Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Protein farnesyltransferase | Starlite/ChEMBL | References |
Homo sapiens | farnesyltransferase, CAAX box, alpha | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cellular reversion (functional) | = 85 % | Percentage cellular reversion of H-ras transformed Rat-1 cells at 100 nM | ChEMBL. | 15780629 |
Cellular reversion (functional) | = 85 % | Percentage cellular reversion of H-ras transformed Rat-1 cells at 100 nM | ChEMBL. | 15780629 |
IC50 (binding) | = 0.9 nM | Inhibition of human farnesyltransferase | ChEMBL. | 15780629 |
IC50 (binding) | = 0.9 nM | Inhibition of human farnesyltransferase | ChEMBL. | 15780629 |
IC50 (functional) | = 60 nM | Inhibition of cellular reversion in H-ras transformed Rat-1 cells | ChEMBL. | 15780629 |
IC50 (functional) | = 60 nM | Inhibition of cellular reversion in H-ras transformed Rat-1 cells | ChEMBL. | 15780629 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.