Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | corticotropin releasing hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Schistosoma japonicum | IPR001879,Hormone receptor, extracellular,domain-containing | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | corticotropin releasing hormone receptor 1 | 444 aa | 445 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | adenosine deaminase | 0.0445 | 1 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.0445 | 1 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.0445 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0445 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0445 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.0145 | 0.2202 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.6233 | 0.6233 |
Plasmodium vivax | adenosine deaminase, putative | 0.0445 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0145 | 0.2202 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0145 | 0.2202 | 0.5 |
Loa Loa (eye worm) | AMP deaminase | 0.0145 | 0.2202 | 0.2202 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0445 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase 2, putative | 0.0145 | 0.2202 | 0.5 |
Echinococcus multilocularis | adenosine deaminase | 0.0445 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0445 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0145 | 0.2202 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0445 | 1 | 0.5 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0445 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.6233 | 0.6233 |
Schistosoma mansoni | adenosine deaminase | 0.0445 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0145 | 0.2202 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.0445 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0145 | 0.2202 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0245 | 0.4815 | 0.4815 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.2202 | 0.2202 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0445 | 1 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0145 | 0.2202 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.4815 | 0.4815 |
Brugia malayi | adenosine monophosphate deaminase | 0.0145 | 0.2202 | 0.2202 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0445 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0445 | 1 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0204 | 0.3745 | 0.1978 |
Trypanosoma brucei | AMP deaminase, putative | 0.0145 | 0.2202 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.6233 | 0.6233 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0145 | 0.2202 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0145 | 0.2202 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.0445 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.6233 | 0.6233 |
Trypanosoma brucei | AMP deaminase, putative | 0.0145 | 0.2202 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0204 | 0.3745 | 0.1978 |
Mycobacterium ulcerans | adenosine deaminase | 0.0445 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.