Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opioid receptor, kappa 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 0.3497 | 0.3497 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0565 | 0.4132 | 0.5 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0496 | 0.3497 | 0.3497 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1205 | 1 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0496 | 0.3497 | 0.3497 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0115 | 0 | 0.5 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0496 | 0.3497 | 0.3497 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1205 | 1 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1205 | 1 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1205 | 1 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0496 | 0.3497 | 0.3497 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1205 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0162 | 0.043 | 0.5 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0496 | 0.3497 | 0.3497 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0565 | 0.4132 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0162 | 0.043 | 0.5 |
Schistosoma mansoni | patched 1 | 0.0496 | 0.3497 | 0.3497 |
Brugia malayi | CHE-14 protein | 0.0496 | 0.3497 | 0.3497 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0162 | 0.043 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0565 | 0.4132 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1205 | 1 | 1 |
Echinococcus multilocularis | protein patched | 0.0496 | 0.3497 | 0.3497 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0496 | 0.3497 | 0.3497 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0496 | 0.3497 | 0.3497 |
Onchocerca volvulus | 0.0115 | 0 | 0.5 | |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1205 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0115 | 0 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0565 | 0.4132 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1205 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1205 | 1 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0496 | 0.3497 | 0.3497 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 1.7 mg kg-1 | Effective dose of the compound to inhibit acetic acid-inducedwrithing after subcutaneous administration in mice | ChEMBL. | 15686919 |
ED50 (functional) | = 1.7 mg kg-1 | Effective dose of the compound to inhibit acetic acid-inducedwrithing after subcutaneous administration in mice | ChEMBL. | 15686919 |
ED50 (functional) | = 140 mg kg-1 | Effective dose of the compound that induced platform sedation after subcutaneous administration in mice | ChEMBL. | 15686919 |
ED50 (functional) | = 140 mg kg-1 | Effective dose of the compound that induced platform sedation after subcutaneous administration in mice | ChEMBL. | 15686919 |
Index (functional) | = 81 | Peripheral restriction index (Platform sedation ED50/Writhing ED50) in mouse | ChEMBL. | 15686919 |
Inhibition (functional) | = 84 % | In vivo inhibition of formalin induced flinching after i.paw dosing of compound at 300 ug | ChEMBL. | 15686919 |
Inhibition (functional) | = 84 % | In vivo inhibition of formalin induced flinching after i.paw dosing of compound at 300 ug | ChEMBL. | 15686919 |
Ki (binding) | = 2.9 nM | Displacement of bound [3H]-diprenorphine from membranes expressing cloned human kappa opioid receptor | ChEMBL. | 15686919 |
Ki (binding) | = 2.9 nM | Displacement of bound [3H]-diprenorphine from membranes expressing cloned human kappa opioid receptor | ChEMBL. | 15686919 |
Ratio (binding) | = 79 | Selectivity ratio of inhibition of kappa opioid receptor to that of delta receptor was determined | ChEMBL. | 15686919 |
Ratio (binding) | = 330 | Selectivity ratio of inhibition of kappa opioid receptor to that of mu receptor was determined | ChEMBL. | 15686919 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.