Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0243 | 0.4665 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0511 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0081 | 0.0081 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.0792 | 0.0792 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.0711 | 0.0711 |
Echinococcus granulosus | thymidylate synthase | 0.0511 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.0081 | 0.0081 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0081 | 0.0081 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0511 | 1 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.0653 | 0.1399 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0594 | 0.0594 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0511 | 1 | 0.5 |
Onchocerca volvulus | 0.0511 | 1 | 0.5 | |
Mycobacterium ulcerans | thymidylate synthase | 0.0511 | 1 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0511 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0511 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0511 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0243 | 0.4665 | 0.4665 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.0711 | 0.0711 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.0711 | 0.0711 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0511 | 1 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0511 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0511 | 1 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0081 | 0.0081 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.0653 | 0.1399 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.0711 | 0.0711 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.0792 | 0.0792 |
Loa Loa (eye worm) | thymidylate synthase | 0.0511 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.0081 | 0.0081 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0511 | 1 | 0.5 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.0081 | 0.0081 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.0081 | 0.0081 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.005 uM | Inhibition of human ERG potassium channel | ChEMBL. | 18243713 |
IC50 (binding) | = 0.25 uM | Inhibitory concentration against IKr potassium channel | ChEMBL. | 15324906 |
IC50 (binding) | = 0.25 uM | Inhibitory concentration against IKr potassium channel | ChEMBL. | 15324906 |
Km (binding) | = 970 uM | Drug glucuronidation reaction catalyzed by human recombinant UGT2B7 | ChEMBL. | 15781124 |
Km (binding) | = 1060 uM | Drug glucuronidation reaction catalyzed by human recombinant UGT1A9 | ChEMBL. | 15781124 |
Vmax (binding) | = 21 pmol/min/mg protein | Drug glucuronidation reaction catalyzed by human recombinant UGT2B7 | ChEMBL. | 15781124 |
Vmax (binding) | = 92 pmol/min/mg protein | Drug glucuronidation reaction catalyzed by human recombinant UGT1A9 | ChEMBL. | 15781124 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.