Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.065 | 0.9598 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.0677 | 0.0056 |
Onchocerca volvulus | 0.0035 | 0.065 | 1 | |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0197 | 0.5548 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0197 | 0.5548 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0197 | 0.5548 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0223 | 0.6322 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0197 | 0.5548 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.065 | 0.1027 |
Onchocerca volvulus | 0.0035 | 0.065 | 1 | |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.065 | 0.1171 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.065 | 0.1027 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0197 | 0.5548 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.065 | 0.9598 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.065 | 0.9598 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.065 | 0.9598 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0677 | 0.0056 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.0677 | 0.0677 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.065 | 0.065 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0677 | 0.0677 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.065 | 0.9598 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0032 | 0.0564 | 0.0892 |
Schistosoma mansoni | hypothetical protein | 0.0345 | 1 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.065 | 0.065 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.065 | 0.9598 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0677 | 0.0056 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.065 | 0.1027 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.065 | 0.065 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.0677 | 0.122 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.0677 | 0.0677 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.065 | 0.065 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0197 | 0.5548 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.065 | 0.9598 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.065 | 0.1171 |
Onchocerca volvulus | 0.0035 | 0.065 | 1 | |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.065 | 0.1027 |
Echinococcus multilocularis | geminin | 0.0345 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.065 | 0.9598 |
Brugia malayi | beta-lactamase | 0.0035 | 0.065 | 0.9598 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.065 | 0.9598 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.065 | 0.1171 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0677 | 0.0677 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0197 | 0.5548 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0677 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.126 | 0.126 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0197 | 0.5548 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0677 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0345 | 1 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.065 | 0.1171 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.065 | 0.1027 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.065 | 0.1171 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.065 | 0.1027 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.065 | 0.1027 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.0677 | 0.122 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.065 | 0.9598 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.065 | 0.1027 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.065 | 0.9598 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.0677 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.065 | 0.1171 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.065 | 0.1171 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.065 | 0.1171 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0677 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.0677 | 0.122 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.065 | 0.9598 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.065 | 0.1027 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0677 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.065 | 0.9598 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0.0564 | 0.1016 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.065 | 0.9598 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.065 | 0.1171 |
Brugia malayi | Inositol-1 | 0.0036 | 0.0677 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0197 | 0.5548 | 0.8776 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.065 | 0.1027 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.065 | 0.9598 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0677 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 40 uM | Binding affinity against purified rat Fatty-acid amide hydrolase (FAAH) expressed in Escherichia coli | ChEMBL. | 15582420 |
Ki (binding) | = 40 uM | Binding affinity against purified rat Fatty-acid amide hydrolase (FAAH) expressed in Escherichia coli | ChEMBL. | 15582420 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.