Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0568 | 0.3957 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0568 | 0.3957 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1211 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0568 | 0.3957 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0568 | 0.3957 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0498 | 0.3303 | 0.3303 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0498 | 0.3303 | 0.3303 |
Echinococcus multilocularis | protein patched | 0.0498 | 0.3303 | 0.3303 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1211 | 1 | 0.5 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0498 | 0.3303 | 0.3303 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1211 | 1 | 0.5 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1211 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1211 | 1 | 0.5 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1211 | 1 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1211 | 1 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1211 | 1 | 0.5 |
Echinococcus multilocularis | protein dispatched 1 | 0.0498 | 0.3303 | 0.3303 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0498 | 0.3303 | 0.3303 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1211 | 1 | 1 |
Schistosoma mansoni | patched 1 | 0.0498 | 0.3303 | 0.3303 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0498 | 0.3303 | 0.3303 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0498 | 0.3303 | 0.3303 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 72 uM | In vitro inhibitory concentration against Chymotrypsin-like catalytic activity of the human 20S Proteasome | ChEMBL. | 11392546 |
IC50 (functional) | = 72 uM | In vitro inhibitory concentration against Chymotrypsin-like activity of the purified human placenta 20S Proteasome | ChEMBL. | 11392545 |
IC50 (functional) | = 72 uM | In vitro inhibitory concentration against Chymotrypsin-like catalytic activity of the human 20S Proteasome | ChEMBL. | 11392546 |
IC50 (functional) | = 72 uM | In vitro inhibitory concentration against Chymotrypsin-like activity of the purified human placenta 20S Proteasome | ChEMBL. | 11392545 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.