Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0027 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.1192 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0137 | 0.1017 | 0.1017 |
Echinococcus granulosus | geminin | 0.0181 | 0.139 | 0.1233 |
Brugia malayi | thymidylate synthase | 0.0335 | 0.2708 | 0.2708 |
Brugia malayi | MH2 domain containing protein | 0.0127 | 0.0935 | 0.0935 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.1192 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0127 | 0.0935 | 0.0861 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0267 | 0.009 |
Mycobacterium tuberculosis | Hypothetical protein | 0.016 | 0.1211 | 0.0216 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.1192 | 1 | 1 |
Plasmodium falciparum | adenosylhomocysteinase | 0.1192 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0472 | 0.3873 | 0.3822 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.1192 | 1 | 1 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.1192 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0472 | 0.3873 | 0.3822 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.1192 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.016 | 0.1211 | 0.1211 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.0267 | 0.0267 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.016 | 0.1211 | 0.1139 |
Echinococcus granulosus | thymidylate synthase | 0.0335 | 0.2708 | 0.2575 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0374 | 0.3038 | 0.2079 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0267 | 0.009 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0738 | 0.6132 | 0.6062 |
Schistosoma mansoni | dihydrofolate reductase | 0.0137 | 0.1017 | 0.0853 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0267 | 0.009 |
Onchocerca volvulus | 0.0335 | 0.2708 | 0.5 | |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0137 | 0.1017 | 0.0943 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0472 | 0.3873 | 0.3822 |
Schistosoma mansoni | adenosylhomocysteinase | 0.1192 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0267 | 0.009 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0267 | 0.009 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0472 | 0.3873 | 0.3822 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.139 | 0.1233 |
Echinococcus granulosus | dihydrofolate reductase | 0.0137 | 0.1017 | 0.0853 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.139 | 0.1233 |
Mycobacterium ulcerans | thymidylate synthase | 0.0335 | 0.2708 | 0.1883 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.1192 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0335 | 0.2708 | 0.1883 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0137 | 0.1017 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0472 | 0.3873 | 0.3822 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0738 | 0.6132 | 0.6062 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0335 | 0.2708 | 0.2575 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.1192 | 1 | 1 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.1192 | 1 | 1 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.1192 | 1 | 1 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.1192 | 1 | 1 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.1192 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0267 | 0.009 |
Loa Loa (eye worm) | thymidylate synthase | 0.0335 | 0.2708 | 0.2648 |
Brugia malayi | dihydrofolate reductase family protein | 0.0137 | 0.1017 | 0.1017 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.1192 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0127 | 0.0935 | 0.0861 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.0267 | 0.0188 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0179 | 0.0179 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.1192 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0738 | 0.6132 | 0.6062 |
Echinococcus granulosus | adenosylhomocysteinase | 0.1192 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0267 | 0.009 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.1192 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0137 | 0.1017 | 0.0853 |
Echinococcus multilocularis | geminin | 0.0181 | 0.139 | 0.1233 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0738 | 0.6132 | 0.6062 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0335 | 0.2708 | 0.1883 |
Echinococcus multilocularis | thymidylate synthase | 0.0335 | 0.2708 | 0.2575 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0472 | 0.3873 | 0.3822 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | 0 uM | Antiproliferative activity was evaluated using HCT-116 cells in WST-1 assay; ND is Not determined | ChEMBL. | 15225706 |
GI50 (functional) | 0 uM | Ability of compound to inhibit anchorage independent colony formation (soft agar growth assay) in HCT-116 cells; ND is Not determined | ChEMBL. | 15225706 |
Inhibition (functional) | = 6 % | Inhibitory activity in EGF-stimulated Elk1-luciferase reporter assay in HeLa cells at 20 uM | ChEMBL. | 15225706 |
Inhibition (functional) | = 6 % | Inhibitory activity in EGF-stimulated Elk1-luciferase reporter assay in HeLa cells at 20 uM | ChEMBL. | 15225706 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.