Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sphingosine-1-phosphate receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | sphingosine-1-phosphate receptor 5 | Starlite/ChEMBL | References |
Homo sapiens | sphingosine-1-phosphate receptor 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3167 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0059 | 0.0078 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0059 | 0.0078 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0059 | 0.0078 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3167 | 1 | 1 |
Onchocerca volvulus | 0.005 | 0.0059 | 0.0092 | |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.2417 | 0.7609 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.2417 | 0.7609 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.2417 | 0.7609 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.2417 | 0.7609 | 1 |
Loa Loa (eye worm) | reduced folate carrier family protein | 0.005 | 0.0059 | 0.0078 |
Onchocerca volvulus | Folate transporter 1 homolog | 0.005 | 0.0059 | 0.0092 |
Echinococcus multilocularis | thymidylate synthase | 0.2057 | 0.6459 | 0.8489 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0059 | 0.0078 |
Onchocerca volvulus | 0.005 | 0.0059 | 0.0092 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3167 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.2417 | 0.7609 | 1 |
Onchocerca volvulus | 0.005 | 0.0059 | 0.0092 | |
Giardia lamblia | Hypothetical protein | 0.005 | 0.0059 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0059 | 0.0078 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0148 | 0.0372 | 0.0484 |
Onchocerca volvulus | Folate transporter 1 homolog | 0.005 | 0.0059 | 0.0092 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.2417 | 0.7609 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3167 | 1 | 1 |
Echinococcus multilocularis | folate receptor beta | 0.0829 | 0.2544 | 0.3344 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2417 | 0.7609 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.2417 | 0.7609 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0979 | 0.302 | 0.3966 |
Echinococcus granulosus | Major facilitator superfamily general substrate transporter | 0.0149 | 0.0374 | 0.0492 |
Onchocerca volvulus | 0.2057 | 0.6459 | 1 | |
Onchocerca volvulus | Folate transporter 1 homolog | 0.005 | 0.0059 | 0.0092 |
Mycobacterium ulcerans | thymidylate synthase | 0.2057 | 0.6459 | 0.8488 |
Entamoeba histolytica | hypothetical protein | 0.005 | 0.0059 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0979 | 0.302 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0064 | 0.0084 |
Onchocerca volvulus | 0.005 | 0.0059 | 0.0092 | |
Onchocerca volvulus | 0.0033 | 0.0004 | 0.0006 | |
Echinococcus multilocularis | dihydrofolate reductase | 0.2417 | 0.7609 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3167 | 1 | 0.5 |
Brugia malayi | Reduced folate carrier family protein | 0.005 | 0.0059 | 0.0078 |
Brugia malayi | hypothetical protein | 0.0979 | 0.302 | 0.3969 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.2057 | 0.6459 | 0.8488 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0059 | 0.0078 |
Echinococcus granulosus | folate receptor beta | 0.0829 | 0.2544 | 0.3344 |
Echinococcus granulosus | thymidylate synthase | 0.2057 | 0.6459 | 0.8489 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2057 | 0.6459 | 0.8489 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0148 | 0.0372 | 0.0484 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0059 | 0.0078 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0059 | 0.0078 |
Loa Loa (eye worm) | thymidylate synthase | 0.2057 | 0.6459 | 0.8489 |
Brugia malayi | thymidylate synthase | 0.2057 | 0.6459 | 0.8489 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0059 | 0.0078 |
Echinococcus multilocularis | Major facilitator superfamily, general substrate transporter | 0.0149 | 0.0374 | 0.0492 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.0374 | 0.0491 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0148 | 0.0372 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.2057 | 0.6459 | 0.8488 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2417 | 0.7609 | 1 |
Brugia malayi | folate-like transporter 3 | 0.005 | 0.0059 | 0.0078 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0059 | 0.0078 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | nM | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand; na denotes not active | ChEMBL. | 15341948 |
EC50 (binding) | nM | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand; na denotes not active | ChEMBL. | 15341948 |
EC50 (binding) | 0 nM | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 2 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand; na denotes not active | ChEMBL. | 15341948 |
EC50 (binding) | 0 nM | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 3 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand; na denotes not active | ChEMBL. | 15341948 |
EC50 (binding) | = 6.6 nM | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand; partial agonist | ChEMBL. | 15341948 |
EC50 (binding) | = 6.6 nM | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 5 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand; partial agonist | ChEMBL. | 15341948 |
EC50 (binding) | = 37 nM | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 1 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand; partial agonist | ChEMBL. | 15341948 |
EC50 (binding) | = 37 nM | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 1 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand; partial agonist | ChEMBL. | 15341948 |
EC50 (binding) | = 48 nM | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand | ChEMBL. | 15341948 |
EC50 (binding) | = 48 nM | In vitro binding affinity towards human Sphingosine 1-phosphate receptor 4 expressed in HEK293T cells was determined using [gamma-35S]-GTP as radioligand | ChEMBL. | 15341948 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.