TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 521.605 | Formula: C27H23NO6S2
H donors: 1 H acceptors: 3 LogP: 5.47 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: COc1cccc(c1)COc1cc(ccc1OCc1ccccc1)/C=C/1\SC(=S)N(C1=O)CC(=O)O
InChi: 1S/C27H23NO6S2/c1-32-21-9-5-8-20(12-21)17-34-23-13-19(10-11-22(23)33-16-18-6-3-2-4-7-18)14-24-26(31)28(15-25(29)30)27(35)36-24/h2-14H,15-17H2,1H3,(H,29,30)/b24-14-
InChiKey: OFFVDSOJLJVRSA-OYKKKHCWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Candida albicans	similar to dolichyl-P-mannose:protein mannosyltransferase involved in mannosylation of serine and threonine residues	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	mannosyltransferase 1, putative	Get druggable targets OG5_131422	All targets in OG5_131422
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_131422	All targets in OG5_131422
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_131422	All targets in OG5_131422
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_131422	All targets in OG5_131422
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_131422	All targets in OG5_131422
Trichomonas vaginalis	mannosyltransferase 1, putative	Get druggable targets OG5_131422	All targets in OG5_131422
Trichomonas vaginalis	mannosyltransferase 1, putative	Get druggable targets OG5_131422	All targets in OG5_131422
Candida albicans	similar to dolichyl-P-mannose:protein mannosyltransferase involved in mannosylation of serine and threonine residues	Get druggable targets OG5_131422	All targets in OG5_131422
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_131422	All targets in OG5_131422
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_131422	All targets in OG5_131422
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_131422	All targets in OG5_131422
Candida albicans	similar to dolichyl-P-mannose:protein mannosyltransferase involved in mannosylation of serine and threonine residues	Get druggable targets OG5_131422	All targets in OG5_131422
Candida albicans	hypothetical protein	Get druggable targets OG5_131422	All targets in OG5_131422

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0097	0.0227
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0018	0.0097	0.0227
Plasmodium falciparum	glutathione reductase	0.0052	0.0483	0.6816
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.042	0.4983
Schistosoma mansoni	tyrosine kinase	0.0251	0.2718	0.31
Echinococcus granulosus	Niemann Pick C1 protein	0.0156	0.1647	0.1882
Brugia malayi	hypothetical protein	0.0011	0.0016	0.0015
Toxoplasma gondii	bifunctional GMP synthase/glutamine amidotransferase protein	0.0072	0.0701	0.1906
Plasmodium falciparum	GMP synthase [glutamine-hydrolyzing]	0.0072	0.0701	1
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0109	0.112	1
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0011	0.0016	0.0189
Leishmania major	GMP synthase, putative,glutamine amidotransferase, putative	0.0072	0.0701	0.1718
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.0014
Echinococcus granulosus	sterol regulatory element binding protein	0.0047	0.042	0.0476
Brugia malayi	glutathione reductase	0.0052	0.0483	0.055
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0047	0.042	0.0476
Brugia malayi	Protein kinase domain containing protein	0.0251	0.2718	0.311
Trypanosoma brucei	NAD+ synthase, putative	0.002	0.0112	0.0268
Mycobacterium ulcerans	NAD synthetase	0.002	0.0112	0.1408
Entamoeba histolytica	NAD synthetase, putative	0.002	0.0112	0.0873
Brugia malayi	hypothetical protein	0.0011	0.0016	0.0015
Echinococcus granulosus	stromal cell derived factor 2	0.0031	0.024	0.027
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.007	0.0683	0.0778
Brugia malayi	Furin-like cysteine rich region family protein	0.0787	0.8732	1
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.0031	0.024	0.0272
Echinococcus multilocularis	protein patched	0.0047	0.042	0.0416
Loa Loa (eye worm)	hypothetical protein	0.0031	0.024	0.027
Trypanosoma cruzi	GMP synthase, putative	0.0024	0.016	0.0401
Trichomonas vaginalis	mannosyltransferase 1, putative	0.0085	0.0842	1
Trypanosoma brucei	fructose-1,6-bisphosphatase	0.0331	0.3608	1
Brugia malayi	MIR domain containing protein	0.0031	0.024	0.0272
Trichomonas vaginalis	glutathione reductase, putative	0.0018	0.0097	0.1157
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0423	0.4642	0.5314
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0251	0.2718	0.3109
Plasmodium vivax	GMP synthetase, putative	0.0072	0.0701	1
Schistosoma mansoni	hypothetical protein	0.0018	0.009	0.0085
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0031	0.024	0.0257
Trypanosoma cruzi	NAD+ synthase, putative	0.002	0.0112	0.0268
Schistosoma mansoni	tyrosine kinase	0.0418	0.4592	0.525
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0018	0.0097	0.1191
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.012	0.1238	0.8837
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.009	0.01
Entamoeba histolytica	hypothetical protein	0.004	0.0342	0.2949
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0018	0.0097	0.0227
Echinococcus multilocularis	dnaJ subfamily B	0.0454	0.4991	0.4989
Trichomonas vaginalis	conserved hypothetical protein	0.0085	0.0842	1
Echinococcus granulosus	thioredoxin glutathione reductase	0.0052	0.0483	0.0548
Brugia malayi	TAR-binding protein	0.007	0.0683	0.0779
Schistosoma mansoni	tar DNA-binding protein	0.007	0.0683	0.0765
Echinococcus granulosus	nibrin	0.0011	0.0016	0.0014
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0011	0.0016	0.0189
Schistosoma mansoni	stromal cell-derived factor 2 precursor-like protein	0.0031	0.024	0.0257
Schistosoma mansoni	cpg binding protein	0.0034	0.0272	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0047	0.042	0.0476
Echinococcus granulosus	insulin receptor	0.0251	0.2718	0.3109
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0052	0.0483	0.2985
Plasmodium vivax	glutathione reductase, putative	0.0052	0.0483	0.6816
Brugia malayi	fructose-1,6-bisphosphatase	0.0331	0.3608	0.413
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0018	0.0097	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.009	0.0086
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0018	0.0097	0.846
Echinococcus granulosus	replication factor c subunit 1	0.0011	0.0016	0.0014
Brugia malayi	topoisomerase	0.0011	0.0016	0.0015
Schistosoma mansoni	patched 1	0.0047	0.042	0.0463
Trichomonas vaginalis	nh(3)-dependent NAD(+) synthetase, putative	0.002	0.0112	0.1333
Trypanosoma brucei	trypanothione reductase	0.0052	0.0483	0.1299
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0083	0.0984
Entamoeba histolytica	hypothetical protein	0.004	0.0342	0.2949
Schistosoma mansoni	hypothetical protein	0.0018	0.009	0.0085
Schistosoma mansoni	tyrosine kinase	0.0787	0.8732	1
Loa Loa (eye worm)	thioredoxin reductase	0.0052	0.0483	0.0548
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0083	0.0984
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0018	0.0097	0.0227
Trichomonas vaginalis	mannosyltransferase 1, putative	0.0017	0.0083	0.0984
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.0331	0.3608	1
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0016	0.0189
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0018	0.0097	0.0227
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0083	0.0984
Loa Loa (eye worm)	TK/INSR protein kinase	0.0251	0.2718	0.3109
Schistosoma mansoni	glutamine-dependent NAD(+) synthetase	0.002	0.0112	0.0111
Toxoplasma gondii	glutamine-dependent NAD(+) synthetase protein, putative	0.002	0.0112	0.0268
Loa Loa (eye worm)	glutathione reductase	0.0052	0.0483	0.0548
Mycobacterium tuberculosis	Probable GMP synthase [glutamine-hydrolyzing] GuaA (glutamine amidotransferase) (GMP synthetase)	0.0026	0.0191	0.0722
Schistosoma mansoni	tyrosine kinase	0.0251	0.2718	0.31
Trichomonas vaginalis	mannosyltransferase, putative	0.0017	0.0083	0.0984
Plasmodium falciparum	thioredoxin reductase	0.0052	0.0483	0.6816
Schistosoma mansoni	ryanodine receptor related	0.0031	0.024	0.0257
Schistosoma mansoni	hypothetical protein	0.0045	0.0401	0.0442
Trichomonas vaginalis	mannosyltransferase 1, putative	0.0085	0.0842	1
Echinococcus multilocularis	expressed conserved protein	0.0103	0.1046	0.1042
Echinococcus multilocularis	ryanodine receptor 44f	0.0031	0.024	0.0236
Echinococcus granulosus	fructose 16 bisphosphatase 1	0.0331	0.3608	0.4129
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.0014
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0097	0.0227
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.012	0.1238	0.8906
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0018	0.0097	0.0109
Toxoplasma gondii	thioredoxin reductase	0.0052	0.0483	0.1299
Toxoplasma gondii	sedoheptulose-1,7-bisphosphatase	0.0123	0.1275	0.3504
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0013	0.0043	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0083	0.0984
Mycobacterium ulcerans	GMP synthase	0.0072	0.0701	1
Onchocerca volvulus		0.0032	0.0251	1
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0018	0.0097	0.1191
Echinococcus granulosus	Niemann Pick C1 protein	0.0109	0.112	0.1279
Schistosoma mansoni	tyrosine kinase	0.0423	0.4642	0.5308
Trichomonas vaginalis	conserved hypothetical protein	0.0085	0.0842	1
Giardia lamblia	NH3-dependent NAD+ synthetase	0.002	0.0112	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.012	0.1238	0.8837
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0011	0.0016	0.0189
Echinococcus granulosus	dnaJ subfamily B	0.0454	0.4991	0.5714
Echinococcus multilocularis	fructose 1,6 bisphosphatase 1	0.0331	0.3608	0.3605
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0018	0.0097	0.0227
Echinococcus multilocularis	replication factor c subunit 1	0.0011	0.0016	0.0012
Trichomonas vaginalis	mannosyltransferase 1, putative	0.0031	0.024	0.2847
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0318	0.036
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.0123	0.1275	0.3504
Trypanosoma cruzi	trypanothione reductase, putative	0.0018	0.0097	0.0227
Schistosoma mansoni	hypothetical protein	0.0038	0.0318	0.0347
Brugia malayi	hypothetical protein	0.004	0.0342	0.0388
Schistosoma mansoni	tyrosine kinase	0.0418	0.4592	0.525
Plasmodium vivax	glutamine-dependent NAD(+) synthetase, putative	0.002	0.0112	0.1408
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0068	0.0652	0.073
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.009	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0031	0.024	0.027
Brugia malayi	Pax transcription activation domain interacting protein	0.0011	0.0016	0.0015
Brugia malayi	RNA recognition motif domain containing protein	0.007	0.0683	0.0779
Mycobacterium leprae	Probable GMP synthase [glutamine-hydrolyzing] GuaA (Glutamine amidotransferase) (GMP synthetase)	0.0026	0.0191	0.1273
Schistosoma mansoni	GMP synthetase	0.0072	0.0701	0.0785
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0342	0.0338
Mycobacterium leprae	Conserved membrane protein	0.0017	0.0083	0.0488
Echinococcus multilocularis	stromal cell derived factor 2	0.0031	0.024	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.0014
Onchocerca volvulus		0.0031	0.024	0.9519
Echinococcus granulosus	expressed conserved protein	0.0103	0.1046	0.1194
Mycobacterium tuberculosis	Probable oxidoreductase	0.0133	0.1388	1
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0083	0.0984
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0342	0.0374
Plasmodium falciparum	thioredoxin reductase	0.0018	0.0097	0.1191
Echinococcus multilocularis		0.0244	0.2629	0.2626
Loa Loa (eye worm)	RNA binding protein	0.007	0.0683	0.0778
Echinococcus granulosus	GMP synthase glutamine hydrolyzing	0.0072	0.0701	0.0798
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0055	0.0515	0.0585
Echinococcus granulosus	cpg binding protein	0.0034	0.0272	0.0307
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0083	0.0984
Toxoplasma gondii	NADPH-glutathione reductase	0.0018	0.0097	0.0227
Brugia malayi	GMP synthase	0.0072	0.0701	0.08
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0013	0.0043	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.0085	0.0842	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0132	0.1381	0.1578
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0016	0.0189
Echinococcus granulosus	tar DNA binding protein	0.007	0.0683	0.0778
Schistosoma mansoni	tar DNA-binding protein	0.007	0.0683	0.0765
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0097	0.0227
Echinococcus granulosus	epidermal growth factor receptor	0.0787	0.8732	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.009	0.0098
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0251	0.2718	0.2715
Brugia malayi	CHE-14 protein	0.0047	0.042	0.0478
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.012	0.1238	0.8837
Echinococcus multilocularis	nibrin	0.0011	0.0016	0.0012
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0083	0.0984
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0018	0.0097	0.1191
Echinococcus multilocularis	epidermal growth factor receptor	0.0423	0.4642	0.464
Loa Loa (eye worm)	MH2 domain-containing protein	0.0132	0.1381	0.1578
Entamoeba histolytica	MIR domain protein	0.0031	0.024	0.2028
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.009	0.0086
Toxoplasma gondii	fructose-bisphospatase II	0.0331	0.3608	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0787	0.8732	0.8732
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0097	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0109	0.112	0.1279
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0016	0.0189
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0342	0.0387
Echinococcus granulosus	Protein patched homolog 1	0.0047	0.042	0.0476
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0133	0.1388	1
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.0011	0.0016	0.0015
Brugia malayi	cation channel family protein	0.0031	0.024	0.0272
Schistosoma mansoni	tyrosine kinase	0.0418	0.4592	0.525
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.0014
Mycobacterium tuberculosis	Probable reductase	0.012	0.1238	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0515	0.0585
Trichomonas vaginalis	conserved hypothetical protein	0.0085	0.0842	1
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0083	0.0984
Schistosoma mansoni	cpg binding protein	0.0032	0.0251	0.027
Schistosoma mansoni	fructose-16-bisphosphatase-related	0.0331	0.3608	0.4121
Echinococcus multilocularis	GPCR, family 2	0.0018	0.009	0.0086
Treponema pallidum	NADH oxidase	0.0018	0.0097	0.846
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0055	0.0515	0.0586
Echinococcus multilocularis	cpg binding protein	0.0034	0.0272	0.0268
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.012	0.1238	0.8837
Echinococcus granulosus	GPCR family 2	0.0018	0.009	0.0098
Trichomonas vaginalis	mannosyltransferase 1, putative	0.0017	0.0083	0.0984
Schistosoma mansoni	tar DNA-binding protein	0.007	0.0683	0.0765
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0083	0.0984
Trichomonas vaginalis	replication factor C large subunit, putative	0.0011	0.0016	0.0189
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0016	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0031	0.024	0.027
Mycobacterium leprae	PROBABLE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE NADE (NAD(+) SYNTHASE [GLUTAMINE-HYDROLYSING])	0.002	0.0112	0.0703
Mycobacterium tuberculosis	Glutamine-dependent NAD(+) synthetase NadE (NAD(+) synthase [glutamine-hydrolysing])	0.002	0.0112	0.0115
Echinococcus multilocularis	insulin receptor	0.0251	0.2718	0.2715
Treponema pallidum	NAD synthetase	0.002	0.0112	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0133	0.1388	1
Echinococcus granulosus	ryanodine receptor 44f	0.0031	0.024	0.027
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.009	0.0098
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0011	0.0016	0.0189
Brugia malayi	Thioredoxin reductase	0.0052	0.0483	0.055
Trichomonas vaginalis	mercuric reductase, putative	0.0018	0.0097	0.1157
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.0123	0.1275	0.3504
Plasmodium vivax	thioredoxin reductase, putative	0.0052	0.0483	0.6816
Trypanosoma cruzi	GMP synthase [glutamine-hydrolysing]	0.0052	0.0481	0.1296
Echinococcus multilocularis	Niemann Pick C1 protein	0.0156	0.1647	0.1644
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0018	0.0097	0.0094
Echinococcus multilocularis	tar DNA binding protein	0.007	0.0683	0.0679
Trichomonas vaginalis	mannosyltransferase 1, putative	0.0085	0.0842	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.0014
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0018	0.0097	0.1751
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.0571	0.1546
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0018	0.0097	0.0107
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0318	0.0361
Trypanosoma cruzi	trypanothione reductase, putative	0.0052	0.0483	0.1299
Schistosoma mansoni	hypothetical protein	0.0018	0.009	0.0085
Mycobacterium ulcerans	hypothetical protein	0.0017	0.0083	0.0978
Schistosoma mansoni	hypothetical protein	0.0045	0.0401	0.0442
Schistosoma mansoni	hypothetical protein	0.0045	0.0401	0.0442
Brugia malayi	Niemann-Pick C1 protein precursor	0.0109	0.112	0.128
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0018	0.0097	0.1191
Leishmania major		0.0331	0.3608	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0018	0.0097	0.1751
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0018	0.0097	0.0227
Trichomonas vaginalis	mannosyltransferase 1, putative	0.0017	0.0083	0.0984
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.0011	0.0016	0.0000031374
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0251	0.0283
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0018	0.0097	0.1191
Echinococcus multilocularis	protein dispatched 1	0.0054	0.0494	0.049
Leishmania major	trypanothione reductase	0.0052	0.0483	0.1097
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.0331	0.3608	1
Schistosoma mansoni	hypothetical protein	0.0045	0.0401	0.0442
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0018	0.0097	0.0094
Echinococcus granulosus	epidermal growth factor receptor	0.0423	0.4642	0.5314
Trichomonas vaginalis	conserved hypothetical protein	0.0085	0.0842	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0133	0.1388	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0109	0.112	0.1117
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0787	0.8732	1
Plasmodium falciparum	glutathione reductase	0.0018	0.0097	0.1191
Schistosoma mansoni	tar DNA-binding protein	0.007	0.0683	0.0765
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.009	0.01
Loa Loa (eye worm)	hypothetical protein	0.0018	0.009	0.0098
Entamoeba histolytica	hypothetical protein	0.004	0.0342	0.2949
Trypanosoma cruzi	NAD+ synthase, putative	0.002	0.0112	0.0268
Trichomonas vaginalis	conserved hypothetical protein	0.0085	0.0842	1
Trypanosoma brucei	sedoheptulose-1,7-bisphosphatase	0.0123	0.1275	0.3504
Loa Loa (eye worm)	fructose-1,6-bisphosphatase	0.0331	0.3608	0.4129
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0097	0.0227
Echinococcus multilocularis	GMP synthase (glutamine hydrolyzing)	0.0072	0.0701	0.0697
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0055	0.0515	0.0586
Schistosoma mansoni	hypothetical protein	0.0018	0.009	0.0085
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0052	0.0483	0.0479
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0018	0.0097	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0538	0.0612
Entamoeba histolytica	hypothetical protein	0.004	0.0342	0.2949
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0083	0.0984
Wolbachia endosymbiont of Brugia malayi	GMP synthase	0.0052	0.0481	1
Brugia malayi	RNA binding protein	0.007	0.0683	0.0779
Toxoplasma gondii	ATPase, AAA family protein	0.0011	0.0016	0.00000096464
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0016	0.0189
Trypanosoma brucei	GMP synthase [glutamine-hydrolysing]	0.0072	0.0701	0.1906
Echinococcus multilocularis	sterol regulatory element binding protein	0.0047	0.042	0.0416
Loa Loa (eye worm)	MIR domain-containing protein	0.0031	0.024	0.027
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0111	0.1139	0.1289
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.012	0.1238	0.8837
Brugia malayi	MH2 domain containing protein	0.0132	0.1381	0.1579
Trichomonas vaginalis	conserved hypothetical protein	0.0085	0.0842	1
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0018	0.0097	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0701	0.0798
Schistosoma mansoni	tar DNA-binding protein	0.007	0.0683	0.0765
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0018	0.0097	0.1191
Trichomonas vaginalis	mannosyltransferase 1, putative	0.0017	0.0083	0.0984
Brugia malayi	DKFZp564C0469 protein	0.0011	0.0016	0.0015
Schistosoma mansoni	chromosome transmission fidelity factor	0.0011	0.0016	0.00000039751
Toxoplasma gondii	fructose-bisphospatase I	0.0123	0.1275	0.3504
Schistosoma mansoni	tyrosine kinase	0.0423	0.4642	0.5308
Schistosoma mansoni	cpg binding protein	0.0034	0.0272	0.0293
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0251	0.0285
Schistosoma mansoni	hypothetical protein	0.0454	0.4991	0.5708
Loa Loa (eye worm)	TAR-binding protein	0.007	0.0683	0.0778
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0018	0.0097	0.1191
Leishmania major	NAD synthase, putative	0.002	0.0112	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.0014
Plasmodium falciparum	glutamine-dependent NAD(+) synthetase, putative	0.002	0.0112	0.1408
Schistosoma mansoni	hypothetical protein	0.004	0.0342	0.0374

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 7.5 uM	In vitro inhibition of Candida albicans protein mannosyl transferase 1	ChEMBL.	15225710
IC50 (binding)	= 7.5 uM	In vitro inhibition of Candida albicans protein mannosyl transferase 1	ChEMBL.	15225710
IC50 (functional)	> 100 uM	In vitro inhibition of Candida albicans G418-sensitive proliferation	ChEMBL.	15225710
IC50 (functional)	> 100 uM	In vitro inhibition of Candida albicans G418-sensitive proliferation	ChEMBL.	15225710

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL361547

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 321520