Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, ionotropic, N-methyl-D-aspartate 3A | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | References | |
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Protein kinase domain containing protein | 0.0245 | 0.2311 | 0.2311 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0128 | 0.0583 | 0.0493 |
Loa Loa (eye worm) | TK/EPH protein kinase | 0.0155 | 0.0986 | 0.0986 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.035 | 0.3876 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0098 | 0.0137 | 0.0137 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0128 | 0.0583 | 0.0583 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0763 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.035 | 0.3876 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.035 | 0.3876 | 0.3876 |
Schistosoma mansoni | tyrosine kinase | 0.0245 | 0.2311 | 0.2311 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0098 | 0.0137 | 0.0042 |
Toxoplasma gondii | fructose-bisphospatase II | 0.035 | 0.3876 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.035 | 0.3876 | 0.3876 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0098 | 0.0137 | 0.0042 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0156 | 0.099 | 0.099 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.035 | 0.3876 | 0.3876 |
Echinococcus granulosus | insulin receptor | 0.0245 | 0.2311 | 0.2238 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0098 | 0.0137 | 0.0042 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0249 | 0.2377 | 0.2304 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.035 | 0.3876 | 0.3818 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0249 | 0.2377 | 0.2377 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0156 | 0.099 | 0.0904 |
Echinococcus multilocularis | 0.0236 | 0.2178 | 0.2178 | |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0245 | 0.2311 | 0.2311 |
Echinococcus granulosus | glutamate receptor 2 | 0.0098 | 0.0137 | 0.0042 |
Onchocerca volvulus | 0.0117 | 0.0424 | 0.5 | |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0098 | 0.0137 | 0.0137 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0104 | 0.0231 | 0.0231 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.0095 | 0.0095 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0763 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0098 | 0.0137 | 0.0137 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.041 | 0.4771 | 0.4771 |
Echinococcus granulosus | epidermal growth factor receptor | 0.041 | 0.4771 | 0.4722 |
Schistosoma mansoni | tyrosine kinase | 0.041 | 0.4771 | 0.4771 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.041 | 0.4771 | 0.4722 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0763 | 1 | 1 |
Echinococcus granulosus | ephrin type A receptor 4 A | 0.0136 | 0.0699 | 0.0611 |
Schistosoma mansoni | ephrin receptor | 0.0123 | 0.0508 | 0.0508 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.035 | 0.3876 | 0.3876 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0098 | 0.0137 | 0.0042 |
Echinococcus multilocularis | ephrin type A receptor 4 A | 0.0136 | 0.0699 | 0.0699 |
Schistosoma mansoni | tyrosine kinase | 0.041 | 0.4771 | 0.4771 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0104 | 0.0231 | 0.0138 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0098 | 0.0137 | 0.0137 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0156 | 0.099 | 0.099 |
Schistosoma mansoni | tyrosine kinase | 0.0405 | 0.4688 | 0.4688 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0098 | 0.0137 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0424 | 0.0424 |
Schistosoma mansoni | tyrosine kinase | 0.0245 | 0.2311 | 0.2311 |
Schistosoma mansoni | tyrosine kinase | 0.0763 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0405 | 0.4688 | 0.4688 |
Leishmania major | 0.035 | 0.3876 | 0.5 | |
Echinococcus multilocularis | insulin receptor | 0.0245 | 0.2311 | 0.2311 |
Schistosoma mansoni | tyrosine kinase | 0.0405 | 0.4688 | 0.4688 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.035 | 0.3876 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0193 | 0.155 | 0.155 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.5 mg kg-1 | Analgesic activity in po dosed mouse assessed as licking behavior measured after 20 to 25 mins by formalin test | ChEMBL. | 21453995 |
ED50 (functional) | = 0.5 mg kg-1 | In vivo analgesic activity was tested using formalin test in mouse upon p.o. administration | ChEMBL. | 15225705 |
ED50 (functional) | = 0.5 mg kg-1 | In vivo analgesic activity was tested using formalin test in mouse upon p.o. administration | ChEMBL. | 15225705 |
IC50 (binding) | = 15 nM | Inhibition of NMDA-evoked increased intracellular [Ca2+] in cells expressing NR1/NR2B receptor | ChEMBL. | 15225705 |
IC50 (binding) | = 15 nM | Inhibition of NMDA-evoked increased intracellular [Ca2+] in cells expressing NR1/NR2B receptor | ChEMBL. | 15225705 |
IC50 (binding) | = 54 nM | Inhibition of [3H]-Ro-25-6981 binding to NMDA receptor | ChEMBL. | 15225705 |
IC50 (binding) | = 54 nM | Inhibition of [3H]-Ro-25-6981 binding to NMDA receptor | ChEMBL. | 15225705 |
Inhibition (binding) | = 7 % | Inhibitory activity against recombinant NR1/NR2A receptor expressed in cells | ChEMBL. | 15225705 |
Inhibition (binding) | = 7 % | Inhibitory activity against recombinant NR1/NR2A receptor expressed in cells | ChEMBL. | 15225705 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.