Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opioid receptor, kappa 1 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2300 nM | Displacement of bound [3H]-diprenorphine from membranes expressing cloned human kappa opioid receptor | ChEMBL. | 15686919 |
Ki (binding) | = 2300 nM | Displacement of bound [3H]-diprenorphine from membranes expressing cloned human kappa opioid receptor | ChEMBL. | 15686919 |
Ratio (binding) | > 43 | Selectivity ratio of inhibition of kappa opioid receptor to that of mu receptor was determined | ChEMBL. | 15686919 |
Ratio (binding) | > 43 | Selectivity ratio of inhibition of kappa opioid receptor to that of delta receptor was determined | ChEMBL. | 15686919 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.