Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0258 | 0.0245 | 0.0145 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0658 | 0.7324 | 0.7257 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0809 | 1 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0658 | 0.7324 | 1 |
Leishmania major | 0.0658 | 0.7324 | 0.5 | |
Echinococcus multilocularis | insulin receptor | 0.0258 | 0.0245 | 0.0145 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0658 | 0.7324 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0658 | 0.7324 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0434 | 0.3366 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.043 | 0.3285 | 0.3117 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0809 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0809 | 1 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0658 | 0.7324 | 0.7257 |
Schistosoma mansoni | tyrosine kinase | 0.0809 | 1 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0658 | 0.7324 | 0.7257 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0434 | 0.3366 | 0.32 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0658 | 0.7324 | 0.7297 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0658 | 0.7324 | 0.7257 |
Schistosoma mansoni | tyrosine kinase | 0.0434 | 0.3366 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.043 | 0.3285 | 0.3117 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0434 | 0.3366 | 0.3299 |
Schistosoma mansoni | tyrosine kinase | 0.0434 | 0.3366 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.043 | 0.3285 | 0.3117 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0658 | 0.7324 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 8 ug ml-1 | Minimal inhibitory concentration of the compound against Enterococcus faecalis ATCC 29212 | ChEMBL. | 15324881 |
MIC (functional) | > 16 ug ml-1 | Minimal inhibitory concentration of the compound against Salmonella abony NCTC 6017 | ChEMBL. | 15324881 |
MIC (functional) | > 16 ug ml-1 | Minimal inhibitory concentration of the compound against Salmonella typhi (MDR) ICH 098 | ChEMBL. | 15324881 |
MIC (functional) | > 16 ug ml-1 | Minimal inhibitory concentration of the compound against Staphylococcus aureus ATCC 25923 | ChEMBL. | 15324881 |
MIC (functional) | = 16 ug ml-1 | Minimal inhibitory concentration of the compound against methicillin resistant Staphylococcus aureus ST450 | ChEMBL. | 15324881 |
MIC (functional) | > 16 ug ml-1 | Minimal inhibitory concentration of the compound against Bacillus cereus | ChEMBL. | 15324881 |
MIC (functional) | = 16 ug ml-1 | Minimal inhibitory concentration of the compound against Staphylococcus epidermidis ATCC 12228 | ChEMBL. | 15324881 |
MIC (functional) | = 16 ug ml-1 | Minimal inhibitory concentration of the compound against methicillin resistant Staphylococcus epidermidis ATCC 23760 | ChEMBL. | 15324881 |
MIC (functional) | = 16 ug ml-1 | Minimal inhibitory concentration of the compound against Enterococcus faecalis (VRE) ATCC 346-VRE | ChEMBL. | 15324881 |
MIC (functional) | > 16 ug ml-1 | Minimal inhibitory concentration of the compound against Enterococcus faecium 6A-VRE | ChEMBL. | 15324881 |
MIC (functional) | = 16 ug ml-1 | Minimal inhibitory concentration of the compound against Enterococcus durans ATCC 581 | ChEMBL. | 15324881 |
MIC (functional) | > 16 ug ml-1 | Minimal inhibitory concentration of the compound against Escherichia coli ATCC 25922 | ChEMBL. | 15324881 |
MIC (functional) | > 16 ug ml-1 | Minimal inhibitory concentration of the compound against Pseudomonas aeruginosa ATCC 27853 | ChEMBL. | 15324881 |
MIC (functional) | > 16 ug ml-1 | Minimal inhibitory concentration of the compound against Klebsiella pneumoniae ATCC 15380 | ChEMBL. | 15324881 |
MIC (functional) | > 16 ug ml-1 | Minimal inhibitory concentration of the compound against Serratia marcescens ATCC 12999 | ChEMBL. | 15324881 |
MIC (functional) | > 16 ug ml-1 | Minimal inhibitory concentration of the compound against Escherichia coli ATCC 25922 | ChEMBL. | 15324881 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.