Detailed information for compound 320135

Basic information

Technical information
  • TDR Targets ID: 320135
  • Name: 5-(hydroxymethyl)-3-methyl-2-[6-[methyl-[2-(m ethylamino)ethyl]amino]purin-9-yl]oxolane-3,4 -diol
  • MW: 352.389 | Formula: C15H24N6O4
  • H donors: 4 H acceptors: 6 LogP: -1.35 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNCCN(c1ncnc2c1ncn2C1OC(C(C1(C)O)O)CO)C
  • InChi: 1S/C15H24N6O4/c1-15(24)11(23)9(6-22)25-14(15)21-8-19-10-12(17-7-18-13(10)21)20(3)5-4-16-2/h7-9,11,14,16,22-24H,4-6H2,1-3H3
  • InChiKey: NNUVVRMSYBHBAL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(hydroxymethyl)-3-methyl-2-[6-[methyl-[2-(methylamino)ethyl]amino]purin-9-yl]tetrahydrofuran-3,4-diol
  • 5-(hydroxymethyl)-3-methyl-2-[6-[methyl-[2-(methylamino)ethyl]amino]-9-purinyl]tetrahydrofuran-3,4-diol
  • 3-methyl-2-[6-[methyl-[2-(methylamino)ethyl]amino]purin-9-yl]-5-methylol-tetrahydrofuran-3,4-diol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0142 0.0223
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0039 0.0036
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0011 0.0018 0.0007
Brugia malayi Tachykinin-like peptides receptor 99D 0.0011 0.0018 0.0007
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0095 0.012
Schistosoma mansoni neuropeptide receptor 0.0011 0.0018 0.0029
Trichomonas vaginalis CAMK family protein kinase 0.0306 0.4289 0.6162
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0074
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0511 0.7258 1
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0306 0.0405
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0149 0.5273
Brugia malayi nuclear receptor NHR-88 0.0015 0.0067 0.0074
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0013 0.003
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0018 0.0007
Brugia malayi GnHR receptor homolog 0.0011 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Schistosoma mansoni biogenic amine receptor 0.0011 0.0018 0.0029
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0249 0.0484
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0013 0.0044 0.0042
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0018 0.0007
Echinococcus multilocularis retinol dehydrogenase 11 0.0013 0.0044 0.0042
Plasmodium falciparum importin beta, putative 0.0028 0.0262 0.4616
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0095 0.012
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0142 0.0177
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.1441 0.3291
Brugia malayi serine/threonine-protein kinase plk-2 0.0306 0.4289 0.5901
Brugia malayi hypothetical protein 0.0044 0.0496 0.0666
Loa Loa (eye worm) hypothetical protein 0.0027 0.025 0.0326
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0095 0.012
Loa Loa (eye worm) hypothetical protein 0.0031 0.0306 0.0405
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0095 0.012
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.1441 0.197
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0149 0.2684
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.1441 0.1403
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0142 0.0177
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Onchocerca volvulus 0.0013 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0013 0.0044 0.0042
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0306 0.0405
Onchocerca volvulus 0.011 0.1441 0.2058
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0074
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0018 0.0111 0.0135
Schistosoma mansoni chromobox protein 0.0011 0.0013 0.0021
Loa Loa (eye worm) hypothetical protein 0.0013 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.0031 0.0306 0.0405
Schistosoma mansoni retinal dehydrogenase 0.0013 0.0044 0.007
Plasmodium vivax glutathione reductase, putative 0.0048 0.0552 0.3828
Onchocerca volvulus 0.0013 0.0044 0.0044
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0013 0.0044 0.01
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0018 0.0007
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0011 0.0018 0.0007
Toxoplasma gondii exonuclease III APE 0.002 0.0149 0.0327
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0018 0.0111 0.0158
Schistosoma mansoni hypothetical protein 0.0301 0.422 0.671
Loa Loa (eye worm) oxidoreductase 0.0013 0.0044 0.0042
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0013 0.00000000016449
Onchocerca volvulus 0.0031 0.0305 0.042
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0142 0.023
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0095 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0306 0.0405
Schistosoma mansoni chromobox protein 0.0011 0.0013 0.0021
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0018 0.0111 0.0244
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0445 0.0622
Brugia malayi hypothetical protein 0.0011 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.011 0.1441 0.197
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0149 0.0239
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0419 0.056
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0092 0.0109
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0067 0.0074
Brugia malayi Serotonin receptor 0.0011 0.0018 0.0007
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0018 0.0007
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0149 0.0187
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0142 0.0312
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0013 0.00000000016449
Onchocerca volvulus Neuropeptide F receptor homolog 0.0011 0.0018 0.0007
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0044 0.0042
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0013 0.00000000017177
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.025 0.0565
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.1441 0.3102
Brugia malayi sulfakinin receptor protein 0.0011 0.0018 0.0007
Schistosoma mansoni loxhd1 0.0044 0.0496 0.0789
Onchocerca volvulus 0.0015 0.0067 0.0077
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.1415 0.1934
Schistosoma mansoni hypothetical protein 0.0011 0.0018 0.0029
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0011 0.0018 0.0029
Brugia malayi putative neuropeptide receptor NPR1 0.0011 0.0018 0.0007
Plasmodium falciparum glutathione reductase 0.0017 0.0095 0.1514
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.0135
Brugia malayi SET domain containing protein 0.0014 0.0056 0.0059
Schistosoma mansoni rab6-interacting 0.0044 0.0496 0.0789
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0018 0.0111 0.0158
Loa Loa (eye worm) hypothetical protein 0.0031 0.0306 0.0405
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0044 0.007
Loa Loa (eye worm) TAR-binding protein 0.0138 0.1847 0.253
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.025 0.0457
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.1447 0.1409
Echinococcus granulosus sex peptide receptor 0.0011 0.0018 0.0007
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0013 0.0044 0.0044
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0835 0.1184
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0067 0.0074
Mycobacterium ulcerans hypothetical protein 0.0029 0.0267 0.0494
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0198 0.0436
Schistosoma mansoni hypothetical protein 0.0018 0.0111 0.0176
Echinococcus granulosus neuropeptide receptor 0.0011 0.0018 0.0007
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0249 0.4385
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1216 0.166
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0149 0.0247
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0018 0.0029
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0142 0.0177
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0044 0.0042
Loa Loa (eye worm) oxidoreductase 0.0013 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.0013 0.0044 0.0042
Toxoplasma gondii ABC1 family protein 0.011 0.1441 0.3169
Schistosoma mansoni opsin-like receptor 0.0011 0.0018 0.0029
Onchocerca volvulus 0.0011 0.0018 0.0007
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0434 0.0606
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Echinococcus granulosus orexin receptor type 2 0.0011 0.0018 0.0007
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0134 0.179 0.1754
Schistosoma mansoni kinase 0.0156 0.2118 0.3368
Schistosoma mansoni cpg binding protein 0.0033 0.033 0.0525
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0067 0.0077
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.1441 0.3291
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0039 0.0062
Onchocerca volvulus 0.0085 0.1081 0.154
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0013 0.0044 0.01
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0347 0.046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0018 0.0007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0116 0.0148
Echinococcus granulosus g protein coupled receptor 0.0011 0.0018 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.4419 0.635
Echinococcus multilocularis oxidoreductase 0.0013 0.0044 0.0042
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0011 0.0018 0.0007
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0067 0.0106
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0011 0.0018 0.0007
Brugia malayi hypothetical protein 0.0011 0.0018 0.0007
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0013 0.0044 0.0044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0092 0.0109
Loa Loa (eye worm) hypothetical protein 0.011 0.1441 0.197
Mycobacterium tuberculosis Conserved protein 0.011 0.1441 0.1403
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1216 0.1934
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0403 0.0562
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0124 0.1654 0.2265
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0013 0.0021
Giardia lamblia Kinase, CMGC MAPK 0.0171 0.2335 0.5235
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0306 0.0405
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0306 0.0405
Trypanosoma brucei polo-like protein kinase 0.0306 0.4289 1
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0013 0.00000000016449
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0262 0.0576
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0347 0.046
Echinococcus granulosus peptide allatostatin:somatostatin 0.0011 0.0018 0.0007
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.1415 0.1934
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0198 0.3957
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0347 0.046
Onchocerca volvulus 0.049 0.6951 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0142 0.0177
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.0018 0.0111 0.0067
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.1441 0.2058
Trichomonas vaginalis CAMK family protein kinase 0.0306 0.4289 0.6162
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0044 0.007
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0011 0.0018 0.0029
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0018 0.0029
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0013 0.0044 0.0042
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0434 0.0919
Loa Loa (eye worm) hypothetical protein 0.0013 0.0044 0.0042
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0018 0.0007
Echinococcus multilocularis neuropeptide FF receptor 2 0.0011 0.0018 0.0007
Trichomonas vaginalis steroid dehydrogenase, putative 0.0013 0.0044 0.0044
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0171 0.2335 0.5134
Giardia lamblia Kinase, PLK 0.0306 0.4289 0.9702
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0044 0.007
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0756 0.1025
Echinococcus multilocularis carbonyl reductase 1 0.0013 0.0044 0.0042
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0011 0.0018 0.0007
Schistosoma mansoni biogenic amine receptor 0.0011 0.0018 0.0029
Schistosoma mansoni ap endonuclease 0.002 0.0149 0.0236
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0018 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0018 0.0029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0018 0.0029
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0013 0.0044 0.0044
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0044 0.0097
Brugia malayi G-protein coupled receptor 0.0011 0.0018 0.0007
Schistosoma mansoni alpha-1 adrenergic receptor 0.0011 0.0018 0.0029
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0249 0.4385
Trypanosoma brucei hypothetical protein, conserved 0.011 0.1441 0.3291
Schistosoma mansoni tar DNA-binding protein 0.0138 0.1847 0.2936
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0018 0.0007
Onchocerca volvulus 0.0013 0.0044 0.0044
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0403 0.0562
Brugia malayi Thioredoxin reductase 0.0048 0.0552 0.0743
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0067 0.0074
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0013 0.0044 0.0042
Brugia malayi Serotonin receptor 0.0011 0.0018 0.0007
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0011 0.0018 0.0007
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0031 0.0024
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0044 0.007
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0024 0.0014
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0029 0.0267 0.0524
Schistosoma mansoni hypothetical protein 0.0074 0.092 0.1463
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0142 0.2384
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1216 0.166
Loa Loa (eye worm) oxidoreductase 0.0013 0.0044 0.0042
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0018 0.0111 0.0158
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0044 0.007
Plasmodium vivax SET domain protein, putative 0.0062 0.0756 0.5246
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0018 0.0007
Echinococcus multilocularis snurportin 1 0.0301 0.422 0.5807
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0044 0.007
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0025 0.0017
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0013 0.003
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0198 0.0364
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0306 0.0405
Brugia malayi chromobox protein homolog 3 0.0038 0.0403 0.0538
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0074
Mycobacterium leprae PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT 0.0018 0.0111 0.0329
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0018 0.0007
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0095 0.0209
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0198 0.3436
Schistosoma mansoni amine GPCR 0.0011 0.0018 0.0029
Mycobacterium tuberculosis Probable reductase 0.011 0.1447 0.1409
Brugia malayi Importin beta-1 subunit 0.0028 0.0262 0.0343
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0011 0.0018 0.0029
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0013 0.0093
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0018 0.0111 0.0158
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0018 0.0111 0.0135
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0198 0.0343
Echinococcus granulosus fmrfamide receptor 0.0011 0.0018 0.0007
Echinococcus granulosus tar DNA binding protein 0.0138 0.1847 0.253
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0044 0.0042
Echinococcus granulosus retinol dehydrogenase 11 0.0013 0.0044 0.0042
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0306 0.0405
Echinococcus multilocularis Chromo domain 0.0011 0.0013 0.00000000016449
Plasmodium falciparum thioredoxin reductase 0.0048 0.0552 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0306 0.0405
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Schistosoma mansoni amine GPCR 0.0011 0.0018 0.0029
Schistosoma mansoni neuropeptide f receptor 76f 0.0011 0.0018 0.0029
Onchocerca volvulus 0.0013 0.0044 0.0044
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.1447 0.1409
Brugia malayi hypothetical protein 0.0027 0.0249 0.0326
Brugia malayi hypothetical protein 0.0011 0.0018 0.0007
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0013 0.0044 0.0042
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0018 0.0111 0.0135
Echinococcus granulosus hypothetical protein 0.0011 0.0018 0.0007
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0044 0.007
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0013 0.0044 0.01
Echinococcus granulosus hypothetical protein 0.0013 0.0044 0.0042
Trypanosoma brucei trypanothione reductase 0.0048 0.0552 0.1196
Mycobacterium ulcerans aldehyde dehydrogenase 0.0018 0.0111 0.0149
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0434 0.058
Plasmodium falciparum glutathione reductase 0.0048 0.0552 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0044 0.0042
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0044 0.0042
Echinococcus multilocularis G-protein coupled receptor, putative 0.0011 0.0018 0.0007
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0029 0.0267 0.0494
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0713 0.0966
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0018 0.0111 0.0158
Onchocerca volvulus 0.0011 0.0018 0.0007
Onchocerca volvulus 0.0044 0.0496 0.0696
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0067 0.0074
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0018 0.0029
Schistosoma mansoni carbonyl reductase 0.0013 0.0044 0.007
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0044 0.007
Brugia malayi hypothetical protein 0.0013 0.0044 0.0042
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0011 0.0018 0.0029
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0306 0.0405
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0018 0.0007
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0095 0.0209
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.0013 0.0044 0.0042
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0149 0.0232
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0835 0.1133
Plasmodium vivax hypothetical protein, conserved 0.011 0.1441 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0095 0.1514
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0018 0.0111 0.0067
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0306 0.0487
Echinococcus granulosus retinol dehydrogenase 11 0.0013 0.0044 0.0042
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.025 0.0457
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0315 0.4419 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.1081 0.1719
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0018 0.0111 0.0135
Echinococcus multilocularis orexin receptor type 2 0.0011 0.0018 0.0007
Echinococcus granulosus snurportin 1 0.0301 0.422 0.5807
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Schistosoma mansoni coup transcription factor 0.0031 0.0306 0.0487
Loa Loa (eye worm) hypothetical protein 0.002 0.0149 0.0188
Treponema pallidum gamma-glutamyl phosphate reductase 0.0018 0.0111 0.0037
Schistosoma mansoni myosin xvIII 0.0011 0.0018 0.0029
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0434 1
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0018 0.0111 0.0158
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0092 0.0147
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0149 0.0105
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0018 0.0111 0.0244
Brugia malayi Dehydrogenases, short chain protein 30 0.0013 0.0044 0.0042
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0018 0.0007
Echinococcus multilocularis Polycystic kidney disease protein 0.0044 0.0496 0.0666
Brugia malayi conserved hypotetical protein 0.0015 0.0067 0.0074
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.0018 0.0111 0.0067
Schistosoma mansoni hypothetical protein 0.0011 0.0018 0.0029
Loa Loa (eye worm) hypothetical protein 0.0038 0.0403 0.0538
Echinococcus multilocularis chromobox protein 1 0.0068 0.0835 0.1133
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0305 0.0402
Echinococcus granulosus carbonyl reductase 1 0.0013 0.0044 0.0042
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0018 0.0111 0.0141
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0306 0.4289 0.5901
Echinococcus multilocularis neuropeptide s receptor 0.0511 0.7258 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0044 0.0097
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0018 0.0007
Echinococcus granulosus somatostatin receptor 0.0011 0.0018 0.0007
Brugia malayi AMP-binding enzyme family protein 0.0027 0.025 0.0326
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0029 0.0267 0.0494
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0018 0.0007
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.1625 0.1588
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0018 0.0111 0.0251
Entamoeba histolytica hypothetical protein 0.0011 0.0013 0.003
Onchocerca volvulus 0.0013 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Plasmodium vivax importin-beta 2, putative 0.0028 0.0262 0.1817
Trichomonas vaginalis CAMK family protein kinase 0.0152 0.206 0.295
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0013 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.0031 0.0306 0.0405
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0095 0.0151
Loa Loa (eye worm) hypothetical protein 0.0085 0.1081 0.1474
Onchocerca volvulus 0.0011 0.0018 0.0007
Onchocerca volvulus 0.0011 0.0018 0.0007
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0171 0.2335 0.3204
Entamoeba histolytica hypothetical protein 0.0039 0.0419 0.0948
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0142 0.0217
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0154 0.2083 0.4529
Mycobacterium ulcerans hypothetical protein 0.0029 0.0267 0.0494
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0074
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0756 0.1202
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0142 0.0312
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0238 0.3295 0.473
Echinococcus granulosus Chromo domain 0.0011 0.0013 0.00000000016449
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0013 0.0044 0.0042
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0031 0.0024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0133 0.009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0018 0.0029
Loa Loa (eye worm) oxidoreductase 0.0013 0.0044 0.0042
Echinococcus granulosus allatostatin A receptor 0.0011 0.0018 0.0007
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.025 0.1009
Echinococcus multilocularis geminin 0.0168 0.229 0.3142
Echinococcus multilocularis transient receptor potential cation channel 0.0013 0.0044 0.0042
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0029 0.0267 0.0365
Schistosoma mansoni carbonyl reductase 0.0013 0.0044 0.007
Brugia malayi hypothetical protein 0.0011 0.0018 0.0007
Schistosoma mansoni chromobox protein 0.0068 0.0835 0.1327
Brugia malayi RNA recognition motif domain containing protein 0.0138 0.1847 0.253
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0184 0.0247
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0018 0.0007
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.1447 0.6879
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.011 0.1441 0.197
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0018 0.0111 0.0135
Trichomonas vaginalis set domain proteins, putative 0.049 0.6951 1
Leishmania major hypothetical protein, conserved 0.0027 0.0249 0.0456
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0018 0.0029
Brugia malayi Dehydrogenases, short chain protein 2 0.0013 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0171 0.2335 0.5396
Echinococcus multilocularis sex peptide receptor 0.0011 0.0018 0.0007
Brugia malayi hypothetical protein 0.0011 0.0018 0.0007
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.1441 0.2058
Trichomonas vaginalis CMGC family protein kinase 0.0171 0.2335 0.3346
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0306 0.0405
Brugia malayi hypothetical protein 0.0013 0.0044 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.0306 0.4289 0.6162
Echinococcus granulosus lipoxygenase domain containing protein 0.0044 0.0496 0.0666
Brugia malayi Heterochromatin protein 1 0.0068 0.0835 0.1133
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0018 0.0111 0.0158
Echinococcus multilocularis chromobox protein 1 0.0068 0.0835 0.1133
Onchocerca volvulus 0.0013 0.0044 0.0044
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0315 0.4419 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0095 0.0113
Loa Loa (eye worm) oxidoreductase 0.0013 0.0044 0.0042
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0044 0.0097
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0018 0.0007
Brugia malayi hypothetical protein 0.0011 0.0018 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0306 0.0405
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Echinococcus multilocularis tar DNA binding protein 0.0138 0.1847 0.253
Mycobacterium leprae PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD 0.0018 0.0111 0.0329
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.1447 0.1409
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0134 0.179 0.2846
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0067 0.0074
Echinococcus granulosus Polycystic kidney disease protein 0.0044 0.0496 0.0666
Loa Loa (eye worm) hypothetical protein 0.0031 0.0306 0.0405
Echinococcus multilocularis lipoxygenase domain containing protein 0.0044 0.0496 0.0666
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0756 0.1202
Loa Loa (eye worm) oxidoreductase 0.0013 0.0044 0.0042
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0134 0.179 0.3877
Brugia malayi CXXC zinc finger family protein 0.0031 0.0305 0.0402
Plasmodium falciparum LCCL domain-containing protein 0.0044 0.0496 0.897
Loa Loa (eye worm) hypothetical protein 0.0108 0.1415 0.1934
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0074
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0013 0.000000051648
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0434 0.0866
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0018 0.0111 0.0149
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0013 0.0044 0.0097
Toxoplasma gondii thioredoxin reductase 0.0048 0.0552 0.1213
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0044 0.0042
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0249 0.0484
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0198 0.0436
Toxoplasma gondii oxidoreductase, putative 0.0013 0.0044 0.0097
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.4419 0.635
Onchocerca volvulus 0.0011 0.0018 0.0007
Schistosoma mansoni adenoreceptor 0.0011 0.0018 0.0029
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0067 0.0074
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.025 0.0565
Mycobacterium ulcerans piperideine-6-carboxilic acid dehydrogenase Pcd 0.0018 0.0111 0.0149
Brugia malayi nuclear receptor NHR-67 0.0015 0.0067 0.0074
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0013 0.0044 0.0568
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0013 0.0021
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0018 0.0007
Mycobacterium ulcerans gamma-glutamyl phosphate reductase 0.0018 0.0111 0.0149
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0044 0.0042
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0061 0.0068
Onchocerca volvulus 0.0011 0.0018 0.0007
Brugia malayi dehydrogenases, short chain protein 2 0.0013 0.0044 0.0042
Loa Loa (eye worm) TYRA-2 protein 0.0011 0.0018 0.0007
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0095 0.0658
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0149 0.0232
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0324 0.4547 0.6258
Brugia malayi G-protein coupled receptor 0.0011 0.0018 0.0007
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0184 0.0247
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0044 0.0042
Echinococcus granulosus neuropeptide receptor A26 0.0511 0.7258 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0306 0.0405
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0306 0.0422
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0018 0.0111 0.0251
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0154 0.2083 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0149 0.0188
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0306 0.0405
Brugia malayi hypothetical protein 0.0011 0.0018 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0018 0.0029
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0044 0.007
Echinococcus granulosus hypothetical protein 0.0013 0.0044 0.0042
Onchocerca volvulus 0.0013 0.0044 0.0044
Onchocerca volvulus 0.0013 0.0044 0.0044
Trichomonas vaginalis CMGC family protein kinase 0.0171 0.2335 0.3346
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0445 0.0622
Trichomonas vaginalis CMGC family protein kinase 0.0171 0.2335 0.3346
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0013 0.0044 0.01
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0133 0.009
Echinococcus granulosus carbonyl reductase 1 0.0013 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.0067 0.0106
Brugia malayi AMP-binding enzyme family protein 0.0027 0.025 0.0326
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0067 0.0074
Loa Loa (eye worm) dehydrogenase 0.0013 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.0027 0.025 0.0326
Brugia malayi Dopamine receptor 0.0011 0.0018 0.0007
Echinococcus granulosus dro:myosuppressin receptor 0.0011 0.0018 0.0007
Onchocerca volvulus 0.0011 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0306 0.0405
Brugia malayi neuropeptide F receptor 0.0011 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0013 0.00000000016449
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0306 0.0405
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0171 0.2335 0.5396
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0306 0.4289 0.5901
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0018 0.0111 0.0141
Schistosoma mansoni hypothetical protein 0.0011 0.0018 0.0029
Brugia malayi G protein-coupled receptor 0.0011 0.0018 0.0007
Echinococcus granulosus 7TM GPCR rhodopsin 0.0011 0.0018 0.0007
Brugia malayi hypothetical protein 0.0011 0.0018 0.0007
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0044 0.0042
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0149 0.0124
Brugia malayi hypothetical protein 0.0017 0.0092 0.0109
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0134 0.179 0.2452
Loa Loa (eye worm) hypothetical protein 0.0017 0.0092 0.0109
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0011 0.0018 0.0007
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.1625 0.1588
Onchocerca volvulus 0.0011 0.0018 0.0007
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0306 0.0487
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0095 0.1514
Schistosoma mansoni carbonyl reductase 0.0013 0.0044 0.007
Schistosoma mansoni aldehyde dehydrogenase 0.0324 0.4547 0.7229
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0095 0.0051
Loa Loa (eye worm) hypothetical protein 0.0206 0.2841 0.3903
Loa Loa (eye worm) hypothetical protein 0.0031 0.0306 0.0405
Trichomonas vaginalis CAMK family protein kinase 0.0306 0.4289 0.6162
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0044 0.007
Leishmania major importin beta-1 subunit, putative 0.0023 0.0184 0.0312
Echinococcus multilocularis carbonyl reductase 1 0.0013 0.0044 0.0042
Echinococcus granulosus geminin 0.0168 0.229 0.3142
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0018 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0073 0.0917 0.1457
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0018 0.0029
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.025 0.0207
Echinococcus granulosus neuropeptide receptor 0.0011 0.0018 0.0007
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0306 0.0405
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.025 0.0457
Loa Loa (eye worm) hypothetical protein 0.002 0.0149 0.0188
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0306 0.0422
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0018 0.0007
Brugia malayi CHD4 protein 0.0013 0.0039 0.0036
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0018 0.0007
Mycobacterium ulcerans aldehyde dehydrogenase 0.0324 0.4547 1
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0092 0.0109
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0013 0.00000000017177
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0018 0.0111 0.0244
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0044 0.0097
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0044 0.007
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0044 0.007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0029 0.0267 0.0524
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0044 0.0042
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0095 0.1305
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0142 0.0185
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0067 0.0074
Echinococcus granulosus WW domain containing oxidoreductase 0.0013 0.0044 0.0042
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0018 0.0111 0.0149
Entamoeba histolytica short chain dehydrogenase family protein 0.0013 0.0044 0.01
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0074
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0306 0.0405
Loa Loa (eye worm) hypothetical protein 0.0013 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0248 0.3447 0.8017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0306 0.0405
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0552 0.0743
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0044 0.0042
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.025 0.0457
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.1081 0.1474
Mycobacterium leprae Probable lipase LipE 0.011 0.1441 0.685
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0134 0.179 0.2452
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0011 0.0018 0.0007
Echinococcus granulosus bloom syndrome protein 0.002 0.0142 0.0177
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0018 0.0029
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0013 0.00000000016449
Loa Loa (eye worm) hypothetical protein 0.0017 0.0092 0.0109
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0306 0.0487
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0198 0.0155
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0149 0.1037
Schistosoma mansoni hypothetical protein 0.0168 0.229 0.3641
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0306 0.0405
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0306 0.0487
Onchocerca volvulus 0.0011 0.0018 0.0007
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0306 0.4289 0.9427
Echinococcus multilocularis G protein coupled receptor 139 0.0011 0.0018 0.0007
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0347 0.046
Loa Loa (eye worm) hypothetical protein 0.0031 0.0306 0.0405
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0067 0.0074
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0018 0.0111 0.0251
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0149 0.0247
Brugia malayi Retinol dehydrogenase 12 0.0013 0.0044 0.0042
Echinococcus granulosus Chromobox protein 3 0.0011 0.0013 0.000000051648
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0018 0.0007
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0347 0.046
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0018 0.0007
Mycobacterium leprae PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE 0.0018 0.0111 0.0329
Loa Loa (eye worm) hypothetical protein 0.0013 0.0044 0.0042
Onchocerca volvulus 0.011 0.1441 0.2058
Loa Loa (eye worm) oxidoreductase 0.0013 0.0044 0.0042
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0306 0.0487
Leishmania major aldehyde dehydrogenase, putative 0.0018 0.0111 0.0149
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0142 0.0185
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0013 0.0044 0.0042
Schistosoma mansoni rab6-interacting 0.0044 0.0496 0.0789
Echinococcus multilocularis mitogen activated protein kinase 3 0.0171 0.2335 0.3204
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0068 0.0079
Schistosoma mansoni hypothetical protein 0.0011 0.0018 0.0029
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0095 0.0117
Brugia malayi ecdysteroid receptor 0.0031 0.0306 0.0405
Brugia malayi hypothetical protein 0.0017 0.0092 0.0109
Schistosoma mansoni hypothetical protein 0.0011 0.0013 0.0021
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0013 0.0044 0.0042
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0039 0.0036
Loa Loa (eye worm) glutathione reductase 0.0048 0.0552 0.0743
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0116 0.0148
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0171 0.2335 0.5087
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0013 0.00000000017177
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0018 0.0111 0.0176
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0018 0.0029
Onchocerca volvulus 0.0013 0.0044 0.0044
Toxoplasma gondii aldehyde dehydrogenase 0.0324 0.4547 1
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0018 0.0111 0.0158
Loa Loa (eye worm) hypothetical protein 0.0013 0.0044 0.0042
Brugia malayi larval opioid receptor 0.0011 0.0018 0.0007
Mycobacterium ulcerans gamma-aminobutyraldehyde dehydrogenase 0.0018 0.0111 0.0149
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0306 0.0487
Schistosoma mansoni amine GPCR 0.0011 0.0018 0.0029
Brugia malayi Pre-SET motif family protein 0.043 0.6091 0.8389
Echinococcus multilocularis bloom syndrome protein 0.002 0.0142 0.0177
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0011 0.0018 0.0029
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0011 0.0018 0.0007
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0018 0.0111 0.0149
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0067 0.0074
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0434 0.0982
Onchocerca volvulus 0.0013 0.0044 0.0044
Plasmodium falciparum thioredoxin reductase 0.0017 0.0095 0.1514
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.025 0.0457
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.4419 0.635
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0306 0.0405
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0116 0.0148
Schistosoma mansoni ap endonuclease 0.002 0.0149 0.0236
Schistosoma mansoni aldehyde dehydrogenase 0.0018 0.0111 0.0176
Schistosoma mansoni polycystin 1-related 0.0044 0.0496 0.0789
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0067 0.0074
Onchocerca volvulus 0.0021 0.0161 0.0212
Schistosoma mansoni tar DNA-binding protein 0.0138 0.1847 0.2936
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0306 0.0405
Echinococcus multilocularis g-protein coupled receptor 0.0011 0.0018 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.4419 0.635
Echinococcus multilocularis serotonin receptor 0.0011 0.0018 0.0007
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0306 0.0405
Onchocerca volvulus 0.0011 0.0018 0.0007
Mycobacterium ulcerans beta-lactamase 0.011 0.1441 0.3102
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0198 0.0757
Brugia malayi tailless protein 0.0015 0.0067 0.0074
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0198 0.0239
Loa Loa (eye worm) hypothetical protein 0.011 0.1441 0.197
Schistosoma mansoni lipoxygenase 0.0044 0.0496 0.0789
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0044 0.007
Schistosoma mansoni zinc finger protein 0.0015 0.0067 0.0106
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0018 0.0111 0.0135
Loa Loa (eye worm) hypothetical protein 0.0013 0.0044 0.0042
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0149 0.0187
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0018 0.0111 0.0158
Loa Loa (eye worm) hypothetical protein 0.011 0.1441 0.197
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0116 0.0148
Toxoplasma gondii oxidoreductase, putative 0.0013 0.0044 0.0097
Brugia malayi nuclear receptor RXR 0.0017 0.0092 0.0109
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0095 0.012
Mycobacterium leprae conserved hypothetical protein 0.011 0.1441 0.685
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0013 0.0044 0.0044
Schistosoma mansoni neuropeptide receptor 0.0011 0.0018 0.0029
Brugia malayi nuclear receptor NHR-88 0.0031 0.0306 0.0405
Entamoeba histolytica hypothetical protein 0.0023 0.0184 0.0417
Mycobacterium ulcerans aldehyde dehydrogenase 0.0324 0.4547 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0149 0.0188
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0306 0.0405
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0198 0.1376
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0142 0.2384
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0095 0.0117
Echinococcus granulosus neuropeptide FF receptor 2 0.0011 0.0018 0.0007
Schistosoma mansoni hypothetical protein 0.0444 0.629 1
Leishmania major hypothetical protein, conserved 0.0248 0.3447 0.7557
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0262 0.0513
Echinococcus granulosus G protein coupled receptor 139 0.0011 0.0018 0.0007
Brugia malayi Doublecortin family protein 0.0044 0.0496 0.0666
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0074
Entamoeba histolytica hypothetical protein 0.0011 0.0013 0.003
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0013 0.0044 0.01
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0013 0.0044 0.0044
Wolbachia endosymbiont of Brugia malayi bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 0.0018 0.0111 0.1719
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0095 0.0112
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0306 0.4289 0.5901
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0306 0.0487
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0067 0.0074
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0306 0.0487
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0095 0.0112
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0149 0.0195
Brugia malayi nuclear hormone receptor 0.0221 0.3055 0.4199
Loa Loa (eye worm) hypothetical protein 0.0017 0.0092 0.0109
Echinococcus granulosus carbonyl reductase 1 0.0013 0.0044 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0403 0.0562
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0142 0.0177
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0068 0.0079
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0044 0.007
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0249 0.1731
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.0027 0.025 0.0326
Schistosoma mansoni hypothetical protein 0.0012 0.0031 0.0049
Schistosoma mansoni hypothetical protein 0.0034 0.0347 0.0552
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0142 0.0177
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0324 0.4547 0.6258
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0018 0.0007
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0044 0.0042
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0044 0.007
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0149 0.2514
Loa Loa (eye worm) hypothetical protein 0.0027 0.0249 0.0326
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0044 0.0042
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0434 0.058
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0306 0.0405
Mycobacterium ulcerans aldehyde dehydrogenase 0.0324 0.4547 1
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0018 0.0111 0.0135
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0095 0.1305
Brugia malayi neuropeptide F receptor 0.0011 0.0018 0.0007
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0092 0.0109
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0067 0.0074
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0018 0.0007
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0018 0.0111 0.0158
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.1447 0.1409
Loa Loa (eye worm) doublecortin family protein 0.0044 0.0496 0.0666
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0018 0.0029
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0074
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.0018 0.0111 0.0251
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.025 0.0457
Onchocerca volvulus 0.0013 0.0044 0.0044
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.025 0.0457
Schistosoma mansoni amine GPCR 0.0011 0.0018 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0756 0.1202
Echinococcus granulosus tachykinin peptides receptor 99D 0.0011 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0074
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0011 0.0018 0.0007
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0018 0.0111 0.0244
Echinococcus granulosus GPCR family 2 0.0034 0.0347 0.046
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0306 0.0405
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0013 0.0021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1216 0.166
Schistosoma mansoni aldehyde dehydrogenase 0.0018 0.0111 0.0176
Echinococcus granulosus importin subunit beta 1 0.0028 0.0262 0.0343
Plasmodium falciparum steroid dehydrogenase, putative 0.0013 0.0044 0.0568
Echinococcus multilocularis steroid dehydrogenase 0.0013 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.0062 0.0756 0.1025
Onchocerca volvulus 0.0031 0.0306 0.0422
Schistosoma mansoni nuclear receptor 0.0015 0.0067 0.0106
Plasmodium vivax heterochromatin protein 1, putative 0.0011 0.0013 0.0093
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0306 0.0405
Trypanosoma brucei protein kinase, putative 0.0171 0.2335 0.5396
Mycobacterium tuberculosis Probable hydrolase 0.011 0.1441 0.1403
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.1447 0.1409
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.025 0.0457
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.025 0.1009
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Echinococcus multilocularis conserved hypothetical protein 0.0013 0.0044 0.0042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.4419 0.635
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0018 0.0007
Echinococcus multilocularis carbonyl reductase 1 0.0013 0.0044 0.0042
Loa Loa (eye worm) DR-78 0.0015 0.0067 0.0074
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0013 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0306 0.0405
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0018 0.0111 0.0158
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0095 0.0113
Onchocerca volvulus 0.0011 0.0013 0.000000053934
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.1441 0.1403
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0434 0.0919
Onchocerca volvulus 0.0011 0.0018 0.0007
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0434 0.0919
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.4419 0.635
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.1625 0.1588
Brugia malayi glutathione reductase 0.0048 0.0552 0.0743
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0011 0.0018 0.0007
Loa Loa (eye worm) RNA binding protein 0.0138 0.1847 0.253
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0013 0.0044 0.0042
Brugia malayi beta-lactamase family protein 0.011 0.1441 0.197
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0067 0.0077
Schistosoma mansoni DNA helicase recq5 0.002 0.0142 0.0225
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0044 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0306 0.0405
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0154 0.2083 0.2048
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0306 0.0405
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.1441 0.2291
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0025 0.0017
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0095 0.012
Echinococcus multilocularis RUN 0.0044 0.0496 0.0666
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0018 0.0007
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0552 0.0743
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0018 0.0007
Echinococcus granulosus 7tm_1 domain containing protein 0.0011 0.0018 0.0007
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0742 0.1631
Schistosoma mansoni opsin-like receptor 0.0011 0.0018 0.0029
Brugia malayi RNA binding protein 0.0138 0.1847 0.253
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0018 0.0029
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0306 0.0405
Brugia malayi RE15519p 0.0011 0.0018 0.0007
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0262 0.0343
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.422 0.5807
Loa Loa (eye worm) RecQ helicase 0.002 0.0142 0.0177
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0198 1
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0044 0.007
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0013 0.0044 0.0042
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0095 0.0658
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0013 0.0044 0.0044
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0262 0.0513
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0018 0.0111 0.0176
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0306 0.0487
Plasmodium vivax multidomain scavenger receptor, putative 0.0044 0.0496 0.3443
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0013 0.0044 0.0097
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0018 0.0111 0.0149
Schistosoma mansoni cpg binding protein 0.0033 0.033 0.0525
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0044 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0306 0.0405
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0018 0.0111 0.0149
Onchocerca volvulus 0.0011 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0067 0.0074
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0011 0.0018 0.0029
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0018 0.0007
Entamoeba histolytica hypothetical protein, conserved 0.0013 0.0044 0.01
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0011 0.0018 0.0007
Brugia malayi beta-lactamase 0.011 0.1441 0.197
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.0018 0.0111 0.0067
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0092 0.0147
Echinococcus multilocularis allatostatin A receptor 0.0011 0.0018 0.0007
Schistosoma mansoni opsin-like receptor 0.0011 0.0018 0.0029
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0018 0.0007
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0013 0.0029
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Entamoeba histolytica hypothetical protein, conserved 0.0013 0.0044 0.01
Echinococcus granulosus alpha 1A adrenergic receptor 0.0011 0.0018 0.0007
Trypanosoma cruzi polo-like protein kinase, putative 0.0306 0.4289 1
Echinococcus multilocularis cpg binding protein 0.0033 0.033 0.0438
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0095 0.012
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0011 0.0018 0.0007
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.043 0.6091 0.8389
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0018 0.0007
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0095 0.012
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0419 0.0666
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0242 0.033
Echinococcus granulosus chromobox protein 1 0.0068 0.0835 0.1133
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.1441 0.197
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0445 0.0622
Schistosoma mansoni hypothetical protein 0.0044 0.0496 0.0789
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0149 0.0247
Treponema pallidum fructose-bisphosphate aldolase 0.0315 0.4419 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0306 0.0405
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.1441 0.1403
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0018 0.0007
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0116 0.0148
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0013 0.0044 0.0044
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0095 0.012
Loa Loa (eye worm) hypothetical protein 0.0034 0.0347 0.046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0306 0.0405
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0552 0.051
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0306 0.0487
Echinococcus granulosus oxidoreductase 0.0013 0.0044 0.0042
Brugia malayi Dopamine receptor protein 1 0.0011 0.0018 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0306 0.0405
Brugia malayi TAR-binding protein 0.0138 0.1847 0.253
Schistosoma mansoni neuropeptide receptor 0.0011 0.0018 0.0029
Brugia malayi ecdysone receptor 0.0015 0.0067 0.0074
Schistosoma mansoni hypothetical protein 0.0034 0.0347 0.0552
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0044 0.007
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0013 0.003
Plasmodium vivax steroid dehydrogenase, putative 0.0013 0.0044 0.0305
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.1625 0.7751
Echinococcus multilocularis retinol dehydrogenase 13 0.0013 0.0044 0.0042
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0134 0.179 0.3877
Trichomonas vaginalis CAMK family protein kinase 0.0306 0.4289 0.6162
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0149 0.0234
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0013 0.0044 0.007
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0018 0.0111 0.0135
Brugia malayi Aldehyde dehydrogenase protein 4 0.0018 0.0111 0.0135
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0347 0.046
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0095 0.0113
Brugia malayi nuclear receptor RXR 0.0015 0.0067 0.0074
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0018 0.0111 0.0135
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0011 0.0018 0.0029
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.1441 0.2058
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0044 0.007
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0018 0.0111 0.0135
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0018 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.4419 0.635
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1216 0.166
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 0.0018 0.0111 0.0149
Echinococcus multilocularis carbonyl reductase 1 0.0013 0.0044 0.0042
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1216 0.166
Onchocerca volvulus 0.0011 0.0018 0.0007
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.1441 0.197
Onchocerca volvulus 0.0027 0.025 0.0341
Echinococcus multilocularis lipoxygenase domain containing protein 0.0044 0.0496 0.0666
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0306 0.0487
Onchocerca volvulus Serine\/threonine kinase homolog 0.0306 0.4289 0.6162
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0018 0.0111 0.0158
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0018 0.0007
Schistosoma mansoni tar DNA-binding protein 0.0138 0.1847 0.2936
Schistosoma mansoni amine GPCR 0.0011 0.0018 0.0029
Echinococcus granulosus serotonin receptor 0.0011 0.0018 0.0007
Entamoeba histolytica hypothetical protein 0.0039 0.0419 0.0948
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0074
Echinococcus multilocularis serotonin receptor 0.0011 0.0018 0.0007
Brugia malayi hypothetical protein 0.0015 0.0067 0.0074
Loa Loa (eye worm) hypothetical protein 0.0017 0.0092 0.0109
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0434 0.0954
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0018 0.0111 0.0158
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0018 0.0007
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.0018 0.0111 0.0067
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.1441 0.1403
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0011 0.0018 0.0007
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0011 0.0018 0.0007
Loa Loa (eye worm) dehydrogenase 0.0013 0.0044 0.0042
Trypanosoma brucei hypothetical protein, conserved 0.0248 0.3447 0.8017
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0011 0.0018 0.0007
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0018 0.0007
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0013 0.0044 0.0044
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.1081 0.1474
Trichomonas vaginalis esterase, putative 0.011 0.1441 0.2058
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0149 0.1032
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0142 0.0177
Brugia malayi hypothetical protein 0.0018 0.0109 0.0132
Echinococcus granulosus lipoxygenase domain containing protein 0.0044 0.0496 0.0666
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Echinococcus multilocularis GPCR, family 2 0.0034 0.0347 0.046
Brugia malayi AKH receptor 0.0011 0.0018 0.0007
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0018 0.0029
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0306 0.0405
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0306 0.0405
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0116 0.0148
Brugia malayi oxidoreductase 0.0013 0.0044 0.0042
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0835 0.1184
Schistosoma mansoni hypothetical protein 0.0168 0.229 0.3641
Schistosoma mansoni hypothetical protein 0.0034 0.0347 0.0552
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0116 0.0148
Leishmania major trypanothione reductase 0.0048 0.0552 0.1127
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0029 0.0267 0.0494
Loa Loa (eye worm) hypothetical protein 0.0044 0.0496 0.0666
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0221 0.3055 0.4199
Entamoeba histolytica serine/threonine protein kinase, putative 0.0306 0.4289 0.9705
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0044 0.0097
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0074
Trichomonas vaginalis CMGC family protein kinase 0.0171 0.2335 0.3346
Echinococcus granulosus RUN 0.0044 0.0496 0.0666
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0044 0.007
Echinococcus multilocularis retinol dehydrogenase 11 0.0013 0.0044 0.0042
Entamoeba histolytica hypothetical protein 0.0011 0.0013 0.003
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0011 0.0018 0.0007
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.1441 0.2291
Brugia malayi hypothetical protein 0.0011 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0116 0.0148
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0013 0.0044 0.0044
Echinococcus granulosus cpg binding protein 0.0033 0.033 0.0438
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0142 0.0177
Schistosoma mansoni inositol monophosphatase 0.004 0.0434 0.069
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0095 0.012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0306 0.0405
Echinococcus multilocularis somatostatin receptor 0.0011 0.0018 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0171 0.2335 0.3712
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0018 0.0007
Echinococcus multilocularis dro:myosuppressin receptor 0.0011 0.0018 0.0007
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0434 0.0866
Brugia malayi hypothetical protein 0.0011 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0324 0.4547 1
Mycobacterium ulcerans hypothetical protein 0.0027 0.025 0.0457
Echinococcus granulosus g-protein coupled receptor 0.0011 0.0018 0.0007
Mycobacterium tuberculosis Conserved protein 0.011 0.1441 0.1403
Loa Loa (eye worm) aldehyde dehydrogenase 0.0018 0.0111 0.0135
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 0.0018 0.0111 0.0149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0306 0.0405
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0018 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.0306 0.4289 0.6162
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0434 0.0606
Onchocerca volvulus 0.0073 0.0917 0.1302
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0011 0.0018 0.0007
Onchocerca volvulus 0.0044 0.0496 0.0696
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0018 0.0111 0.0135
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0018 0.0029
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.0135
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0133 0.009
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.1415 0.1934
Loa Loa (eye worm) hypothetical protein 0.002 0.0149 0.0188
Schistosoma mansoni aldehyde dehydrogenase 0.0018 0.0111 0.0176
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0306 0.0405
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0044 0.0305
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0844 0.1342
Onchocerca volvulus 0.0011 0.0018 0.0007
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0013 0.0044 0.0044
Leishmania major aldehyde dehydrogenase, putative 0.0018 0.0111 0.0149
Mycobacterium ulcerans methylmalonate semialdehyde dehydrogenase, MmsA 0.0018 0.0111 0.0149
Echinococcus granulosus carbonyl reductase 1 0.0013 0.0044 0.0042
Loa Loa (eye worm) melatonin receptor type 1A 0.0011 0.0018 0.0007
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0134 0.179 0.3877
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0018 0.0007
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0018 0.0007
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0031 0.0024
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.025 0.0457
Brugia malayi G protein-coupled receptor F59B2.13 0.0011 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0095 0.0116
Brugia malayi steroid hormone receptor 0.0031 0.0306 0.0405
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0095 0.0112
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0171 0.2335 0.5396
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0306 0.0405
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0095 0.012
Mycobacterium tuberculosis Conserved protein 0.011 0.1441 0.1403
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0249 0.0548
Brugia malayi Melatonin receptor type 1A 0.0011 0.0018 0.0007
Schistosoma mansoni growth hormone secretagogue receptor 0.0011 0.0018 0.0029
Schistosoma mansoni neuropeptide receptor 0.0011 0.0018 0.0029
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0018 0.0007
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0198 0.0343
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.4419 0.635
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0142 0.0177
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0095 0.0113
Onchocerca volvulus 0.011 0.1441 0.2058
Giardia lamblia Fructose-bisphosphate aldolase 0.0315 0.4419 1
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0198 0.0343
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0184 0.0247
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0018 0.0111 0.0158
Brugia malayi ORL1-like opioid receptor 0.0011 0.0018 0.0007
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0067 0.0074
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0552 0.0743
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0347 0.046
Schistosoma mansoni biogenic amine receptor 0.0011 0.0018 0.0029
Brugia malayi follicle stimulating hormone receptor 0.0511 0.7258 1
Brugia malayi RNA, U transporter 1 0.008 0.1016 0.1384
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.0018 0.0111 0.0067
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0552 0.3828
Mycobacterium tuberculosis Conserved protein 0.0029 0.0267 0.0224
Leishmania major hypothetical protein, conserved 0.011 0.1441 0.3102
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0067 0.0074
Schistosoma mansoni hypothetical protein 0.0039 0.0419 0.0666
Schistosoma mansoni hypothetical protein 0.0034 0.0347 0.0552
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0067 0.0074
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0044 0.007
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0306 0.0405
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0013 0.0044 0.0044
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.0013 0.0000000022145
Entamoeba histolytica hypothetical protein 0.0039 0.0419 0.0948
Onchocerca volvulus 0.0011 0.0018 0.0007
Mycobacterium ulcerans pyrroline-5-carboxylate dehydrogenase, RocA 0.0018 0.0111 0.0149
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0138 0.1847 0.253
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0018 0.0111 0.0149
Schistosoma mansoni lipoxygenase 0.0124 0.1654 0.263
Loa Loa (eye worm) hypothetical protein 0.011 0.1441 0.197
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.025 0.0457
Trichomonas vaginalis CAMK family protein kinase 0.0152 0.206 0.295
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0013 0.0044 0.0042
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1216 0.166
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0171 0.2335 0.5396
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0044 0.0042
Echinococcus multilocularis neuropeptide receptor A26 0.0511 0.7258 1
Trichomonas vaginalis CAMK family protein kinase 0.0306 0.4289 0.6162
Schistosoma mansoni nuclear receptor 0.0015 0.0067 0.0106
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0324 0.4547 0.4523
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1216 0.1934
Brugia malayi MAP kinase sur-1 0.0171 0.2335 0.3204
Loa Loa (eye worm) beta-lactamase 0.011 0.1441 0.197
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0067 0.0106
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0013 0.0044 0.0097
Echinococcus multilocularis dnaJ subfamily B 0.0444 0.629 0.8663
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0013 0.0044 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0242 0.033
Schistosoma mansoni short chain dehydrogenase 0.0013 0.0044 0.007
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.1441 0.2058
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0184 0.0331
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Onchocerca volvulus 0.0011 0.0018 0.0007
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0149 0.2527
Mycobacterium ulcerans lipase LipD 0.011 0.1441 0.3102
Mycobacterium ulcerans hypothetical protein 0.011 0.1441 0.3102
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0149 0.0106
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.1441 0.1403
Loa Loa (eye worm) inositol-1 0.004 0.0434 0.058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0018 0.0029
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0025 0.0017
Echinococcus granulosus steroid dehydrogenase 0.0013 0.0044 0.0042
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.1441 0.1403
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0092 0.0109
Trypanosoma cruzi hypothetical protein, conserved 0.0248 0.3447 0.8017
Schistosoma mansoni aldehyde dehydrogenase 0.0018 0.0111 0.0176
Echinococcus multilocularis citrate lyase subunit beta protein 0.0029 0.0267 0.035
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0756 0.1662
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1216 0.1934
Schistosoma mansoni inositol monophosphatase 0.004 0.0434 0.069
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0095 0.012
Brugia malayi hypothetical protein 0.0039 0.0419 0.056
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0018 0.0007
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.092 0.1252
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0018 0.0111 0.0135
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0133 0.009
Echinococcus granulosus dnaJ subfamily B 0.0444 0.629 0.8663
Echinococcus granulosus citrate lyase subunit beta protein 0.0029 0.0267 0.035
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0044 0.0042
Brugia malayi dehydrogenases, short chain protein 9 0.0013 0.0044 0.0042
Onchocerca volvulus 0.0015 0.0067 0.0077
Loa Loa (eye worm) oxidoreductase 0.0013 0.0044 0.0042
Leishmania major aldehyde dehydrogenase, putative 0.0018 0.0111 0.0149
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0013 0.0044 0.007
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.1441 0.197
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.012 0.1599 0.2188
Brugia malayi AMP-binding enzyme family protein 0.0027 0.025 0.0326
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0434 0.0606
Echinococcus granulosus mitogen activated protein kinase 0.0171 0.2335 0.3204
Schistosoma mansoni DNA helicase recq1 0.002 0.0142 0.0225
Brugia malayi Inositol-1 0.004 0.0434 0.058
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.025 0.0207
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0074
Echinococcus multilocularis mitogen activated protein kinase 0.0171 0.2335 0.3204
Loa Loa (eye worm) oxidoreductase 0.0013 0.0044 0.0042
Brugia malayi aldehyde dehydrogenase 0.0018 0.0111 0.0135
Brugia malayi Pre-SET motif family protein 0.0062 0.0756 0.1025
Loa Loa (eye worm) hypothetical protein 0.0013 0.0044 0.0042
Echinococcus multilocularis steroid dehydrogenase 0.0013 0.0044 0.0042
Giardia lamblia Alcohol dehydrogenase 0.0018 0.0111 0.0153
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0018 0.0111 0.0158
Schistosoma mansoni tar DNA-binding protein 0.0138 0.1847 0.2936
Echinococcus granulosus chromobox protein 1 0.0068 0.0835 0.1133
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0018 0.0007
Echinococcus granulosus mitogen activated protein kinase 3 0.0171 0.2335 0.3204
Onchocerca volvulus Sepiapterin reductase homolog 0.0013 0.0044 0.0044
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0306 0.0405
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0011 0.0018 0.0007
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0018 0.0111 0.0158
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0044 0.007
Echinococcus granulosus neuropeptide s receptor 0.0511 0.7258 1
Brugia malayi hypothetical protein 0.0015 0.0067 0.0074
Loa Loa (eye worm) hypothetical protein 0.0028 0.0262 0.0343
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0149 0.0195
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Schistosoma mansoni aldehyde dehydrogenase 0.0018 0.0111 0.0176
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0029 0.0267 0.0494
Entamoeba histolytica hypothetical protein 0.0039 0.0419 0.0948
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0011 0.0018 0.0007
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0171 0.2335 0.5087
Toxoplasma gondii carbonyl reductase 1, putative 0.0013 0.0044 0.0097
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.1081 0.1474
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0011 0.0018 0.0007
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0092 0.0109
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0124 0.1654 0.2265
Brugia malayi Dopamine receptor protein 2 0.0011 0.0018 0.0007
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0142 0.0185
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0373 0.0331
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0756 0.1025
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0018 0.0007
Onchocerca volvulus 0.003 0.0284 0.039
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0067 0.0106
Schistosoma mansoni cpg binding protein 0.0031 0.0305 0.0484
Entamoeba histolytica recQ family helicase, putative 0.002 0.0142 0.0321
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0013 0.0029
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0018 0.0111 0.0067
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0067 0.0074
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0095 0.012
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0013 0.0044 0.007
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0018 0.0111 0.0158
Schistosoma mansoni chromobox protein 0.0068 0.0835 0.1327
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0031 0.0024
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0149 0.0187
Loa Loa (eye worm) hypothetical protein 0.0015 0.0067 0.0074
Onchocerca volvulus 0.0013 0.0044 0.0044
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0419 0.056
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0306 0.0405
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0018 0.0029
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0149 0.0336
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0171 0.2335 0.5396
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0018 0.0007
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0142 0.023
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Brugia malayi nuclear hormone receptor 0.0031 0.0306 0.0405
Brugia malayi putative neuropeptide receptor 0.0011 0.0018 0.0007
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0013 0.0044 0.0568
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0018 0.0111 0.0067
Entamoeba histolytica hypothetical protein 0.0013 0.0044 0.01
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0134 0.179 0.2452
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0018 0.0007
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0018 0.0007
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0044 0.0042
Entamoeba histolytica hypothetical protein 0.0024 0.0198 0.0449
Echinococcus granulosus g protein coupled receptor 0.0011 0.0018 0.0007
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0756 0.1025
Trypanosoma cruzi polo-like protein kinase, putative 0.0306 0.4289 1
Echinococcus granulosus g protein coupled receptor 0.0011 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0007
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0018 0.0111 0.0067
Loa Loa (eye worm) hypothetical protein 0.0044 0.0496 0.0666
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0095 0.0113
Mycobacterium ulcerans bifunctional acetaldehyde-CoA/alcohol dehydrogenase 0.0018 0.0111 0.0149
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0044 0.007
Brugia malayi hypothetical protein 0.0044 0.0496 0.0666
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0018 0.0111 0.0135
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0029 0.0267 0.0224
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0306 0.0487
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0067 0.0074
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0373 0.1614
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0552 0.1196
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0044 0.007
Entamoeba histolytica short chain dehydrogenase family protein 0.0013 0.0044 0.01
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.1441 0.2058
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0011 0.0018 0.0029
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0095 0.0113
Schistosoma mansoni steroid dehydrogenase 0.0013 0.0044 0.007
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0149 0.0187
Schistosoma mansoni importin beta-1 0.0028 0.0262 0.0416
Schistosoma mansoni tar DNA-binding protein 0.0138 0.1847 0.2936
Schistosoma mansoni histamine h1 receptor 0.0011 0.0018 0.0029
Loa Loa (eye worm) hypothetical protein 0.0013 0.0044 0.0042
Mycobacterium ulcerans aldehyde dehydrogenase (NAD+) dependent 0.0018 0.0111 0.0149
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0067 0.0074
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0018 0.0029
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.1441 0.3102
Loa Loa (eye worm) hypothetical protein 0.003 0.0284 0.0374
Schistosoma mansoni serine/threonine protein kinase 0.0306 0.4289 0.6819
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.025 0.0565
Brugia malayi beta-lactamase family protein 0.011 0.1441 0.197
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.0013 0.0029
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0067 0.0106
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0013 0.0044 0.0044
Onchocerca volvulus 0.0011 0.0018 0.0007
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0249 0.0484
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0039 0.0036
Schistosoma mansoni aldehyde dehydrogenase 0.0324 0.4547 0.7229
Loa Loa (eye worm) hypothetical protein 0.0074 0.092 0.1252

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) = 300 uM Cytotoxicity concentration to inhibit hepatitis C virus RNA replication in a subgenomic replicon cell line ChEMBL. 15664842
EC50 (functional) = 200 uM Inhibition of hepatitis C virus RNA replication in a subgenomic replicon cell line ChEMBL. 15664842

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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