Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adrenoceptor beta 3 | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor beta 2, surface | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | 0 nM | Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-1 adrenergic receptor; Not determined | ChEMBL. | 15686912 |
EC50 (functional) | = 2.2 nM | Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-2 adrenergic receptor | ChEMBL. | 15686912 |
EC50 (functional) | = 2.2 nM | Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-2 adrenergic receptor | ChEMBL. | 15686912 |
EC50 (functional) | = 3.2 nM | Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-3 adrenergic receptor | ChEMBL. | 15686912 |
EC50 (functional) | = 3.2 nM | Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-3 adrenergic receptor | ChEMBL. | 15686912 |
IA50 (functional) | = 49 % | Intrinsic activity against human beta-1 adrenergic receptor IA) as a percentage of maximal stimulation with isoproterenol | ChEMBL. | 15686912 |
IA50 (functional) | = 49 % | Intrinsic activity against human beta-1 adrenergic receptor IA) as a percentage of maximal stimulation with isoproterenol | ChEMBL. | 15686912 |
IA50 (functional) | = 78 % | Intrinsic activity against human beta-2 adrenergic receptor IA) as a percentage of maximal stimulation with isoproterenol | ChEMBL. | 15686912 |
IA50 (functional) | = 78 % | Intrinsic activity against human beta-2 adrenergic receptor IA) as a percentage of maximal stimulation with isoproterenol | ChEMBL. | 15686912 |
IA50 (functional) | = 110 % | Intrinsic activity against human beta-3 adrenergic receptor IA) as a percentage of maximal stimulation with isoproterenol | ChEMBL. | 15686912 |
IA50 (functional) | = 110 % | Intrinsic activity against human beta-3 adrenergic receptor IA) as a percentage of maximal stimulation with isoproterenol | ChEMBL. | 15686912 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.