Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0062 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0062 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0062 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0062 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0062 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0062 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0062 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0062 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0062 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0062 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0062 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0062 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0062 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0062 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0062 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0062 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0062 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0062 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0062 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0062 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0062 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0062 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0062 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0062 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0062 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0062 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0062 | 0.5 | 0.5 | |
Brugia malayi | nuclear receptor NHR-88 | 0.0062 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0062 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0062 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0062 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0062 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0062 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0062 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0062 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0062 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0062 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.48 uM | Inhibitory concentration of the compound against Vascular Endothelial Growth Factor dependent Human Umbilical Vascular Endothelial Cells (VEGF-HUVEC) | ChEMBL. | 15664824 |
Zone of inhibition (functional) | = 0 uM | Zone of inhibition by the compound against L1210 Cells at dose of 200 ug/disk; No inhibition | ChEMBL. | 15664824 |
Zone of inhibition (functional) | = 0 uM | Zone of inhibition by the compound against L1210 Cells at dose of 200 ug/disk; No inhibition | ChEMBL. | 15664824 |
Zone of inhibition (functional) | = 400 uM | Zone of inhibition by the compound against Normal fibroblasts at dose of 200 ug/disk; Range 0-400 | ChEMBL. | 15664824 |
Zone of inhibition (functional) | = 610 uM | Zone of inhibition by the compound against HCT116 human tumor cells at dose of 200 ug/disk | ChEMBL. | 15664824 |
Zone of inhibition (functional) | = 610 uM | Zone of inhibition by the compound against HCT116 human tumor cells at dose of 200 ug/disk | ChEMBL. | 15664824 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.