Detailed information for compound 320172

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 312.406 | Formula: C19H24N2O2
  • H donors: 0 H acceptors: 2 LogP: 2.54 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)c1ccc2c(c1)CCC1=C(C(=O)CCN21)C)CC
  • InChi: 1S/C19H24N2O2/c1-4-20(5-2)19(23)15-7-9-17-14(12-15)6-8-16-13(3)18(22)10-11-21(16)17/h7,9,12H,4-6,8,10-11H2,1-3H3
  • InChiKey: SFFYDXMRUCNZSV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum acyl-CoA synthetase 0.0047 0.0269 0.2195
Echinococcus multilocularis bloom syndrome protein 0.0017 0.0038 0.0032
Schistosoma mansoni RAR-like nuclear receptor 0.0143 0.103 0.1024
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0068 0.0433 0.0458
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0143 0.103 0.1503
Mycobacterium tuberculosis Probable lipase LipE 0.0032 0.0151 0.0853
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0017 0.0038 0.0034
Loa Loa (eye worm) hypothetical protein 0.0063 0.0393 0.0574
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0248 0.1516
Schistosoma mansoni jumonji domain containing protein 0.0014 0.0009 0.0002
Onchocerca volvulus Huntingtin homolog 0.0119 0.0837 0.8043
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0028 0.0122 0.0659
Schistosoma mansoni acetyl-CoA synthetase 0.0018 0.0045 0.0039
Trichomonas vaginalis importin beta-1, putative 0.0061 0.0382 1
Loa Loa (eye worm) hypothetical protein 0.0143 0.103 0.1503
Brugia malayi nuclear hormone receptor family member odr-7 0.0068 0.0433 0.0587
Schistosoma mansoni thyroid hormone receptor 0.1283 1 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0063 0.0393 0.2497
Loa Loa (eye worm) hypothetical protein 0.0032 0.0151 0.022
Trypanosoma brucei hypothetical protein, conserved 0.0032 0.0151 0.0418
Loa Loa (eye worm) hypothetical protein 0.0063 0.0393 0.0574
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0446 0.3412 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0017 0.0038 0.0088
Echinococcus granulosus JmjC domain containing protein 4 0.0014 0.0009 0.0002
Brugia malayi nuclear receptor NHR-88 0.0143 0.103 0.1395
Echinococcus granulosus neuropeptide receptor A26 0.0394 0.3 0.3215
Loa Loa (eye worm) hypothetical protein 0.0143 0.103 0.1503
Echinococcus multilocularis phd:f box containing protein 0.0014 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0143 0.103 0.1503
Echinococcus multilocularis carbonic anhydrase II 0.0446 0.3412 0.3408
Loa Loa (eye worm) hypothetical protein 0.0068 0.0433 0.0633
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0248 0.1516
Echinococcus multilocularis importin 5 0.0014 0.0013 0.0007
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0017 0.0038 0.0252
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0018 0.0045 0.0108
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0018 0.0045 0.0108
Brugia malayi hypothetical protein 0.0068 0.0433 0.0587
Entamoeba histolytica acyl-CoA synthetase, putative 0.0063 0.0393 0.8238
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0032 0.0151 0.0144
Loa Loa (eye worm) hypothetical protein 0.0047 0.0269 0.0392
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0061 0.0382 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0017 0.0038 0.0034
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0143 0.103 0.1503
Mycobacterium tuberculosis Probable hydrolase 0.0032 0.0151 0.0853
Schistosoma mansoni nuclear receptor 0.0068 0.0433 0.0427
Schistosoma mansoni DNA helicase recq1 0.0017 0.0038 0.0032
Trichomonas vaginalis DNA helicase recq, putative 0.0017 0.0038 0.0687
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0143 0.103 0.1395
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0013 0.0006 0.0009
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0143 0.103 0.1024
Loa Loa (eye worm) hypothetical protein 0.0023 0.0083 0.0121
Brugia malayi latrophilin 2 splice variant baaae 0.0029 0.0129 0.0175
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0158 0.1147 0.1225
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0248 0.1516
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0056 0.0338 0.0331
Onchocerca volvulus 0.0068 0.0433 0.3942
Brugia malayi Latrophilin receptor protein 2 0.0013 0.0006 0.0009
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0032 0.0151 0.022
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0056 0.0338 0.0967
Echinococcus granulosus Nuclear hormone receptor HR96 0.0068 0.0433 0.0458
Brugia malayi Intermediate filament tail domain containing protein 0.0024 0.0086 0.0117
Loa Loa (eye worm) carbonic anhydrase 3 0.0446 0.3412 0.4981
Echinococcus granulosus phd:f box containing protein 0.0014 0.0009 0.0002
Loa Loa (eye worm) kap beta 3 protein 0.0014 0.0013 0.0019
Loa Loa (eye worm) hypothetical protein 0.0068 0.0433 0.0633
Echinococcus granulosus bloom syndrome protein 0.0017 0.0038 0.0034
Onchocerca volvulus Protein ultraspiracle homolog 0.0143 0.103 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0433 0.0633
Schistosoma mansoni hypothetical protein 0.0297 0.2242 0.2237
Brugia malayi jmjC domain containing protein 0.0014 0.0009 0.0012
Loa Loa (eye worm) nuclear receptor NHR-67 0.0068 0.0433 0.0633
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0018 0.0045 0.0042
Loa Loa (eye worm) hypothetical protein 0.0068 0.0433 0.0633
Loa Loa (eye worm) DR-78 0.0068 0.0433 0.0633
Loa Loa (eye worm) hypothetical protein 0.0047 0.0269 0.0392
Toxoplasma gondii HEAT repeat-containing protein 0.0075 0.0494 0.4102
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0017 0.0038 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0143 0.103 0.1395
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0018 0.0045 0.0136
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0017 0.0038 0.0088
Brugia malayi nuclear hormone receptor 0.0143 0.103 0.1395
Echinococcus granulosus microtubule associated protein 2 0.1196 0.9318 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0068 0.0433 0.0427
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0014 0.0009 0.0002
Brugia malayi beta-lactamase family protein 0.0032 0.0151 0.0204
Brugia malayi kap beta 3 protein 0.0014 0.0013 0.0018
Schistosoma mansoni hypothetical protein 0.0029 0.0129 0.0123
Schistosoma mansoni nuclear hormone receptor 0.0068 0.0433 0.0427
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.0068 0.0433 0.0633
Mycobacterium ulcerans aldehyde dehydrogenase 0.0158 0.1147 1
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0045 0.0061
Entamoeba histolytica acyl-CoA synthetase, putative 0.0063 0.0393 0.8238
Schistosoma mansoni nuclear hormone receptor 0.0068 0.0433 0.0427
Onchocerca volvulus Bile acid receptor homolog 0.0143 0.103 1
Echinococcus multilocularis neuropeptide s receptor 0.0394 0.3 0.2995
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0143 0.103 0.1503
Schistosoma mansoni hypothetical protein 0.0297 0.2242 0.2237
Trichomonas vaginalis esterase, putative 0.0032 0.0151 0.3732
Schistosoma mansoni jumonji/arid domain-containing protein 0.0051 0.0305 0.0299
Echinococcus granulosus ecdysone induced protein 78C 0.0143 0.103 0.1099
Echinococcus multilocularis beta LACTamase domain containing family member 0.0032 0.0151 0.0144
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0143 0.103 0.1024
Schistosoma mansoni aldehyde dehydrogenase 0.0158 0.1147 0.1141
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0143 0.103 0.1024
Trichomonas vaginalis ran, putative 0.0056 0.0338 0.8795
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0143 0.103 0.1395
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0051 0.0305 0.0321
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0143 0.103 0.1503
Brugia malayi photoreceptor-specific nuclear receptor 0.0143 0.103 0.1395
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0446 0.3412 0.4981
Mycobacterium tuberculosis Probable lipase LipD 0.0032 0.0151 0.0853
Mycobacterium ulcerans hypothetical protein 0.0032 0.0151 0.0958
Loa Loa (eye worm) hypothetical protein 0.0032 0.0151 0.022
Echinococcus multilocularis ecdysone induced protein 78C 0.0143 0.103 0.1024
Brugia malayi ecdysteroid receptor 0.0143 0.103 0.1395
Echinococcus granulosus FTZ F1 alpha 0.0143 0.103 0.1099
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0018 0.0045 0.0066
Loa Loa (eye worm) hypothetical protein 0.0047 0.0269 0.0392
Schistosoma mansoni DNA helicase recq5 0.0017 0.0038 0.0032
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0045 0.0136
Entamoeba histolytica Ran family GTPase 0.0056 0.0338 0.7039
Trichomonas vaginalis DNA helicase recq1, putative 0.0017 0.0038 0.0687
Loa Loa (eye worm) hypothetical protein 0.0075 0.0494 0.0722
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0076 0.0497 0.0527
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0012
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0018 0.0045 0.0136
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0018 0.0045 0.0061
Echinococcus granulosus importin 5 0.0014 0.0013 0.0007
Leishmania major carbonic anhydrase-like protein 0.0446 0.3412 1
Echinococcus granulosus importin subunit beta 1 0.0075 0.0494 0.0524
Mycobacterium ulcerans acyl-CoA synthetase 0.0063 0.0393 0.3157
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0056
Brugia malayi Nuclear hormone receptor-like 1 0.0883 0.6849 0.9279
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0446 0.3412 0.4622
Echinococcus multilocularis FTZ F1 alpha 0.0143 0.103 0.1024
Loa Loa (eye worm) hypothetical protein 0.0068 0.0433 0.0633
Brugia malayi Importin beta-1 subunit 0.0075 0.0494 0.067
Mycobacterium tuberculosis Probable esterase LipL 0.0032 0.0151 0.0853
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0018 0.0045 0.0136
Loa Loa (eye worm) hypothetical protein 0.0068 0.0433 0.0633
Echinococcus multilocularis snurportin 1 0.0805 0.6239 0.6237
Onchocerca volvulus 0.0032 0.0151 0.1072
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0068 0.0433 0.0427
Schistosoma mansoni hypothetical protein 0.0164 0.1193 0.1187
Loa Loa (eye worm) hypothetical protein 0.0068 0.0433 0.0633
Loa Loa (eye worm) hypothetical protein 0.0119 0.0837 0.1222
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0143 0.103 0.1099
Schistosoma mansoni nuclear receptor 0.0068 0.0433 0.0427
Schistosoma mansoni hypothetical protein 0.1139 0.8871 0.887
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0028 0.0122 0.2216
Loa Loa (eye worm) hypothetical protein 0.0164 0.1193 0.1742
Brugia malayi hypothetical protein 0.0119 0.0837 0.1134
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0063 0.0393 0.2497
Plasmodium vivax acetyl-CoA synthetase, putative 0.0018 0.0045 0.0756
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0068 0.0433 0.3942
Echinococcus granulosus geminin 0.0297 0.2242 0.2401
Loa Loa (eye worm) latrophilin receptor protein 2 0.0013 0.0006 0.0009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0248 0.1516
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0143 0.103 0.1395
Toxoplasma gondii HEAT repeat-containing protein 0.0014 0.0013 0.0038
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0014 0.0009 0.0002
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0143 0.103 0.1024
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0143 0.103 0.1099
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0032 0.0151 0.0958
Brugia malayi hypothetical protein 0.0076 0.0497 0.0673
Trichomonas vaginalis antibiotic synthetase, putative 0.0018 0.0045 0.0873
Echinococcus multilocularis transportin 1 0.0014 0.0013 0.0007
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0061 0.0382 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0018 0.0045 0.0136
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0068 0.0433 0.0458
Loa Loa (eye worm) hypothetical protein 0.0068 0.0433 0.0633
Schistosoma mansoni phosphatidylserine receptor 0.0014 0.0009 0.0002
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0143 0.103 0.1024
Echinococcus multilocularis lamin 0.0024 0.0086 0.008
Loa Loa (eye worm) hypothetical protein 0.0076 0.0497 0.0726
Leishmania major importin beta-1 subunit, putative 0.0061 0.0382 0.1098
Trypanosoma brucei importin beta-1 subunit, putative 0.0075 0.0494 0.1428
Echinococcus granulosus intermediate filament protein 0.0024 0.0086 0.0086
Echinococcus multilocularis JmjC domain containing protein 4 0.0014 0.0009 0.0002
Brugia malayi jmjC domain containing protein 0.0051 0.0305 0.0413
Loa Loa (eye worm) hypothetical protein 0.0068 0.0433 0.0633
Trichomonas vaginalis DNA helicase recq, putative 0.0017 0.0038 0.0687
Echinococcus granulosus translational activator gcn1 0.0014 0.0013 0.0007
Plasmodium vivax transportin, putative 0.0014 0.0013 0.0092
Mycobacterium ulcerans aldehyde dehydrogenase 0.0158 0.1147 1
Leishmania major hypothetical protein, conserved 0.0032 0.0151 0.0418
Echinococcus granulosus neuropeptide s receptor 0.0394 0.3 0.3215
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0143 0.103 0.1503
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0018 0.0045 0.0136
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0031 0.0148 0.3663
Mycobacterium leprae conserved hypothetical protein 0.0032 0.0151 0.3034
Schistosoma mansoni carbonic anhydrase 0.0164 0.1193 0.1187
Loa Loa (eye worm) hypothetical protein 0.0032 0.0151 0.022
Brugia malayi jmjC domain containing protein 0.0014 0.0009 0.0012
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0018 0.0045 0.0108
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0269 0.2027
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0056 0.0338 0.0457
Brugia malayi Bloom's syndrome protein homolog 0.0017 0.0038 0.0052
Schistosoma mansoni retinoic acid receptor RXR 0.0143 0.103 0.1024
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0056 0.0338 0.2779
Schistosoma mansoni aldehyde dehydrogenase 0.0158 0.1147 0.1141
Loa Loa (eye worm) hypothetical protein 0.0024 0.0086 0.0126
Echinococcus granulosus carbonic anhydrase 0.0164 0.1193 0.1274
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0056 0.0338 0.0967
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0143 0.103 0.1395
Trichomonas vaginalis antibiotic synthetase, putative 0.0018 0.0045 0.0873
Loa Loa (eye worm) hypothetical protein 0.0018 0.0045 0.0066
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0143 0.103 0.1024
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0024 0.0086 0.0126
Mycobacterium tuberculosis Conserved protein 0.0032 0.0151 0.0853
Leishmania major 4-coumarate:coa ligase-like protein 0.0063 0.0393 0.113
Schistosoma mansoni microtubule-associated protein tau 0.1196 0.9318 0.9318
Brugia malayi orphan nuclear receptor NR2E1 0.0068 0.0433 0.0587
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0063 0.0393 1
Brugia malayi beta-lactamase 0.0032 0.0151 0.0204
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0143 0.103 0.1024
Toxoplasma gondii HEAT repeat-containing protein 0.0014 0.0013 0.0038
Brugia malayi nuclear receptor RXR 0.0076 0.0497 0.0673
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0018 0.0045 0.0136
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0045 0.0061
Brugia malayi Nuclear hormone receptor E75 0.0068 0.0433 0.0587
Brugia malayi intermediate filament protein 0.0024 0.0086 0.0117
Loa Loa (eye worm) hypothetical protein 0.0164 0.1193 0.1742
Brugia malayi Nuclear hormone receptor-like 1 0.095 0.7382 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0143 0.103 0.1024
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0068 0.0433 0.0427
Schistosoma mansoni importin beta-1 0.0075 0.0494 0.0488
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0032 0.0151 0.0144
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0031 0.0148 0.0935
Echinococcus multilocularis lysine specific demethylase 5A 0.0051 0.0305 0.0299
Echinococcus granulosus carbonic anhydrase II 0.0446 0.3412 0.3657
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0148 0.0411
Brugia malayi tailless protein 0.0068 0.0433 0.0587
Echinococcus multilocularis carbonic anhydrase 0.0164 0.1193 0.1187
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0014 0.0013 0.0013
Brugia malayi nuclear receptor RXR 0.0068 0.0433 0.0587
Echinococcus granulosus carbonic anhydrase 0.0164 0.1193 0.1274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0143 0.103 0.1503
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0056 0.0338 1
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0151 0.2927
Echinococcus granulosus lamin dm0 0.0024 0.0086 0.0086
Brugia malayi AMP-binding enzyme family protein 0.0063 0.0393 0.0532
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.0009 0.0012
Onchocerca volvulus 0.0025 0.0098 0.0533
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0076 0.0497 0.0491
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0143 0.103 0.1395
Echinococcus granulosus Nuclear hormone receptor HR96 0.0068 0.0433 0.0458
Plasmodium falciparum transportin 0.0014 0.0013 0.0038
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0805 0.6239 0.9109
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0143 0.103 0.1024
Brugia malayi nuclear hormone receptor 0.0068 0.0433 0.0587
Loa Loa (eye worm) hypothetical protein 0.0073 0.0474 0.0692
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0018 0.0045 0.0039
Loa Loa (eye worm) RecQ helicase 0.0017 0.0038 0.0056
Schistosoma mansoni jumonji/arid domain-containing protein 0.0051 0.0305 0.0299
Schistosoma mansoni coup transcription factor 0.0143 0.103 0.1024
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0018 0.0045 0.0108
Echinococcus granulosus lysine specific demethylase 6a 0.0014 0.0009 0.0002
Schistosoma mansoni carbonic anhydrase-related 0.0164 0.1193 0.1187
Schistosoma mansoni importin-beta 2 0.0014 0.0013 0.0007
Leishmania major GTP-binding protein, putative 0.0056 0.0338 0.0967
Onchocerca volvulus 0.0024 0.0086 0.0415
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.0009 0.0012
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.1139 0.8871 0.887
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0038 0.0052
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0446 0.3412 1
Brugia malayi conserved hypotetical protein 0.0068 0.0433 0.0587
Echinococcus granulosus beta LACTamase domain containing family member 0.0032 0.0151 0.0155
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0047 0.0269 0.5
Trypanosoma brucei importin beta-1 subunit, putative 0.0075 0.0494 0.1428
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0076 0.0497 0.0491
Echinococcus granulosus carbonic anhydrase 0.0164 0.1193 0.1274
Loa Loa (eye worm) hypothetical protein 0.0143 0.103 0.1503
Leishmania major 4-coumarate:coa ligase-like protein 0.0063 0.0393 0.113
Schistosoma mansoni carbonic anhydrase-related 0.0164 0.1193 0.1187
Echinococcus multilocularis musashi 0.0024 0.0086 0.008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0143 0.103 0.1099
Leishmania major acetyl-CoA synthetase, putative 0.0018 0.0045 0.0108
Mycobacterium ulcerans beta-lactamase 0.0032 0.0151 0.0958
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0032 0.0151 0.0853
Loa Loa (eye worm) hypothetical protein 0.0143 0.103 0.1503
Echinococcus multilocularis geminin 0.0297 0.2242 0.2237
Schistosoma mansoni protein phosphatase 2C 0.0014 0.0009 0.0002
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0031 0.0148 0.3663
Trichomonas vaginalis D-aminoacylase, putative 0.0032 0.0151 0.3732
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0063 0.0393 0.3157
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0203 0.1498 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0068 0.0433 0.0633
Plasmodium vivax importin-beta 2, putative 0.0075 0.0494 1
Mycobacterium tuberculosis Conserved protein 0.0032 0.0151 0.0853
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0063 0.0393 0.3157
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0056 0.0338 0.2779
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0032 0.0151 0.0853
Schistosoma mansoni phd/f-box containing protein 0.0014 0.0009 0.0002
Echinococcus granulosus transportin 1 0.0014 0.0013 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0063 0.0393 0.3157
Schistosoma mansoni lamin 0.0024 0.0086 0.008
Schistosoma mansoni inositol monophosphatase 0.0031 0.0148 0.0142
Onchocerca volvulus 0.0032 0.0151 0.1072
Loa Loa (eye worm) hypothetical protein 0.0076 0.0497 0.0726
Loa Loa (eye worm) hypothetical protein 0.0143 0.103 0.1503
Schistosoma mansoni zinc finger protein 0.0068 0.0433 0.0427
Leishmania major hypothetical protein, conserved 0.0014 0.0013 0.0013
Echinococcus granulosus lamin 0.0024 0.0086 0.0086
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0063 0.0393 1
Loa Loa (eye worm) steroid hormone receptor 0.0143 0.103 0.1503
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0017 0.0038 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0143 0.103 0.1395
Echinococcus multilocularis carbonic anhydrase 0.0164 0.1193 0.1187
Brugia malayi nuclear hormone receptor family member nhr-6 0.0068 0.0433 0.0587
Schistosoma mansoni nuclear hormone receptor 0.0143 0.103 0.1024
Mycobacterium ulcerans aldehyde dehydrogenase 0.0158 0.1147 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0151 0.022
Trichomonas vaginalis penicillin-binding protein, putative 0.0032 0.0151 0.3732
Loa Loa (eye worm) hypothetical protein 0.0047 0.0269 0.0392
Mycobacterium ulcerans acyl-CoA synthetase 0.0063 0.0393 0.3157
Brugia malayi Steroid receptor seven-up type 2 0.0143 0.103 0.1395
Brugia malayi jmjC domain containing protein 0.0014 0.0009 0.0012
Echinococcus multilocularis inositol monophosphatase 1 0.0031 0.0148 0.0142
Brugia malayi beta-lactamase family protein 0.0032 0.0151 0.0204
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0042 0.0235 0.0343
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0164 0.1193 0.1616
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0018 0.0045 0.031
Brugia malayi jmjC domain containing protein 0.0051 0.0305 0.0413
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0073 0.0474 1
Echinococcus granulosus snurportin 1 0.0805 0.6239 0.6694
Echinococcus granulosus lysine specific demethylase 5A 0.0051 0.0305 0.0321
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0148 0.0411
Loa Loa (eye worm) hypothetical protein 0.0164 0.1193 0.1742
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0045 0.0136
Onchocerca volvulus 0.0143 0.103 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0009
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0158 0.1147 0.1141
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0042 0.0235 0.0318
Brugia malayi AMP-binding enzyme family protein 0.0063 0.0393 0.0532
Plasmodium falciparum importin beta, putative 0.0075 0.0494 0.4102
Brugia malayi nuclear receptor NHR-67 0.0068 0.0433 0.0587
Brugia malayi Nuclear hormone receptor-like 1 0.0883 0.6849 0.9279
Echinococcus multilocularis importin subunit beta 1 0.0075 0.0494 0.0488
Loa Loa (eye worm) hypothetical protein 0.0068 0.0433 0.0633
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0164 0.1193 0.1616
Trypanosoma brucei carbonic anhydrase-like protein 0.0446 0.3412 1
Echinococcus multilocularis microtubule associated protein 2 0.1196 0.9318 0.9318
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0038 0.0052
Brugia malayi Nuclear hormone receptor E75 0.0068 0.0433 0.0587
Loa Loa (eye worm) intermediate filament protein 0.0024 0.0086 0.0126
Trichomonas vaginalis D-aminoacylase, putative 0.0032 0.0151 0.3732
Loa Loa (eye worm) beta-lactamase 0.0032 0.0151 0.022
Echinococcus granulosus GTP binding nuclear protein Ran 0.0056 0.0338 0.0356
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0164 0.1193 0.1742
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0143 0.103 0.1395
Loa Loa (eye worm) hypothetical protein 0.0076 0.0497 0.0726
Entamoeba histolytica recQ family helicase, putative 0.0017 0.0038 0.0549
Brugia malayi jmjC domain containing protein 0.0014 0.0009 0.0012
Mycobacterium ulcerans esterase/lipase LipP 0.0032 0.0151 0.0958
Trypanosoma cruzi importin beta-1 subunit, putative 0.0061 0.0382 0.1098
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0056 0.0338 0.0967
Schistosoma mansoni ran 0.0056 0.0338 0.0331
Echinococcus multilocularis translational activator gcn1 0.0014 0.0013 0.0007
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0073 0.0474 1
Loa Loa (eye worm) nuclear hormone receptor 0.0068 0.0433 0.0633
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0068 0.0433 0.0427
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0031 0.0148 0.1179
Echinococcus multilocularis neuropeptide receptor A26 0.0394 0.3 0.2995
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0018 0.0045 0.0066
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0446 0.3412 0.3408
Echinococcus granulosus thyroid hormone receptor alpha 0.0068 0.0433 0.0458
Echinococcus granulosus inositol monophosphatase 1 0.0031 0.0148 0.0152
Trichomonas vaginalis D-aminoacylase, putative 0.0032 0.0151 0.3732
Loa Loa (eye worm) hypothetical protein 0.0143 0.103 0.1503
Entamoeba histolytica acyl-coA synthetase, putative 0.0063 0.0393 0.8238
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0151 0.0418
Loa Loa (eye worm) hypothetical protein 0.0076 0.0497 0.0726
Mycobacterium ulcerans lipase LipD 0.0032 0.0151 0.0958
Echinococcus multilocularis carbonic anhydrase 0.0164 0.1193 0.1187
Brugia malayi hypothetical protein 0.0068 0.0433 0.0587
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0018 0.0045 0.0699
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0143 0.103 0.1024
Onchocerca volvulus 0.0063 0.0393 0.3532
Trichomonas vaginalis inositol monophosphatase, putative 0.0031 0.0148 0.3663
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0038 0.0252
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0143 0.103 0.1395
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0047 0.0269 0.1652
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0143 0.103 0.1395
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0045 0.0136
Echinococcus granulosus jumonji domain containing 1A 0.0014 0.0009 0.0002
Loa Loa (eye worm) oxidoreductase 0.0018 0.0045 0.0066
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0068 0.0433 0.0427
Plasmodium falciparum carbonic anhydrase 0.0164 0.1193 1
Toxoplasma gondii hypothetical protein 0.0164 0.1193 1
Schistosoma mansoni lamin 0.0024 0.0086 0.008
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0143 0.103 0.1024
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0068 0.0433 0.0427
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0143 0.103 0.1503
Schistosoma mansoni nuclear receptor nhr-48 0.0068 0.0433 0.0427
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0143 0.103 0.1099
Loa Loa (eye worm) hypothetical protein 0.0032 0.0151 0.022
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0143 0.103 0.1099
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0018 0.0045 0.0061
Entamoeba histolytica hypothetical protein 0.0061 0.0382 0.8003
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0143 0.103 0.1395
Loa Loa (eye worm) inositol-1 0.0031 0.0148 0.0216
Schistosoma mansoni steroid hormone receptor ad4bp 0.0143 0.103 0.1024
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0051 0.0305 0.0299
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0045 0.0136
Trichomonas vaginalis penicillin-binding protein, putative 0.0032 0.0151 0.3732
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0076 0.0497 0.0491
Brugia malayi hypothetical protein 0.0076 0.0497 0.0673
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.1139 0.8871 0.952
Toxoplasma gondii ABC1 family protein 0.0032 0.0151 0.1201
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0143 0.103 0.1099
Echinococcus multilocularis jumonji domain containing 1A 0.0014 0.0009 0.0002
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0017 0.0038 0.0056
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0032 0.0151 0.0853
Brugia malayi nuclear receptor NHR-88 0.0068 0.0433 0.0587
Loa Loa (eye worm) hypothetical protein 0.0047 0.0269 0.0392
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0038 0.0252
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0045 0.0061
Loa Loa (eye worm) hypothetical protein 0.0032 0.0151 0.022
Echinococcus multilocularis nuclear receptor nhr 48 0.0068 0.0433 0.0427
Loa Loa (eye worm) hypothetical protein 0.0068 0.0433 0.0633
Schistosoma mansoni jumonji domain containing protein 0.0051 0.0305 0.0299
Loa Loa (eye worm) hypothetical protein 0.0119 0.0837 0.1222
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0148 0.0411
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0031 0.0148 0.5
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0063 0.0393 0.3157
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0158 0.1147 0.3344
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0164 0.1193 0.1616
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0143 0.103 0.1395
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0143 0.103 0.1099
Onchocerca volvulus 0.0024 0.0086 0.0415
Brugia malayi AMP-binding enzyme family protein 0.0063 0.0393 0.0532
Loa Loa (eye worm) hypothetical protein 0.0063 0.0393 0.0574
Loa Loa (eye worm) jmjC domain-containing protein 0.0051 0.0305 0.0445
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0056 0.0338 0.0493
Toxoplasma gondii propionate-CoA ligase 0.0018 0.0045 0.031
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0164 0.1193 0.1616
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0883 0.6849 1
Loa Loa (eye worm) hypothetical protein 0.0143 0.103 0.1503
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0143 0.103 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0047 0.0269 0.5351
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0446 0.3412 0.4622
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0017 0.0038 0.0252
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0014 0.0009 0.0002
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0018 0.0045 0.031
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0143 0.103 0.1395
Loa Loa (eye worm) hypothetical protein 0.0875 0.6786 0.9907
Brugia malayi ecdysone receptor 0.0068 0.0433 0.0587
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0151 0.0418
Toxoplasma gondii aldehyde dehydrogenase 0.0158 0.1147 0.9609
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0014 0.0013 0.0013
Brugia malayi RNA, U transporter 1 0.0214 0.1589 0.2153
Loa Loa (eye worm) hypothetical protein 0.0042 0.0235 0.0343
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0018 0.0045 0.0108
Brugia malayi Calcitonin receptor-like protein seb-1 0.0042 0.0235 0.0318
Echinococcus multilocularis lamin dm0 0.0024 0.0086 0.008
Mycobacterium leprae Probable lipase LipE 0.0032 0.0151 0.3034
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.0009 0.0012
Leishmania major acetyl-CoA synthetase, putative 0.0018 0.0045 0.0108
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0446 0.3412 0.3408
Leishmania major 4-coumarate:coa ligase-like protein 0.0063 0.0393 0.113
Brugia malayi Inositol-1 0.0031 0.0148 0.0201
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0018 0.0045 0.031
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0032 0.0151 0.0204
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0063 0.0393 0.3157
Loa Loa (eye worm) hypothetical protein 0.0076 0.0497 0.0726
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0056 0.0338 0.6774
Schistosoma mansoni ran 0.0056 0.0338 0.0331
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0018 0.0045 0.0108
Onchocerca volvulus 0.0032 0.0151 0.1072
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0068 0.0433 0.0587
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0068 0.0433 0.0427
Echinococcus multilocularis lysine specific demethylase 6a 0.0014 0.0009 0.0002
Onchocerca volvulus Huntingtin homolog 0.0119 0.0837 0.8043
Echinococcus granulosus nuclear receptor nhr 48 0.0068 0.0433 0.0458
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0158 0.1147 0.7614
Schistosoma mansoni intermediate filament proteins 0.0024 0.0086 0.008
Schistosoma mansoni carbonic anhydrase-related 0.0164 0.1193 0.1187
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0018 0.0045 0.0108
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0031 0.0148 0.2932
Schistosoma mansoni hypothetical protein 0.0805 0.6239 0.6237
Mycobacterium ulcerans hypothetical protein 0.0063 0.0393 0.3157
Brugia malayi steroid hormone receptor 0.0143 0.103 0.1395
Schistosoma mansoni inositol monophosphatase 0.0031 0.0148 0.0142
Mycobacterium tuberculosis Conserved protein 0.0032 0.0151 0.0853
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0045 0.0061
Loa Loa (eye worm) hypothetical protein 0.0029 0.0129 0.0188
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0012
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0148 0.0411
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0017 0.0038 0.0032
Loa Loa (eye worm) hypothetical protein 0.0018 0.0045 0.0066
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0018 0.0045 0.0136
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0164 0.1193 0.1616
Onchocerca volvulus 0.0068 0.0433 0.3942
Schistosoma mansoni thyroid hormone receptor 0.1283 1 1
Loa Loa (eye worm) importin-beta domain-containing protein 0.0014 0.0013 0.0019
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0143 0.103 0.1024
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0068 0.0433 0.3942

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) nM Inhibitory concentration against human steroid 5-alpha-reductase 2 receptor expressed in CHO 1829 cells; la= low activity ChEMBL. 15582428
IC50 (binding) nM Inhibitory concentration against human steroid 5-alpha-reductase I receptor expressed in CHO 1827 cells; la= low activity ChEMBL. 15582428
IC50 (binding) la 0 nM Inhibitory concentration against human steroid 5-alpha-reductase I receptor expressed in CHO 1827 cells; la= low activity ChEMBL. 15582428
IC50 (binding) la 0 nM Inhibitory concentration against human steroid 5-alpha-reductase 2 receptor expressed in CHO 1829 cells; la= low activity ChEMBL. 15582428

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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