Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldo keto reductase | 0.0454 | 0.2746 | 0.2746 |
Onchocerca volvulus | 0.0454 | 0.2746 | 1 | |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.0217 | 0.1167 | 0.2655 |
Loa Loa (eye worm) | oxidoreductase | 0.0454 | 0.2746 | 0.2746 |
Plasmodium vivax | purine nucleoside phosphorylase, putative | 0.0217 | 0.1167 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.0116 | 0.0116 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0454 | 0.2746 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0217 | 0.1167 | 0.1167 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0217 | 0.1167 | 0.2655 |
Toxoplasma gondii | aldo/keto reductase family oxidoreductase | 0.0132 | 0.0596 | 0.1826 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0217 | 0.1167 | 0.1167 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0217 | 0.1167 | 0.2655 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0217 | 0.1167 | 0.1167 |
Brugia malayi | purine nucleoside phosphorylase I, inosine and guanosine-specific family protein | 0.0217 | 0.1167 | 0.1167 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0454 | 0.2746 | 1 |
Onchocerca volvulus | 0.0454 | 0.2746 | 1 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0454 | 0.2746 | 0.2746 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0217 | 0.1167 | 0.1167 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0217 | 0.1167 | 0.1167 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0454 | 0.2746 | 1 |
Treponema pallidum | uridine phosphorylase (udp) | 0.0217 | 0.1167 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0454 | 0.2746 | 1 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0217 | 0.1167 | 0.2655 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0454 | 0.2746 | 0.2746 |
Loa Loa (eye worm) | S-methyl-5'-thioadenosine phosphorylase MTAP | 0.0217 | 0.1167 | 0.1167 |
Entamoeba histolytica | aldose reductase, putative | 0.0454 | 0.2746 | 1 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0217 | 0.1167 | 0.2655 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0217 | 0.1167 | 0.1167 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0217 | 0.1167 | 0.2655 |
Mycobacterium tuberculosis | Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase | 0.0217 | 0.1167 | 0.3996 |
Toxoplasma gondii | phosphorylase family protein | 0.0217 | 0.1167 | 0.3996 |
Echinococcus multilocularis | uridine phosphorylase 1 | 0.1544 | 1 | 1 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0217 | 0.1167 | 0.1167 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0454 | 0.2746 | 0.2746 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0454 | 0.2746 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0217 | 0.1167 | 0.1167 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0454 | 0.2746 | 0.2746 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0454 | 0.2746 | 0.2746 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0454 | 0.2746 | 1 |
Leishmania major | aldo/keto reductase, putative,aldo/keto reductase family-like protein | 0.0132 | 0.0596 | 0.1826 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0217 | 0.1167 | 0.3996 |
Loa Loa (eye worm) | oxidoreductase | 0.0454 | 0.2746 | 0.2746 |
Loa Loa (eye worm) | oxidoreductase | 0.0454 | 0.2746 | 0.2746 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0217 | 0.1167 | 0.2655 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0454 | 0.2746 | 0.2746 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0217 | 0.1167 | 0.2655 |
Leishmania major | prostaglandin f synthase, putative | 0.0454 | 0.2746 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.0454 | 0.2746 | 1 |
Schistosoma mansoni | uridine phosphorylase | 0.1544 | 1 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0454 | 0.2746 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0454 | 0.2746 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0217 | 0.1167 | 0.2655 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0217 | 0.1167 | 0.1167 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0217 | 0.1167 | 0.2655 |
Brugia malayi | glutamate-cysteine ligase modifier subunit | 0.0132 | 0.0596 | 0.0596 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0217 | 0.1167 | 0.2655 |
Echinococcus granulosus | voltage gated potassium channel subunit | 0.0132 | 0.0596 | 0.0596 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0454 | 0.2746 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0454 | 0.2746 | 0.2746 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0217 | 0.1167 | 0.1167 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0454 | 0.2746 | 1 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0217 | 0.1167 | 0.0607 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0454 | 0.2746 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0454 | 0.2746 | 0.2746 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0454 | 0.2746 | 1 |
Mycobacterium leprae | probable uridine phosphorylase | 0.1544 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0217 | 0.1167 | 0.1167 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0454 | 0.2746 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0454 | 0.2746 | 0.2746 |
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | 0.0217 | 0.1167 | 0.2655 |
Schistosoma mansoni | pol-related | 0.0454 | 0.2746 | 0.2746 |
Schistosoma mansoni | aldo-keto reductase | 0.0454 | 0.2746 | 0.2746 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0454 | 0.2746 | 0.2746 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0454 | 0.2746 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0217 | 0.1167 | 0.1167 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0217 | 0.1167 | 0.2655 |
Leishmania major | methylthioadenosine phosphorylase, putative | 0.0217 | 0.1167 | 0.3996 |
Leishmania major | nucleoside phosphorylase-like protein | 0.0217 | 0.1167 | 0.3996 |
Entamoeba histolytica | aldose reductase, putative | 0.0454 | 0.2746 | 1 |
Echinococcus multilocularis | voltage gated potassium channel subunit | 0.0132 | 0.0596 | 0.0596 |
Loa Loa (eye worm) | glutamate-cysteine ligase modifier subunit | 0.0132 | 0.0596 | 0.0596 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0454 | 0.2746 | 0.2746 |
Echinococcus multilocularis | aldo keto reductase | 0.0454 | 0.2746 | 0.2746 |
Mycobacterium ulcerans | 5'-methylthioadenosine phosphorylase | 0.0217 | 0.1167 | 0.3996 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0217 | 0.1167 | 0.3996 |
Toxoplasma gondii | aldo-keto reductase | 0.0132 | 0.0596 | 0.1826 |
Onchocerca volvulus | 0.0454 | 0.2746 | 1 | |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0217 | 0.1167 | 0.1167 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.0116 | 0.0116 |
Schistosoma mansoni | uridine phosphorylase | 0.1544 | 1 | 1 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0217 | 0.1167 | 0.2655 |
Brugia malayi | NADH-dependent xylose reductase | 0.0132 | 0.0596 | 0.0596 |
Onchocerca volvulus | 0.0454 | 0.2746 | 1 | |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0454 | 0.2746 | 0.2287 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0454 | 0.2746 | 0.2746 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.0217 | 0.1167 | 0.2655 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0454 | 0.2746 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.0454 | 0.2746 | 1 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.0217 | 0.1167 | 0.3996 |
Trypanosoma cruzi | aldo-keto reductase | 0.0454 | 0.2746 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0454 | 0.2746 | 1 |
Echinococcus granulosus | uridine phosphorylase 1 | 0.1544 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0454 | 0.2746 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0454 | 0.2746 | 0.2746 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0323 | 0.1869 | 0.1354 |
Loa Loa (eye worm) | oxidoreductase | 0.0454 | 0.2746 | 0.2746 |
Mycobacterium ulcerans | bifunctional Mta/Sah nucleosidase Mtn | 0.0217 | 0.1167 | 0.3996 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0454 | 0.2746 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0217 | 0.1167 | 0.1167 |
Echinococcus granulosus | methylthioadenosine phosphorylase | 0.0217 | 0.1167 | 0.1167 |
Toxoplasma gondii | phosphorylase family protein | 0.0217 | 0.1167 | 0.3996 |
Giardia lamblia | Aldose reductase | 0.0454 | 0.2746 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0217 | 0.1167 | 0.2655 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0116 | 0.0116 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0217 | 0.1167 | 0.1167 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0217 | 0.1167 | 0.3996 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0217 | 0.1167 | 0.2655 |
Entamoeba histolytica | MTA/SAH nucleosidase, putative | 0.0217 | 0.1167 | 0.2655 |
Echinococcus multilocularis | methylthioadenosine phosphorylase | 0.0217 | 0.1167 | 0.1167 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0454 | 0.2746 | 0.2746 |
Toxoplasma gondii | oxidoreductase, aldo/keto reductase family protein | 0.0132 | 0.0596 | 0.1826 |
Toxoplasma gondii | Purine nucleoside phosphorylase | 0.0217 | 0.1167 | 0.3996 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0454 | 0.2746 | 0.2746 |
Schistosoma mansoni | potassium channel beta | 0.0132 | 0.0596 | 0.0596 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0454 | 0.2746 | 0.2746 |
Entamoeba histolytica | hypothetical protein | 0.0217 | 0.1167 | 0.2655 |
Trypanosoma brucei | uridine phosphorylase | 0.0217 | 0.1167 | 0.2655 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0454 | 0.2746 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0454 | 0.2746 | 0.2746 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0217 | 0.1167 | 0.1167 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0454 | 0.2746 | 1 |
Treponema pallidum | pfs protein (pfs) | 0.0217 | 0.1167 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0454 | 0.2746 | 0.2746 |
Plasmodium falciparum | purine nucleoside phosphorylase | 0.0217 | 0.1167 | 1 |
Onchocerca volvulus | 0.0454 | 0.2746 | 1 | |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0116 | 0.0116 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0454 | 0.2746 | 0.2746 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0454 | 0.2746 | 0.2746 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0454 | 0.2746 | 0.2746 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0454 | 0.2746 | 0.2746 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0454 | 0.2746 | 0.2746 |
Loa Loa (eye worm) | uridine phosphorylase | 0.1544 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0217 | 0.1167 | 0.2655 |
Echinococcus multilocularis | aldehyde reductase | 0.0323 | 0.1869 | 0.1869 |
Giardia lamblia | Aldose reductase | 0.0454 | 0.2746 | 1 |
Echinococcus granulosus | aldo keto reductase family 1, member B4 | 0.0132 | 0.0596 | 0.0596 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0217 | 0.1167 | 0.2655 |
Onchocerca volvulus | 0.0454 | 0.2746 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0454 | 0.2746 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0217 | 0.1167 | 0.2655 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0217 | 0.1167 | 0.1167 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0454 | 0.2746 | 0.2746 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0217 | 0.1167 | 0.2655 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0454 | 0.2746 | 0.2746 |
Mycobacterium ulcerans | hypothetical protein | 0.0132 | 0.0596 | 0.1826 |
Echinococcus granulosus | aldehyde reductase | 0.0323 | 0.1869 | 0.1869 |
Mycobacterium ulcerans | oxidoreductase | 0.0454 | 0.2746 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0132 | 0.0596 | 0.1826 |
Loa Loa (eye worm) | oxidoreductase | 0.0454 | 0.2746 | 0.2746 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0454 | 0.2746 | 0.2746 |
Schistosoma mansoni | aldo-keto reductase | 0.0454 | 0.2746 | 0.2746 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0217 | 0.1167 | 0.1167 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0217 | 0.1167 | 0.1167 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0454 | 0.2746 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0454 | 0.2746 | 0.2746 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0217 | 0.1167 | 0.2655 |
Echinococcus multilocularis | aldo keto reductase | 0.0454 | 0.2746 | 0.2746 |
Chlamydia trachomatis | AMP nucleosidase | 0.0217 | 0.1167 | 0.5 |
Brugia malayi | MTAP | 0.0217 | 0.1167 | 0.1167 |
Loa Loa (eye worm) | hypothetical protein | 0.0454 | 0.2746 | 0.2746 |
Treponema pallidum | purine nucleoside phosphorylase (deoD) | 0.0217 | 0.1167 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0454 | 0.2746 | 0.2746 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0454 | 0.2746 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.0454 | 0.2746 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0454 | 0.2746 | 0.2746 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0454 | 0.2746 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MPC8 (functional) | > 32 ug ml-1 | In vitro minimum potentiation concentration to achieve an 8-fold reduction in fluconazole MIC against Candida albicans strain YEM15 (over-expressing both CDR1 and CDR2) | ChEMBL. | 15380214 |
MPC8 (functional) | > 32 ug ml-1 | In vitro minimum potentiation concentration to achieve an 8-fold reduction in fluconazole MIC against Candida glabrata strain YEM19 (over-expressing both CgDR1 and CgDR2) | ChEMBL. | 15380214 |
MPC8 (functional) | > 32 ug ml-1 | In vitro minimum potentiation concentration to achieve an 8-fold reduction in fluconazole MIC against Candida albicans strain YEM15 (over-expressing both CDR1 and CDR2) | ChEMBL. | 15380214 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.