Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1252 | 1 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0516 | 0.3493 | 0.3493 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.012 | 0 | 0.5 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0588 | 0.4128 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0516 | 0.3493 | 0.3493 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0516 | 0.3493 | 0.3493 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1252 | 1 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0516 | 0.3493 | 0.3493 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0516 | 0.3493 | 0.3493 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1252 | 1 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1252 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0588 | 0.4128 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0516 | 0.3493 | 0.3493 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1252 | 1 | 1 |
Echinococcus multilocularis | protein patched | 0.0516 | 0.3493 | 0.3493 |
Onchocerca volvulus | 0.012 | 0 | 0.5 | |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0516 | 0.3493 | 0.3493 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1252 | 1 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0516 | 0.3493 | 0.3493 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0169 | 0.0433 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0169 | 0.0433 | 0.5 |
Schistosoma mansoni | patched 1 | 0.0516 | 0.3493 | 0.3493 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0588 | 0.4128 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0169 | 0.0433 | 0.5 |
Brugia malayi | CHE-14 protein | 0.0516 | 0.3493 | 0.3493 |
Loa Loa (eye worm) | hypothetical protein | 0.1252 | 1 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0516 | 0.3493 | 0.3493 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.012 | 0 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1252 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0588 | 0.4128 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1252 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 64 nM | Compound was tested for cytotoxicity against paclitaxel sensitive KB-3-1 cell line | ChEMBL. | 15261301 |
IC50 (functional) | = 64 nM | Compound was tested for cytotoxicity against paclitaxel sensitive KB-3-1 cell line | ChEMBL. | 15261301 |
IC50 (functional) | = 270 nM | Compound was tested for cytotoxicity against paclitaxel resistant KB-8-5 cell line expressing P-glycoprotein | ChEMBL. | 15261301 |
IC50 (functional) | = 270 nM | Compound was tested for cytotoxicity against paclitaxel resistant KB-8-5 cell line expressing P-glycoprotein | ChEMBL. | 15261301 |
IC50 (functional) | > 3000 nM | Compound was tested for cytotoxicity against paclitaxel resistant KB-V1 cell line expressing P-glycoprotein | ChEMBL. | 15261301 |
IC50 (functional) | > 3000 nM | Compound was tested for cytotoxicity against paclitaxel resistant KB-V1 cell line expressing P-glycoprotein | ChEMBL. | 15261301 |
Inhibition (functional) | = 89 % | Compound was evaluated for the ability to inhibit cell-free tubulin polymerisation at 0.5 uM | ChEMBL. | 15261301 |
Inhibition (functional) | = 89 % | Compound was evaluated for the ability to inhibit cell-free tubulin polymerisation at 0.5 uM | ChEMBL. | 15261301 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 15261301 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.