Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | retinoic acid receptor RXR | 0.0361 | 0.105 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0654 | 0.895 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0323 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0361 | 0.105 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0654 | 0.895 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 300 uM | Cytotoxicity concentration to inhibit hepatitis C virus RNA replication in a subgenomic replicon cell line | ChEMBL. | 15664842 |
EC50 (functional) | = 80 uM | Inhibition of hepatitis C virus RNA replication in a subgenomic replicon cell line | ChEMBL. | 15664842 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.