Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nitric oxide synthase 1 (neuronal) | Starlite/ChEMBL | References |
Homo sapiens | nitric oxide synthase 2, inducible | Starlite/ChEMBL | References |
Homo sapiens | nitric oxide synthase 3 (endothelial cell) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0091 | 0.4858 | 0.4293 |
Echinococcus granulosus | histone deacetylase 6 | 0.0126 | 0.8574 | 0.8395 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0091 | 0.4858 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0126 | 0.8574 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0126 | 0.8574 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0126 | 0.8574 | 0.8574 |
Trypanosoma brucei | histone deacetylase 4 | 0.0126 | 0.8574 | 1 |
Giardia lamblia | Hypothetical protein | 0.0081 | 0.3745 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0081 | 0.3745 | 0.6018 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0065 | 0.2063 | 0.1274 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0056 | 0.1113 | 0.1113 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0126 | 0.8574 | 0.8395 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0126 | 0.8574 | 1 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0065 | 0.2063 | 0.1069 |
Echinococcus granulosus | histone deacetylase 1 | 0.0065 | 0.2063 | 0.1069 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0065 | 0.2063 | 0.1274 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0139 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase | 0.0126 | 0.8574 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0091 | 0.4858 | 0.4214 |
Echinococcus multilocularis | histone deacetylase | 0.0126 | 0.8574 | 0.8395 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0091 | 0.4858 | 0.4858 |
Leishmania major | p450 reductase, putative | 0.0091 | 0.4858 | 0.4293 |
Brugia malayi | Histone deacetylase family protein | 0.0126 | 0.8574 | 1 |
Trypanosoma brucei | histone deacetylase, putative | 0.0126 | 0.8574 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0081 | 0.3745 | 1 |
Plasmodium falciparum | histone deacetylase, putative | 0.0126 | 0.8574 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0139 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0091 | 0.4858 | 0.4293 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0091 | 0.4858 | 0.4293 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.3004 | 0.2535 |
Leishmania major | histone deacetylase, putative | 0.0126 | 0.8574 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0091 | 0.4858 | 0.4293 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0091 | 0.4858 | 0.4293 |
Echinococcus granulosus | histone deacetylase 7 | 0.0126 | 0.8574 | 0.8395 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0126 | 0.8574 | 0.8574 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0065 | 0.2063 | 0.1069 |
Echinococcus granulosus | histone deacetylase | 0.0126 | 0.8574 | 0.8395 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0126 | 0.8574 | 0.8395 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0091 | 0.4858 | 0.4293 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0065 | 0.2063 | 0.1069 |
Leishmania major | cytochrome P450 reductase, putative | 0.0081 | 0.3745 | 0.2583 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0091 | 0.4858 | 0.4293 |
Brugia malayi | Histone deacetylase family protein | 0.0126 | 0.8574 | 1 |
Brugia malayi | flavodoxin family protein | 0.0091 | 0.4858 | 0.502 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0091 | 0.4858 | 0.4293 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0126 | 0.8574 | 0.8395 |
Schistosoma mansoni | histone deacetylase | 0.0065 | 0.2063 | 0.2063 |
Chlamydia trachomatis | sulfite reductase | 0.0056 | 0.1113 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0091 | 0.4858 | 0.4214 |
Plasmodium vivax | histone deacetylase, putative | 0.0126 | 0.8574 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0091 | 0.4858 | 0.4293 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0065 | 0.2063 | 0.1274 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0091 | 0.4858 | 0.4214 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0065 | 0.2063 | 0.5 |
Echinococcus granulosus | histone deacetylase 3 | 0.0065 | 0.2063 | 0.1069 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.2063 | 0.1274 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0091 | 0.4858 | 0.502 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.1578 | 0.0623 |
Leishmania major | histone deacetylase, putative | 0.0126 | 0.8574 | 1 |
Brugia malayi | Histone deacetylase 1 | 0.0065 | 0.2063 | 0.1274 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.4858 | 0.502 |
Entamoeba histolytica | histone deacetylase, putative | 0.0065 | 0.2063 | 0.5 |
Brugia malayi | histone deacetylase 11 | 0.0065 | 0.2063 | 0.1274 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0065 | 0.2063 | 0.2063 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0065 | 0.2063 | 0.1274 |
Trypanosoma brucei | histone deacetylase 3 | 0.0126 | 0.8574 | 1 |
Plasmodium falciparum | histone deacetylase 2 | 0.0126 | 0.8574 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0126 | 0.8574 | 0.8395 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0091 | 0.4858 | 0.4293 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0126 | 0.8574 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0091 | 0.4858 | 0.502 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0126 | 0.8574 | 1 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0065 | 0.2063 | 0.1274 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0065 | 0.2063 | 0.2063 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0091 | 0.4858 | 1 |
Echinococcus granulosus | histone deacetylase 8 | 0.0065 | 0.2063 | 0.1069 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0126 | 0.8574 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0091 | 0.4858 | 0.4214 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.2063 | 0.1274 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0081 | 0.3745 | 0.2583 |
Schistosoma mansoni | histone deacetylase | 0.0065 | 0.2063 | 0.2063 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0091 | 0.4858 | 0.4293 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.3 uM | Inhibitory activity against Inducible nitric oxide synthase | ChEMBL. | 15357988 |
IC50 (binding) | = 1.3 uM | Inhibitory activity against Inducible nitric oxide synthase | ChEMBL. | 15357988 |
IC50 (binding) | = 1.9 uM | Inhibitory activity against Endothelial nitric oxide synthase | ChEMBL. | 15357988 |
IC50 (binding) | = 1.9 uM | Inhibitory activity against Endothelial nitric oxide synthase | ChEMBL. | 15357988 |
IC50 (binding) | = 3.1 uM | Inhibitory activity against Neuronal nitric oxide synthase | ChEMBL. | 15357988 |
IC50 (binding) | = 3.1 uM | Inhibitory activity against Neuronal nitric oxide synthase | ChEMBL. | 15357988 |
Ratio (binding) | = 1.4 uM | Ratio between Endothelial nitric oxide synthase and Inducible nitric oxide synthase | ChEMBL. | 15357988 |
Ratio (binding) | = 1.4 uM | Ratio between Endothelial nitric oxide synthase and Inducible nitric oxide synthase | ChEMBL. | 15357988 |
Ratio (binding) | = 2.3 uM | Ratio between Neuronal nitric oxide synthase and Inducible nitric oxide synthase | ChEMBL. | 15357988 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.