Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | corticotropin releasing hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Schistosoma japonicum | IPR001879,Hormone receptor, extracellular,domain-containing | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | corticotropin releasing hormone receptor 1 | 444 aa | 445 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | thymidylate synthase | 0.0109 | 0.0201 | 0.0201 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.11 | 0.423 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.11 | 0.423 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0245 | 0.0753 | 0.0753 |
Loa Loa (eye worm) | thymidylate synthase | 0.0109 | 0.0201 | 0.0201 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.11 | 0.423 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.2518 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2518 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.11 | 0.423 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.2518 | 1 | 1 |
Onchocerca volvulus | 0.0109 | 0.0201 | 0.5 | |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.11 | 0.423 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.11 | 0.423 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.2518 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.0753 | 0.0753 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2518 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.2518 | 1 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.2518 | 1 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0204 | 0.0586 | 0.0393 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0204 | 0.0586 | 0.0393 |
Schistosoma mansoni | dihydrofolate reductase | 0.2518 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.2518 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.