Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0014 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0014 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0014 | 0.5 | 0.5 | |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0014 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0014 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0014 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 86 uM | Antagonistic activity against HOXA1-PBX1/DNA complex formation by electrophoretic mobility shift assay | ChEMBL. | 15225688 |
IC50 (functional) | = 142 uM | Antagonistic activity against BRN1/DNA interaction by electrophoretic mobility shift assay | ChEMBL. | 15225688 |
IC50 (functional) | = 142 uM | Antagonistic activity against BRN1/DNA interaction by electrophoretic mobility shift assay | ChEMBL. | 15225688 |
IC50 (functional) | = 148 uM | Antagonistic activity against BRN2/DNA interaction by electrophoretic mobility shift assay | ChEMBL. | 15225688 |
IC50 (functional) | = 148 uM | Antagonistic activity against BRN2/DNA interaction by electrophoretic mobility shift assay | ChEMBL. | 15225688 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.