TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 228.243 | Formula: C14H12O3
H donors: 0 H acceptors: 2 LogP: 1.95 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: O=C1C(=C2OCCc3c2c(C1=O)c(C)cc3)C
InChi: 1S/C14H12O3/c1-7-3-4-9-5-6-17-14-8(2)12(15)13(16)10(7)11(9)14/h3-4H,5-6H2,1-2H3
InChiKey: LVDJCCWQOQWPKZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0041	0.0212	0.0153
Schistosoma mansoni	glutamate receptor NMDA	0.0027	0.0101	0.0079
Schistosoma mansoni	nAChR subunit	0.0076	0.0489	0.0468
Brugia malayi	Hexokinase family protein	0.0397	0.3017	0.3009
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0069	0.0435	0.0424
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.0027	0.0101	0.009
Schistosoma mansoni	nAChR subunit	0.0035	0.0166	0.0143
Brugia malayi	Guanylyl cyclase protein 23	0.0027	0.0101	0.009
Onchocerca volvulus		0.0076	0.0489	0.0432
Schistosoma mansoni	metabotropic glutamate receptor	0.024	0.1785	0.1766
Echinococcus granulosus	nAChR subunit	0.0041	0.0212	0.0201
Loa Loa (eye worm)	LGC-31 protein	0.0076	0.0489	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0212	0.0201
Schistosoma mansoni	dimethyladenosine transferase	0.0022	0.006	0.0038
Trichomonas vaginalis	dimethyladenosine transferase, putative	0.0022	0.006	0.1146
Loa Loa (eye worm)	hypothetical protein	0.0408	0.3103	0.3095
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0076	0.0489	0.0479
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0027	0.0101	0.009
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0076	0.0489	0.0479
Onchocerca volvulus		0.0041	0.0212	0.0153
Brugia malayi	Receptor family ligand binding region containing protein	0.0027	0.0101	0.009
Plasmodium vivax	DNA gyrase subunit B, putative	0.0026	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0101	0.009
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0078	0.05	0.0489
Brugia malayi	Cation transporter family protein	0.0076	0.0489	0.0479
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0027	0.0101	0.009
Wolbachia endosymbiont of Brugia malayi	DNA gyrase, topoisomerase II, B subunit, GyrB	0.0026	0.009	1
Echinococcus granulosus	dimethyladenosine transferase	0.0022	0.006	0.0049
Trypanosoma brucei	polo-like protein kinase	0.0069	0.0435	0.0377
Echinococcus multilocularis	nAChR subunit	0.0076	0.0489	0.0479
Schistosoma mansoni	nAChR subunit	0.0076	0.0489	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0101	0.009
Schistosoma mansoni	dimethyladenosine transferase	0.0022	0.006	0.0038
Entamoeba histolytica	hypothetical protein	0.0041	0.0212	0.0153
Schistosoma mansoni	hypothetical protein	0.0047	0.0256	0.0234
Echinococcus granulosus	survival motor neuron protein 1	0.0174	0.1258	0.1248
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0076	0.0489	0.0479
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0035	0.0166	0.0154
Schistosoma mansoni	nAChR subunit	0.0076	0.0489	0.0468
Leishmania major	extracellular receptor, putative	0.0027	0.0101	0.0041
Plasmodium falciparum	dimethyladenosine transferase, putative	0.0022	0.006	0.006
Loa Loa (eye worm)	GABA receptor subunit	0.0041	0.0212	0.0201
Entamoeba histolytica	hexokinase 1	0.1282	1	1
Plasmodium vivax	hexokinase, putative	0.1282	1	1
Echinococcus granulosus	hexokinase	0.1282	1	1
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0061	0.0369	0.0311
Schistosoma mansoni	nAChR subunit	0.0076	0.0489	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0353	0.2676	0.2668
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0299	0.0288
Schistosoma mansoni	nAChR subunit	0.0076	0.0489	0.0468
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0076	0.0489	0.0479
Loa Loa (eye worm)	acetylcholine receptor protein	0.0035	0.0166	0.0154
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0206	0.1513	0.1503
Schistosoma mansoni	neurotransmitter gated ion channel	0.0035	0.0166	0.0143
Echinococcus granulosus	hexokinase type 2	0.1282	1	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0166	0.0154
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0074	0.0469	0.0458
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0353	0.2676	0.2668
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0076	0.0489	0.0479
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0027	0.0101	0.0041
Onchocerca volvulus		0.0035	0.0166	0.0106
Loa Loa (eye worm)	glutamate receptor	0.0113	0.0779	0.0769
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0489	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0022	0.006	0.0049
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0206	0.1513	0.1503
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0035	0.0166	0.0154
Onchocerca volvulus		0.0076	0.0489	0.0432
Brugia malayi	hypothetical protein	0.0027	0.0101	0.009
Echinococcus multilocularis	dimethyladenosine transferase	0.0022	0.006	0.0049
Entamoeba histolytica	hexokinase 2	0.1282	1	1
Leishmania major	mitochondrial DNA topoisomerase II	0.0061	0.0369	0.0311
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0035	0.0166	0.0154
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0076	0.0489	0.0479
Wolbachia endosymbiont of Brugia malayi	dimethyladenosine transferase	0.0022	0.006	0.6727
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0041	0.0212	0.0201
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0206	0.1513	0.1503
Treponema pallidum	dimethyladenosine transferase	0.0022	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0489	0.0479
Echinococcus granulosus	atrial natriuretic peptide receptor	0.0027	0.0101	0.009
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0074	0.0469	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0166	0.0154
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0035	0.0166	0.0154
Brugia malayi	hypothetical protein	0.0035	0.0166	0.0154
Chlamydia trachomatis	DNA gyrase subunit B	0.0026	0.009	0.407
Onchocerca volvulus	Hexokinase homolog	0.0804	0.6232	0.6209
Mycobacterium ulcerans	dimethyladenosine transferase	0.0022	0.006	0.0545
Trichomonas vaginalis	CAMK family protein kinase	0.0069	0.0435	0.8698
Trichomonas vaginalis	CAMK family protein kinase	0.0069	0.0435	0.8698
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0489	0.0479
Schistosoma mansoni	tyrosine kinase	0.0027	0.0101	0.0079
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0076	0.0489	0.0479
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0041	0.0212	0.0201
Brugia malayi	excitatory GABA receptor EXP-1A	0.0076	0.0489	0.0479
Chlamydia trachomatis	DNA gyrase subunit B	0.0042	0.022	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0076	0.0489	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0166	0.0154
Loa Loa (eye worm)	ACC-1 protein	0.0076	0.0489	0.0479
Echinococcus multilocularis	dimethyladenosine transferase	0.0022	0.006	0.0049
Echinococcus multilocularis	glycine receptor subunit beta	0.0076	0.0489	0.0479
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0035	0.0166	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0489	0.0479
Plasmodium falciparum	DNA topoisomerase 2	0.0078	0.05	0.05
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0159	0.0147
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0206	0.1513	0.1503
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0206	0.1513	0.1503
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.007	0.0439	0.0381
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0035	0.0166	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0212	0.0201
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0076	0.0489	0.0468
Loa Loa (eye worm)	TOPoisomerase family member	0.0078	0.05	0.0489
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0326	0.2463	0.2446
Schistosoma mansoni	metabotropic glutamate receptor	0.014	0.0992	0.0972
Schistosoma mansoni	neurotransmitter gated ion channel	0.0041	0.0212	0.019
Echinococcus granulosus	dimethyladenosine transferase	0.0022	0.006	0.0049
Mycobacterium tuberculosis	Probable 23S rRNA methyltransferase Erm(37)	0.0022	0.006	0.0545
Trypanosoma brucei	hexokinase, putative	0.1282	1	1
Loa Loa (eye worm)	glutamate receptor	0.0287	0.2153	0.2144
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0166	0.0154
Schistosoma mansoni	survival motor neuron protein	0.0035	0.0168	0.0145
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0056	0.0332	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0101	0.009
Schistosoma mansoni	nAChR subunit	0.0076	0.0489	0.0468
Toxoplasma gondii	ribosomal RNA (adenine(1779)-N(6)/adenine(1780)-N(6))- dimethyltransferase, putative	0.0022	0.006	0.006
Schistosoma mansoni	hexokinase	0.1282	1	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0076	0.0489	0.0468
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0076	0.0489	0.0468
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0027	0.0101	0.009
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0076	0.0489	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0166	0.0154
Trichomonas vaginalis	CAMK family protein kinase	0.0069	0.0435	0.8698
Trichomonas vaginalis	CAMK family protein kinase	0.0069	0.0435	0.8698
Trypanosoma cruzi	extracellular receptor, putative	0.0027	0.0101	0.0041
Echinococcus multilocularis	nmda type glutamate receptor	0.0027	0.0101	0.009
Chlamydia trachomatis	rRNA small subunit methyltransferase A	0.0022	0.006	0.2738
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0041	0.0212	0.0201
Echinococcus multilocularis	hexokinase	0.1282	1	1
Mycobacterium tuberculosis	DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0026	0.009	0.0811
Onchocerca volvulus	Poor gastrulation protein homolog	0.0047	0.0256	0.0197
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0027	0.0101	0.009
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0076	0.0489	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0166	0.0154
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0035	0.0166	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0212	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0101	0.009
Echinococcus granulosus	hexokinase	0.1282	1	1
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0061	0.0369	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0489	0.0479
Toxoplasma gondii	hexokinase	0.1282	1	1
Echinococcus granulosus	nAChR subunit	0.0076	0.0489	0.0479
Entamoeba histolytica	hypothetical protein	0.0027	0.0101	0.0041
Onchocerca volvulus		0.0076	0.0489	0.0432
Echinococcus granulosus	tyrosine kinase	0.0027	0.0101	0.009
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0027	0.0101	0.009
Brugia malayi	hexokinase type II	0.0408	0.3103	0.3095
Toxoplasma gondii	DNA topoisomerase 2, putative	0.0078	0.05	0.05
Echinococcus multilocularis	glutamate receptor 2	0.0027	0.0101	0.009
Loa Loa (eye worm)	hypothetical protein	0.0022	0.006	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0019	0.0008
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0047	0.0256	0.0245
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0076	0.0489	0.0479
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0206	0.1513	0.1503
Trypanosoma cruzi	hexokinase, putative	0.1282	1	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0212	0.0201
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.026	0.194	0.1931
Mycobacterium tuberculosis	Probable oxidoreductase	0.0154	0.1107	1
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0069	0.0435	0.0424
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0076	0.0489	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0299	0.0288
Echinococcus granulosus	receptor type guanylyl cyclase	0.0027	0.0101	0.009
Loa Loa (eye worm)	ribosomal RNA adenine dimethylase	0.0022	0.006	0.0049
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0078	0.05	0.0489
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0166	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0019	0.0008
Onchocerca volvulus		0.1282	1	1
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0027	0.0101	0.009
Trypanosoma brucei	hexokinase	0.1282	1	1
Giardia lamblia	Kinase, PLK	0.0069	0.0435	0.9087
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0076	0.0489	0.0479
Onchocerca volvulus		0.0076	0.0489	0.0432
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0076	0.0489	0.0468
Loa Loa (eye worm)	hexokinase	0.0804	0.6232	0.6228
Schistosoma mansoni	neurotransmitter gated ion channel	0.0035	0.0166	0.0143
Plasmodium falciparum	DNA gyrase subunit B	0.0026	0.009	0.009
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0035	0.0166	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0212	0.0201
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0076	0.0489	0.0479
Echinococcus granulosus	nmda type glutamate receptor	0.0027	0.0101	0.009
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0166	0.0154
Onchocerca volvulus		0.0076	0.0489	0.0432
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0027	0.0101	0.009
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0069	0.0435	0.0424
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0489	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0101	0.009
Trypanosoma brucei	hexokinase	0.1282	1	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0166	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0101	0.009
Onchocerca volvulus		0.0035	0.0166	0.0106
Schistosoma mansoni	protein kinase	0.0027	0.0101	0.0079
Echinococcus multilocularis	glycine receptor subunit beta	0.0076	0.0489	0.0479
Onchocerca volvulus	Putative DNA topoisomerase 2, mitochondrial	0.0056	0.0332	0.0273
Onchocerca volvulus		0.1282	1	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0035	0.0166	0.0154
Trichomonas vaginalis	CAMK family protein kinase	0.0069	0.0435	0.8698
Plasmodium falciparum	hexokinase	0.1282	1	1
Trypanosoma cruzi	polo-like protein kinase, putative	0.0069	0.0435	0.0377
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0035	0.0168	0.0156
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0027	0.0101	0.009
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0041	0.0212	0.019
Schistosoma mansoni	acetylcholine receptor-related	0.0035	0.0166	0.0143
Onchocerca volvulus		0.0804	0.6232	0.6209
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.007	0.0439	0.0381
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0076	0.0489	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0469	0.0458
Onchocerca volvulus		0.0027	0.0101	0.0041
Echinococcus granulosus	glycine receptor subunit beta	0.0076	0.0489	0.0479
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0035	0.0166	0.0154
Echinococcus granulosus	glutamate receptor 2	0.0027	0.0101	0.009
Loa Loa (eye worm)	hypothetical protein	0.0174	0.1258	0.1248
Trichomonas vaginalis	DNA topoisomerase II, putative	0.0078	0.05	1
Brugia malayi	Cation transporter family protein	0.0076	0.0489	0.0479
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0078	0.05	0.0489
Mycobacterium ulcerans	DNA gyrase subunit B	0.0026	0.009	0.0811
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0035	0.0166	0.0143
Toxoplasma gondii	dimethyladenosine transferase	0.0022	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0408	0.3103	0.3095
Brugia malayi	Cation transporter family protein	0.0076	0.0489	0.0479
Brugia malayi	Hexokinase family protein	0.0804	0.6232	0.6228
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0041	0.0212	0.019
Onchocerca volvulus		0.0076	0.0489	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0166	0.0154
Plasmodium vivax	dimethyladenosine transferase, putative	0.0022	0.006	0.006
Echinococcus granulosus	glutamate receptor 2	0.0027	0.0101	0.009
Loa Loa (eye worm)	hexokinase	0.1282	1	1
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0076	0.0489	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0489	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0166	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0489	0.0479
Brugia malayi	Probable DNA topoisomerase II	0.0078	0.05	0.0489
Brugia malayi	hypothetical protein	0.0174	0.1258	0.1248
Schistosoma mansoni	kinase	0.0035	0.0166	0.0144
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0076	0.0489	0.0479
Trichomonas vaginalis	CAMK family protein kinase	0.0069	0.0435	0.8698
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0076	0.0489	0.0479
Trichomonas vaginalis	CAMK family protein kinase	0.0034	0.0159	0.3137
Schistosoma mansoni	serine/threonine protein kinase	0.0069	0.0435	0.0414
Trypanosoma cruzi	polo-like protein kinase, putative	0.0069	0.0435	0.0377
Trypanosoma cruzi	DNA topoisomerase II, putative	0.007	0.0439	0.0381
Brugia malayi	metabotropic glutamate receptor type 2	0.014	0.0992	0.0982
Giardia lamblia	DNA topoisomerase II	0.0074	0.0473	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0019	0.0008
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0027	0.0101	0.009
Echinococcus granulosus	hexokinase	0.1282	1	1
Leishmania major	DNA topoisomerase ii	0.007	0.0439	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0489	0.0479
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0076	0.0489	0.0479
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0076	0.0489	0.0479
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0069	0.0435	0.0377
Plasmodium vivax	DNA topoisomerase II, putative	0.0078	0.05	0.05
Treponema pallidum	hexokinase (hxk)	0.1282	1	1
Echinococcus multilocularis	hexokinase	0.1282	1	1
Echinococcus multilocularis	nAChR subunit	0.0041	0.0212	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0489	0.0479
Onchocerca volvulus		0.1282	1	1
Schistosoma mansoni	DNA topoisomerase II	0.0078	0.05	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0212	0.0201
Brugia malayi	Hexokinase family protein	0.1282	1	1
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0069	0.0435	0.0377
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0076	0.0489	0.0479
Onchocerca volvulus	Putative nachr subunit	0.0206	0.1513	0.1462
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0056	0.0332	0.0273
Schistosoma mansoni	tyrosine kinase	0.0027	0.0101	0.0079
Loa Loa (eye worm)	hexokinase	0.1282	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0069	0.0435	0.8698
Onchocerca volvulus		0.0027	0.0101	0.0041
Trichomonas vaginalis	CAMK family protein kinase	0.0034	0.0159	0.3137
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0076	0.0489	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0489	0.0479
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0076	0.0489	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0101	0.009
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0489	0.0479
Loa Loa (eye worm)	ACC-1 protein	0.0076	0.0489	0.0479
Brugia malayi	hypothetical protein	0.0035	0.0166	0.0154
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0076	0.0489	0.0479
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0078	0.05	0.0489
Trypanosoma cruzi	DNA topoisomerase II, putative	0.007	0.0439	0.0381
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0027	0.0101	0.009
Echinococcus multilocularis	survival motor neuron protein 1	0.0174	0.1258	0.1248
Brugia malayi	Receptor family ligand binding region containing protein	0.0074	0.0469	0.0458
Schistosoma mansoni	nAChR subunit	0.0035	0.0166	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0489	0.0479
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0035	0.0166	0.0154
Echinococcus multilocularis	tyrosine kinase	0.0027	0.0101	0.009
Schistosoma mansoni	nAChR subunit	0.0076	0.0489	0.0468
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0636	0.4908	0.4908
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0212	0.0201
Loa Loa (eye worm)	hexokinase	0.0397	0.3017	0.3009
Brugia malayi	hypothetical protein	0.0035	0.0166	0.0154
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0076	0.0489	0.0479
Trypanosoma brucei	DNA topoisomerase ii	0.0061	0.0369	0.0311
Brugia malayi	hypothetical protein	0.0035	0.0166	0.0154
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0076	0.0489	0.0479
Echinococcus multilocularis	glutamate receptor 2	0.0027	0.0101	0.009
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0076	0.0489	0.0479
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0076	0.0489	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0489	0.0479
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0035	0.0166	0.0154
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0353	0.2676	0.2668
Mycobacterium ulcerans	short chain dehydrogenase	0.0154	0.1107	1
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0035	0.0166	0.0154
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0076	0.0489	0.0479
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0041	0.0212	0.0201
Trypanosoma cruzi	hexokinase, putative	0.1282	1	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0212	0.0201
Loa Loa (eye worm)	metabotropic glutamate receptor 8	0.0027	0.0101	0.009
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0076	0.0489	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0166	0.0154
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0027	0.0101	0.009
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.024	0.1785	0.1776
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0027	0.0101	0.009
Brugia malayi	ribosomal RNA adenine dimethylase family protein	0.0022	0.006	0.0049
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0076	0.0489	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0874	0.6785	0.6781
Brugia malayi	hypothetical protein	0.0035	0.0166	0.0154
Leishmania major	hexokinase, putative	0.1282	1	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0166	0.0154
Brugia malayi	Probable dimethyladenosine transferase	0.0022	0.006	0.0049
Treponema pallidum	DNA gyrase, subunit B (gyrB)	0.0026	0.009	0.009
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0076	0.0489	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0166	0.0154
Plasmodium falciparum	apicoplast dimethyladenosine synthase, putative	0.0022	0.006	0.006
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0076	0.0489	0.0479
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0287	0.2153	0.2144
Onchocerca volvulus	Metabotropic glutamate receptor homolog	0.0047	0.0256	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0212	0.0201
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0206	0.1513	0.1503
Plasmodium vivax	dimethyladenosine transferase, putative	0.0022	0.006	0.006
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0076	0.0489	0.0479
Echinococcus granulosus	glycine receptor subunit beta	0.0076	0.0489	0.0479
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0026	0.009	0.009
Onchocerca volvulus		0.0035	0.0166	0.0106
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0069	0.0435	0.0377
Entamoeba histolytica	DNA topoisomerase II, putative	0.0078	0.05	0.0442
Loa Loa (eye worm)	hexokinase type II	0.1282	1	1
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0206	0.1513	0.1503
Echinococcus granulosus	GPCR family 3 C terminal	0.0047	0.0256	0.0245
Leishmania major	hexokinase, putative	0.1282	1	1
Echinococcus multilocularis	hexokinase	0.1282	1	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0166	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0206	0.1513	0.1503
Echinococcus granulosus	metabotropic glutamate receptor 2	0.024	0.1785	0.1776
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0489	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0489	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0159	0.0147
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0027	0.0101	0.009
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0256	0.0245
Brugia malayi	serine/threonine-protein kinase plk-2	0.0069	0.0435	0.0424
Echinococcus multilocularis	hexokinase type 2	0.1282	1	1
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0076	0.0489	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0489	0.0479
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0076	0.0489	0.0468
Onchocerca volvulus		0.0035	0.0168	0.0108
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0076	0.0489	0.0479
Schistosoma mansoni	hypothetical protein	0.0035	0.0168	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0489	0.0479
Echinococcus multilocularis	GPCR, family 3, C terminal	0.0047	0.0256	0.0245

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC50 (functional)	= 16 ug ml-1	Minimum inhibitory concentration of the compound against methicillin-resistant Staphylococcus aureus	ChEMBL.	15357984
MIC90 (functional)	= 16 ug ml-1	Minimum inhibitory concentration of the compound against methicillin-resistant Staphylococcus aureus	ChEMBL.	15357984

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL182528

Bibliographic References

No literature references available for this target.

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Detailed information for compound 321596