TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 476.589 | Formula: C27H33FN6O
H donors: 1 H acceptors: 2 LogP: 5.2 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCc1nc2n(c1C(=O)NN1CCN(CC1)c1ccccc1F)CCN2c1c(C)cc(cc1C)C
InChi: 1S/C27H33FN6O/c1-5-22-25(26(35)30-32-12-10-31(11-13-32)23-9-7-6-8-21(23)28)34-15-14-33(27(34)29-22)24-19(3)16-18(2)17-20(24)4/h6-9,16-17H,5,10-15H2,1-4H3,(H,30,35)
InChiKey: IERYICVNLAWODN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	corticotropin releasing hormone receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	Get druggable targets OG5_130760	All targets in OG5_130760
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	Get druggable targets OG5_130760	All targets in OG5_130760
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	Get druggable targets OG5_130760	All targets in OG5_130760
Schistosoma japonicum	IPR001879,Hormone receptor, extracellular,domain-containing	Get druggable targets OG5_130760	All targets in OG5_130760
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130760	All targets in OG5_130760

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	corticotropin releasing hormone receptor 1	444 aa	445 aa	25.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0204	0.8099	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0038	0.0417	0.0515
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.1854	0.5395
Schistosoma mansoni	hypothetical protein	0.0032	0.0132	0.0383
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0038	0.0417	0.0417
Leishmania major	hypothetical protein, conserved	0.0031	0.0081	0.0235
Toxoplasma gondii	PHD-finger domain-containing protein	0.0032	0.0132	0.0306
Echinococcus multilocularis	dna polymerase kappa	0.0087	0.2676	0.3304
Echinococcus granulosus	fibronectin type III domain-containing protein	0.0031	0.0081	0.01
Echinococcus multilocularis	peregrin	0.0042	0.0611	0.0754
Echinococcus granulosus	EG95	0.0031	0.0081	0.01
Trypanosoma brucei	unspecified product	0.004	0.0507	0.1474
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0104	0.3472	0.4288
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0032	0.0132	0.0383
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0417	0.1089
Mycobacterium ulcerans	DNA polymerase IV	0.0087	0.2676	1
Echinococcus granulosus	lysine specific demethylase 5A	0.0038	0.0441	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0081	0.0081
Schistosoma mansoni	factor for adipocyte differentiation	0.0031	0.0081	0.0235
Schistosoma mansoni	chromobox protein	0.0076	0.2172	0.6322
Echinococcus granulosus	anosmin 1	0.0031	0.0081	0.01
Trypanosoma brucei	DNA polymerase kappa, putative	0.0087	0.2676	0.7786
Echinococcus granulosus	roundabout 2	0.0031	0.0081	0.01
Mycobacterium leprae	conserved hypothetical protein	0.0038	0.0417	0.5
Trichomonas vaginalis	chromobox protein, putative	0.0076	0.2172	0.5668
Echinococcus multilocularis	Phosphotidylinositol phosphatase PTPRQ	0.0031	0.0081	0.01
Brugia malayi	RNA binding protein	0.0069	0.1854	0.1854
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.063	0.1644
Echinococcus granulosus	dna polymerase kappa	0.0087	0.2676	0.3304
Trypanosoma brucei	DNA polymerase IV, putative	0.0087	0.2676	0.7786
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0081	0.0081
Trichomonas vaginalis	CAMK family protein kinase	0.0051	0.1034	0.2697
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.063	0.1644
Trichomonas vaginalis	CAMK family protein kinase	0.0103	0.3436	0.8966
Brugia malayi	ImpB/MucB/SamB family protein	0.0086	0.2619	0.2619
Loa Loa (eye worm)	myotactin form A	0.0031	0.0081	0.0081
Schistosoma mansoni	titin	0.0031	0.0112	0.0325
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0031	0.0081	0.01
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0417	0.0417
Echinococcus multilocularis	roundabout 2	0.0031	0.0081	0.01
Brugia malayi	Fibronectin type III domain containing protein	0.0031	0.0081	0.0081
Echinococcus multilocularis	usherin	0.0031	0.0081	0.01
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0031	0.0081	0.0081
Trypanosoma brucei	Fibronectin type III domain containing protein, putative	0.0031	0.0081	0.0235
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0031	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0081	0.0081
Giardia lamblia	DINP protein human, muc B family	0.0065	0.1668	0.4651
Trypanosoma brucei	DNA polymerase kappa, putative	0.0047	0.0832	0.2422
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0475	0.0587
Trypanosoma brucei	DNA polymerase kappa, putative	0.0047	0.0839	0.2441
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0031	0.0081	0.0081
Echinococcus granulosus	PHD finger protein rhinoceros	0.0032	0.0132	0.0162
Trypanosoma brucei	DNA polymerase kappa, putative	0.0087	0.2676	0.7786
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0417	0.1214
Onchocerca volvulus		0.0031	0.0081	0.0235
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0058	0.1336	0.3889
Brugia malayi	Lethal protein 805	0.0031	0.0081	0.0081
Brugia malayi	Fibronectin type III domain containing protein	0.0031	0.0081	0.0081
Trichomonas vaginalis	CAMK family protein kinase	0.0103	0.3436	0.8966
Schistosoma mansoni	kinase	0.0053	0.1097	0.3191
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0417	0.0417
Brugia malayi	TAR-binding protein	0.0069	0.1854	0.1854
Plasmodium falciparum	phd finger protein, putative	0.0032	0.0132	0.028
Trichomonas vaginalis	chromobox protein, putative	0.0046	0.078	0.2034
Loa Loa (eye worm)	jmjC domain-containing protein	0.0038	0.0441	0.0441
Echinococcus multilocularis	transfer RNA-Phe	0.0031	0.0081	0.01
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0056	0.0146
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0417	0.1214
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0103	0.3436	1
Echinococcus granulosus	chromobox protein 1	0.0076	0.2172	0.2682
Brugia malayi	beta-lactamase family protein	0.0038	0.0417	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0043	0.063	0.063
Trypanosoma brucei	DNA polymerase kappa, putative	0.0087	0.2676	0.7786
Trypanosoma brucei	unspecified product	0.004	0.0507	0.1474
Echinococcus granulosus	dna polymerase eta	0.0086	0.2619	0.3234
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0103	0.3436	1
Echinococcus multilocularis	cell adhesion molecule	0.0031	0.0081	0.01
Echinococcus granulosus	G1Y162 protein	0.0031	0.0081	0.01
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0417	0.1214
Schistosoma mansoni	jumonji domain containing protein	0.0083	0.2484	0.7229
Schistosoma mansoni	titin	0.0031	0.0081	0.0235
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0417	0.1089
Echinococcus granulosus	anosmin 1	0.0031	0.0081	0.01
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0031	0.0081	0.0081
Onchocerca volvulus		0.0031	0.0081	0.0235
Trypanosoma brucei	DNA polymerase kappa, putative	0.0047	0.0839	0.2441
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0081	0.0081
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0046	0.078	0.2269
Trichomonas vaginalis	chromobox protein, putative	0.0046	0.078	0.2034
Leishmania major	hypothetical protein, conserved	0.0038	0.0417	0.1214
Echinococcus granulosus	peregrin	0.0042	0.0611	0.0754
Plasmodium vivax	hypothetical protein, conserved	0.0032	0.0132	0.028
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0031	0.0081	0.01
Brugia malayi	jmjC domain containing protein	0.0104	0.3472	0.3472
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0031	0.0081	0.0081
Echinococcus multilocularis	fibronectin type III domain-containing protein	0.0031	0.0081	0.01
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0031	0.0081	0.0081
Trichomonas vaginalis	chromobox protein, putative	0.0076	0.2172	0.5668
Loa Loa (eye worm)	PHD-finger family protein	0.0032	0.0132	0.0132
Loa Loa (eye worm)	lethal protein 805	0.0031	0.0081	0.0081
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0103	0.3436	0.4243
Loa Loa (eye worm)	projectin	0.0031	0.0081	0.0081
Toxoplasma gondii	ABC1 family protein	0.0038	0.0417	0.0971
Plasmodium falciparum	MO15-related protein kinase	0.0131	0.4694	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0038	0.0441	0.1282
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0046	0.0776	0.1805
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0081	0.0081
Onchocerca volvulus		0.0031	0.0081	0.0235
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0031	0.0081	0.0081
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0031	0.0081	0.0081
Echinococcus multilocularis	tar DNA binding protein	0.0069	0.1854	0.2289
Echinococcus granulosus	titin	0.0031	0.0112	0.0138
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0031	0.0081	0.0235
Trichomonas vaginalis	DNA polymerase eta, putative	0.0087	0.2676	0.6981
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0031	0.0081	0.01
Echinococcus granulosus	roundabout 2	0.0031	0.0081	0.01
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0417	0.1089
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0031	0.0081	0.01
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0032	0.0132	0.0162
Schistosoma mansoni	nephrin	0.0031	0.0081	0.0235
Onchocerca volvulus		0.0031	0.0081	0.0235
Trypanosoma brucei	DNA polymerase kappa, putative	0.0087	0.2676	0.7786
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0417	0.0417
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0058	0.1336	0.3889
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0031	0.0081	0.0235
Echinococcus multilocularis	titin	0.0031	0.0081	0.01
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0031	0.0081	0.0235
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0058	0.1336	0.165
Plasmodium vivax	hypothetical protein, conserved	0.0038	0.0417	0.0889
Schistosoma mansoni	hypothetical protein	0.0041	0.0564	0.1643
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0031	0.0081	0.0081
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0058	0.1336	0.0972
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0204	0.8099	1
Echinococcus granulosus	jumonji domain containing protein	0.0044	0.0707	0.0873
Brugia malayi	Protein-tyrosine phosphatase	0.0031	0.0081	0.0081
Brugia malayi	myotactin form B	0.0031	0.0081	0.0081
Giardia lamblia	Kinase, PLK	0.0103	0.3436	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0104	0.3472	0.4288
Trypanosoma brucei	DNA polymerase kappa, putative	0.0065	0.1668	0.4856
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0081	0.0081
Echinococcus granulosus	chromobox protein 1	0.0076	0.2172	0.2682
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0564	0.0564
Trypanosoma cruzi	DNA polymerase eta, putative	0.0086	0.2619	0.7622
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0031	0.0081	0.01
Loa Loa (eye worm)	CAMK protein kinase	0.0031	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0832	0.0832
Onchocerca volvulus		0.0038	0.0417	0.1214
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0081	0.0081
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0031	0.0081	0.0081
Trypanosoma cruzi	polo-like protein kinase, putative	0.0103	0.3436	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0081	0.0081
Echinococcus multilocularis	Netrin receptor DCC	0.0031	0.0081	0.01
Trichomonas vaginalis	CAMK family protein kinase	0.0103	0.3436	0.8966
Schistosoma mansoni	hypothetical protein	0.0031	0.0081	0.0235
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.1444	0.1444
Trypanosoma brucei	DNA polymerase kappa, putative	0.0047	0.0832	0.2422
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0243	0.987	1
Trypanosoma brucei	hypothetical protein, conserved	0.0038	0.0417	0.1214
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0103	0.3436	0.3436
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0031	0.0081	0.01
Loa Loa (eye worm)	beta-lactamase	0.0038	0.0417	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0081	0.0081
Brugia malayi	SPRY domain containing protein	0.0031	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0081	0.0081
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0475	0.1383
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0058	0.1336	0.1336
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.1854	0.5395
Brugia malayi	myotactin form A	0.0031	0.0081	0.0081
Trichomonas vaginalis	CAMK family protein kinase	0.0112	0.3833	1
Onchocerca volvulus	Alhambra homolog	0.0032	0.0132	0.0383
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0417	0.1089
Echinococcus granulosus	Fibronectin type III	0.0031	0.0081	0.01
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0132	0.0132
Schistosoma mansoni	factor for adipocyte differentiation	0.0031	0.0081	0.0235
Loa Loa (eye worm)	TAR-binding protein	0.0069	0.1854	0.1854
Trypanosoma brucei	DNA polymerase kappa, putative	0.0087	0.2676	0.7786
Brugia malayi	jmjC domain containing protein	0.0038	0.0441	0.0441
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.1854	0.5395
Schistosoma mansoni	protein tyrosine phosphatase	0.0031	0.0081	0.0235
Schistosoma mansoni	serine/threonine protein kinase	0.0103	0.3436	1
Brugia malayi	beta-lactamase	0.0038	0.0417	0.0417
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0058	0.1336	0.2908
Schistosoma mansoni	ephrin receptor	0.0031	0.0081	0.0235
Leishmania major	DNA polymerase eta, putative	0.0086	0.2619	0.7622
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0031	0.0081	0.0081
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0031	0.0081	0.01
Onchocerca volvulus		0.0031	0.0081	0.0235
Trypanosoma brucei	DNA polymerase kappa, putative	0.0087	0.2676	0.7786
Schistosoma mansoni	nephrin	0.0031	0.0081	0.0235
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0031	0.0081	0.0235
Brugia malayi	hypothetical protein	0.0031	0.0081	0.0081
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0031	0.0112	0.0112
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0475	0.0587
Schistosoma mansoni	hypothetical protein	0.0031	0.0081	0.0235
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0065	0.1668	0.1324
Echinococcus multilocularis	anosmin 1	0.0031	0.0081	0.01
Echinococcus multilocularis	lysine specific demethylase 5A	0.0038	0.0441	0.0544
Echinococcus multilocularis	chromobox protein 1	0.0076	0.2172	0.2682
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0069	0.1854	0.1854
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0103	0.3436	0.4243
Echinococcus multilocularis	titin	0.0031	0.0112	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1181	0.1181
Echinococcus granulosus	roundabout 2	0.0031	0.0081	0.01
Brugia malayi	PHD-finger family protein	0.0032	0.0132	0.0132
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0058	0.1336	0.165
Echinococcus granulosus	histone lysine N methyltransferase NSD3	0.0036	0.0314	0.0387
Brugia malayi	Heterochromatin protein 1	0.0076	0.2172	0.2172
Trypanosoma brucei	DNA polymerase IV, putative	0.0087	0.2676	0.7786
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0031	0.0081	0.01
Trypanosoma cruzi	DNA polymerase eta, putative	0.0046	0.0776	0.2258
Onchocerca volvulus		0.0038	0.0417	0.1214
Echinococcus granulosus	anosmin 1	0.0031	0.0081	0.01
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0031	0.0081	0.0081
Brugia malayi	Fibronectin type III domain containing protein	0.0031	0.0081	0.0081
Trypanosoma cruzi	polo-like protein kinase, putative	0.0103	0.3436	1
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0031	0.0112	0.0112
Plasmodium vivax	cyclin dependent kinase 7 (cdk7), putative	0.0131	0.4694	1
Brugia malayi	hypothetical protein	0.0031	0.0081	0.0081
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0031	0.0081	0.01
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0031	0.0081	0.0081
Brugia malayi	Fibronectin type III domain containing protein	0.0031	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0417	0.0417
Schistosoma mansoni	tripartite motif protein trim9	0.0031	0.0081	0.0235
Echinococcus multilocularis	Fibronectin type III domain containing protein	0.0031	0.0081	0.01
Echinococcus multilocularis	Netrin receptor DCC	0.0031	0.0081	0.01
Onchocerca volvulus		0.0031	0.0081	0.0235
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0031	0.0081	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0417	0.0417
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.1444	0.1444
Trichomonas vaginalis	esterase, putative	0.0038	0.0417	0.1089
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0087	0.2676	0.7786
Schistosoma mansoni	cell adhesion molecule	0.0031	0.0081	0.0235
Echinococcus granulosus	titin	0.0031	0.0112	0.0138
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0043	0.063	0.1834
Trypanosoma brucei	DNA polymerase kappa, putative	0.0087	0.2676	0.7786
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0081	0.0081
Echinococcus multilocularis	roundabout 2	0.0031	0.0081	0.01
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0031	0.0112	0.0112
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0038	0.0441	0.1282
Brugia malayi	RNA recognition motif domain containing protein	0.0069	0.1854	0.1854
Echinococcus granulosus	nephrin	0.0031	0.0081	0.01
Onchocerca volvulus		0.0031	0.0081	0.0235
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0031	0.0081	0.01
Schistosoma mansoni	titin	0.0031	0.0081	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2619	0.2619
Echinococcus multilocularis	histone lysine N methyltransferase NSD3	0.0036	0.0314	0.0387
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0031	0.0081	0.0081
Trichomonas vaginalis	CAMK family protein kinase	0.0103	0.3436	0.8966
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0087	0.2676	0.6981
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0081	0.0081
Trypanosoma brucei	DNA polymerase kappa, putative	0.0087	0.2676	0.7786
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0031	0.0081	0.0081
Leishmania major	DNA polymerase kappa, putative	0.0065	0.1668	0.4856
Toxoplasma gondii	cell-cycle-associated protein kinase, putative	0.0122	0.4298	1
Echinococcus multilocularis	neuroglian	0.0031	0.0081	0.01
Brugia malayi	polk-prov protein	0.0047	0.0832	0.0832
Schistosoma mansoni	chromobox protein	0.0076	0.2172	0.6322
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0205	0.0205
Brugia malayi	serine/threonine-protein kinase plk-2	0.0103	0.3436	0.3436
Echinococcus granulosus	tar DNA binding protein	0.0069	0.1854	0.2289
Schistosoma mansoni	hypothetical protein	0.0039	0.0475	0.1383
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0031	0.0081	0.0081
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0112	0.0325
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0031	0.0081	0.0081
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0031	0.0081	0.01
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.1854	0.5395
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0031	0.0081	0.0235
Loa Loa (eye worm)	RNA binding protein	0.0069	0.1854	0.1854
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0081	0.0081
Trypanosoma brucei	DNA polymerase kappa, putative	0.0087	0.2676	0.7786
Echinococcus multilocularis	chromobox protein 1	0.0076	0.2172	0.2682
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0081	0.0081
Brugia malayi	ImpB/MucB/SamB family protein	0.0058	0.1336	0.1336
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0087	0.2676	0.7786
Loa Loa (eye worm)	heterochromatin protein 1	0.0076	0.2172	0.2172
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0031	0.0081	0.01
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0081	0.0081
Echinococcus multilocularis	roundabout 2	0.0031	0.0081	0.01
Echinococcus granulosus	Netrin receptor DCC	0.0031	0.0081	0.01
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0031	0.0081	0.0081
Onchocerca volvulus		0.0031	0.0081	0.0235
Echinococcus granulosus	Fibronectin type III domain containing protein	0.0031	0.0081	0.01
Echinococcus multilocularis	anosmin 1	0.0031	0.0081	0.01
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0031	0.0081	0.01
Loa Loa (eye worm)	UNCoordinated family member	0.0031	0.0081	0.0081
Schistosoma mansoni	DNA polymerase eta	0.0086	0.2619	0.7622
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0103	0.3436	1
Leishmania major	DNA polymerase eta, putative	0.0046	0.0776	0.2258
Brugia malayi	chromobox protein homolog 3	0.0043	0.063	0.063
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0031	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0081	0.0081
Echinococcus granulosus	Netrin receptor DCC	0.0031	0.0081	0.01
Trypanosoma brucei	unspecified product	0.008	0.2343	0.6819
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0087	0.2676	0.7786
Schistosoma mansoni	cell adhesion molecule	0.0031	0.0081	0.0235
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0417	0.1214
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.1854	0.5395
Brugia malayi	hypothetical protein	0.0039	0.0475	0.0475
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0031	0.0081	0.0081
Schistosoma mansoni	hypothetical protein	0.0031	0.0081	0.0235
Onchocerca volvulus		0.0033	0.0205	0.0597
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0031	0.0081	0.0235
Trypanosoma cruzi	hypothetical protein, conserved	0.0031	0.0081	0.0235
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0031	0.0081	0.01
Echinococcus multilocularis	jumonji domain containing protein	0.0044	0.0707	0.0873
Echinococcus multilocularis	Fibronectin, type III	0.0031	0.0081	0.01
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0031	0.0081	0.01
Loa Loa (eye worm)	hypothetical protein	0.0245	1	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0031	0.0081	0.0081
Schistosoma mansoni	myosin-binding protein-related	0.0031	0.0081	0.0235
Brugia malayi	Fibronectin type III domain containing protein	0.0031	0.0081	0.0081
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0417	0.1089
Onchocerca volvulus		0.0031	0.0081	0.0235
Echinococcus granulosus	usherin	0.0031	0.0081	0.01
Trypanosoma brucei	DNA polymerase eta, putative	0.0086	0.2619	0.7622
Brugia malayi	Fibronectin type III domain containing protein	0.0031	0.0081	0.0081
Schistosoma mansoni	cell adhesion molecule	0.0031	0.0081	0.0235
Schistosoma mansoni	neuroglian	0.0031	0.0081	0.0235
Mycobacterium ulcerans	DNA polymerase IV	0.0087	0.2676	1
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0065	0.1668	0.4856
Brugia malayi	beta-lactamase family protein	0.0038	0.0417	0.0417
Onchocerca volvulus		0.0031	0.0081	0.0235
Brugia malayi	Bromodomain containing protein	0.0032	0.0132	0.0132
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0056	0.0146
Schistosoma mansoni	cell adhesion molecule	0.0031	0.0081	0.0235
Onchocerca volvulus		0.0031	0.0112	0.0325
Onchocerca volvulus		0.0038	0.0417	0.1214
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0081	0.0081
Echinococcus granulosus	cell adhesion molecule	0.0031	0.0081	0.01
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0564	0.0564
Echinococcus multilocularis	anosmin 1	0.0031	0.0081	0.01
Schistosoma mansoni	hemicentin	0.0031	0.0081	0.0235
Trichomonas vaginalis	CAMK family protein kinase	0.0103	0.3436	0.8966
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0081	0.0081
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0038	0.0417	0.0417
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0031	0.0081	0.0081
Echinococcus multilocularis	dna polymerase eta	0.0086	0.2619	0.3234
Schistosoma mansoni	cell adhesion molecule	0.0031	0.0081	0.0235
Onchocerca volvulus		0.0031	0.0081	0.0235
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0031	0.0081	0.01
Trypanosoma brucei	DNA polymerase kappa, putative	0.0047	0.0839	0.2441
Echinococcus granulosus	contactin	0.0031	0.0081	0.01
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0031	0.0081	0.0081
Toxoplasma gondii	PHD-finger domain-containing protein	0.0032	0.0132	0.0306
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0038	0.0417	0.0515
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0087	0.2676	0.7786
Schistosoma mansoni	factor for adipocyte differentiation	0.0031	0.0081	0.0235
Trypanosoma brucei	polo-like protein kinase	0.0103	0.3436	1
Brugia malayi	Lethal protein 805	0.0031	0.0081	0.0081
Onchocerca volvulus		0.0031	0.0081	0.0235
Brugia malayi	protein unc-22	0.0031	0.0112	0.0112
Trypanosoma brucei	DNA polymerase IV, putative	0.008	0.2343	0.6819
Echinococcus granulosus	neuroglian	0.0031	0.0081	0.01
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0417	0.0417
Loa Loa (eye worm)	jmjC domain-containing protein	0.0066	0.1695	0.1695
Trichomonas vaginalis	CAMK family protein kinase	0.0051	0.1034	0.2697
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0031	0.0081	0.01
Trichomonas vaginalis	CAMK family protein kinase	0.0103	0.3436	0.8966
Onchocerca volvulus		0.0031	0.0081	0.0235
Mycobacterium leprae	Probable lipase LipE	0.0038	0.0417	0.5
Schistosoma mansoni	SET domain protein	0.0036	0.0314	0.0913

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	> 10000 nM	Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells	ChEMBL.	15990298
Ki (binding)	> 10000 nM	Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells	ChEMBL.	15990298

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 319817