Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Voltage-gated L-type calcium channel alpha-1D subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0322 | 0.1343 | 0.5 | |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0551 | 0.3667 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1174 | 1 | 0.5 |
Onchocerca volvulus | 0.0322 | 0.1343 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.1343 | 0.1343 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.1343 | 0.1343 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1174 | 1 | 0.5 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1174 | 1 | 0.5 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0483 | 0.2982 | 0.2982 |
Echinococcus granulosus | translocator protein | 0.0322 | 0.1343 | 0.1343 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0483 | 0.2982 | 0.2982 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0483 | 0.2982 | 0.2982 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0551 | 0.3667 | 1 |
Schistosoma mansoni | peripheral-type benzodiazepine receptor | 0.0322 | 0.1343 | 0.1343 |
Loa Loa (eye worm) | hypothetical protein | 0.0483 | 0.2982 | 0.2982 |
Echinococcus multilocularis | protein dispatched 1 | 0.0483 | 0.2982 | 0.2982 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0483 | 0.2982 | 0.2982 |
Brugia malayi | TspO/MBR family protein | 0.0322 | 0.1343 | 0.1343 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0483 | 0.2982 | 0.2982 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1174 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.1343 | 0.1343 |
Onchocerca volvulus | 0.0322 | 0.1343 | 0.5 | |
Brugia malayi | CHE-14 protein | 0.0483 | 0.2982 | 0.2982 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1174 | 1 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0483 | 0.2982 | 0.2982 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0551 | 0.3667 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1174 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0551 | 0.3667 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1174 | 1 | 1 |
Schistosoma mansoni | patched 1 | 0.0483 | 0.2982 | 0.2982 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0483 | 0.2982 | 0.2982 |
Onchocerca volvulus | 0.0322 | 0.1343 | 0.5 | |
Echinococcus multilocularis | translocator protein | 0.0322 | 0.1343 | 0.1343 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1174 | 1 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1174 | 1 | 1 |
Echinococcus multilocularis | protein patched | 0.0483 | 0.2982 | 0.2982 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.1343 | 0.1343 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = -6.87 | Inhibition of [3H]-nitrendipine binding to L-type [Ca2+] channel in rat cortex homogenate, activity expressed as pIC50 | ChEMBL. | 9016337 |
Log IC50 (binding) | = 6.87 | Inhibition of [3H]-nitrendipine binding to L-type [Ca2+] channel in rat cortex homogenate, activity expressed as pIC50 | ChEMBL. | 9016337 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.