Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0348 | 0.3299 | 0.32 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0325 | 0.2773 | 0.5 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0325 | 0.2773 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0344 | 0.3217 | 0.3117 |
Echinococcus multilocularis | insulin receptor | 0.0207 | 0.0145 | 0.0145 |
Schistosoma mansoni | tyrosine kinase | 0.0344 | 0.3217 | 0.3117 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0348 | 0.3299 | 0.32 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0207 | 0.0145 | 0.0145 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0325 | 0.2773 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0648 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0344 | 0.3217 | 0.3117 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0348 | 0.3299 | 0.3299 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0648 | 1 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0325 | 0.2773 | 0.2773 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0325 | 0.2773 | 0.5 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0325 | 0.2773 | 0.2666 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0325 | 0.2773 | 0.2666 |
Schistosoma mansoni | tyrosine kinase | 0.0348 | 0.3299 | 0.32 |
Leishmania major | 0.0325 | 0.2773 | 0.5 | |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0325 | 0.2773 | 0.2666 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0648 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0348 | 0.3299 | 0.32 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0648 | 1 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0325 | 0.2773 | 0.2666 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 90 uM | Inhibitory concentration against human liver cathepsin L | ChEMBL. | 15380210 |
IC50 (binding) | = 150 uM | Inhibitory concentration against human liver cathepsin B | ChEMBL. | 15380210 |
IC50 (binding) | = 250 uM | Inhibitory concentration against Paramecium tetraurelia cathepsin L | ChEMBL. | 15380210 |
Ki (binding) | = 110 uM | Tested for inhibitory effect on human liver cathepsin L | ChEMBL. | 15380210 |
Ki (binding) | = 180 uM | Tested for inhibitory effect on human liver cathepsin B | ChEMBL. | 15380210 |
Ki (binding) | = 240 uM | Tested for inhibitory effect on Paramecium tetraurelia cathepsin L | ChEMBL. | 15380210 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
12 literature references were collected for this gene.