Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | AMP deaminase, putative | 0.0065 | 0.1244 | 1 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.0065 | 0.1244 | 0.2254 |
Leishmania major | hypothetical protein, conserved | 0.0065 | 0.1244 | 0.2254 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.3455 | 0.3327 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.3455 | 0.3327 |
Treponema pallidum | adenosine deaminase | 0.0199 | 0.5521 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.0065 | 0.1244 | 1 |
Schistosoma mansoni | adenosine deaminase-related | 0.0199 | 0.5521 | 0.5433 |
Echinococcus multilocularis | adenosine deaminase | 0.0199 | 0.5521 | 0.5433 |
Echinococcus granulosus | adenosine deaminase | 0.0199 | 0.5521 | 0.5433 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.1244 | 0.1073 |
Trypanosoma cruzi | AMP deaminase 2, putative | 0.0065 | 0.1244 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.0065 | 0.1244 | 1 |
Entamoeba histolytica | AMP deaminase, putative | 0.0065 | 0.1244 | 0.2254 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.0065 | 0.1244 | 0.2254 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0199 | 0.5521 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.0065 | 0.1244 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0199 | 0.5521 | 0.5 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.034 | 1 | 1 |
Brugia malayi | adenosine monophosphate deaminase | 0.0065 | 0.1244 | 0.1975 |
Schistosoma mansoni | hypothetical protein | 0.034 | 1 | 1 |
Plasmodium falciparum | AMP deaminase, putative | 0.0065 | 0.1244 | 0.1975 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0199 | 0.5521 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.5521 | 0.5433 |
Echinococcus multilocularis | AMP deaminase 2 | 0.0065 | 0.1244 | 0.1073 |
Plasmodium falciparum | adenosine deaminase | 0.0199 | 0.5521 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0065 | 0.1244 | 1 |
Entamoeba histolytica | AMP deaminase, putative | 0.0065 | 0.1244 | 0.2254 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0065 | 0.1244 | 1 |
Brugia malayi | Adenosine/AMP deaminase family protein | 0.0199 | 0.5521 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0065 | 0.1244 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.0199 | 0.5521 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0199 | 0.5521 | 1 |
Toxoplasma gondii | AMP deaminase | 0.0065 | 0.1244 | 0.1975 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0065 | 0.1244 | 1 |
Schistosoma mansoni | AMP deaminase | 0.0065 | 0.1244 | 0.1073 |
Echinococcus granulosus | AMP deaminase 2 | 0.0065 | 0.1244 | 0.1073 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0199 | 0.5521 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.034 | 1 | 1 |
Leishmania major | adenine aminohydrolase | 0.0199 | 0.5521 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0199 | 0.5521 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0065 | 0.1244 | 1 |
Brugia malayi | RNA, U transporter 1 | 0.0091 | 0.2061 | 0.3507 |
Schistosoma mansoni | adenosine deaminase | 0.0199 | 0.5521 | 0.5433 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.3455 | 0.3327 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0199 | 0.5521 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0065 | 0.1244 | 1 |
Leishmania major | AMP deaminase, putative | 0.0065 | 0.1244 | 0.2254 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.3455 | 0.3327 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.0065 | 0.1244 | 0.2254 |
Mycobacterium ulcerans | adenosine deaminase | 0.0199 | 0.5521 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0199 | 0.5521 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0065 | 0.1244 | 1 |
Plasmodium vivax | adenosine/AMP deaminase, putative | 0.0065 | 0.1244 | 0.1975 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0199 | 0.5521 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.0065 | 0.1244 | 0.1073 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | NA 0 uM | In vitro antihelmintic activity against Haemonchus contortus after 24 h of incubation using larval mobility assay; NA denotes <50% inhibition of mortality at 100 ppm | ChEMBL. | 15225722 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.