protein 0.0048 0.0139 0.0287
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0033 0.0066 0.0135
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0029 0.0047 0.0095
Loa Loa (eye worm) nuclear receptor NHR-67 0.0048 0.0139 0.0287
Echinococcus multilocularis transient receptor potential cation channel 0.0034 0.0072 0.0071
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0108 0.0225
Entamoeba histolytica fructokinase, putative 0.0117 0.0466 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0053 0.0232
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0191 0.0189
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.009 1
Brugia malayi bZIP transcription factor family protein 0.0085 0.0314 0.0653
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0102 0.0396 0.0823
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0138 0.0136
Brugia malayi Cytochrome P450 family protein 0.0047 0.0132 0.0273
Echinococcus multilocularis adenosine kinase 0.1029 0.4786 0.4785
Brugia malayi hypothetical protein 0.0054 0.0167 0.0345
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0102 0.0396 0.0823
Trichomonas vaginalis ribokinase, putative 0.0117 0.0466 0.2091
Leishmania major putative PfkB family sugar kinase 0.0117 0.0466 0.097
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0053 0.0232
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.0429 0.8683
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0033 0.0066 0.0065
Schistosoma mansoni alpha glucosidase 0.0037 0.0086 0.0084
Leishmania major hypothetical protein, conserved 0.0033 0.0066 0.0135
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0033 0.0066 0.0065
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0138 0.6812
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0048 0.0139 0.0241
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0033 0.0066 0.0135
Brugia malayi Nuclear hormone receptor-like 1 0.0054 0.0167 0.0345
Echinococcus granulosus potassium voltage gated channel protein 0.0033 0.0066 0.0065
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0086 0.0176
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0066 0.0065
Mycobacterium tuberculosis Probable reductase 0.011 0.0429 0.8807
Echinococcus granulosus transient receptor potential cation channel 0.0033 0.0066 0.0065
Echinococcus granulosus transient receptor potential cation channel 0.0034 0.0072 0.0071
Echinococcus granulosus voltage gated hydrogen channel 1 0.0033 0.0066 0.0065
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0033 0.0066 0.0065
Echinococcus multilocularis voltage dependent calcium channel 0.0033 0.0066 0.0065
Toxoplasma gondii thioredoxin reductase 0.0048 0.0138 0.0284
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0033 0.0066 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0027 0.0113
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0066 0.0291
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0102 0.0396 0.0823
Trichomonas vaginalis ribokinase, putative 0.0117 0.0466 0.2091
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0053 0.0107
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0053 0.5
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0086 0.0084
Mycobacterium ulcerans carbohydrate kinase CbhK 0.0117 0.0466 0.3745
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0085 0.0084
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0033 0.0066 0.0135
Echinococcus multilocularis thyroid hormone receptor alpha 0.0102 0.0396 0.0394
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0071 0.0312
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0265 0.1167 0.2436
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.0429 0.8807
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0038 0.0076
Echinococcus granulosus dna polymerase kappa 0.0042 0.0108 0.0106
Echinococcus granulosus hyperpolarization activated cyclic 0.0033 0.0066 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0038 0.0164
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0029 0.0047 0.0369
Brugia malayi hypothetical protein 0.0048 0.0139 0.0287
Brugia malayi cytochrome P450 0.0029 0.0047 0.0095
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0033 0.0066 0.0065
Schistosoma mansoni peroxidasin 0.0027 0.0038 0.0036
Leishmania major cytochrome p450-like protein 0.0029 0.0047 0.0095
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0102 0.0396 0.0394
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0201 0.0417
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0066 0.0065
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0033 0.0066 0.0065
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0066 0.0065
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0048 0.0139 0.0137
Brugia malayi Nuclear hormone receptor-like 1 0.0102 0.0396 0.0823
Brugia malayi Nuclear hormone receptor E75 0.0048 0.0139 0.0287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0082 0.0363
Echinococcus granulosus transient receptor potential gamma protein 0.0033 0.0066 0.0065
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.0439 0.0915
Echinococcus multilocularis potassium voltage gated channel protein 0.0033 0.0066 0.0065
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0033 0.0066 0.0065
Echinococcus multilocularis ryanodine receptor 44f 0.0033 0.0066 0.0065
Brugia malayi Glycosyl hydrolases family 31 protein 0.0167 0.0703 0.1466
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0083 0.0303 0.063
Plasmodium falciparum glutathione reductase 0.0048 0.0138 1
Echinococcus multilocularis jun protein 0.0085 0.0314 0.0313
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0029 0.0047 0.0941
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0102 0.0396 0.0823
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0033 0.0066 0.0135
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.0076
Echinococcus granulosus nuclear receptor nhr 48 0.0048 0.0139 0.0137
Brugia malayi glutathione reductase 0.0048 0.0138 0.0284
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0048 0.0139 0.0287
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0206 0.4203
Echinococcus multilocularis calcium activated potassium channel 0.0033 0.0066 0.0065
Brugia malayi nuclear hormone receptor family member nhr-6 0.0048 0.0139 0.0287
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0086 0.0176
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0135
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.0076
Trypanosoma cruzi cytochrome P450, putative 0.0047 0.0132 0.0273
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0735 0.3304
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.009 0.0188
Brugia malayi ion channel NompC 0.0033 0.0066 0.0135
Echinococcus multilocularis two pore calcium channel protein 1 0.0033 0.0066 0.0065
Brugia malayi Cell death protein 3 precursor 0.006 0.0197 0.0408
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0108 0.0222
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0053 0.0232
Brugia malayi cation channel family protein 0.0033 0.0066 0.0135
Brugia malayi Cytochrome P450 family protein 0.0029 0.0047 0.0095
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0086 0.1819
Echinococcus multilocularis sodium channel protein 0.0033 0.0066 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0055 0.0241
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0029 0.0047 0.0941
Echinococcus multilocularis hyperpolarization activated cyclic 0.0033 0.0066 0.0065
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0102 0.0396 0.0394
Loa Loa (eye worm) hypothetical protein 0.0048 0.0139 0.0287
Echinococcus multilocularis potassium voltage gated channel protein 0.0033 0.0066 0.0065
Brugia malayi Cyclic-nucleotide gated cation channel 0.0033 0.0066 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0082 0.0363
Loa Loa (eye worm) hypothetical protein 0.0102 0.0396 0.0823
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0102 0.0396 0.0823
Loa Loa (eye worm) steroid hormone receptor 0.0102 0.0396 0.0823
Onchocerca volvulus 0.0102 0.0396 0.0853
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0033 0.0066 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0126 0.0562
Trypanosoma brucei cytochrome P450, putative 0.0047 0.0132 0.0276
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.0487 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.009 0.0398
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0102 0.0396 0.0394
Entamoeba histolytica ribokinase, putative 0.0117 0.0466 1
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0038 0.0076
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0206 0.0204
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0033 0.0066 0.0135
Echinococcus granulosus transient receptor potential cation channel 0.0033 0.0066 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0102 0.0396 0.0823
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0029 0.0047 0.0369
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0029 0.0047 0.0941
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0033 0.0066 0.0065
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.0429 0.8807
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0086 0.038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0201 0.02
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0029 0.0047 0.0369
Brugia malayi ecdysteroid receptor 0.0102 0.0396 0.0823
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0201 0.02
Brugia malayi nuclear receptor NHR-88 0.0048 0.0139 0.0287
Brugia malayi Cytochrome P450 family protein 0.0047 0.0132 0.0273
Loa Loa (eye worm) nuclear hormone receptor 0.0048 0.0139 0.0287
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0082 0.0169
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0108 0.0856
Schistosoma mansoni hypothetical protein 0.0029 0.0047 0.0046
Brugia malayi hypothetical protein 0.0027 0.0038 0.0076
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0033 0.0066 0.0135
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0029 0.0047 0.0095
Echinococcus multilocularis voltage dependent calcium channel 0.0033 0.0066 0.0065
Toxoplasma gondii cytochrome p450 superfamily protein 0.0029 0.0047 0.0095
Leishmania major hypothetical protein, unknown function 0.0033 0.0066 0.0135
Toxoplasma gondii hypothetical protein 0.0033 0.0066 0.0135
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0135
Brugia malayi Pre-SET motif family protein 0.0428 0.194 0.4052
Echinococcus multilocularis nuclear receptor nhr 48 0.0048 0.0139 0.0137
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0048 0.0139 0.0137
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0066 0.0065
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0029 0.0047 0.0369
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0135
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0102 0.0396 0.0394
Loa Loa (eye worm) voltage-gated potassium channel 0.0033 0.0066 0.0135
Schistosoma mansoni hypothetical protein 0.0033 0.0066 0.0065
Brugia malayi steroid hormone receptor 0.0102 0.0396 0.0823
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0102 0.0396 0.0394
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0102 0.0396 0.0823
Loa Loa (eye worm) voltage-dependent calcium channel 0.0033 0.0066 0.0135
Trypanosoma cruzi adenosine kinase, putative 0.0117 0.0466 0.097
Echinococcus granulosus calcium activated potassium channel 0.0033 0.0066 0.0065
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0102 0.0396 0.0394
Trypanosoma cruzi adenosine kinase, putative 0.1029 0.4786 1
Loa Loa (eye worm) glutaminase 2 0.0281 0.1241 0.259
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0053 0.1175
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0102 0.0396 0.0823
Loa Loa (eye worm) hypothetical protein 0.0048 0.0139 0.0287
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0029 0.0047 0.0369
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0033 0.0066 0.0065
Echinococcus multilocularis transient receptor potential cation channel 0.0033 0.0066 0.0065
Schistosoma mansoni calcium-activated potassium channel 0.0033 0.0066 0.0065
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0066 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0027 0.0114
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0135
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0033 0.0066 0.0065
Echinococcus granulosus potassium voltage gated channel protein 0.0033 0.0066 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.006 0.0125
Schistosoma mansoni RAR-like nuclear receptor 0.0102 0.0396 0.0394
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0135
Schistosoma mansoni alpha-glucosidase 0.0144 0.0593 0.0591
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0053 0.0232
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0033 0.0066 0.0065
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0102 0.0396 0.0394
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0108 0.0478
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0071 0.0145
Entamoeba histolytica hypothetical protein 0.0037 0.0085 0.1801
Loa Loa (eye worm) glutathione reductase 0.0048 0.0138 0.0284
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0029 0.0047 0.0369
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0135
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.0076
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0735 0.3304
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0039 0.017
Leishmania major ATP-dependent phosphofructokinase 0.0112 0.0439 0.0915
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0029 0.0047 0.0941
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0108 0.0222
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0135
Schistosoma mansoni ryanodine receptor related 0.0033 0.0066 0.0065
Loa Loa (eye worm) hypothetical protein 0.0102 0.0396 0.0823
Toxoplasma gondii transporter, cation channel family protein 0.0033 0.0066 0.0135
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0108 0.0225
Brugia malayi nuclear hormone receptor family member odr-7 0.0048 0.0139 0.0287
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.0126 0.0264
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0102 0.0396 0.0394
Schistosoma mansoni nuclear receptor nhr-48 0.0048 0.0139 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0108 0.0225
Echinococcus multilocularis peroxidasin 0.0027 0.0038 0.0036
Trypanosoma cruzi ribokinase, putative 0.0117 0.0466 0.097
Loa Loa (eye worm) hypothetical protein 0.0054 0.0167 0.0345
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.0703 0.0702
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0038 0.0076
Trichomonas vaginalis ribokinase, putative 0.0117 0.0466 0.2091
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0206 0.0204
Entamoeba histolytica hypothetical protein 0.0037 0.0085 0.1801
Trypanosoma brucei ribokinase, putative 0.0117 0.0466 0.0973
Brugia malayi phosphofructokinase 0.0112 0.0439 0.0915
Loa Loa (eye worm) phosphofructokinase 0.0112 0.0439 0.0915
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0135
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0033 0.0066 0.0065
Trypanosoma cruzi cytochrome P450, putative 0.0047 0.0132 0.0273
Echinococcus multilocularis transient receptor potential cation channel 0.0033 0.0066 0.0065
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0029 0.0047 0.0941
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.1167 0.5252
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0102 0.0396 0.0823
Schistosoma mansoni ribokinase 0.0117 0.0466 0.0464
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0086 0.0176
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0112 0.0439 1
Echinococcus multilocularis sodium leak channel non selective protein 0.0033 0.0066 0.0065
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0046 0.0126 0.2688
Echinococcus multilocularis transient receptor potential cation channel 0.0033 0.0066 0.0065
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0033 0.0066 0.0065
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0033 0.0066 0.0135
Schistosoma mansoni two-pore calcium channel 0.0033 0.0066 0.0065
Loa Loa (eye worm) blistered cuticle protein 3 0.0027 0.0038 0.0076
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0066 0.0065
Loa Loa (eye worm) hypothetical protein 0.0102 0.0396 0.0823
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.0076
Echinococcus granulosus two pore calcium channel protein 2 0.0033 0.0066 0.0065
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0102 0.0396 0.0394
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0053 0.0107
Schistosoma mansoni vesicular amine transporter 0.0033 0.0066 0.0065
Loa Loa (eye worm) cytochrome P450 0.0029 0.0047 0.0095
Loa Loa (eye worm) hypothetical protein 0.0048 0.0139 0.0287
Brugia malayi voltage-dependent calcium channel 0.0033 0.0066 0.0135
Schistosoma mansoni jun-related protein 0.0069 0.0239 0.0237
Echinococcus multilocularis 6 phosphofructokinase 0.0112 0.0439 0.0438
Loa Loa (eye worm) hypothetical protein 0.0455 0.2066 0.4315
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0033 0.0066 0.0135
Trypanosoma brucei unspecified product 0.0035 0.0076 0.0159
Giardia lamblia DINP protein human, muc B family 0.0021 0.0012 0.0212
Schistosoma mansoni hypothetical protein 0.0069 0.0239 0.0237
Loa Loa (eye worm) hypothetical protein 0.0032 0.006 0.0121
Onchocerca volvulus 0.0048 0.0139 0.0241
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.0439 0.0918
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0086 0.038
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0033 0.0066 0.0065
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0138 0.0136
Schistosoma mansoni thyroid hormone receptor 0.0102 0.0396 0.0394
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.0439 0.1972
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0126 0.0562
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0108 0.0225
Brugia malayi hypothetical protein 0.0054 0.0167 0.0345
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.0439 0.0915
Brugia malayi cation channel family protein 0.0033 0.0066 0.0135
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0066 0.0065
Onchocerca volvulus Glucosylceramidase homolog 0.0174 0.0735 0.1662
Echinococcus multilocularis two pore calcium channel protein 2 0.0033 0.0066 0.0065
Brugia malayi 6-phosphofructokinase 0.0112 0.0439 0.0915
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.0076
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0108 0.0856
Echinococcus granulosus Nuclear hormone receptor HR96 0.0048 0.0139 0.0137
Loa Loa (eye worm) hypothetical protein 0.0054 0.0167 0.0345
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0033 0.0066 0.0139
Loa Loa (eye worm) hypothetical protein 0.0033 0.0066 0.0135
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.0487 1
Onchocerca volvulus 0.0067 0.0227 0.0452
Brugia malayi ecdysone receptor 0.0048 0.0139 0.0287
Loa Loa (eye worm) hypothetical protein 0.0117 0.0466 0.097
Onchocerca volvulus Bile acid receptor homolog 0.0102 0.0396 0.0853
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.0439 0.0438
Schistosoma mansoni thyroid hormone receptor 0.0102 0.0396 0.0394
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0038 0.0076
Trichomonas vaginalis glutaminase, putative 0.0281 0.1241 0.5584
Leishmania major adenosine kinase, putative 0.1029 0.4786 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0086 0.1819
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0039 0.017
Trichomonas vaginalis glucosylceramidase, putative 0.0265 0.1167 0.5252
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.0076
Onchocerca volvulus 0.0117 0.0466 0.102
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0033 0.0066 0.0065
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0108 0.0222
Loa Loa (eye worm) hypothetical protein 0.0054 0.0167 0.0345
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.0126 0.0261
Echinococcus multilocularis hyperpolarization activated cyclic 0.0033 0.0066 0.0065
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0033 0.0066 0.0135
Echinococcus granulosus potassium voltage gated channel protein 0.0033 0.0066 0.0065

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.031 uM Inhibitory concentration was measured against growth hormone secretagogue receptor using cellular function assay with fluorescent calcium indicator ChEMBL. 15780615
IC50 (binding) = 0.047 uM Inhibitory concentration was measured against growth hormone secretagogue receptor ChEMBL. 15780615

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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