Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carbonic anhydrase | 0.0496 | 0.4059 | 0.4059 |
Brugia malayi | Cathepsin L-like precursor | 0.0227 | 0.0847 | 0.0847 |
Brugia malayi | Cathepsin L-like precursor | 0.0227 | 0.0847 | 0.0847 |
Brugia malayi | Cathepsin L-like precursor | 0.0227 | 0.0847 | 0.0847 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0496 | 0.4059 | 0.3984 |
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 0.4059 | 0.4059 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0496 | 0.4059 | 0.4059 |
Echinococcus multilocularis | carbonic anhydrase | 0.0496 | 0.4059 | 0.3984 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0192 | 0.0421 | 0.03 |
Leishmania major | carbonic anhydrase-like protein | 0.0993 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0496 | 0.4059 | 0.4059 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0167 | 0.0124 | 0.0124 |
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 0.4059 | 0.4059 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0245 | 0.106 | 0.0947 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0496 | 0.4059 | 0.4059 |
Leishmania major | cathepsin L-like protease | 0.0227 | 0.0847 | 0.0531 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0375 | 0.2614 | 0.2614 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0227 | 0.0847 | 0.0847 |
Brugia malayi | Glutamate receptor 2 precursor | 0.035 | 0.2317 | 0.2317 |
Brugia malayi | Cathepsin L-like precursor | 0.0227 | 0.0847 | 0.0847 |
Echinococcus granulosus | glutamate receptor 4 | 0.0183 | 0.0321 | 0.0321 |
Giardia lamblia | Cathepsin B precursor | 0.0184 | 0.0334 | 0.5 |
Loa Loa (eye worm) | cathepsin B | 0.0184 | 0.0334 | 0.0334 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0227 | 0.0847 | 0.0531 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0227 | 0.0847 | 0.0847 |
Loa Loa (eye worm) | ctsf protein | 0.0227 | 0.0847 | 0.0847 |
Echinococcus multilocularis | cysteine protease | 0.0227 | 0.0847 | 0.0732 |
Echinococcus multilocularis | cysteine protease | 0.0227 | 0.0847 | 0.0732 |
Leishmania major | cathepsin L-like protease | 0.0227 | 0.0847 | 0.0531 |
Echinococcus granulosus | cathepsin b | 0.0479 | 0.3853 | 0.3853 |
Echinococcus multilocularis | glutamate receptor 2 | 0.035 | 0.2317 | 0.2221 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.0375 | 0.2614 | 0.2614 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0496 | 0.4059 | 0.4059 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0192 | 0.0421 | 0.0421 |
Schistosoma mansoni | glutamate receptor kainate | 0.0167 | 0.0124 | 0.0124 |
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 0.4059 | 0.4059 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0496 | 0.4059 | 0.4059 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Onchocerca volvulus | 0.0227 | 0.0847 | 1 | |
Echinococcus granulosus | glutamate receptor 1 | 0.0183 | 0.0321 | 0.0321 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.0847 | 0.0847 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0313 | 0.1875 | 0.1773 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0227 | 0.0847 | 0.0847 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0192 | 0.0421 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0321 | 0.0321 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0479 | 0.3853 | 0.3853 |
Leishmania major | cathepsin L-like protease | 0.0227 | 0.0847 | 0.0531 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0227 | 0.0847 | 0.0531 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0227 | 0.0847 | 0.0531 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0184 | 0.0334 | 0.0334 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0192 | 0.0421 | 0.03 |
Echinococcus granulosus | cathepsin b | 0.0479 | 0.3853 | 0.3853 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0227 | 0.0847 | 0.0847 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0227 | 0.0847 | 0.0847 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0375 | 0.2614 | 0.2521 |
Onchocerca volvulus | 0.0227 | 0.0847 | 1 | |
Echinococcus granulosus | carbonic anhydrase | 0.0496 | 0.4059 | 0.4059 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0227 | 0.0847 | 0.0531 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0227 | 0.0847 | 0.0847 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0993 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0227 | 0.0847 | 0.0732 |
Leishmania major | cathepsin L-like protease | 0.0227 | 0.0847 | 0.0531 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0227 | 0.0847 | 0.0531 |
Schistosoma mansoni | glutamate receptor kainate | 0.0167 | 0.0124 | 0.0124 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0479 | 0.3853 | 0.3853 |
Echinococcus multilocularis | carbonic anhydrase | 0.0496 | 0.4059 | 0.3984 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0993 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0479 | 0.3853 | 0.3853 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0227 | 0.0847 | 0.0847 |
Schistosoma mansoni | hypothetical protein | 0.0496 | 0.4059 | 0.4059 |
Onchocerca volvulus | 0.0227 | 0.0847 | 1 | |
Toxoplasma gondii | cathepsin CPL | 0.0227 | 0.0847 | 0.1378 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.035 | 0.2317 | 0.2317 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0227 | 0.0847 | 0.0847 |
Onchocerca volvulus | Cathepsin L homolog | 0.0227 | 0.0847 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0227 | 0.0847 | 0.0531 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Leishmania major | cathepsin L-like protease | 0.0227 | 0.0847 | 0.0531 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0496 | 0.4059 | 0.4059 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0227 | 0.0847 | 0.0847 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0496 | 0.4059 | 0.4059 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0479 | 0.3853 | 0.3776 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0227 | 0.0847 | 0.0531 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0479 | 0.3853 | 0.3853 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0993 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0192 | 0.0421 | 0.0421 |
Brugia malayi | Cathepsin L-like precursor | 0.0227 | 0.0847 | 0.0847 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0245 | 0.106 | 0.106 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0227 | 0.0847 | 0.0847 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0227 | 0.0847 | 0.0732 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0227 | 0.0847 | 0.0847 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0277 | 0.1444 | 0.1444 |
Leishmania major | cathepsin L-like protease | 0.0227 | 0.0847 | 0.0531 |
Echinococcus granulosus | glutamate receptor 2 | 0.0313 | 0.1875 | 0.1875 |
Brugia malayi | Cathepsin L-like precursor | 0.0227 | 0.0847 | 0.0847 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0227 | 0.0847 | 0.0531 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0167 | 0.0124 | 0.0124 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Plasmodium vivax | vivapain-2 | 0.0227 | 0.0847 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0321 | 0.0321 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0993 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0192 | 0.0421 | 0.03 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0184 | 0.0334 | 0.0334 |
Onchocerca volvulus | 0.0227 | 0.0847 | 1 | |
Brugia malayi | Glutamate receptor 1 precursor | 0.035 | 0.2317 | 0.2317 |
Echinococcus granulosus | carbonic anhydrase II | 0.0993 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0993 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0479 | 0.3853 | 0.3853 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0375 | 0.2614 | 0.2521 |
Toxoplasma gondii | hypothetical protein | 0.0496 | 0.4059 | 1 |
Onchocerca volvulus | 0.0227 | 0.0847 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0184 | 0.0334 | 0.5 |
Plasmodium vivax | vivapain-2 | 0.0227 | 0.0847 | 0.5 |
Leishmania major | cysteine peptidase A (CPA) | 0.0227 | 0.0847 | 0.0531 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0184 | 0.0334 | 0.394 |
Plasmodium falciparum | carbonic anhydrase | 0.0496 | 0.4059 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0993 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0993 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0227 | 0.0847 | 0.0531 |
Schistosoma mansoni | glutamate receptor kainate | 0.0167 | 0.0124 | 0.0124 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0993 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0227 | 0.0847 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0496 | 0.4059 | 0.4059 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0227 | 0.0847 | 0.0531 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0227 | 0.0847 | 0.0531 |
Onchocerca volvulus | 0.0227 | 0.0847 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0479 | 0.3853 | 0.3853 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0496 | 0.4059 | 0.4059 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0227 | 0.0847 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0167 | 0.0124 | 0.0124 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0167 | 0.0124 | 0.0124 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0227 | 0.0847 | 0.0732 |
Schistosoma mansoni | carbonic anhydrase | 0.0496 | 0.4059 | 0.4059 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0227 | 0.0847 | 0.0531 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0227 | 0.0847 | 0.0847 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0227 | 0.0847 | 0.0732 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0167 | 0.0124 | 0.0124 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0496 | 0.4059 | 0.4059 |
Leishmania major | cathepsin L-like protease | 0.0227 | 0.0847 | 0.0531 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0321 | 0.0321 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0167 | 0.0124 | 0.0124 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0227 | 0.0847 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0227 | 0.0847 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0227 | 0.0847 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0227 | 0.0847 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0227 | 0.0847 | 0.0847 |
Giardia lamblia | Cathepsin B precursor | 0.0184 | 0.0334 | 0.5 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0227 | 0.0847 | 0.0847 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0993 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0479 | 0.3853 | 0.3853 |
Onchocerca volvulus | 0.0227 | 0.0847 | 1 | |
Echinococcus multilocularis | glutamate receptor 4 | 0.0183 | 0.0321 | 0.0199 |
Echinococcus multilocularis | cathepsin b | 0.0479 | 0.3853 | 0.3776 |
Loa Loa (eye worm) | fibroinase | 0.0227 | 0.0847 | 0.0847 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log IC50 (functional) | = 6.9 | Inhibitory activity against MCP-1 induced Calcium flux in THP11-cells | ChEMBL. | 15729771 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.