Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Metabotropic glutamate receptor 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0031 | 0.0297 | 0.0184 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0031 | 0.0297 | 0.29 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.0743 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0031 | 0.0297 | 0.29 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0031 | 0.0297 | 0.2897 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.0911 | 0.0805 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1026 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 0.1026 | 0.0751 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.006 | 0.1026 | 0.0817 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0387 | 0.9221 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0031 | 0.0297 | 0.0184 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0297 | 0.2897 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0031 | 0.0297 | 0.0184 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0031 | 0.0297 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0297 | 0.2897 |
Schistosoma mansoni | thyroid hormone receptor | 0.0419 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0031 | 0.0297 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0031 | 0.0297 | 0.2897 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0031 | 0.0297 | 0.29 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0031 | 0.0297 | 0.29 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0297 | 0.2897 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0297 | 0.2897 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0031 | 0.0297 | 0.29 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0297 | 0.2897 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0031 | 0.0297 | 0.29 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0297 | 0.2897 |
Schistosoma mansoni | hypothetical protein | 0.0387 | 0.9221 | 0.9212 |
Loa Loa (eye worm) | glutamate receptor | 0.0049 | 0.0743 | 0.7241 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0031 | 0.0297 | 0.0184 |
Brugia malayi | nuclear receptor NHR-88 | 0.0031 | 0.0297 | 0.29 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0031 | 0.0297 | 0.2897 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0031 | 0.0297 | 0.29 |
Schistosoma mansoni | coup transcription factor | 0.0031 | 0.0297 | 0.0184 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0041 | 0.0544 | 0.0277 |
Onchocerca volvulus | 0.0031 | 0.0297 | 0.5 | |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0044 | 0.0628 | 0.8166 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0031 | 0.0297 | 0.0184 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0031 | 0.0297 | 0.0184 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0031 | 0.0297 | 0.29 |
Brugia malayi | nuclear hormone receptor | 0.0031 | 0.0297 | 0.29 |
Schistosoma mansoni | nuclear hormone receptor | 0.0031 | 0.0297 | 0.0184 |
Schistosoma mansoni | thyroid hormone receptor | 0.0419 | 1 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0031 | 0.0297 | 0.29 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0387 | 0.9221 | 0.9197 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0031 | 0.0297 | 0.29 |
Brugia malayi | steroid hormone receptor | 0.0031 | 0.0297 | 0.29 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0031 | 0.0297 | 0.29 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0031 | 0.0297 | 0.2897 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0031 | 0.0297 | 0.29 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0031 | 0.0297 | 0.29 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0041 | 0.0544 | 0.0254 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0031 | 0.0297 | 0.2897 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0297 | 0.2897 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0041 | 0.0544 | 0.0434 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0031 | 0.0297 | 0.29 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0031 | 0.0297 | 0.0184 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0031 | 0.0297 | 0.29 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0297 | 0.2897 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0031 | 0.0297 | 0.0184 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0031 | 0.0297 | 0.2897 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0031 | 0.0297 | 0.29 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0031 | 0.0297 | 0.2897 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0031 | 0.0297 | 0.0184 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0031 | 0.0297 | 0.2897 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0031 | 0.0297 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0031 | 0.0297 | 0.29 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.29 uM | Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay | ChEMBL. | 15686891 |
IC50 (binding) | = 0.29 uM | Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay | ChEMBL. | 15686891 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.