Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanin-concentrating hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0416 | 1 |
Brugia malayi | hypothetical protein | 0.002 | 0.0416 | 1 |
Brugia malayi | hypothetical protein | 0.002 | 0.0416 | 1 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.002 | 0.0416 | 0.0682 |
Loa Loa (eye worm) | doublecortin family protein | 0.002 | 0.0416 | 1 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.002 | 0.0416 | 0.0682 |
Leishmania major | oxidoreductase-like protein | 0.0013 | 0 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.002 | 0.0416 | 0.0682 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0013 | 0 | 0.5 |
Leishmania major | pteridine reductase 1 | 0.0013 | 0 | 0.5 |
Trypanosoma brucei | pteridine reductase 1 | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | loxhd1 | 0.002 | 0.0416 | 0.0682 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0416 | 0.0682 |
Trichomonas vaginalis | hypothetical protein | 0.0185 | 1 | 0.5 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.002 | 0.0416 | 0.0682 |
Onchocerca volvulus | 0.002 | 0.0416 | 1 | |
Brugia malayi | Doublecortin family protein | 0.002 | 0.0416 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0416 | 1 |
Onchocerca volvulus | 0.002 | 0.0416 | 1 | |
Echinococcus multilocularis | RUN | 0.002 | 0.0416 | 0.0682 |
Schistosoma mansoni | polycystin 1-related | 0.002 | 0.0416 | 0.0682 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0013 | 0 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0118 | 0.611 | 1 |
Schistosoma mansoni | rab6-interacting | 0.002 | 0.0416 | 0.0682 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0118 | 0.611 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0185 | 1 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.002 | 0.0416 | 0.0416 |
Schistosoma mansoni | lipoxygenase | 0.0083 | 0.4053 | 0.6633 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.002 | 0.0416 | 0.0682 |
Schistosoma mansoni | rab6-interacting | 0.002 | 0.0416 | 0.0682 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.002 | 0.0416 | 0.0416 |
Echinococcus granulosus | RUN | 0.002 | 0.0416 | 0.0682 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0185 | 1 | 1 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0013 | 0 | 0.5 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0013 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0185 | 1 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0185 | 1 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0185 | 1 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0185 | 1 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0118 | 0.611 | 1 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.002 | 0.0416 | 0.0682 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0013 | 0 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0185 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.71 uM | Binding affinity against human Melanin-concentrating hormone receptor 1 stably transfected CHO cells was determined using scintillation proximity assay (SPA) | ChEMBL. | 15380202 |
IC50 (binding) | = 0.71 uM | Binding affinity against human Melanin-concentrating hormone receptor 1 stably transfected CHO cells was determined using scintillation proximity assay (SPA) | ChEMBL. | 15380202 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.